| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Tang Capital Management LLC | 3,785,991 | -135,228 | 104,190,472.32 | 4.602 | 5.7453 | 06/30/2026 |
| 2 | Madison Avenue Partners LP | 3,447,807 | 1,234,638 | 94,883,648.64 | 4.0156 | 5.2321 | 06/30/2026 |
| 3 | Prosight Management LP | 2,043,344 | 969,232 | 56,232,826.88 | 9.1041 | 3.1008 | 06/30/2026 |
| 4 | EcoR1 Capital, LLC | 1,667,119 | 0 | 45,879,114.88 | 1.9386 | 2.5299 | 06/30/2026 |
| 5 | Columbia Management Investment Advisers LLC | 1,010,016 | -55,317 | 27,795,640.32 | 0.0057 | 1.5327 | 06/30/2026 |
| 6 | DME Capital Management LP | 482,746 | 0 | 13,285,169.92 | 0.3387 | 0.7326 | 06/30/2026 |
| 7 | Renaissance Technologies LLC | 407,800 | 97,200 | 11,222,656 | 0.015 | 0.6188 | 06/30/2026 |
| 8 | BlackRock Fund Advisors | 295,640 | 20,347 | 8,136,012.8 | 0.0001 | 0.4486 | 06/30/2026 |
| 9 | Point72 Asset Management LP | 269,814 | -216,395 | 7,425,281.28 | 0.0111 | 0.4094 | 06/30/2026 |
| 10 | Threadneedle Asset Management Ltd. | 262,233 | -123,673 | 7,216,652.16 | 0.01 | 0.3979 | 06/30/2026 |
| 11 | D. E. Shaw & Co. LP | 197,844 | -77,155 | 5,444,666.88 | 0.0033 | 0.3002 | 06/30/2026 |
| 12 | Millennium Management LLC | 181,090 | -158,264 | 4,983,596.8 | 0.0033 | 0.2748 | 06/30/2026 |
| 13 | UBS Securities LLC | 167,450 | -181,660 | 4,608,224 | 0.0017 | 0.2541 | 06/30/2026 |
| 14 | Susquehanna Financial Group LLLP | 151,886 | 144,918 | 4,179,902.72 | 0.0038 | 0.2305 | 06/30/2026 |
| 15 | DAFNA Capital Management LLC | 130,175 | 0 | 3,582,416 | 0.6583 | 0.1975 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Columbia Variable Portfolio - Overseas Core Fund | 346,549 | -39,357 | 9,537,028.48 | 0.2406 | 0.5259 | 03/31/2026 |
| 2 | iShares Biotechnology ETF | 305,498 | 27,114 | 8,407,304.96 | 0.0843 | 0.4636 | 07/31/2026 |
| 3 | ALPS Medical Breakthroughs ETF | 70,545 | 12,246 | 1,941,398.4 | 0.901 | 0.1071 | 07/31/2026 |
| 4 | Variable Portfolio - Partners Small Cap Value Fund | 45,889 | 0 | 1,262,865.28 | 0.2802 | 0.0696 | 03/31/2026 |
| 5 | Avantis International Equity ETF | 30,449 | 9,950 | 837,956.48 | 0.0045 | 0.0462 | 07/31/2026 |
| 6 | Barometer Disciplined Leadership Equity Fund | 27,700 | 0 | 762,304 | 0.7319 | 0.042 | 12/31/2025 |
| 7 | Schwab International Opportunities Fund | 20,618 | -12,083 | 567,407.36 | 0.0626 | 0.0313 | 05/31/2026 |
| 8 | ActivePassive International Equity ETF | 19,505 | 5,489 | 536,777.6 | 0.0464 | 0.0296 | 07/31/2026 |
| 9 | Erste Stock Biotec | 14,000 | 0 | 385,280 | 0.1155 | 0.0212 | 04/30/2026 |
| 10 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 12,167 | 2,487 | 334,835.84 | 0.0273 | 0.0185 | 07/31/2026 |
| 11 | Fidelity Nasdaq Composite Index Fund | 10,150 | 2,299 | 279,328 | 0.001 | 0.0154 | 06/30/2026 |
| 12 | Avantis International Small Cap Equity ETF | 7,249 | 1,817 | 199,492.48 | 0.0595 | 0.011 | 07/31/2026 |
| 13 | Invesco Markets Plc - NASDAQ Biotech UCITS ETF | 5,122 | 369 | 140,957.44 | 0.0277 | 0.0078 | 07/31/2026 |
| 14 | Steward Values Enhanced International Fund | 4,674 | -27,204 | 128,628.48 | 0.0373 | 0.0071 | 06/30/2026 |
| 15 | Invesco NASDAQ Future Gen 200 ETF | 3,943 | 3,943 | 108,511.36 | 0.4754 | 0.006 | 07/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Madison Avenue Partners LP | 3,447,807 | 1,234,638 | 94,883,648.64 | 4.0156 | 5.2321 | 06/30/2026 |
| 2 | Prosight Management LP | 2,043,344 | 969,232 | 56,232,826.88 | 9.1041 | 3.1008 | 06/30/2026 |
| 3 | Susquehanna Financial Group LLLP | 151,886 | 144,918 | 4,179,902.72 | 0.0038 | 0.2305 | 06/30/2026 |
| 4 | Renaissance Technologies LLC | 407,800 | 97,200 | 11,222,656 | 0.015 | 0.6188 | 06/30/2026 |
| 5 | Two Sigma Investments LP | 81,749 | 65,389 | 2,249,732.48 | 0.0017 | 0.1241 | 06/30/2026 |
| 6 | Goldman Sachs & Co. LLC (Private Banking) | 56,581 | 45,437 | 1,557,109.12 | 0.0003 | 0.0859 | 06/30/2026 |
| 7 | Schonfeld Strategic Advisors LLC | 32,597 | 32,597 | 897,069.44 | 0.0046 | 0.0495 | 06/30/2026 |
| 8 | denkapparat GmbH | 21,324 | 21,324 | 586,836.48 | 0.1835 | 0.0324 | 06/30/2026 |
| 9 | Marshall Wace LLP | 32,399 | 21,199 | 891,620.48 | 0.0007 | 0.0492 | 06/30/2026 |
| 10 | BlackRock Fund Advisors | 295,640 | 20,347 | 8,136,012.8 | 0.0001 | 0.4486 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Segall Bryant & Hamill LLC | 0 | -448,096 | 0 | 0 | 0 | |
| 2 | Point72 Asset Management LP | 269,814 | -216,395 | 7,425,281.28 | 0.0111 | 0.4094 | 06/30/2026 |
| 3 | UBS Securities LLC | 167,450 | -181,660 | 4,608,224 | 0.0017 | 0.2541 | 06/30/2026 |
| 4 | Hudson Bay Capital Management LP | 0 | -170,000 | 0 | 0 | 0 | |
| 5 | Millennium Management LLC | 181,090 | -158,264 | 4,983,596.8 | 0.0033 | 0.2748 | 06/30/2026 |
| 6 | Tang Capital Management LLC | 3,785,991 | -135,228 | 104,190,472.32 | 4.602 | 5.7453 | 06/30/2026 |
| 7 | Threadneedle Asset Management Ltd. | 262,233 | -123,673 | 7,216,652.16 | 0.01 | 0.3979 | 06/30/2026 |
| 8 | D. E. Shaw & Co. LP | 197,844 | -77,155 | 5,444,666.88 | 0.0033 | 0.3002 | 06/30/2026 |
| 9 | FIAM LLC | 0 | -56,968 | 0 | 0 | 0 | |
| 10 | Columbia Management Investment Advisers LLC | 1,010,016 | -55,317 | 27,795,640.32 | 0.0057 | 1.5327 | 06/30/2026 |
Data provided by FactSet Research Systems Inc.