| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Tang Capital Management LLC | 3,785,991 | -507,110 | 100,745,220.51 | 4.8593 | 5.7453 | 03/31/2026 |
| 2 | Madison Avenue Partners LP | 2,465,179 | 269,404 | 65,598,413.19 | 2.1837 | 3.741 | 03/31/2026 |
| 3 | EcoR1 Capital, LLC | 1,667,119 | 0 | 44,362,036.59 | 1.6524 | 2.5299 | 03/31/2026 |
| 4 | Prosight Management LP | 1,550,000 | 400,000 | 41,245,500 | 7.1468 | 2.3522 | 03/31/2026 |
| 5 | Columbia Management Investment Advisers LLC | 1,078,125 | 60,440 | 28,688,906.25 | 0.0063 | 1.6361 | 03/31/2026 |
| 6 | DME Capital Management LP | 482,746 | 0 | 12,845,871.06 | 0.3815 | 0.7326 | 03/31/2026 |
| 7 | Segall Bryant & Hamill LLC | 428,086 | -59,110 | 11,391,368.46 | 0.1548 | 0.6496 | 03/31/2026 |
| 8 | Threadneedle Asset Management Ltd. | 346,549 | -52,700 | 9,221,668.89 | 0.0126 | 0.5259 | 03/31/2026 |
| 9 | Point72 Asset Management LP | 332,125 | -111,744 | 8,837,846.25 | 0.0139 | 0.504 | 03/31/2026 |
| 10 | Renaissance Technologies LLC | 315,400 | -40,800 | 8,392,794 | 0.0121 | 0.4786 | 03/31/2026 |
| 11 | BlackRock Fund Advisors | 272,459 | 72,439 | 7,250,133.99 | 0.0001 | 0.4135 | 03/31/2026 |
| 12 | D. E. Shaw & Co. LP | 215,718 | 14,549 | 5,740,255.98 | 0.0041 | 0.3274 | 03/31/2026 |
| 13 | UBS Securities LLC | 174,466 | 21,801 | 4,642,540.26 | 0.0017 | 0.2648 | 03/31/2026 |
| 14 | DAFNA Capital Management LLC | 130,175 | 0 | 3,463,956.75 | 0.7752 | 0.1975 | 03/31/2026 |
| 15 | Millennium Management LLC | 107,912 | -44,990 | 2,871,538.32 | 0.0021 | 0.1638 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Columbia Overseas Value Fund | 746,801 | 49,483 | 19,872,374.61 | 0.2957 | 1.1333 | 04/30/2026 |
| 2 | Columbia Variable Portfolio - Overseas Core Fund | 385,906 | -13,343 | 10,268,958.66 | 0.2564 | 0.5856 | 12/31/2025 |
| 3 | iShares Biotechnology ETF | 266,233 | 59,154 | 7,084,460.13 | 0.0916 | 0.404 | 04/30/2026 |
| 4 | Segall Bryant & Hamill Small Cap Value Fund | 94,152 | -11,740 | 2,505,384.72 | 0.6067 | 0.1429 | 03/31/2026 |
| 5 | Columbia Overseas Core Fund | 90,697 | -7,392 | 2,413,447.17 | 0.2485 | 0.1376 | 04/30/2026 |
| 6 | ALPS Medical Breakthroughs ETF | 64,155 | 38,688 | 1,707,164.55 | 1.1517 | 0.0974 | 04/30/2026 |
| 7 | Variable Portfolio - Partners Small Cap Value Fund | 45,889 | -2,720 | 1,221,106.29 | 0.2684 | 0.0696 | 12/31/2025 |
| 8 | Pacific Select Fund - Large Cap Growth Portfolio | 42,565 | -1,600 | 1,132,654.65 | 0.0875 | 0.0646 | 12/31/2025 |
| 9 | Steward Values Enhanced International Fund | 31,441 | -437 | 836,645.01 | 0.2752 | 0.0477 | 03/31/2026 |
| 10 | Avantis International Equity ETF | 30,449 | 9,950 | 810,247.89 | 0.0052 | 0.0462 | 04/30/2026 |
| 11 | Barometer Disciplined Leadership Equity Fund | 27,700 | 19,600 | 737,097 | 0.7469 | 0.042 | 12/31/2025 |
| 12 | Schwab International Opportunities Fund | 25,332 | -8,703 | 674,084.52 | 0.0714 | 0.0384 | 02/28/2026 |
| 13 | ActivePassive International Equity ETF | 18,113 | 4,268 | 481,986.93 | 0.048 | 0.0275 | 04/30/2026 |
| 14 | Erste Stock Biotec | 14,000 | 0 | 372,540 | 0.1406 | 0.0212 | 01/30/2026 |
| 15 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 10,268 | 613 | 273,231.48 | 0.0319 | 0.0156 | 04/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Prosight Management LP | 1,550,000 | 400,000 | 41,245,500 | 7.1468 | 2.3522 | 03/31/2026 |
| 2 | Madison Avenue Partners LP | 2,465,179 | 269,404 | 65,598,413.19 | 2.1837 | 3.741 | 03/31/2026 |
| 3 | Old Mission Capital LLC | 95,591 | 95,591 | 2,543,676.51 | 0.0556 | 0.1451 | 03/31/2026 |
| 4 | Broadfin Holdings LLC | 90,000 | 90,000 | 2,394,900 | 1.716 | 0.1366 | 12/31/2025 |
| 5 | Citadel Advisors LLC | 101,799 | 89,196 | 2,708,871.39 | 0.0025 | 0.1545 | 03/31/2026 |
| 6 | BlackRock Fund Advisors | 272,459 | 72,439 | 7,250,133.99 | 0.0001 | 0.4135 | 03/31/2026 |
| 7 | Tower Research Capital LLC | 66,536 | 65,939 | 1,770,522.96 | 0.0392 | 0.101 | 03/31/2026 |
| 8 | Columbia Management Investment Advisers LLC | 1,078,125 | 60,440 | 28,688,906.25 | 0.0063 | 1.6361 | 03/31/2026 |
| 9 | Acadian Asset Management LLC | 45,942 | 45,942 | 1,222,516.62 | 0.0014 | 0.0697 | 03/31/2026 |
| 10 | Numeric Investors LLC | 80,209 | 44,012 | 2,134,361.49 | 0.0052 | 0.1217 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Tang Capital Management LLC | 3,785,991 | -507,110 | 100,745,220.51 | 4.8593 | 5.7453 | 03/31/2026 |
| 2 | Hudson Bay Capital Management LP | 77,500 | -167,500 | 2,062,275 | 0.0117 | 0.1176 | 03/31/2026 |
| 3 | Point72 Asset Management LP | 332,125 | -111,744 | 8,837,846.25 | 0.0139 | 0.504 | 03/31/2026 |
| 4 | Cubist Systematic Strategies LLC | 0 | -104,539 | 0 | 0 | 0 | |
| 5 | Voloridge Investment Management LLC | 13,505 | -74,067 | 359,368.05 | 0.0013 | 0.0205 | 03/31/2026 |
| 6 | Segall Bryant & Hamill LLC | 428,086 | -59,110 | 11,391,368.46 | 0.1548 | 0.6496 | 03/31/2026 |
| 7 | FIAM LLC | 0 | -54,010 | 0 | 0 | 0 | |
| 8 | Threadneedle Asset Management Ltd. | 346,549 | -52,700 | 9,221,668.89 | 0.0126 | 0.5259 | 03/31/2026 |
| 9 | Leap Investments LP | 0 | -51,300 | 0 | 0 | 0 | |
| 10 | PRIMECAP Management Co. | 0 | -50,500 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.