| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Tang Capital Management LLC | 3,921,219 | -68,892 | 132,419,565.63 | 5.8762 | 5.9505 | 12/31/2025 |
| 2 | Madison Avenue Partners LP | 2,213,169 | 336,158 | 74,738,717.13 | 2.3188 | 3.3585 | 12/31/2025 |
| 3 | EcoR1 Capital, LLC | 1,667,119 | 630,174 | 56,298,608.63 | 2.2611 | 2.5299 | 12/31/2025 |
| 4 | Prosight Management LP | 1,074,112 | -699,537 | 36,272,762.24 | 7.5532 | 1.63 | 12/31/2025 |
| 5 | Columbia Management Investment Advisers LLC | 1,065,333 | 1,010,628 | 35,976,295.41 | 0.0083 | 1.6167 | 12/31/2025 |
| 6 | Point72 Asset Management LP | 486,209 | 144,709 | 16,419,277.93 | 0.0246 | 0.7378 | 12/31/2025 |
| 7 | DME Capital Management LP | 482,746 | 0 | 16,302,332.42 | 0.4978 | 0.7326 | 12/31/2025 |
| 8 | Segall Bryant & Hamill LLC | 448,096 | -52,981 | 15,132,201.92 | 0.1692 | 0.68 | 12/31/2025 |
| 9 | Threadneedle Asset Management Ltd. | 385,906 | 385,906 | 13,032,045.62 | 0.0165 | 0.5856 | 12/31/2025 |
| 10 | UBS Securities LLC | 349,110 | 110,676 | 11,789,444.7 | 0.0047 | 0.5298 | 12/31/2025 |
| 11 | Millennium Management LLC | 339,354 | 148,645 | 11,459,984.58 | 0.008 | 0.515 | 12/31/2025 |
| 12 | Renaissance Technologies LLC | 310,600 | -154,100 | 10,488,962 | 0.0158 | 0.4713 | 12/31/2025 |
| 13 | BlackRock Fund Advisors | 275,293 | 83,192 | 9,296,644.61 | 0.0002 | 0.4178 | 12/31/2025 |
| 14 | D. E. Shaw & Co. LP | 274,999 | 121,814 | 9,286,716.23 | 0.0069 | 0.4173 | 12/31/2025 |
| 15 | Hudson Bay Capital Management LP | 170,000 | -345,000 | 5,740,900 | 0.0334 | 0.258 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Columbia Overseas Value Fund | 697,318 | 697,318 | 23,548,428.86 | 0.3539 | 1.0582 | 01/31/2026 |
| 2 | Columbia Variable Portfolio - Overseas Core Fund | 399,249 | 399,249 | 13,482,638.73 | 0.3062 | 0.6059 | 09/30/2025 |
| 3 | iShares Biotechnology ETF | 278,384 | 88,127 | 9,401,027.68 | 0.109 | 0.4225 | 01/30/2026 |
| 4 | Segall Bryant & Hamill Small Cap Value Fund | 94,152 | -19,370 | 3,179,513.04 | 0.7431 | 0.1429 | 01/31/2026 |
| 5 | Columbia Overseas Core Fund | 92,807 | 46,270 | 3,134,092.39 | 0.3075 | 0.1408 | 01/31/2026 |
| 6 | ALPS Medical Breakthroughs ETF | 58,299 | 26,929 | 1,968,757.23 | 1.4303 | 0.0885 | 01/30/2026 |
| 7 | Variable Portfolio - Partners Small Cap Value Fund | 48,609 | 0 | 1,641,525.93 | 0.3407 | 0.0738 | 09/30/2025 |
| 8 | Pacific Select Fund - Large Cap Growth Portfolio | 42,565 | -10,500 | 1,437,420.05 | 0.1158 | 0.0646 | 12/31/2025 |
| 9 | Schwab International Opportunities Fund | 34,035 | 18,844 | 1,149,361.95 | 0.0883 | 0.0516 | 11/30/2025 |
| 10 | Steward Values Enhanced International Fund | 31,878 | -14,548 | 1,076,520.06 | 0.3328 | 0.0484 | 01/31/2026 |
| 11 | Avantis International Equity ETF | 20,499 | 0 | 692,251.23 | 0.005 | 0.0311 | 01/30/2026 |
| 12 | ActivePassive International Equity ETF | 14,016 | -5,506 | 473,320.32 | 0.0462 | 0.0213 | 01/30/2026 |
| 13 | Erste Stock Biotec | 14,000 | 0 | 472,780 | 0.1609 | 0.0212 | 08/29/2025 |
| 14 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 9,680 | 1,113 | 326,893.6 | 0.0337 | 0.0147 | 01/30/2026 |
| 15 | Barometer Disciplined Leadership Equity Fund | 8,100 | 0 | 273,537 | 1.1791 | 0.0123 | 12/31/2024 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Columbia Management Investment Advisers LLC | 1,065,333 | 1,010,628 | 35,976,295.41 | 0.0083 | 1.6167 | 12/31/2025 |
| 2 | EcoR1 Capital, LLC | 1,667,119 | 630,174 | 56,298,608.63 | 2.2611 | 2.5299 | 12/31/2025 |
| 3 | Threadneedle Asset Management Ltd. | 385,906 | 385,906 | 13,032,045.62 | 0.0165 | 0.5856 | 12/31/2025 |
| 4 | Madison Avenue Partners LP | 2,213,169 | 336,158 | 74,738,717.13 | 2.3188 | 3.3585 | 12/31/2025 |
| 5 | Millennium Management LLC | 339,354 | 148,645 | 11,459,984.58 | 0.008 | 0.515 | 12/31/2025 |
| 6 | Point72 Asset Management LP | 486,209 | 144,709 | 16,419,277.93 | 0.0246 | 0.7378 | 12/31/2025 |
| 7 | D. E. Shaw & Co. LP | 274,999 | 121,814 | 9,286,716.23 | 0.0069 | 0.4173 | 12/31/2025 |
| 8 | UBS Securities LLC | 349,110 | 110,676 | 11,789,444.7 | 0.0047 | 0.5298 | 12/31/2025 |
| 9 | Citadel Advisors LLC | 83,911 | 83,911 | 2,833,674.47 | 0.0027 | 0.1273 | 12/31/2025 |
| 10 | BlackRock Fund Advisors | 275,293 | 83,192 | 9,296,644.61 | 0.0002 | 0.4178 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 0 | -1,482,996 | 0 | 0 | 0 | |
| 2 | Prosight Management LP | 1,074,112 | -699,537 | 36,272,762.24 | 7.5532 | 1.63 | 12/31/2025 |
| 3 | Hudson Bay Capital Management LP | 170,000 | -345,000 | 5,740,900 | 0.0334 | 0.258 | 12/31/2025 |
| 4 | Renaissance Technologies LLC | 310,600 | -154,100 | 10,488,962 | 0.0158 | 0.4713 | 12/31/2025 |
| 5 | PRIMECAP Management Co. | 0 | -143,310 | 0 | 0 | 0 | |
| 6 | Centiva Capital LP | 0 | -94,905 | 0 | 0 | 0 | |
| 7 | RBC Dominion Securities, Inc. (Investment Management) | 112 | -79,274 | 3,782.24 | 0 | 0.0002 | 12/31/2025 |
| 8 | Optiver US LLC | 0 | -78,929 | 0 | 0 | 0 | |
| 9 | Tower Research Capital LLC | 548 | -78,587 | 18,505.96 | 0.0004 | 0.0008 | 12/31/2025 |
| 10 | Tang Capital Management LLC | 3,921,219 | -68,892 | 132,419,565.63 | 5.8762 | 5.9505 | 12/31/2025 |
Data provided by FactSet Research Systems Inc.