| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Tang Capital Management LLC | 4,293,101 | 331,304 | 135,790,784.63 | 4.1863 | 6.5149 | 10/27/2025 |
| 2 | Madison Avenue Partners LP | 2,195,775 | 2,195,775 | 69,452,363.25 | 2.8547 | 3.3321 | 09/30/2025 |
| 3 | EcoR1 Capital, LLC | 1,667,119 | 1,029,665 | 52,730,973.97 | 1.9943 | 2.5299 | 09/30/2025 |
| 4 | Prosight Management LP | 1,150,000 | -164,898 | 36,374,500 | 7.9462 | 1.7451 | 09/30/2025 |
| 5 | Columbia Management Investment Advisers LLC | 1,017,685 | 952,985 | 32,189,376.55 | 0.0078 | 1.5444 | 09/30/2025 |
| 6 | Segall Bryant & Hamill LLC | 487,196 | -164,265 | 15,410,009.48 | 0.182 | 0.7393 | 09/30/2025 |
| 7 | DME Capital Management LP | 482,746 | 0 | 15,269,255.98 | 0.5741 | 0.7326 | 09/30/2025 |
| 8 | Point72 Asset Management LP | 443,869 | 443,869 | 14,039,576.47 | 0.0258 | 0.6736 | 09/30/2025 |
| 9 | Threadneedle Asset Management Ltd. | 399,249 | 399,249 | 12,628,245.87 | 0.0163 | 0.6059 | 09/30/2025 |
| 10 | Renaissance Technologies LLC | 356,200 | 25,400 | 11,266,606 | 0.0149 | 0.5405 | 09/30/2025 |
| 11 | Hudson Bay Capital Management LP | 245,000 | -320,000 | 7,749,350 | 0.0491 | 0.3718 | 09/30/2025 |
| 12 | D. E. Shaw & Co. LP | 201,169 | 138,149 | 6,362,975.47 | 0.0051 | 0.3053 | 09/30/2025 |
| 13 | BlackRock Fund Advisors | 200,020 | -12,783 | 6,326,632.6 | 0.0001 | 0.3035 | 09/30/2025 |
| 14 | Millennium Management LLC | 152,902 | 89,838 | 4,836,290.26 | 0.0038 | 0.232 | 09/30/2025 |
| 15 | UBS Securities LLC | 152,665 | 43,744 | 4,828,793.95 | 0.002 | 0.2317 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Columbia Overseas Value Fund | 697,318 | 697,318 | 22,056,168.34 | 0.3922 | 1.0582 | 11/30/2025 |
| 2 | Columbia Variable Portfolio - Overseas Core Fund | 399,249 | 399,249 | 12,628,245.87 | 0.3155 | 0.6059 | 09/30/2025 |
| 3 | iShares Biotechnology ETF | 254,267 | 52,614 | 8,042,465.21 | 0.0955 | 0.3859 | 11/28/2025 |
| 4 | Segall Bryant & Hamill Small Cap Value Fund | 98,542 | -16,444 | 3,116,883.46 | 0.7713 | 0.1495 | 11/30/2025 |
| 5 | Columbia Overseas Core Fund | 96,583 | 96,583 | 3,054,920.29 | 0.3197 | 0.1466 | 11/30/2025 |
| 6 | Variable Portfolio - Partners Small Cap Value Fund | 48,609 | -11,280 | 1,537,502.67 | 0.3521 | 0.0738 | 09/30/2025 |
| 7 | Pacific Select Fund - Large Cap Growth Portfolio | 44,165 | -19,100 | 1,396,938.95 | 0.1043 | 0.067 | 09/30/2025 |
| 8 | Steward Values Enhanced International Fund | 31,878 | -16,350 | 1,008,301.14 | 0.3503 | 0.0484 | 11/30/2025 |
| 9 | ALPS Medical Breakthroughs ETF | 29,514 | -17,708 | 933,527.82 | 0.8942 | 0.0448 | 11/28/2025 |
| 10 | Schwab International Opportunities Fund | 27,198 | 27,198 | 860,272.74 | 0.0735 | 0.0413 | 09/30/2025 |
| 11 | Avantis International Equity ETF | 20,499 | 0 | 648,383.37 | 0.0058 | 0.0311 | 11/28/2025 |
| 12 | PRIMECAP Odyssey Aggressive Growth Fund | 17,000 | -86,700 | 537,710 | 0.0078 | 0.0258 | 09/30/2025 |
| 13 | Erste Stock Biotec | 14,000 | 0 | 442,820 | 0.1548 | 0.0212 | 08/29/2025 |
| 14 | ActivePassive International Equity ETF | 13,886 | -7,724 | 439,214.18 | 0.0462 | 0.0211 | 11/28/2025 |
| 15 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 10,130 | 2,991 | 320,411.9 | 0.0387 | 0.0154 | 11/28/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Madison Avenue Partners LP | 2,195,775 | 2,195,775 | 69,452,363.25 | 2.8547 | 3.3321 | 09/30/2025 |
| 2 | EcoR1 Capital, LLC | 1,667,119 | 1,029,665 | 52,730,973.97 | 1.9943 | 2.5299 | 09/30/2025 |
| 3 | Columbia Management Investment Advisers LLC | 1,017,685 | 952,985 | 32,189,376.55 | 0.0078 | 1.5444 | 09/30/2025 |
| 4 | Point72 Asset Management LP | 443,869 | 443,869 | 14,039,576.47 | 0.0258 | 0.6736 | 09/30/2025 |
| 5 | Threadneedle Asset Management Ltd. | 399,249 | 399,249 | 12,628,245.87 | 0.0163 | 0.6059 | 09/30/2025 |
| 6 | Tang Capital Management LLC | 4,293,101 | 331,304 | 135,790,784.63 | 4.1863 | 6.5149 | 10/27/2025 |
| 7 | D. E. Shaw & Co. LP | 201,169 | 138,149 | 6,362,975.47 | 0.0051 | 0.3053 | 09/30/2025 |
| 8 | Cubist Systematic Strategies LLC | 104,539 | 104,539 | 3,306,568.57 | 0.0455 | 0.1586 | 09/30/2025 |
| 9 | Millennium Management LLC | 152,902 | 89,838 | 4,836,290.26 | 0.0038 | 0.232 | 09/30/2025 |
| 10 | Voloridge Investment Management LLC | 87,572 | 87,572 | 2,769,902.36 | 0.0092 | 0.1329 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 0 | -1,482,196 | 0 | 0 | 0 | |
| 2 | BVF Partners LP | 0 | -1,454,422 | 0 | 0 | 0 | |
| 3 | Deep Track Capital LP | 0 | -741,068 | 0 | 0 | 0 | |
| 4 | Finepoint Capital LP | 0 | -656,587 | 0 | 0 | 0 | |
| 5 | Hudson Bay Capital Management LP | 245,000 | -320,000 | 7,749,350 | 0.0491 | 0.3718 | 09/30/2025 |
| 6 | Newtyn Management LLC | 0 | -200,000 | 0 | 0 | 0 | |
| 7 | Vestal Point Capital LP | 0 | -200,000 | 0 | 0 | 0 | |
| 8 | Prosight Management LP | 1,150,000 | -164,898 | 36,374,500 | 7.9462 | 1.7451 | 09/30/2025 |
| 9 | Segall Bryant & Hamill LLC | 487,196 | -164,265 | 15,410,009.48 | 0.182 | 0.7393 | 09/30/2025 |
| 10 | 683 Capital Management LLC | 0 | -110,100 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.