| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Tang Capital Management LLC | 3,785,991 | 0 | 115,775,604.78 | 5.5601 | 5.7453 | 06/30/2026 |
| 2 | Madison Avenue Partners LP | 3,447,807 | 982,628 | 105,433,938.06 | 4.4851 | 5.2321 | 06/30/2026 |
| 3 | Prosight Management LP | 2,043,344 | 493,344 | 62,485,459.52 | 11.9729 | 3.1008 | 06/30/2026 |
| 4 | EcoR1 Capital, LLC | 1,667,119 | 0 | 50,980,499.02 | 2.3437 | 2.5299 | 06/30/2026 |
| 5 | Columbia Management Investment Advisers LLC | 1,010,016 | -68,109 | 30,886,289.28 | 0.0065 | 1.5327 | 06/30/2026 |
| 6 | DME Capital Management LP | 482,746 | 0 | 14,762,372.68 | 0.409 | 0.7326 | 06/30/2026 |
| 7 | Renaissance Technologies LLC | 407,800 | 92,400 | 12,470,524 | 0.0169 | 0.6188 | 06/30/2026 |
| 8 | BlackRock Fund Advisors | 295,640 | 23,181 | 9,040,671.2 | 0.0002 | 0.4486 | 06/30/2026 |
| 9 | Point72 Asset Management LP | 269,814 | -62,311 | 8,250,912.12 | 0.0132 | 0.4094 | 06/30/2026 |
| 10 | Threadneedle Asset Management Ltd. | 262,233 | -84,316 | 8,019,085.14 | 0.0115 | 0.3979 | 06/30/2026 |
| 11 | D. E. Shaw & Co. LP | 197,844 | -17,874 | 6,050,069.52 | 0.0038 | 0.3002 | 06/30/2026 |
| 12 | Millennium Management LLC | 181,090 | 73,178 | 5,537,732.2 | 0.0038 | 0.2748 | 06/30/2026 |
| 13 | UBS Securities LLC | 167,450 | -7,016 | 5,120,621 | 0.0019 | 0.2541 | 06/30/2026 |
| 14 | Susquehanna Financial Group LLLP | 151,886 | 138,499 | 4,644,673.88 | 0.0043 | 0.2305 | 06/30/2026 |
| 15 | DAFNA Capital Management LLC | 130,175 | 0 | 3,980,751.5 | 0.8561 | 0.1975 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | iShares Biotechnology ETF | 341,669 | 69,776 | 10,448,238.02 | 0.0928 | 0.5185 | 09/30/2026 |
| 2 | Columbia Variable Portfolio - Overseas Core Fund | 280,317 | -66,232 | 8,572,093.86 | 0.2245 | 0.4254 | 06/30/2026 |
| 3 | ALPS Medical Breakthroughs ETF | 88,253 | 34,592 | 2,698,776.74 | 1.3627 | 0.1339 | 09/30/2026 |
| 4 | Steward Values Enhanced International Fund | 33,346 | 1,905 | 1,019,720.68 | 0.2915 | 0.0506 | 09/30/2026 |
| 5 | Avantis International Equity ETF | 30,449 | 0 | 931,130.42 | 0.0049 | 0.0462 | 09/30/2026 |
| 6 | Barometer Disciplined Leadership Equity Fund | 27,700 | 0 | 847,066 | 0.8698 | 0.042 | 12/31/2025 |
| 7 | ActivePassive International Equity ETF | 15,146 | -3,238 | 463,164.68 | 0.0406 | 0.023 | 09/30/2026 |
| 8 | Erste Stock Biotec | 14,000 | 0 | 428,120 | 0.1349 | 0.0212 | 06/30/2026 |
| 9 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 11,929 | 986 | 364,788.82 | 0.0294 | 0.0181 | 09/30/2026 |
| 10 | Avantis International Small Cap Equity ETF | 7,605 | 1,263 | 232,560.9 | 0.0658 | 0.0115 | 09/30/2026 |
| 11 | Invesco Markets Plc - NASDAQ Biotech UCITS ETF | 4,863 | -158 | 148,710.54 | 0.0298 | 0.0074 | 09/30/2026 |
| 12 | Invesco NASDAQ Future Gen 200 ETF | 4,208 | 4,208 | 128,680.64 | 0.6024 | 0.0064 | 09/30/2026 |
| 13 | Avantis International Equity Fund | 2,478 | 1,059 | 75,777.24 | 0.007 | 0.0038 | 06/30/2026 |
| 14 | VanEck Genomics & Healthcare Innovators UCITS ETF | 2,462 | 750 | 75,287.96 | 0.3145 | 0.0037 | 09/30/2026 |
| 15 | Dimensional Funds ICAV - Global Core Equity UCITS ETF | 1,111 | 1,111 | 33,974.38 | 0.0016 | 0.0017 | 09/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Madison Avenue Partners LP | 3,447,807 | 982,628 | 105,433,938.06 | 4.4851 | 5.2321 | 06/30/2026 |
| 2 | Prosight Management LP | 2,043,344 | 493,344 | 62,485,459.52 | 11.9729 | 3.1008 | 06/30/2026 |
| 3 | Susquehanna Financial Group LLLP | 151,886 | 138,499 | 4,644,673.88 | 0.0043 | 0.2305 | 06/30/2026 |
| 4 | Renaissance Technologies LLC | 407,800 | 92,400 | 12,470,524 | 0.0169 | 0.6188 | 06/30/2026 |
| 5 | Millennium Management LLC | 181,090 | 73,178 | 5,537,732.2 | 0.0038 | 0.2748 | 06/30/2026 |
| 6 | Two Sigma Investments LP | 81,749 | 55,889 | 2,499,884.42 | 0.0019 | 0.1241 | 06/30/2026 |
| 7 | Schonfeld Strategic Advisors LLC | 32,597 | 32,597 | 996,816.26 | 0.0052 | 0.0495 | 06/30/2026 |
| 8 | Marshall Wace LLP | 32,399 | 32,399 | 990,761.42 | 0.0008 | 0.0492 | 06/30/2026 |
| 9 | BlackRock Fund Advisors | 295,640 | 23,181 | 9,040,671.2 | 0.0002 | 0.4486 | 06/30/2026 |
| 10 | Morgan Stanley & Co. LLC | 37,455 | 14,025 | 1,145,373.9 | 0.0003 | 0.0568 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Segall Bryant & Hamill LLC | 0 | -426,412 | 0 | 0 | 0 | |
| 2 | Old Mission Capital LLC | 0 | -95,591 | 0 | 0 | 0 | |
| 3 | Threadneedle Asset Management Ltd. | 262,233 | -84,316 | 8,019,085.14 | 0.0115 | 0.3979 | 06/30/2026 |
| 4 | Numeric Investors LLC | 0 | -80,209 | 0 | 0 | 0 | |
| 5 | Hudson Bay Capital Management LP | 0 | -77,500 | 0 | 0 | 0 | |
| 6 | Columbia Management Investment Advisers LLC | 1,010,016 | -68,109 | 30,886,289.28 | 0.0065 | 1.5327 | 06/30/2026 |
| 7 | Tower Research Capital LLC | 823 | -65,713 | 25,167.34 | 0.0006 | 0.0012 | 06/30/2026 |
| 8 | Point72 Asset Management LP | 269,814 | -62,311 | 8,250,912.12 | 0.0132 | 0.4094 | 06/30/2026 |
| 9 | HRT Financial LP | 17,328 | -27,840 | 529,890.24 | 0.0014 | 0.0263 | 06/30/2026 |
| 10 | Optiver US LLC | 0 | -26,535 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.