| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Orbis Investment Management Ltd. | 11,078,006 | 3,157,606 | 327,798,197.54 | 0.7762 | 1.7245 | 09/30/2025 |
| 2 | AllianceBernstein LP | 10,953,913 | 291,538 | 324,126,285.67 | 0.0952 | 1.7052 | 09/30/2025 |
| 3 | Paradigm BioCapital Advisors LP | 3,816,851 | 3,816,851 | 112,940,621.09 | 2.9185 | 0.5942 | 09/30/2025 |
| 4 | Arrowstreet Capital LP | 3,643,139 | 188,761 | 107,800,483.01 | 0.0623 | 0.5671 | 09/30/2025 |
| 5 | BlackRock Fund Advisors | 3,581,614 | 1,077,662 | 105,979,958.26 | 0.0022 | 0.5576 | 12/31/2025 |
| 6 | Renaissance Technologies LLC | 3,492,850 | 726,100 | 103,353,431.5 | 0.1585 | 0.5437 | 12/31/2025 |
| 7 | Harding Loevner LP | 3,484,487 | 561,048 | 103,105,970.33 | 0.3636 | 0.5424 | 09/30/2025 |
| 8 | First Trust Advisors LP | 1,687,388 | -82,922 | 49,929,810.92 | 0.0329 | 0.2627 | 09/30/2025 |
| 9 | Parametric Portfolio Associates LLC | 1,580,595 | 391,896 | 46,769,806.05 | 0.0121 | 0.2461 | 09/30/2025 |
| 10 | Two Sigma Advisers LP | 1,432,800 | -388,200 | 42,396,552 | 0.0836 | 0.223 | 09/30/2025 |
| 11 | Two Sigma Investments LP | 1,391,215 | -227,329 | 41,166,051.85 | 0.0624 | 0.2166 | 09/30/2025 |
| 12 | Pictet Asset Management SA | 1,098,550 | 1,098,550 | 32,506,094.5 | 0.0206 | 0.171 | 12/31/2025 |
| 13 | Brandywine Global Investment Management LLC | 1,031,464 | -713,305 | 30,521,019.76 | 0.185 | 0.1606 | 12/31/2025 |
| 14 | Great Gray Trust Co. LLC (Investment Management) | 1,022,601 | -366,490 | 30,258,763.59 | 0.3219 | 0.1592 | 12/31/2025 |
| 15 | Northern Trust Investments, Inc.(Investment Management) | 882,297 | 78,695 | 26,107,168.23 | 0.0036 | 0.1373 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | AllianceBernstein (Japan) AB US Large Cap Growth Equity Mother | 5,706,859 | 0 | 168,865,957.81 | 0.435 | 0.8884 | 06/16/2025 |
| 2 | iShares Biotechnology ETF | 3,625,576 | 1,145,460 | 107,280,793.84 | 1.2692 | 0.5644 | 01/30/2026 |
| 3 | AB Large Cap Growth Fund | 2,685,340 | 2,685,340 | 79,459,210.6 | 0.3237 | 0.418 | 12/31/2025 |
| 4 | First Trust NYSE Arca Biotechnology Index Fund | 2,354,019 | 736,620 | 69,655,422.21 | 3.0038 | 0.3665 | 01/30/2026 |
| 5 | Orbis SICAV - International Equity Fund | 1,492,525 | 0 | 44,163,814.75 | 0.997 | 0.2323 | 06/30/2025 |
| 6 | AB US Large Cap Growth CIT W Series | 1,022,601 | -366,490 | 30,258,763.59 | 0.3174 | 0.1592 | 12/31/2025 |
| 7 | AB SICAV I - American Growth Portfolio | 973,780 | -218,294 | 28,814,150.2 | 0.3369 | 0.1516 | 12/31/2025 |
| 8 | Orbis SICAV - Global Balanced Fund | 880,873 | 0 | 26,065,032.07 | 0.4575 | 0.1371 | 06/30/2025 |
| 9 | JOHCM Umbrella Fund Plc - Global Select Fund | 553,099 | 553,099 | 16,366,199.41 | 1.6916 | 0.0861 | 11/28/2025 |
| 10 | Federated Hermes Kaufmann Fund | 422,500 | 422,500 | 12,501,775 | 0.2653 | 0.0658 | 12/31/2025 |
| 11 | Avantis International Equity ETF | 395,423 | 111,445 | 11,700,566.57 | 0.0856 | 0.0616 | 01/30/2026 |
| 12 | Russell Investment Co. - Tax Managed US Large Cap Fund | 342,344 | 0 | 10,129,958.96 | 0.0902 | 0.0533 | 12/31/2025 |
| 13 | Federated Hermes Kaufmann Small Cap Fund | 248,000 | 248,000 | 7,338,320 | 0.2428 | 0.0386 | 12/31/2025 |
| 14 | SunAmerica Series Trust - SA AB Growth Portfolio | 187,018 | -76,990 | 5,533,862.62 | 0.3207 | 0.0291 | 12/31/2025 |
| 15 | Mercer Funds - Non US Core Equity Fund | 179,676 | 0 | 5,316,612.84 | 0.1128 | 0.028 | 12/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Paradigm BioCapital Advisors LP | 3,816,851 | 3,816,851 | 112,940,621.09 | 2.9185 | 0.5942 | 09/30/2025 |
| 2 | Orbis Investment Management Ltd. | 11,078,006 | 3,157,606 | 327,798,197.54 | 0.7762 | 1.7245 | 09/30/2025 |
| 3 | Pictet Asset Management SA | 1,098,550 | 1,098,550 | 32,506,094.5 | 0.0206 | 0.171 | 12/31/2025 |
| 4 | BlackRock Fund Advisors | 3,581,614 | 1,077,662 | 105,979,958.26 | 0.0022 | 0.5576 | 12/31/2025 |
| 5 | J.O. Hambro Capital Management Ltd. | 781,548 | 781,548 | 23,126,005.32 | 0.1366 | 0.1217 | 12/31/2025 |
| 6 | Renaissance Technologies LLC | 3,492,850 | 726,100 | 103,353,431.5 | 0.1585 | 0.5437 | 12/31/2025 |
| 7 | Federated Global Investment Management Corp. | 679,379 | 679,379 | 20,102,824.61 | 0.1722 | 0.1058 | 12/31/2025 |
| 8 | Harding Loevner LP | 3,484,487 | 561,048 | 103,105,970.33 | 0.3636 | 0.5424 | 09/30/2025 |
| 9 | Deep Track Capital LP | 481,267 | 481,267 | 14,240,690.53 | 0.2667 | 0.0749 | 09/30/2025 |
| 10 | Strategic Advisers LLC | 830,260 | 413,216 | 24,567,393.4 | 0.0075 | 0.1292 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Citadel Advisors LLC | 51,473 | -3,114,396 | 1,523,086.07 | 0.0016 | 0.008 | 09/30/2025 |
| 2 | Morgan Stanley & Co. LLC | 61,152 | -1,412,019 | 1,809,487.68 | 0.0006 | 0.0095 | 09/30/2025 |
| 3 | Marshall Wace LLP | 533,209 | -1,374,075 | 15,777,654.31 | 0.0171 | 0.083 | 09/30/2025 |
| 4 | JPMorgan Securities LLC (Investment Management) | 5,636 | -910,404 | 166,769.24 | 0.0001 | 0.0009 | 12/31/2025 |
| 5 | Point72 Asset Management LP | 117,879 | -907,956 | 3,488,039.61 | 0.0062 | 0.0184 | 09/30/2025 |
| 6 | Voloridge Investment Management LLC | 130,815 | -818,363 | 3,870,815.85 | 0.0126 | 0.0204 | 09/30/2025 |
| 7 | Brandywine Global Investment Management LLC | 1,031,464 | -713,305 | 30,521,019.76 | 0.185 | 0.1606 | 12/31/2025 |
| 8 | Citadel Securities LLC | 0 | -403,315 | 0 | 0 | 0 | |
| 9 | Avidity Partners Management LP | 248,100 | -401,900 | 7,341,279 | 1.5277 | 0.0386 | 09/30/2025 |
| 10 | Two Sigma Advisers LP | 1,432,800 | -388,200 | 42,396,552 | 0.0836 | 0.223 | 09/30/2025 |
Data provided by FactSet Research Systems Inc.