| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Orbis Investment Management Ltd. | 12,925,578 | 1,847,572 | 331,024,052.58 | 0.7744 | 2.073 | 03/31/2026 |
| 2 | AllianceBernstein LP | 9,557,149 | -1,396,764 | 244,758,585.89 | 0.0692 | 1.5328 | 03/31/2026 |
| 3 | Paradigm BioCapital Advisors LP | 7,967,836 | 4,150,985 | 204,056,279.96 | 4.24 | 1.2779 | 03/31/2026 |
| 4 | Arrowstreet Capital LP | 4,975,324 | 1,332,185 | 127,418,047.64 | 0.058 | 0.798 | 03/31/2026 |
| 5 | Renaissance Technologies LLC | 4,414,550 | 1,593,007 | 113,056,625.5 | 0.153 | 0.708 | 03/31/2026 |
| 6 | Deep Track Capital LP | 3,663,250 | 3,181,983 | 93,815,832.5 | 1.5408 | 0.5875 | 03/31/2026 |
| 7 | BlackRock Fund Advisors | 3,562,490 | 956,904 | 91,235,368.9 | 0.0017 | 0.5714 | 03/31/2026 |
| 8 | Harding Loevner LP | 3,231,601 | -252,886 | 82,761,301.61 | 0.3401 | 0.5183 | 03/31/2026 |
| 9 | First Trust Advisors LP | 2,461,342 | 773,954 | 63,034,968.62 | 0.0354 | 0.3948 | 03/31/2026 |
| 10 | Two Sigma Investments LP | 2,339,432 | 948,217 | 59,912,853.52 | 0.0444 | 0.3752 | 03/31/2026 |
| 11 | Parametric Portfolio Associates LLC | 1,640,297 | 59,702 | 42,008,006.17 | 0.0096 | 0.2631 | 03/31/2026 |
| 12 | Federated Global Investment Management Corp. | 1,251,590 | 828,652 | 32,053,219.9 | 0.2642 | 0.2007 | 03/31/2026 |
| 13 | Brandywine Global Investment Management LLC | 1,162,003 | -250,832 | 29,758,896.83 | 0.1857 | 0.1864 | 03/31/2026 |
| 14 | Pictet Asset Management SA | 1,077,471 | 1,077,471 | 27,594,032.31 | 0.0169 | 0.1728 | 03/31/2026 |
| 15 | Great Gray Trust Co. LLC (Investment Management) | 988,041 | -363,640 | 25,303,730.01 | 0.2553 | 0.1585 | 04/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | AllianceBernstein (Japan) AB US Large Cap Growth Equity Mother | 3,945,189 | -1,761,670 | 101,036,290.29 | 0.2756 | 0.6327 | 12/30/2025 |
| 2 | iShares Biotechnology ETF | 3,467,720 | 164,591 | 88,808,309.2 | 1.0896 | 0.5562 | 05/29/2026 |
| 3 | Orbis SICAV - International Equity Fund | 3,399,025 | 1,906,500 | 87,049,030.25 | 2.0304 | 0.5451 | 12/31/2025 |
| 4 | First Trust NYSE Arca Biotechnology Index Fund | 2,734,409 | 1,528,848 | 70,028,214.49 | 2.6368 | 0.4386 | 05/29/2026 |
| 5 | AB Large Cap Growth Fund | 1,848,858 | -895,272 | 47,349,253.38 | 0.1987 | 0.2965 | 04/30/2026 |
| 6 | Orbis SICAV - Global Balanced Fund | 1,787,954 | 907,081 | 45,789,501.94 | 0.7926 | 0.2868 | 12/31/2025 |
| 7 | AB US Large Cap Growth CIT W Series | 988,041 | -363,640 | 25,303,730.01 | 0.2546 | 0.1585 | 04/30/2026 |
| 8 | AB SICAV I - American Growth Portfolio | 949,870 | -340,744 | 24,326,170.7 | 0.2656 | 0.1523 | 04/30/2026 |
| 9 | Federated Hermes Kaufmann Fund | 520,700 | 272,173 | 13,335,127 | 0.2551 | 0.0835 | 03/31/2026 |
| 10 | Avantis International Equity ETF | 512,663 | 154,774 | 13,129,299.43 | 0.0779 | 0.0822 | 05/29/2026 |
| 11 | JOHCM Umbrella Fund Plc - Global Select Fund | 510,883 | -42,216 | 13,083,713.63 | 1.3924 | 0.0819 | 04/30/2026 |
| 12 | Orbis Instl. Funds Ltd. - Institutional Global Equity Fund | 356,948 | 212,770 | 9,141,438.28 | 0.3405 | 0.0572 | 12/31/2025 |
| 13 | Federated Hermes Kaufmann Small Cap Fund | 350,000 | 182,354 | 8,963,500 | 0.2746 | 0.0561 | 03/31/2026 |
| 14 | Russell Investment Co. - Tax Managed US Large Cap Fund | 342,344 | 0 | 8,767,429.84 | 0.0712 | 0.0549 | 04/30/2026 |
| 15 | Pictet - Global Megatrend Selection | 270,379 | 270,379 | 6,924,406.19 | 0.0643 | 0.0434 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Paradigm BioCapital Advisors LP | 7,967,836 | 4,150,985 | 204,056,279.96 | 4.24 | 1.2779 | 03/31/2026 |
| 2 | Deep Track Capital LP | 3,663,250 | 3,181,983 | 93,815,832.5 | 1.5408 | 0.5875 | 03/31/2026 |
| 3 | Orbis Investment Management Ltd. | 12,925,578 | 1,847,572 | 331,024,052.58 | 0.7744 | 2.073 | 03/31/2026 |
| 4 | Renaissance Technologies LLC | 4,414,550 | 1,593,007 | 113,056,625.5 | 0.153 | 0.708 | 03/31/2026 |
| 5 | Arrowstreet Capital LP | 4,975,324 | 1,332,185 | 127,418,047.64 | 0.058 | 0.798 | 03/31/2026 |
| 6 | Pictet Asset Management SA | 1,077,471 | 1,077,471 | 27,594,032.31 | 0.0169 | 0.1728 | 03/31/2026 |
| 7 | BlackRock Fund Advisors | 3,562,490 | 956,904 | 91,235,368.9 | 0.0017 | 0.5714 | 03/31/2026 |
| 8 | Two Sigma Investments LP | 2,339,432 | 948,217 | 59,912,853.52 | 0.0444 | 0.3752 | 03/31/2026 |
| 9 | Federated Global Investment Management Corp. | 1,251,590 | 828,652 | 32,053,219.9 | 0.2642 | 0.2007 | 03/31/2026 |
| 10 | First Trust Advisors LP | 2,461,342 | 773,954 | 63,034,968.62 | 0.0354 | 0.3948 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Two Sigma Advisers LP | 0 | -1,432,800 | 0 | 0 | 0 | |
| 2 | AllianceBernstein LP | 9,557,149 | -1,396,764 | 244,758,585.89 | 0.0692 | 1.5328 | 03/31/2026 |
| 3 | Marshall Wace LLP | 15,000 | -518,209 | 384,150 | 0.0003 | 0.0024 | 03/31/2026 |
| 4 | Woodline Partners LP | 0 | -459,176 | 0 | 0 | 0 | |
| 5 | Great Gray Trust Co. LLC (Investment Management) | 988,041 | -363,640 | 25,303,730.01 | 0.2553 | 0.1585 | 04/30/2026 |
| 6 | Harding Loevner LP | 3,231,601 | -252,886 | 82,761,301.61 | 0.3401 | 0.5183 | 03/31/2026 |
| 7 | Brandywine Global Investment Management LLC | 1,162,003 | -250,832 | 29,758,896.83 | 0.1857 | 0.1864 | 03/31/2026 |
| 8 | Goldman Sachs & Co. LLC (Private Banking) | 68,981 | -234,262 | 1,766,603.41 | 0.0005 | 0.0111 | 03/31/2026 |
| 9 | Tang Capital Management LLC | 0 | -200,000 | 0 | 0 | 0 | |
| 10 | Avidity Partners Management LP | 50,000 | -198,100 | 1,280,500 | 0.24 | 0.008 | 03/31/2026 |
Data provided by FactSet Research Systems Inc.