| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Orbis Investment Management Ltd. | 14,418,462 | 3,340,456 | 381,079,950.66 | 0.906 | 2.2441 | 12/31/2025 |
| 2 | AllianceBernstein LP | 10,877,094 | -76,819 | 287,481,594.42 | 0.0805 | 1.6929 | 12/31/2025 |
| 3 | Paradigm BioCapital Advisors LP | 7,039,834 | 3,222,983 | 186,062,812.62 | 4.1529 | 1.0957 | 12/31/2025 |
| 4 | Arrowstreet Capital LP | 4,978,058 | 1,334,919 | 131,570,072.94 | 0.0658 | 0.7748 | 12/31/2025 |
| 5 | BlackRock Fund Advisors | 3,581,614 | 976,028 | 94,662,058.02 | 0.0018 | 0.5574 | 12/31/2025 |
| 6 | Renaissance Technologies LLC | 3,492,850 | 671,307 | 92,316,025.5 | 0.1288 | 0.5436 | 12/31/2025 |
| 7 | Harding Loevner LP | 3,370,143 | -114,344 | 89,072,879.49 | 0.3439 | 0.5245 | 12/31/2025 |
| 8 | Parametric Portfolio Associates LLC | 1,690,173 | 109,578 | 44,671,272.39 | 0.0106 | 0.2631 | 12/31/2025 |
| 9 | First Trust Advisors LP | 1,335,273 | -352,115 | 35,291,265.39 | 0.0212 | 0.2078 | 12/31/2025 |
| 10 | Pictet Asset Management SA | 1,077,471 | 1,077,471 | 28,477,558.53 | 0.0177 | 0.1677 | 03/31/2026 |
| 11 | Brandywine Global Investment Management LLC | 1,031,464 | -381,371 | 27,261,593.52 | 0.1676 | 0.1605 | 12/31/2025 |
| 12 | Great Gray Trust Co. LLC (Investment Management) | 995,121 | -356,560 | 26,301,048.03 | 0.2583 | 0.1549 | 03/31/2026 |
| 13 | Northern Trust Investments, Inc.(Investment Management) | 957,029 | 74,732 | 25,294,276.47 | 0.0033 | 0.149 | 12/31/2025 |
| 14 | Two Sigma Investments LP | 895,843 | -495,372 | 23,677,130.49 | 0.033 | 0.1394 | 12/31/2025 |
| 15 | Envestnet Asset Management, Inc. | 862,301 | 52,362 | 22,790,615.43 | 0.0056 | 0.1342 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | AllianceBernstein (Japan) AB US Large Cap Growth Equity Mother | 3,945,189 | -1,761,670 | 104,271,345.27 | 0.2789 | 0.614 | 12/30/2025 |
| 2 | iShares Biotechnology ETF | 3,486,666 | 788,907 | 92,152,582.38 | 1.1517 | 0.5427 | 04/30/2026 |
| 3 | Orbis SICAV - International Equity Fund | 3,399,025 | 1,906,500 | 89,836,230.75 | 2.1456 | 0.529 | 12/31/2025 |
| 4 | First Trust NYSE Arca Biotechnology Index Fund | 2,663,387 | 1,505,666 | 70,393,318.41 | 2.9869 | 0.4145 | 04/30/2026 |
| 5 | AB Large Cap Growth Fund | 1,848,858 | -895,272 | 48,865,316.94 | 0.1956 | 0.2878 | 03/31/2026 |
| 6 | Orbis SICAV - Global Balanced Fund | 1,787,954 | 907,081 | 47,255,624.22 | 0.8328 | 0.2783 | 12/31/2025 |
| 7 | AB US Large Cap Growth CIT W Series | 995,121 | -356,560 | 26,301,048.03 | 0.258 | 0.1549 | 03/31/2026 |
| 8 | AB SICAV I - American Growth Portfolio | 949,870 | -340,744 | 25,105,064.1 | 0.2736 | 0.1478 | 03/31/2026 |
| 9 | Federated Hermes Kaufmann Fund | 520,700 | 272,173 | 13,762,101 | 0.2842 | 0.081 | 03/31/2026 |
| 10 | Avantis International Equity ETF | 486,367 | 141,845 | 12,854,679.81 | 0.081 | 0.0757 | 04/30/2026 |
| 11 | JOHCM Umbrella Fund Plc - Global Select Fund | 466,055 | -116,627 | 12,317,833.65 | 1.2814 | 0.0725 | 03/31/2026 |
| 12 | Orbis Instl. Funds Ltd. - Institutional Global Equity Fund | 356,948 | 212,770 | 9,434,135.64 | 0.3816 | 0.0556 | 12/31/2025 |
| 13 | Federated Hermes Kaufmann Small Cap Fund | 350,000 | 182,354 | 9,250,500 | 0.2996 | 0.0545 | 03/31/2026 |
| 14 | Russell Investment Co. - Tax Managed US Large Cap Fund | 342,344 | 0 | 9,048,151.92 | 0.0748 | 0.0533 | 03/31/2026 |
| 15 | Tema Oncology ETF | 187,724 | 70,703 | 4,961,545.32 | 2.8359 | 0.0292 | 04/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Orbis Investment Management Ltd. | 14,418,462 | 3,340,456 | 381,079,950.66 | 0.906 | 2.2441 | 12/31/2025 |
| 2 | Paradigm BioCapital Advisors LP | 7,039,834 | 3,222,983 | 186,062,812.62 | 4.1529 | 1.0957 | 12/31/2025 |
| 3 | Arrowstreet Capital LP | 4,978,058 | 1,334,919 | 131,570,072.94 | 0.0658 | 0.7748 | 12/31/2025 |
| 4 | Pictet Asset Management SA | 1,077,471 | 1,077,471 | 28,477,558.53 | 0.0177 | 0.1677 | 03/31/2026 |
| 5 | BlackRock Fund Advisors | 3,581,614 | 976,028 | 94,662,058.02 | 0.0018 | 0.5574 | 12/31/2025 |
| 6 | J.O. Hambro Capital Management Ltd. | 711,003 | 711,003 | 18,791,809.29 | 0.1144 | 0.1107 | 03/31/2026 |
| 7 | Renaissance Technologies LLC | 3,492,850 | 671,307 | 92,316,025.5 | 0.1288 | 0.5436 | 12/31/2025 |
| 8 | Susquehanna Financial Group LLLP | 612,323 | 594,371 | 16,183,696.89 | 0.0208 | 0.0953 | 12/31/2025 |
| 9 | Alyeska Investment Group LP | 506,661 | 506,661 | 13,391,050.23 | 0.0352 | 0.0789 | 12/31/2025 |
| 10 | Balyasny Asset Management LP | 379,364 | 379,364 | 10,026,590.52 | 0.0186 | 0.059 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Two Sigma Advisers LP | 340,000 | -1,092,800 | 8,986,200 | 0.016 | 0.0529 | 12/31/2025 |
| 2 | Two Sigma Investments LP | 895,843 | -495,372 | 23,677,130.49 | 0.033 | 0.1394 | 12/31/2025 |
| 3 | Deep Track Capital LP | 0 | -481,267 | 0 | 0 | 0 | |
| 4 | Brandywine Global Investment Management LLC | 1,031,464 | -381,371 | 27,261,593.52 | 0.1676 | 0.1605 | 12/31/2025 |
| 5 | Great Gray Trust Co. LLC (Investment Management) | 995,121 | -356,560 | 26,301,048.03 | 0.2583 | 0.1549 | 03/31/2026 |
| 6 | First Trust Advisors LP | 1,335,273 | -352,115 | 35,291,265.39 | 0.0212 | 0.2078 | 12/31/2025 |
| 7 | Tang Capital Management LLC | 0 | -200,000 | 0 | 0 | 0 | |
| 8 | LPL Financial LLC | 188,637 | -182,942 | 4,985,675.91 | 0.0012 | 0.0294 | 03/31/2026 |
| 9 | Ikarian Capital LLC | 0 | -175,000 | 0 | 0 | 0 | |
| 10 | Marshall Wace LLP | 358,440 | -174,769 | 9,473,569.2 | 0.0083 | 0.0558 | 12/31/2025 |
Data provided by FactSet Research Systems Inc.