| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Orbis Investment Management Ltd. | 12,925,578 | -1,492,884 | 403,924,312.5 | 0.9443 | 2.073 | 03/31/2026 |
| 2 | AllianceBernstein LP | 9,557,149 | -1,319,945 | 298,660,906.25 | 0.0811 | 1.5327 | 03/31/2026 |
| 3 | Paradigm BioCapital Advisors LP | 7,967,836 | 928,002 | 248,994,875 | 4.4428 | 1.2779 | 03/31/2026 |
| 4 | Arrowstreet Capital LP | 4,975,324 | -2,734 | 155,478,875 | 0.0685 | 0.7979 | 03/31/2026 |
| 5 | Renaissance Technologies LLC | 4,414,550 | 921,700 | 137,954,687.5 | 0.185 | 0.708 | 03/31/2026 |
| 6 | BlackRock Fund Advisors | 3,739,805 | 158,191 | 116,868,906.25 | 0.0021 | 0.5998 | 06/30/2026 |
| 7 | Deep Track Capital LP | 3,663,250 | 3,663,250 | 114,476,562.5 | 1.6867 | 0.5875 | 03/31/2026 |
| 8 | Harding Loevner LP | 3,231,601 | -138,542 | 100,987,531.25 | 0.4139 | 0.5183 | 03/31/2026 |
| 9 | First Trust Advisors LP | 2,461,342 | 1,126,069 | 76,916,937.5 | 0.0414 | 0.3947 | 03/31/2026 |
| 10 | Two Sigma Investments LP | 2,339,432 | 1,443,589 | 73,107,250 | 0.0525 | 0.3752 | 03/31/2026 |
| 11 | Parametric Portfolio Associates LLC | 1,640,297 | -49,876 | 51,259,281.25 | 0.0113 | 0.2631 | 03/31/2026 |
| 12 | Federated Global Investment Management Corp. | 1,251,590 | 572,211 | 39,112,187.5 | 0.3104 | 0.2007 | 03/31/2026 |
| 13 | Brandywine Global Investment Management LLC | 1,162,003 | 130,539 | 36,312,593.75 | 0.2207 | 0.1864 | 03/31/2026 |
| 14 | Pictet Asset Management SA | 1,065,927 | -32,623 | 33,310,218.75 | 0.0206 | 0.1709 | 06/30/2026 |
| 15 | Northern Trust Investments, Inc.(Investment Management) | 950,534 | -6,495 | 29,704,187.5 | 0.0037 | 0.1524 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | AllianceBernstein (Japan) AB US Large Cap Growth Equity Mother | 3,945,189 | 0 | 123,287,156.25 | 0.3144 | 0.6327 | 12/30/2025 |
| 2 | iShares Biotechnology ETF | 3,840,484 | 214,908 | 120,015,125 | 1.2291 | 0.6159 | 07/31/2026 |
| 3 | Orbis SICAV - International Equity Fund | 3,399,025 | 0 | 106,219,531.25 | 2.5105 | 0.5451 | 12/31/2025 |
| 4 | First Trust NYSE Arca Biotechnology Index Fund | 3,107,623 | 753,604 | 97,113,218.75 | 3.4928 | 0.4984 | 07/31/2026 |
| 5 | Orbis SICAV - Global Balanced Fund | 1,787,954 | 0 | 55,873,562.5 | 1.0022 | 0.2867 | 12/31/2025 |
| 6 | AB Large Cap Growth Fund | 1,224,436 | -1,112,674 | 38,263,625 | 0.1626 | 0.1964 | 06/30/2026 |
| 7 | AB US Large Cap Growth CIT W Series | 936,031 | -71,690 | 29,250,968.75 | 0.2974 | 0.1501 | 06/30/2026 |
| 8 | AB SICAV I - American Growth Portfolio | 922,820 | -27,050 | 28,838,125 | 0.311 | 0.148 | 06/30/2026 |
| 9 | Avantis International Equity ETF | 546,778 | 151,355 | 17,086,812.5 | 0.0917 | 0.0877 | 07/31/2026 |
| 10 | Federated Hermes Kaufmann Fund | 520,700 | 98,200 | 16,271,875 | 0.3113 | 0.0835 | 06/30/2026 |
| 11 | JOHCM Umbrella Fund Plc - Global Select Fund | 510,883 | 40,924 | 15,965,093.75 | 1.7015 | 0.0819 | 04/30/2026 |
| 12 | Orbis Instl. Funds Ltd. - Institutional Global Equity Fund | 356,948 | 0 | 11,154,625 | 0.4442 | 0.0572 | 12/31/2025 |
| 13 | Federated Hermes Kaufmann Small Cap Fund | 350,000 | 102,000 | 10,937,500 | 0.3504 | 0.0561 | 06/30/2026 |
| 14 | Federated Hermes International Leaders Fund | 343,771 | 343,771 | 10,742,843.75 | 0.7013 | 0.0551 | 06/30/2026 |
| 15 | Russell Investment Co. - Tax Managed US Large Cap Fund | 342,344 | 0 | 10,698,250 | 0.0824 | 0.0549 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Deep Track Capital LP | 3,663,250 | 3,663,250 | 114,476,562.5 | 1.6867 | 0.5875 | 03/31/2026 |
| 2 | Two Sigma Investments LP | 2,339,432 | 1,443,589 | 73,107,250 | 0.0525 | 0.3752 | 03/31/2026 |
| 3 | First Trust Advisors LP | 2,461,342 | 1,126,069 | 76,916,937.5 | 0.0414 | 0.3947 | 03/31/2026 |
| 4 | Paradigm BioCapital Advisors LP | 7,967,836 | 928,002 | 248,994,875 | 4.4428 | 1.2779 | 03/31/2026 |
| 5 | Renaissance Technologies LLC | 4,414,550 | 921,700 | 137,954,687.5 | 0.185 | 0.708 | 03/31/2026 |
| 6 | Millennium Management LLC | 792,293 | 697,720 | 24,759,156.25 | 0.0164 | 0.1271 | 03/31/2026 |
| 7 | Qube Research & Technologies Ltd. | 677,346 | 637,891 | 21,167,062.5 | 0.0262 | 0.1086 | 03/31/2026 |
| 8 | Federated Global Investment Management Corp. | 1,251,590 | 572,211 | 39,112,187.5 | 0.3104 | 0.2007 | 03/31/2026 |
| 9 | Morgan Stanley & Co. LLC | 477,347 | 417,249 | 14,917,093.75 | 0.0043 | 0.0766 | 03/31/2026 |
| 10 | Wells Fargo Clearing Services LLC | 316,195 | 312,882 | 9,881,093.75 | 0.003 | 0.0507 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Orbis Investment Management Ltd. | 12,925,578 | -1,492,884 | 403,924,312.5 | 0.9443 | 2.073 | 03/31/2026 |
| 2 | AllianceBernstein LP | 9,557,149 | -1,319,945 | 298,660,906.25 | 0.0811 | 1.5327 | 03/31/2026 |
| 3 | Susquehanna Financial Group LLLP | 0 | -612,323 | 0 | 0 | 0 | |
| 4 | Balyasny Asset Management LP | 0 | -379,364 | 0 | 0 | 0 | |
| 5 | Woodline Partners LP | 0 | -369,188 | 0 | 0 | 0 | |
| 6 | Marshall Wace LLP | 15,000 | -343,440 | 468,750 | 0.0004 | 0.0024 | 03/31/2026 |
| 7 | Two Sigma Advisers LP | 0 | -340,000 | 0 | 0 | 0 | |
| 8 | Goldman Sachs & Co. LLC (Private Banking) | 68,981 | -323,184 | 2,155,656.25 | 0.0006 | 0.0111 | 03/31/2026 |
| 9 | LPL Financial LLC | 144,321 | -294,020 | 4,510,031.25 | 0.001 | 0.0231 | 06/30/2026 |
| 10 | Neos Investment Management LLC | 0 | -140,733 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.