| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | AllianceBernstein LP | 10,662,375 | -4,062,783 | 318,698,388.75 | 0.0916 | 1.6107 | 06/30/2025 |
| 2 | Orbis Investment Management Ltd. | 7,920,400 | 2,209,659 | 236,740,756 | 0.6624 | 1.1965 | 06/30/2025 |
| 3 | Arrowstreet Capital LP | 3,454,378 | 2,084,966 | 103,251,358.42 | 0.0657 | 0.5218 | 06/30/2025 |
| 4 | Citadel Advisors LLC | 3,165,869 | -1,178,437 | 94,627,824.41 | 0.1038 | 0.4782 | 06/30/2025 |
| 5 | Harding Loevner LP | 2,923,439 | 42,613 | 87,381,591.71 | 0.2993 | 0.4416 | 06/30/2025 |
| 6 | Renaissance Technologies LLC | 2,766,750 | 504,400 | 82,698,157.5 | 0.1014 | 0.418 | 06/30/2025 |
| 7 | BlackRock Fund Advisors | 2,503,952 | -443,287 | 74,843,125.28 | 0.0016 | 0.3783 | 06/30/2025 |
| 8 | Marshall Wace LLP | 1,907,284 | -274,226 | 57,008,718.76 | 0.0614 | 0.2881 | 06/30/2025 |
| 9 | Two Sigma Advisers LP | 1,821,000 | -152,700 | 54,429,690 | 0.1026 | 0.2751 | 06/30/2025 |
| 10 | First Trust Advisors LP | 1,770,310 | 60,504 | 52,914,565.9 | 0.0372 | 0.2674 | 06/30/2025 |
| 11 | Brandywine Global Investment Management LLC | 1,744,769 | 27,372 | 52,151,145.41 | 0.3327 | 0.2636 | 06/30/2025 |
| 12 | Two Sigma Investments LP | 1,618,544 | -281,222 | 48,378,280.16 | 0.0805 | 0.2445 | 06/30/2025 |
| 13 | Morgan Stanley & Co. LLC | 1,473,171 | -141,446 | 44,033,081.19 | 0.0146 | 0.2225 | 06/30/2025 |
| 14 | Parametric Portfolio Associates LLC | 1,188,699 | -6,410 | 35,530,213.11 | 0.0096 | 0.1796 | 06/30/2025 |
| 15 | Point72 Asset Management LP | 1,025,835 | 101,632 | 30,662,208.15 | 0.0565 | 0.155 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | AllianceBernstein (Japan) AB US Large Cap Growth Equity Mother | 5,706,859 | 213,522 | 170,578,015.51 | 0.4169 | 0.8621 | 06/16/2025 |
| 2 | iShares Biotechnology ETF | 2,670,531 | -314,366 | 79,822,171.59 | 1.2495 | 0.4034 | 09/30/2025 |
| 3 | First Trust NYSE Arca Biotechnology Index Fund | 1,591,311 | -99,865 | 47,564,285.79 | 4.1146 | 0.2404 | 09/30/2025 |
| 4 | AB US Large Cap Growth CIT W Series | 1,380,211 | 148,500 | 41,254,506.79 | 0.3929 | 0.2085 | 08/31/2025 |
| 5 | AB SICAV I - American Growth Portfolio | 1,192,074 | -52,729 | 35,631,091.86 | 0.4047 | 0.1801 | 08/29/2025 |
| 6 | Avantis International Equity ETF | 323,096 | 171,807 | 9,657,339.44 | 0.0988 | 0.0488 | 09/30/2025 |
| 7 | AB Disruptors ETF | 282,112 | 282,112 | 8,432,327.68 | 0.71 | 0.0426 | 09/30/2025 |
| 8 | SunAmerica Series Trust - SA AB Growth Portfolio | 257,908 | -9,537 | 7,708,870.12 | 0.3978 | 0.039 | 08/31/2025 |
| 9 | Fidelity Enhanced International ETF | 247,381 | 34,255 | 7,394,218.09 | 0.1598 | 0.0374 | 09/30/2025 |
| 10 | Lincoln VIP - AllianceBernstein Large Cap Growth Fund | 205,222 | -6,560 | 6,134,085.58 | 0.3553 | 0.031 | 06/30/2025 |
| 11 | Mercer Funds - Non US Core Equity Fund | 179,676 | 179,676 | 5,370,515.64 | 0.139 | 0.0271 | 09/30/2025 |
| 12 | Orbis SICAV - International Equity Fund | 175,563 | 0 | 5,247,578.07 | 0.1544 | 0.0265 | 12/31/2024 |
| 13 | Orbis Instl. Funds Ltd. - Institutional Global Equity Fund | 144,178 | 0 | 4,309,480.42 | 0.212 | 0.0218 | 12/31/2024 |
| 14 | AllianceBernstein VP - Large Cap Growth Portfolio | 139,807 | -7,260 | 4,178,831.23 | 0.4008 | 0.0211 | 08/31/2025 |
| 15 | Tema Oncology ETF | 132,043 | 29,294 | 3,946,765.27 | 4.7164 | 0.0199 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Orbis Investment Management Ltd. | 7,920,400 | 2,209,659 | 236,740,756 | 0.6624 | 1.1965 | 06/30/2025 |
| 2 | Arrowstreet Capital LP | 3,454,378 | 2,084,966 | 103,251,358.42 | 0.0657 | 0.5218 | 06/30/2025 |
| 3 | Avidity Partners Management LP | 650,000 | 650,000 | 19,428,500 | 3.0795 | 0.0982 | 06/30/2025 |
| 4 | Renaissance Technologies LLC | 2,766,750 | 504,400 | 82,698,157.5 | 0.1014 | 0.418 | 06/30/2025 |
| 5 | Woodline Partners LP | 493,506 | 493,506 | 14,750,894.34 | 0.0699 | 0.0746 | 06/30/2025 |
| 6 | ABC Arbitrage Asset Management SA | 447,055 | 447,055 | 13,362,473.95 | 1.5467 | 0.0675 | 06/30/2025 |
| 7 | Citadel Securities LLC | 403,315 | 320,967 | 12,055,085.35 | 0.0355 | 0.0609 | 06/30/2025 |
| 8 | Jane Street Capital LLC | 360,489 | 219,655 | 10,775,016.21 | 0.0144 | 0.0545 | 06/30/2025 |
| 9 | Old Mission Capital LLC | 216,712 | 216,712 | 6,477,521.68 | 0.164 | 0.0327 | 06/30/2025 |
| 10 | Strategic Advisers LLC | 417,044 | 210,147 | 12,465,445.16 | 0.0041 | 0.063 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | AllianceBernstein LP | 10,662,375 | -4,062,783 | 318,698,388.75 | 0.0916 | 1.6107 | 06/30/2025 |
| 2 | Citadel Advisors LLC | 3,165,869 | -1,178,437 | 94,627,824.41 | 0.1038 | 0.4782 | 06/30/2025 |
| 3 | Cubist Systematic Strategies LLC | 384,546 | -873,597 | 11,494,079.94 | 0.1153 | 0.0581 | 06/30/2025 |
| 4 | DDD Partners LLC | 0 | -601,050 | 0 | 0 | 0 | |
| 5 | Millennium Management LLC | 386,296 | -482,534 | 11,546,387.44 | 0.0095 | 0.0584 | 06/30/2025 |
| 6 | BlackRock Fund Advisors | 2,503,952 | -443,287 | 74,843,125.28 | 0.0016 | 0.3783 | 06/30/2025 |
| 7 | Voloridge Investment Management LLC | 949,178 | -364,107 | 28,370,930.42 | 0.0981 | 0.1434 | 06/30/2025 |
| 8 | Two Sigma Investments LP | 1,618,544 | -281,222 | 48,378,280.16 | 0.0805 | 0.2445 | 06/30/2025 |
| 9 | Marshall Wace LLP | 1,907,284 | -274,226 | 57,008,718.76 | 0.0614 | 0.2881 | 06/30/2025 |
| 10 | Hardman Johnston Global Advisors LLC | 0 | -226,911 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.