| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Darwin Global Management Ltd. | 18,433,047 | 18,433,047 | 1,016,029,550.64 | 16.1972 | 2.9537 | 09/28/2026 |
| 2 | Paradigm BioCapital Advisors LP | 13,133,131 | 5,165,295 | 723,898,180.72 | 15.099 | 2.1045 | 06/30/2026 |
| 3 | Orbis Investment Management Ltd. | 11,368,161 | -1,557,417 | 626,613,034.32 | 1.3589 | 1.8216 | 06/30/2026 |
| 4 | AllianceBernstein LP | 8,644,877 | -912,272 | 476,505,620.24 | 0.1361 | 1.3853 | 06/30/2026 |
| 5 | Deep Track Capital LP | 5,650,000 | 1,986,750 | 311,428,000 | 5.0084 | 0.9054 | 06/30/2026 |
| 6 | Arrowstreet Capital LP | 4,975,324 | 0 | 274,239,858.88 | 0.112 | 0.7973 | 06/30/2026 |
| 7 | BlackRock Fund Advisors | 3,739,805 | 177,315 | 206,138,051.6 | 0.0038 | 0.5993 | 06/30/2026 |
| 8 | Renaissance Technologies LLC | 3,517,850 | -896,700 | 193,903,892 | 0.2657 | 0.5637 | 06/30/2026 |
| 9 | Two Sigma Investments LP | 3,506,843 | 1,167,411 | 193,297,186.16 | 0.1455 | 0.5619 | 06/30/2026 |
| 10 | Harding Loevner LP | 3,086,318 | -145,283 | 170,117,848.16 | 0.7647 | 0.4946 | 06/30/2026 |
| 11 | First Trust Advisors LP | 2,756,522 | 295,180 | 151,939,492.64 | 0.0818 | 0.4417 | 06/30/2026 |
| 12 | Citadel Advisors LLC | 1,919,023 | 1,919,023 | 105,776,547.76 | 0.0777 | 0.3075 | 06/30/2026 |
| 13 | Qube Research & Technologies Ltd. | 1,689,284 | 1,011,938 | 93,113,334.08 | 0.1035 | 0.2707 | 06/30/2026 |
| 14 | Parametric Portfolio Associates LLC | 1,478,909 | -161,388 | 81,517,464.08 | 0.0179 | 0.237 | 06/30/2026 |
| 15 | Federated Global Investment Management Corp. | 1,424,132 | 172,542 | 78,498,155.84 | 0.7081 | 0.2282 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | iShares Biotechnology ETF | 4,326,344 | 839,678 | 238,468,081.28 | 2.0408 | 0.6933 | 10/30/2026 |
| 2 | AllianceBernstein (Japan) AB US Large Cap Growth Equity Mother | 3,945,189 | 0 | 217,458,817.68 | 0.5497 | 0.6322 | 12/30/2025 |
| 3 | American Funds New Perspective Fund | 3,078,594 | 3,078,594 | 169,692,101.28 | 0.1065 | 0.4933 | 09/30/2026 |
| 4 | First Trust NYSE Arca Biotechnology Index Fund | 2,677,204 | 13,817 | 147,567,484.48 | 4.7141 | 0.429 | 10/30/2026 |
| 5 | Orbis SICAV - International Equity Fund | 2,212,589 | -1,186,436 | 121,957,905.68 | 2.6672 | 0.3545 | 06/30/2026 |
| 6 | Orbis SICAV - Global Balanced Fund | 1,727,709 | -60,245 | 95,231,320.08 | 1.5706 | 0.2769 | 06/30/2026 |
| 7 | AB SICAV I - American Growth Portfolio | 944,437 | -5,433 | 52,057,367.44 | 0.5618 | 0.1513 | 09/30/2026 |
| 8 | AB US Large Cap Growth CIT W Series | 868,771 | -119,270 | 47,886,657.52 | 0.5196 | 0.1392 | 08/31/2026 |
| 9 | Pictet - Biotech | 721,543 | 0 | 39,771,450.16 | 1.9721 | 0.1156 | 03/31/2026 |
| 10 | JOHCM Umbrella Fund Plc - Global Select Fund | 561,312 | 50,429 | 30,939,517.44 | 3.6495 | 0.0899 | 07/31/2026 |
| 11 | Federated Hermes Kaufmann Fund | 520,700 | 0 | 28,700,984 | 0.5936 | 0.0834 | 06/30/2026 |
| 12 | Avantis International Equity ETF | 511,829 | 25,462 | 28,212,014.48 | 0.1446 | 0.082 | 10/30/2026 |
| 13 | BlackRock Health Sciences Opportunities Portfolio | 453,944 | 453,944 | 25,021,393.28 | 0.3663 | 0.0727 | 09/30/2026 |
| 14 | CIF - Capital Group New Perspective Fund (Lux) | 367,965 | 367,965 | 20,282,230.8 | 0.1077 | 0.059 | 09/30/2026 |
| 15 | Orbis Instl. Funds Ltd. - Institutional Global Equity Fund | 356,948 | 0 | 19,674,973.76 | 0.7862 | 0.0572 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Darwin Global Management Ltd. | 18,433,047 | 18,433,047 | 1,016,029,550.64 | 16.1972 | 2.9537 | 09/28/2026 |
| 2 | Paradigm BioCapital Advisors LP | 13,133,131 | 5,165,295 | 723,898,180.72 | 15.099 | 2.1045 | 06/30/2026 |
| 3 | Deep Track Capital LP | 5,650,000 | 1,986,750 | 311,428,000 | 5.0084 | 0.9054 | 06/30/2026 |
| 4 | Citadel Advisors LLC | 1,919,023 | 1,919,023 | 105,776,547.76 | 0.0777 | 0.3075 | 06/30/2026 |
| 5 | Two Sigma Investments LP | 3,506,843 | 1,167,411 | 193,297,186.16 | 0.1455 | 0.5619 | 06/30/2026 |
| 6 | Qube Research & Technologies Ltd. | 1,689,284 | 1,011,938 | 93,113,334.08 | 0.1035 | 0.2707 | 06/30/2026 |
| 7 | Marshall Wace LLP | 829,659 | 814,659 | 45,730,804.08 | 0.038 | 0.1329 | 06/30/2026 |
| 8 | JPMorgan Securities LLC (Investment Management) | 668,448 | 667,157 | 36,844,853.76 | 0.0174 | 0.1071 | 06/30/2026 |
| 9 | UBS Securities LLC | 855,183 | 633,896 | 47,137,686.96 | 0.0177 | 0.137 | 06/30/2026 |
| 10 | Citadel Securities LLC | 556,968 | 556,968 | 30,700,076.16 | 0.0749 | 0.0892 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Orbis Investment Management Ltd. | 11,368,161 | -1,557,417 | 626,613,034.32 | 1.3589 | 1.8216 | 06/30/2026 |
| 2 | AllianceBernstein LP | 8,644,877 | -912,272 | 476,505,620.24 | 0.1361 | 1.3853 | 06/30/2026 |
| 3 | Renaissance Technologies LLC | 3,517,850 | -896,700 | 193,903,892 | 0.2657 | 0.5637 | 06/30/2026 |
| 4 | Morgan Stanley & Co. LLC | 118,288 | -359,059 | 6,520,034.56 | 0.0019 | 0.019 | 06/30/2026 |
| 5 | Parametric Portfolio Associates LLC | 1,478,909 | -161,388 | 81,517,464.08 | 0.0179 | 0.237 | 06/30/2026 |
| 6 | Fidelity Management & Research Co. LLC | 37,266 | -161,139 | 2,054,101.92 | 0.0001 | 0.006 | 06/30/2026 |
| 7 | Harding Loevner LP | 3,086,318 | -145,283 | 170,117,848.16 | 0.7647 | 0.4946 | 06/30/2026 |
| 8 | JPMorgan Asset Management (UK) Ltd. | 0 | -142,085 | 0 | 0 | 0 | |
| 9 | Great Gray Trust Co. LLC (Investment Management) | 868,771 | -119,270 | 47,886,657.52 | 0.4817 | 0.1392 | 08/31/2026 |
| 10 | Strategic Advisers LLC | 723,267 | -85,893 | 39,866,477.04 | 0.0104 | 0.1159 | 06/30/2026 |
Data provided by FactSet Research Systems Inc.