| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | HHLR Advisors Ltd. | 5,980,568 | 0 | 8,193,378.16 | 0.0781 | 5.1833 | 06/30/2026 |
| 2 | Morgan Stanley & Co. LLC | 3,651,754 | -186,444 | 5,002,902.98 | 0.0015 | 3.1649 | 06/30/2026 |
| 3 | AIHC Capital Management Ltd. | 2,878,033 | 615,100 | 3,942,905.21 | 1.648 | 2.4944 | 06/30/2026 |
| 4 | Marshall Wace LLP | 1,231,946 | 1,231,946 | 1,687,766.02 | 0.0014 | 1.0677 | 06/30/2026 |
| 5 | Candriam Belgium SA | 1,132,563 | 0 | 1,551,611.31 | 0.0037 | 0.9816 | 06/30/2026 |
| 6 | Adage Capital Management LP | 1,000,000 | 0 | 1,370,000 | 0.0019 | 0.8667 | 06/30/2026 |
| 7 | Two Sigma Investments LP | 851,348 | 851,348 | 1,166,346.76 | 0.0009 | 0.7379 | 06/30/2026 |
| 8 | Renaissance Technologies LLC | 758,226 | 485,814 | 1,038,769.62 | 0.0014 | 0.6571 | 06/30/2026 |
| 9 | Citadel Securities LLC | 622,831 | 467,728 | 853,278.47 | 0.0021 | 0.5398 | 06/30/2026 |
| 10 | BlackRock Fund Advisors | 597,571 | 56,931 | 818,672.27 | 0 | 0.5179 | 06/30/2026 |
| 11 | E Fund Management Co., Ltd. | 589,020 | 589,020 | 806,957.4 | 0.0007 | 0.5105 | 06/30/2026 |
| 12 | Exome Asset Management LLC | 576,960 | 0 | 790,435.2 | 0.5661 | 0.5 | 06/30/2026 |
| 13 | SSgA Funds Management, Inc. | 360,376 | -9,731 | 493,715.12 | 0 | 0.3123 | 06/30/2026 |
| 14 | Woodline Partners LP | 350,000 | -350,000 | 479,500 | 0.0015 | 0.3033 | 06/30/2026 |
| 15 | Fiera Capital (UK) Ltd. | 315,681 | 0 | 432,482.97 | 0.0164 | 0.2736 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Candriam Equities L - Oncology | 1,132,563 | 0 | 1,551,611.31 | 0.0859 | 0.9816 | 03/31/2026 |
| 2 | iShares Biotechnology ETF | 658,233 | 118,715 | 901,779.21 | 0.0082 | 0.5705 | 09/30/2026 |
| 3 | E Fund Global Pharmaceutical Industry Hybrid Fund | 589,020 | -441,851 | 806,957.4 | 0.4469 | 0.5105 | 06/30/2026 |
| 4 | Belfius Equities - Cure | 490,585 | 0 | 672,101.45 | 0.0859 | 0.4252 | 03/31/2026 |
| 5 | OAKS Emerging Umbrella Fund - Emerging & Frontier Opp. Fd. | 315,681 | 0 | 432,482.97 | 0.218 | 0.2736 | 06/30/2026 |
| 6 | State Street SPDR Portfolio Emerging Markets ETF | 297,936 | -5,529 | 408,172.32 | 0.0024 | 0.2582 | 09/30/2026 |
| 7 | ALPS Medical Breakthroughs ETF | 150,167 | 150,167 | 205,728.79 | 0.1064 | 0.1301 | 09/30/2026 |
| 8 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 95,169 | 8,313 | 130,381.53 | 0.0107 | 0.0825 | 09/30/2026 |
| 9 | Invesco NASDAQ Future Gen 200 ETF | 65,859 | 44,299 | 90,226.83 | 0.4282 | 0.0571 | 09/30/2026 |
| 10 | Abaris Biotechnology Opportunities | 65,500 | 0 | 89,735 | 0.5537 | 0.0568 | 12/31/2025 |
| 11 | Fidelity Nasdaq Composite Index Fund | 44,124 | -24,725 | 60,449.88 | 0.0002 | 0.0382 | 08/31/2026 |
| 12 | Invesco Markets Plc - NASDAQ Biotech UCITS ETF | 36,653 | -1,362 | 50,214.61 | 0.0103 | 0.0318 | 09/30/2026 |
| 13 | DFA World (ex-US) Core Equity Portfolio | 26,330 | 5,200 | 36,072.1 | 0.0007 | 0.0228 | 07/31/2026 |
| 14 | DFA Emerging Markets Core Equity 2 Portfolio | 20,035 | 0 | 27,447.95 | 0.0001 | 0.0174 | 07/31/2026 |
| 15 | China Universal Nasdaq Biotechnology Index ETF | 17,864 | 924 | 24,473.68 | 0.0103 | 0.0155 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Marshall Wace LLP | 1,231,946 | 1,231,946 | 1,687,766.02 | 0.0014 | 1.0677 | 06/30/2026 |
| 2 | Two Sigma Investments LP | 851,348 | 851,348 | 1,166,346.76 | 0.0009 | 0.7379 | 06/30/2026 |
| 3 | AIHC Capital Management Ltd. | 2,878,033 | 615,100 | 3,942,905.21 | 1.648 | 2.4944 | 06/30/2026 |
| 4 | E Fund Management Co., Ltd. | 589,020 | 589,020 | 806,957.4 | 0.0007 | 0.5105 | 06/30/2026 |
| 5 | Renaissance Technologies LLC | 758,226 | 485,814 | 1,038,769.62 | 0.0014 | 0.6571 | 06/30/2026 |
| 6 | Citadel Securities LLC | 622,831 | 467,728 | 853,278.47 | 0.0021 | 0.5398 | 06/30/2026 |
| 7 | UBS Securities LLC | 301,780 | 238,239 | 413,438.6 | 0.0002 | 0.2615 | 06/30/2026 |
| 8 | ALPS Advisors, Inc. | 117,096 | 117,096 | 160,421.52 | 0.0006 | 0.1015 | 06/30/2026 |
| 9 | Headlands Technologies LLC | 65,183 | 65,183 | 89,300.71 | 0.01 | 0.0565 | 06/30/2026 |
| 10 | BlackRock Fund Advisors | 597,571 | 56,931 | 818,672.27 | 0 | 0.5179 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 0 | -6,032,650 | 0 | 0 | 0 | |
| 2 | Point72 Asset Management LP | 0 | -1,389,403 | 0 | 0 | 0 | |
| 3 | Woodline Partners LP | 350,000 | -350,000 | 479,500 | 0.0015 | 0.3033 | 06/30/2026 |
| 4 | Morgan Stanley & Co. LLC | 3,651,754 | -186,444 | 5,002,902.98 | 0.0015 | 3.1649 | 06/30/2026 |
| 5 | HRT Financial LP | 0 | -107,524 | 0 | 0 | 0 | |
| 6 | XTX Markets LLC | 0 | -101,509 | 0 | 0 | 0 | |
| 7 | AXQ Capital LP | 0 | -83,330 | 0 | 0 | 0 | |
| 8 | Dymon Asia Capital (Singapore) Pte Ltd. | 0 | -80,400 | 0 | 0 | 0 | |
| 9 | Leonteq Securities AG | 0 | -80,000 | 0 | 0 | 0 | |
| 10 | BNP Paribas Financial Markets SNC | 28,836 | -44,266 | 39,505.32 | 0 | 0.025 | 06/30/2026 |
Data provided by FactSet Research Systems Inc.