| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 8,436,641 | 8,436,641 | 27,419,083.25 | 0.0131 | 7.3286 | 12/31/2025 |
| 2 | HHLR Advisors Ltd. | 5,980,568 | 0 | 19,436,846 | 0.128 | 5.1951 | 12/31/2025 |
| 3 | Morgan Stanley & Co. LLC | 3,785,393 | 3,727,098 | 12,302,527.25 | 0.0043 | 3.2882 | 12/31/2025 |
| 4 | Point72 Asset Management LP | 2,298,501 | 2,298,501 | 7,470,128.25 | 0.0112 | 1.9966 | 12/31/2025 |
| 5 | Ariose Capital Management Ltd. | 1,363,515 | 1,267,060 | 4,431,423.75 | 1.4778 | 1.1844 | 12/31/2025 |
| 6 | Candriam Belgium SA | 1,132,563 | 0 | 3,680,829.75 | 0.0094 | 0.9838 | 12/31/2025 |
| 7 | Candriam SCA | 1,132,563 | 0 | 3,680,829.75 | 0.1014 | 0.9838 | 07/31/2025 |
| 8 | Woodline Partners LP | 1,050,000 | 1,050,000 | 3,412,500 | 0.0128 | 0.9121 | 12/31/2025 |
| 9 | Adage Capital Management LP | 1,000,000 | 1,000,000 | 3,250,000 | 0.0048 | 0.8687 | 12/31/2025 |
| 10 | Millennium Management LLC | 846,008 | 846,008 | 2,749,526 | 0.0019 | 0.7349 | 12/31/2025 |
| 11 | Barclays Bank Plc (Private Banking) | 628,923 | 598,553 | 2,043,999.75 | 0.0011 | 0.5463 | 12/31/2025 |
| 12 | BlackRock Fund Advisors | 549,055 | 549,055 | 1,784,428.75 | 0 | 0.4769 | 12/31/2025 |
| 13 | Exome Asset Management LLC | 499,587 | 499,587 | 1,623,657.75 | 0.7796 | 0.434 | 12/31/2025 |
| 14 | AIHC Capital Management Ltd. | 413,979 | 413,979 | 1,345,431.75 | 0.7503 | 0.3596 | 12/31/2025 |
| 15 | SSgA Funds Management, Inc. | 359,878 | 359,878 | 1,169,603.5 | 0 | 0.3126 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Candriam Equities L - Oncology | 1,132,563 | 0 | 3,680,829.75 | 0.1978 | 0.9838 | 07/31/2025 |
| 2 | iShares Biotechnology ETF | 555,226 | 555,226 | 1,804,484.5 | 0.0207 | 0.4823 | 01/30/2026 |
| 3 | Belfius Equities - Cure | 475,744 | 0 | 1,546,168 | 0.1994 | 0.4133 | 07/31/2025 |
| 4 | State Street SPDR Portfolio Emerging Markets ETF | 294,320 | 294,320 | 956,540 | 0.0056 | 0.2557 | 01/30/2026 |
| 5 | ALPS Barrons 400 ETF | 116,177 | 116,177 | 377,575.25 | 0.1836 | 0.1009 | 01/30/2026 |
| 6 | Abaris Biotechnology Opportunities | 100,000 | 0 | 325,000 | 1.4472 | 0.0869 | 06/30/2025 |
| 7 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 72,082 | 72,082 | 234,266.5 | 0.0238 | 0.0626 | 01/30/2026 |
| 8 | State Street SPDR S&P Emerging Markets Small Cap ETF | 55,396 | 55,396 | 180,037 | 0.0227 | 0.0481 | 01/30/2026 |
| 9 | DFA Emerging Markets Small Cap Portfolio | 48,055 | 48,055 | 156,178.75 | 0.0036 | 0.0417 | 11/30/2025 |
| 10 | Fidelity Nasdaq Composite Index Fund | 45,084 | -9,478 | 146,523 | 0.0006 | 0.0392 | 12/31/2025 |
| 11 | DFA Emerging Markets Small Cap Series (The) | 36,480 | 36,480 | 118,560 | 0.0028 | 0.0317 | 10/31/2025 |
| 12 | Invesco Markets Plc - NASDAQ Biotech UCITS ETF | 34,185 | 34,185 | 111,101.25 | 0.0249 | 0.0297 | 01/30/2026 |
| 13 | DFA Emerging Markets Core Equity 2 Portfolio | 20,035 | 3,818 | 65,113.75 | 0.0002 | 0.0174 | 11/30/2025 |
| 14 | DFA Emerging Markets Social Core Equity Portfolio | 18,909 | 0 | 61,454.25 | 0.0029 | 0.0164 | 11/30/2025 |
| 15 | Invesco NASDAQ Future Gen 200 ETF | 15,423 | 15,423 | 50,124.75 | 0.3949 | 0.0134 | 01/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 8,436,641 | 8,436,641 | 27,419,083.25 | 0.0131 | 7.3286 | 12/31/2025 |
| 2 | Morgan Stanley & Co. LLC | 3,785,393 | 3,727,098 | 12,302,527.25 | 0.0043 | 3.2882 | 12/31/2025 |
| 3 | Point72 Asset Management LP | 2,298,501 | 2,298,501 | 7,470,128.25 | 0.0112 | 1.9966 | 12/31/2025 |
| 4 | Ariose Capital Management Ltd. | 1,363,515 | 1,267,060 | 4,431,423.75 | 1.4778 | 1.1844 | 12/31/2025 |
| 5 | Woodline Partners LP | 1,050,000 | 1,050,000 | 3,412,500 | 0.0128 | 0.9121 | 12/31/2025 |
| 6 | Adage Capital Management LP | 1,000,000 | 1,000,000 | 3,250,000 | 0.0048 | 0.8687 | 12/31/2025 |
| 7 | Millennium Management LLC | 846,008 | 846,008 | 2,749,526 | 0.0019 | 0.7349 | 12/31/2025 |
| 8 | Barclays Bank Plc (Private Banking) | 628,923 | 598,553 | 2,043,999.75 | 0.0011 | 0.5463 | 12/31/2025 |
| 9 | BlackRock Fund Advisors | 549,055 | 549,055 | 1,784,428.75 | 0 | 0.4769 | 12/31/2025 |
| 10 | Exome Asset Management LLC | 499,587 | 499,587 | 1,623,657.75 | 0.7796 | 0.434 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | SG Americas Securities LLC | 36,481 | -839,872 | 118,563.25 | 0.0002 | 0.0317 | 12/31/2025 |
| 2 | Two Sigma Advisers LP | 0 | -209,383 | 0 | 0 | 0 | |
| 3 | Abaris Investment Management AG | 100,000 | -182,000 | 325,000 | 1.4552 | 0.0869 | 06/30/2025 |
| 4 | abrdn, Inc. | 0 | -136,471 | 0 | 0 | 0 | |
| 5 | Two Sigma Investments LP | 0 | -113,262 | 0 | 0 | 0 | |
| 6 | Alberta Investment Management Corp. | 0 | -74,723 | 0 | 0 | 0 | |
| 7 | Renaissance Technologies LLC | 0 | -63,700 | 0 | 0 | 0 | |
| 8 | CreativeOne Wealth LLC | 0 | -37,430 | 0 | 0 | 0 | |
| 9 | Mariner LLC | 0 | -28,760 | 0 | 0 | 0 | |
| 10 | HRT Financial LP | 0 | -25,110 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.