| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 6,032,650 | -2,403,991 | 10,677,790.5 | 0.0048 | 5.2284 | 03/31/2026 |
| 2 | HHLR Advisors Ltd. | 5,980,568 | 0 | 10,585,605.36 | 0.0828 | 5.1833 | 03/31/2026 |
| 3 | Morgan Stanley & Co. LLC | 3,838,198 | 52,805 | 6,793,610.46 | 0.002 | 3.3265 | 03/31/2026 |
| 4 | AIHC Capital Management Ltd. | 2,262,933 | 1,848,954 | 4,005,391.41 | 1.3249 | 1.9613 | 03/31/2026 |
| 5 | Point72 Asset Management LP | 1,389,403 | -909,098 | 2,459,243.31 | 0.0037 | 1.2042 | 03/31/2026 |
| 6 | Candriam Belgium SA | 1,132,563 | 0 | 2,004,636.51 | 0.0049 | 0.9816 | 03/31/2026 |
| 7 | Adage Capital Management LP | 1,000,000 | 0 | 1,770,000 | 0.0024 | 0.8667 | 03/31/2026 |
| 8 | Woodline Partners LP | 700,000 | -350,000 | 1,239,000 | 0.0041 | 0.6067 | 03/31/2026 |
| 9 | Exome Asset Management LLC | 576,960 | 77,373 | 1,021,219.2 | 0.5384 | 0.5 | 03/31/2026 |
| 10 | BlackRock Fund Advisors | 540,640 | -8,415 | 956,932.8 | 0 | 0.4686 | 03/31/2026 |
| 11 | SSgA Funds Management, Inc. | 370,107 | 10,229 | 655,089.39 | 0 | 0.3208 | 03/31/2026 |
| 12 | Fiera Capital (UK) Ltd. | 315,681 | 315,681 | 558,755.37 | 0.0132 | 0.2736 | 03/31/2026 |
| 13 | Barclays Bank Plc (Private Banking) | 298,933 | -329,990 | 529,111.41 | 0.0003 | 0.2591 | 03/31/2026 |
| 14 | Renaissance Technologies LLC | 272,412 | 272,412 | 482,169.24 | 0.0007 | 0.2361 | 03/31/2026 |
| 15 | Taikang Asset Management (Hong Kong) Co., Ltd. | 170,931 | 42,166 | 302,547.87 | 0.0243 | 0.1481 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Candriam Equities L - Oncology | 1,132,563 | 0 | 2,004,636.51 | 0.1155 | 0.9816 | 12/31/2025 |
| 2 | E Fund Global Pharmaceutical Industry Hybrid Fund | 1,030,871 | 0 | 1,824,641.67 | 0.7793 | 0.8934 | 12/31/2025 |
| 3 | iShares Biotechnology ETF | 591,381 | 37,277 | 1,046,744.37 | 0.0116 | 0.5125 | 06/30/2026 |
| 4 | OAKS Emerging Umbrella Fund - Emerging & Frontier Opp. Fd. | 315,681 | 315,681 | 558,755.37 | 0.288 | 0.2736 | 03/31/2026 |
| 5 | State Street SPDR Portfolio Emerging Markets ETF | 297,847 | 7,575 | 527,189.19 | 0.0031 | 0.2581 | 06/30/2026 |
| 6 | ALPS Medical Breakthroughs ETF | 117,096 | 117,096 | 207,259.92 | 0.1103 | 0.1015 | 06/30/2026 |
| 7 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 88,637 | 19,345 | 156,887.49 | 0.0149 | 0.0768 | 06/30/2026 |
| 8 | Fidelity Nasdaq Composite Index Fund | 68,849 | 23,765 | 121,862.73 | 0.0005 | 0.0597 | 05/31/2026 |
| 9 | Abaris Biotechnology Opportunities | 65,500 | 0 | 115,935 | 0.7137 | 0.0568 | 12/31/2025 |
| 10 | Invesco NASDAQ Future Gen 200 ETF | 57,197 | 41,774 | 101,238.69 | 0.5108 | 0.0496 | 06/30/2026 |
| 11 | State Street SPDR S&P Emerging Markets Small Cap ETF | 48,319 | -7,077 | 85,524.63 | 0.0126 | 0.0419 | 06/30/2026 |
| 12 | Invesco Markets Plc - NASDAQ Biotech UCITS ETF | 36,485 | 3,376 | 64,578.45 | 0.014 | 0.0316 | 06/30/2026 |
| 13 | DFA Emerging Markets Small Cap Portfolio | 34,834 | -13,221 | 61,656.18 | 0.0016 | 0.0302 | 03/31/2026 |
| 14 | DFA Emerging Markets Social Core Equity Portfolio | 23,312 | 4,403 | 41,262.24 | 0.0019 | 0.0202 | 03/31/2026 |
| 15 | DFA World (ex-US) Core Equity Portfolio | 21,130 | 6,688 | 37,400.1 | 0.0007 | 0.0183 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | AIHC Capital Management Ltd. | 2,262,933 | 1,848,954 | 4,005,391.41 | 1.3249 | 1.9613 | 03/31/2026 |
| 2 | Fiera Capital (UK) Ltd. | 315,681 | 315,681 | 558,755.37 | 0.0132 | 0.2736 | 03/31/2026 |
| 3 | Renaissance Technologies LLC | 272,412 | 272,412 | 482,169.24 | 0.0007 | 0.2361 | 03/31/2026 |
| 4 | Citadel Securities LLC | 155,103 | 155,103 | 274,532.31 | 0.0006 | 0.1344 | 03/31/2026 |
| 5 | HRT Financial LP | 107,524 | 107,524 | 190,317.48 | 0.0006 | 0.0932 | 03/31/2026 |
| 6 | AXQ Capital LP | 83,330 | 83,330 | 147,494.1 | 0.017 | 0.0722 | 03/31/2026 |
| 7 | Exome Asset Management LLC | 576,960 | 77,373 | 1,021,219.2 | 0.5384 | 0.5 | 03/31/2026 |
| 8 | Leonteq Securities AG | 80,000 | 59,000 | 141,600 | 0.0072 | 0.0693 | 03/31/2026 |
| 9 | Morgan Stanley & Co. LLC | 3,838,198 | 52,805 | 6,793,610.46 | 0.002 | 3.3265 | 03/31/2026 |
| 10 | Taikang Asset Management (Hong Kong) Co., Ltd. | 170,931 | 42,166 | 302,547.87 | 0.0243 | 0.1481 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 6,032,650 | -2,403,991 | 10,677,790.5 | 0.0048 | 5.2284 | 03/31/2026 |
| 2 | Ariose Capital Management Ltd. | 0 | -1,363,515 | 0 | 0 | 0 | |
| 3 | Point72 Asset Management LP | 1,389,403 | -909,098 | 2,459,243.31 | 0.0037 | 1.2042 | 03/31/2026 |
| 4 | Millennium Management LLC | 0 | -846,008 | 0 | 0 | 0 | |
| 5 | Woodline Partners LP | 700,000 | -350,000 | 1,239,000 | 0.0041 | 0.6067 | 03/31/2026 |
| 6 | Barclays Bank Plc (Private Banking) | 298,933 | -329,990 | 529,111.41 | 0.0003 | 0.2591 | 03/31/2026 |
| 7 | Connor, Clark & Lunn Investment Management Ltd. | 0 | -191,714 | 0 | 0 | 0 | |
| 8 | UBS Securities LLC | 63,541 | -118,235 | 112,467.57 | 0 | 0.0551 | 03/31/2026 |
| 9 | ALPS Advisors, Inc. | 0 | -112,451 | 0 | 0 | 0 | |
| 10 | Dymon Asia Capital (Singapore) Pte Ltd. | 0 | -80,400 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.