| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 6,032,650 | -1,958,727 | 8,867,995.5 | 0.004 | 5.2284 | 03/31/2026 |
| 2 | HHLR Advisors Ltd. | 5,980,568 | 0 | 8,791,434.96 | 0.0668 | 5.1833 | 03/31/2026 |
| 3 | Morgan Stanley & Co. LLC | 3,838,198 | 1,606,158 | 5,642,151.06 | 0.0017 | 3.3265 | 03/31/2026 |
| 4 | AIHC Capital Management Ltd. | 2,262,933 | 2,262,933 | 3,326,511.51 | 1.4996 | 1.9613 | 03/31/2026 |
| 5 | Point72 Asset Management LP | 1,389,403 | 750,689 | 2,042,422.41 | 0.003 | 1.2042 | 03/31/2026 |
| 6 | Candriam Belgium SA | 1,132,563 | 0 | 1,664,867.61 | 0.004 | 0.9816 | 03/31/2026 |
| 7 | Adage Capital Management LP | 1,000,000 | -2,338,034 | 1,470,000 | 0.002 | 0.8667 | 03/31/2026 |
| 8 | Woodline Partners LP | 700,000 | -350,000 | 1,029,000 | 0.0035 | 0.6067 | 03/31/2026 |
| 9 | Exome Asset Management LLC | 576,960 | -862,644 | 848,131.2 | 0.5178 | 0.5 | 03/31/2026 |
| 10 | BlackRock Fund Advisors | 540,640 | 540,640 | 794,740.8 | 0 | 0.4686 | 03/31/2026 |
| 11 | SSgA Funds Management, Inc. | 370,107 | 32,707 | 544,057.29 | 0 | 0.3208 | 03/31/2026 |
| 12 | Fiera Capital (UK) Ltd. | 315,681 | 315,681 | 464,051.07 | 0.0108 | 0.2736 | 03/31/2026 |
| 13 | Barclays Bank Plc (Private Banking) | 298,933 | -96,498 | 439,431.51 | 0.0002 | 0.2591 | 03/31/2026 |
| 14 | Renaissance Technologies LLC | 272,412 | 208,812 | 400,445.64 | 0.0006 | 0.2361 | 03/31/2026 |
| 15 | Taikang Asset Management (Hong Kong) Co., Ltd. | 170,931 | 170,931 | 251,268.57 | 0.0197 | 0.1481 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Candriam Equities L - Oncology | 1,132,563 | 0 | 1,664,867.61 | 0.1023 | 0.9816 | 11/28/2025 |
| 2 | E Fund Global Pharmaceutical Industry Hybrid Fund | 1,030,871 | 1,030,871 | 1,515,380.37 | 0.7312 | 0.8934 | 12/31/2025 |
| 3 | iShares Biotechnology ETF | 517,078 | 517,078 | 760,104.66 | 0.0097 | 0.4481 | 05/29/2026 |
| 4 | Belfius Equities - Cure | 491,774 | 0 | 722,907.78 | 0.1023 | 0.4262 | 11/28/2025 |
| 5 | OAKS Emerging Umbrella Fund - Emerging & Frontier Opp. Fd. | 315,681 | 315,681 | 464,051.07 | 0.2465 | 0.2736 | 02/27/2026 |
| 6 | State Street SPDR Portfolio Emerging Markets ETF | 303,465 | 16,537 | 446,093.55 | 0.0026 | 0.263 | 05/29/2026 |
| 7 | Abaris Biotechnology Opportunities | 100,000 | 0 | 147,000 | 0.8316 | 0.0867 | 06/30/2025 |
| 8 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 81,176 | 81,176 | 119,328.72 | 0.0135 | 0.0704 | 05/29/2026 |
| 9 | Fidelity Nasdaq Composite Index Fund | 68,849 | 23,765 | 101,208.03 | 0.0004 | 0.0597 | 04/30/2026 |
| 10 | State Street SPDR S&P Emerging Markets Small Cap ETF | 48,319 | -7,077 | 71,028.93 | 0.0099 | 0.0419 | 05/29/2026 |
| 11 | DFA Emerging Markets Small Cap Series (The) | 48,055 | 11,575 | 70,640.85 | 0.0018 | 0.0416 | 01/31/2026 |
| 12 | Invesco Markets Plc - NASDAQ Biotech UCITS ETF | 36,657 | 36,657 | 53,885.79 | 0.0133 | 0.0318 | 05/29/2026 |
| 13 | DFA Emerging Markets Small Cap Portfolio | 34,834 | -13,221 | 51,205.98 | 0.0013 | 0.0302 | 03/31/2026 |
| 14 | Invesco NASDAQ Future Gen 200 ETF | 23,427 | 23,427 | 34,437.69 | 0.1977 | 0.0203 | 05/29/2026 |
| 15 | DFA Emerging Markets Social Core Equity Portfolio | 23,312 | 4,403 | 34,268.64 | 0.0016 | 0.0202 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | AIHC Capital Management Ltd. | 2,262,933 | 2,262,933 | 3,326,511.51 | 1.4996 | 1.9613 | 03/31/2026 |
| 2 | Morgan Stanley & Co. LLC | 3,838,198 | 1,606,158 | 5,642,151.06 | 0.0017 | 3.3265 | 03/31/2026 |
| 3 | Point72 Asset Management LP | 1,389,403 | 750,689 | 2,042,422.41 | 0.003 | 1.2042 | 03/31/2026 |
| 4 | BlackRock Fund Advisors | 540,640 | 540,640 | 794,740.8 | 0 | 0.4686 | 03/31/2026 |
| 5 | Fiera Capital (UK) Ltd. | 315,681 | 315,681 | 464,051.07 | 0.0108 | 0.2736 | 03/31/2026 |
| 6 | Renaissance Technologies LLC | 272,412 | 208,812 | 400,445.64 | 0.0006 | 0.2361 | 03/31/2026 |
| 7 | Taikang Asset Management (Hong Kong) Co., Ltd. | 170,931 | 170,931 | 251,268.57 | 0.0197 | 0.1481 | 03/31/2026 |
| 8 | Citadel Securities LLC | 155,103 | 155,103 | 228,001.41 | 0.0005 | 0.1344 | 03/31/2026 |
| 9 | HRT Financial LP | 107,524 | 107,524 | 158,060.28 | 0.0005 | 0.0932 | 03/31/2026 |
| 10 | BlackRock Advisors (UK) Ltd. | 86,856 | 86,856 | 127,678.32 | 0 | 0.0753 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Adage Capital Management LP | 1,000,000 | -2,338,034 | 1,470,000 | 0.002 | 0.8667 | 03/31/2026 |
| 2 | Janus Henderson Investors US LLC | 6,032,650 | -1,958,727 | 8,867,995.5 | 0.004 | 5.2284 | 03/31/2026 |
| 3 | Ariose Capital Management Ltd. | 0 | -1,704,393 | 0 | 0 | 0 | |
| 4 | Exome Asset Management LLC | 576,960 | -862,644 | 848,131.2 | 0.5178 | 0.5 | 03/31/2026 |
| 5 | SG Americas Securities LLC | 0 | -463,894 | 0 | 0 | 0 | |
| 6 | Woodline Partners LP | 700,000 | -350,000 | 1,029,000 | 0.0035 | 0.6067 | 03/31/2026 |
| 7 | UBS Securities LLC | 63,541 | -231,537 | 93,405.27 | 0 | 0.0551 | 03/31/2026 |
| 8 | Connor, Clark & Lunn Investment Management Ltd. | 0 | -164,064 | 0 | 0 | 0 | |
| 9 | Superstring Capital Management LP | 0 | -139,886 | 0 | 0 | 0 | |
| 10 | ALPS Advisors, Inc. | 0 | -111,490 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.