| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 8,436,641 | 445,264 | 20,501,037.63 | 0.0094 | 7.3286 | 12/31/2025 |
| 2 | HHLR Advisors Ltd. | 5,980,568 | 0 | 14,532,780.24 | 0.0954 | 5.1951 | 12/31/2025 |
| 3 | Morgan Stanley & Co. LLC | 3,785,393 | 1,553,353 | 9,198,504.99 | 0.0031 | 3.2882 | 12/31/2025 |
| 4 | Point72 Asset Management LP | 2,298,501 | 1,659,787 | 5,585,357.43 | 0.008 | 1.9966 | 12/31/2025 |
| 5 | Ariose Capital Management Ltd. | 1,363,515 | -340,878 | 3,313,341.45 | 0.9751 | 1.1844 | 12/31/2025 |
| 6 | Candriam Belgium SA | 1,132,563 | 0 | 2,752,128.09 | 0.0069 | 0.9838 | 12/31/2025 |
| 7 | Woodline Partners LP | 1,050,000 | 0 | 2,551,500 | 0.0094 | 0.9121 | 12/31/2025 |
| 8 | Adage Capital Management LP | 1,000,000 | -2,338,034 | 2,430,000 | 0.0035 | 0.8687 | 12/31/2025 |
| 9 | Millennium Management LLC | 846,008 | 823,555 | 2,055,799.44 | 0.0014 | 0.7349 | 12/31/2025 |
| 10 | Barclays Bank Plc (Private Banking) | 628,923 | 233,492 | 1,528,282.89 | 0.0008 | 0.5463 | 12/31/2025 |
| 11 | BlackRock Fund Advisors | 549,055 | 549,055 | 1,334,203.65 | 0 | 0.4769 | 12/31/2025 |
| 12 | Exome Asset Management LLC | 499,587 | -940,017 | 1,213,996.41 | 0.6037 | 0.434 | 12/31/2025 |
| 13 | AIHC Capital Management Ltd. | 413,979 | 413,979 | 1,005,968.97 | 0.4756 | 0.3596 | 12/31/2025 |
| 14 | SSgA Funds Management, Inc. | 359,878 | 22,478 | 874,503.54 | 0 | 0.3126 | 12/31/2025 |
| 15 | Connor, Clark & Lunn Investment Management Ltd. | 191,714 | 27,650 | 465,865.02 | 0.001 | 0.1665 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Candriam Equities L - Oncology | 1,132,563 | 0 | 2,752,128.09 | 0.1646 | 0.9838 | 09/30/2025 |
| 2 | E Fund Global Pharmaceutical Industry Hybrid Fund | 1,030,871 | 1,030,871 | 2,505,016.53 | 0.9577 | 0.8955 | 12/31/2025 |
| 3 | iShares Biotechnology ETF | 539,518 | 539,518 | 1,311,028.74 | 0.0161 | 0.4687 | 03/31/2026 |
| 4 | Belfius Equities - Cure | 484,630 | 0 | 1,177,650.9 | 0.1646 | 0.421 | 09/30/2025 |
| 5 | State Street SPDR Portfolio Emerging Markets ETF | 303,465 | 32,465 | 737,419.95 | 0.0042 | 0.2636 | 03/31/2026 |
| 6 | Abaris Biotechnology Opportunities | 100,000 | 0 | 243,000 | 1.0802 | 0.0869 | 06/30/2025 |
| 7 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 86,856 | 86,856 | 211,060.08 | 0.0225 | 0.0754 | 03/31/2026 |
| 8 | Fidelity Nasdaq Composite Index Fund | 56,753 | 2,191 | 137,909.79 | 0.0006 | 0.0493 | 02/28/2026 |
| 9 | State Street SPDR S&P Emerging Markets Small Cap ETF | 51,864 | -1,036 | 126,029.52 | 0.0164 | 0.0451 | 03/31/2026 |
| 10 | DFA Emerging Markets Small Cap Portfolio | 48,055 | 37,881 | 116,773.65 | 0.0027 | 0.0417 | 12/31/2025 |
| 11 | DFA Emerging Markets Small Cap Series (The) | 48,055 | 48,055 | 116,773.65 | 0.0029 | 0.0417 | 01/31/2026 |
| 12 | Invesco Markets Plc - NASDAQ Biotech UCITS ETF | 38,015 | 38,015 | 92,376.45 | 0.0218 | 0.033 | 03/31/2026 |
| 13 | Invesco NASDAQ Future Gen 200 ETF | 21,560 | 21,560 | 52,390.8 | 0.3465 | 0.0187 | 03/31/2026 |
| 14 | DFA Emerging Markets Core Equity 2 Portfolio | 20,035 | 3,818 | 48,685.05 | 0.0001 | 0.0174 | 12/31/2025 |
| 15 | DFA Emerging Markets Social Core Equity Portfolio | 18,909 | 0 | 45,948.87 | 0.0021 | 0.0164 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Point72 Asset Management LP | 2,298,501 | 1,659,787 | 5,585,357.43 | 0.008 | 1.9966 | 12/31/2025 |
| 2 | Morgan Stanley & Co. LLC | 3,785,393 | 1,553,353 | 9,198,504.99 | 0.0031 | 3.2882 | 12/31/2025 |
| 3 | Millennium Management LLC | 846,008 | 823,555 | 2,055,799.44 | 0.0014 | 0.7349 | 12/31/2025 |
| 4 | BlackRock Fund Advisors | 549,055 | 549,055 | 1,334,203.65 | 0 | 0.4769 | 12/31/2025 |
| 5 | Janus Henderson Investors US LLC | 8,436,641 | 445,264 | 20,501,037.63 | 0.0094 | 7.3286 | 12/31/2025 |
| 6 | AIHC Capital Management Ltd. | 413,979 | 413,979 | 1,005,968.97 | 0.4756 | 0.3596 | 12/31/2025 |
| 7 | Barclays Bank Plc (Private Banking) | 628,923 | 233,492 | 1,528,282.89 | 0.0008 | 0.5463 | 12/31/2025 |
| 8 | Taikang Asset Management (Hong Kong) Co., Ltd. | 128,765 | 128,765 | 312,898.95 | 0.0258 | 0.1119 | 12/31/2025 |
| 9 | Dymon Asia Capital (Singapore) Pte Ltd. | 80,400 | 80,400 | 195,372 | 0.034 | 0.0698 | 12/31/2025 |
| 10 | Leonteq Securities AG | 80,000 | 80,000 | 194,400 | 0.0102 | 0.0695 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Adage Capital Management LP | 1,000,000 | -2,338,034 | 2,430,000 | 0.0035 | 0.8687 | 12/31/2025 |
| 2 | Exome Asset Management LLC | 499,587 | -940,017 | 1,213,996.41 | 0.6037 | 0.434 | 12/31/2025 |
| 3 | SG Americas Securities LLC | 0 | -463,894 | 0 | 0 | 0 | |
| 4 | Ariose Capital Management Ltd. | 1,363,515 | -340,878 | 3,313,341.45 | 0.9751 | 1.1844 | 12/31/2025 |
| 5 | Abaris Investment Management AG | 100,000 | -182,000 | 243,000 | 0.5888 | 0.0869 | 06/30/2025 |
| 6 | Superstring Capital Management LP | 0 | -139,886 | 0 | 0 | 0 | |
| 7 | UBS Securities LLC | 181,776 | -113,302 | 441,715.68 | 0.0002 | 0.1579 | 12/31/2025 |
| 8 | LMR Partners LLP | 0 | -100,000 | 0 | 0 | 0 | |
| 9 | Goldman Sachs & Co. LLC (Private Banking) | 140,946 | -77,524 | 342,498.78 | 0.0001 | 0.1224 | 12/31/2025 |
| 10 | Renaissance Technologies LLC | 0 | -63,600 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.