| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RTW Investments LP | 4,869,798 | 0 | 157,927,549.14 | 1.3826 | 9.6648 | 03/31/2026 |
| 2 | Fidelity Management & Research Co. LLC | 4,795,466 | 291,239 | 155,516,962.38 | 0.0077 | 9.5173 | 03/31/2026 |
| 3 | Wellington Management Co. LLP | 4,635,907 | 12,225 | 150,342,464.01 | 0.0235 | 9.2006 | 03/31/2026 |
| 4 | PRIMECAP Management Co. | 3,693,241 | -268,639 | 119,771,805.63 | 0.0731 | 7.3297 | 03/31/2026 |
| 5 | Bellevue Asset Management AG | 2,796,803 | 0 | 90,700,321.29 | 1.5403 | 5.5506 | 03/31/2026 |
| 6 | Vestal Point Capital LP | 2,766,868 | 2,181,868 | 89,729,529.24 | 2.1811 | 5.4912 | 03/31/2026 |
| 7 | Tang Capital Management LLC | 2,649,368 | 20,830 | 85,919,004.24 | 4.0359 | 5.258 | 03/31/2026 |
| 8 | Deep Track Capital LP | 1,931,884 | -72,094 | 62,650,998.12 | 0.9854 | 3.8341 | 03/31/2026 |
| 9 | T. Rowe Price Investment Management, Inc. | 1,891,600 | -4,069,627 | 61,344,588 | 0.0367 | 3.7541 | 03/31/2026 |
| 10 | Logos Global Management LP | 1,500,000 | 650,000 | 48,645,000 | 2.3335 | 2.977 | 03/31/2026 |
| 11 | BVF Partners LP | 1,294,463 | -194,512 | 41,979,435.09 | 1.1923 | 2.569 | 03/31/2026 |
| 12 | Millennium Management LLC | 1,237,403 | 325,806 | 40,128,979.29 | 0.027 | 2.4558 | 03/31/2026 |
| 13 | Armistice Capital LLC | 1,188,000 | 90,000 | 38,526,840 | 1.0195 | 2.3577 | 03/31/2026 |
| 14 | Point72 Asset Management LP | 1,102,271 | 598,120 | 35,746,648.53 | 0.0528 | 2.1876 | 03/31/2026 |
| 15 | Two Sigma Investments LP | 1,021,265 | 661,972 | 33,119,623.95 | 0.0243 | 2.0268 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Health Care Fund | 4,246,274 | 588,466 | 137,706,665.82 | 0.3503 | 8.4273 | 04/30/2026 |
| 2 | BB Biotech AG | 2,796,803 | 0 | 90,700,321.29 | 2.7058 | 5.5506 | 03/31/2026 |
| 3 | Vanguard Capital Opportunity Fund | 2,425,650 | -103,208 | 78,663,829.5 | 0.2557 | 4.814 | 03/31/2026 |
| 4 | Fidelity Growth Company Commingled Pool | 1,430,382 | -246,713 | 46,387,288.26 | 0.0366 | 2.8388 | 06/30/2026 |
| 5 | PRIMECAP Odyssey Aggressive Growth Fund | 1,142,800 | -79,431 | 37,061,004 | 0.4782 | 2.268 | 03/31/2026 |
| 6 | Fidelity Growth Company Fund | 1,015,723 | -152,369 | 32,939,896.89 | 0.0342 | 2.0158 | 06/30/2026 |
| 7 | T Rowe Price Health Sciences Fund | 645,268 | -98,658 | 20,926,041.24 | 0.1766 | 1.2806 | 06/30/2026 |
| 8 | Fidelity Select Port. - Health Care Portfolio | 500,000 | 0 | 16,215,000 | 0.2569 | 0.9923 | 06/30/2026 |
| 9 | iShares Biotechnology ETF | 311,982 | 30,675 | 10,117,576.26 | 0.1101 | 0.6192 | 07/31/2026 |
| 10 | MFS New Discovery Fund | 304,295 | 0 | 9,868,286.85 | 0.4381 | 0.6039 | 06/30/2026 |
| 11 | Fidelity Growth Company K6 Fund | 301,897 | -46,089 | 9,790,519.71 | 0.0364 | 0.5992 | 06/30/2026 |
| 12 | Fidelity Select Port. - Biotechnology Portfolio | 287,200 | -67,700 | 9,313,896 | 0.166 | 0.57 | 06/30/2026 |
| 13 | Candriam Equities L - Oncology | 269,729 | 0 | 8,747,311.47 | 0.5023 | 0.5353 | 12/31/2025 |
| 14 | Fidelity Advisor Health Care Fund | 260,000 | 0 | 8,431,800 | 0.2678 | 0.516 | 06/30/2026 |
| 15 | Fidelity Series Growth Company Fund | 237,570 | -50,500 | 7,704,395.1 | 0.0337 | 0.4715 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vestal Point Capital LP | 2,766,868 | 2,181,868 | 89,729,529.24 | 2.1811 | 5.4912 | 03/31/2026 |
| 2 | Two Sigma Investments LP | 1,021,265 | 661,972 | 33,119,623.95 | 0.0243 | 2.0268 | 03/31/2026 |
| 3 | Logos Global Management LP | 1,500,000 | 650,000 | 48,645,000 | 2.3335 | 2.977 | 03/31/2026 |
| 4 | Point72 Asset Management LP | 1,102,271 | 598,120 | 35,746,648.53 | 0.0528 | 2.1876 | 03/31/2026 |
| 5 | Caption Management LLC | 661,786 | 567,402 | 21,461,719.98 | 0.9038 | 1.3134 | 03/31/2026 |
| 6 | Millennium Management LLC | 1,237,403 | 325,806 | 40,128,979.29 | 0.027 | 2.4558 | 03/31/2026 |
| 7 | Fidelity Management & Research Co. LLC | 4,795,466 | 291,239 | 155,516,962.38 | 0.0077 | 9.5173 | 03/31/2026 |
| 8 | Cantor Fitzgerald & Co. | 250,211 | 250,211 | 8,114,342.73 | 2.0529 | 0.4966 | 03/31/2026 |
| 9 | Hudson Bay Capital Management LP | 633,174 | 249,616 | 20,533,832.82 | 0.1159 | 1.2566 | 03/31/2026 |
| 10 | BlackRock Advisors LLC | 242,482 | 242,482 | 7,863,691.26 | 0.0031 | 0.4812 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Investment Management, Inc. | 1,891,600 | -4,069,627 | 61,344,588 | 0.0367 | 3.7541 | 03/31/2026 |
| 2 | Baker Bros. Advisors LP | 734,397 | -1,588,259 | 23,816,494.71 | 0.106 | 1.4575 | 03/31/2026 |
| 3 | Two Sigma Advisers LP | 0 | -322,300 | 0 | 0 | 0 | |
| 4 | PRIMECAP Management Co. | 3,693,241 | -268,639 | 119,771,805.63 | 0.0731 | 7.3297 | 03/31/2026 |
| 5 | BVF Partners LP | 1,294,463 | -194,512 | 41,979,435.09 | 1.1923 | 2.569 | 03/31/2026 |
| 6 | New York State Common Retirement Fund | 33,982 | -177,158 | 1,102,036.26 | 0.0013 | 0.0674 | 06/30/2026 |
| 7 | TD Asset Management, Inc. | 135,828 | -156,936 | 4,404,902.04 | 0.0021 | 0.2696 | 03/31/2026 |
| 8 | Principal Global Investors LLC | 519,130 | -139,306 | 16,835,385.9 | 0.0071 | 1.0303 | 03/31/2026 |
| 9 | Columbia Management Investment Advisers LLC | 0 | -135,207 | 0 | 0 | 0 | |
| 10 | Exome Asset Management LLC | 0 | -76,750 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.