| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Wellington Management Co. LLP | 5,641,222 | 1,005,315 | 181,196,050.64 | 0.0292 | 11.1958 | 06/30/2026 |
| 2 | RTW Investments LP | 4,869,798 | 0 | 156,417,911.76 | 1.4554 | 9.6648 | 06/30/2026 |
| 3 | PRIMECAP Management Co. | 3,638,241 | -55,000 | 116,860,300.92 | 0.073 | 7.2206 | 06/30/2026 |
| 4 | Bellevue Asset Management AG | 2,788,245 | -8,558 | 89,558,429.4 | 1.5796 | 5.5337 | 06/30/2026 |
| 5 | Tang Capital Management LLC | 2,649,368 | 0 | 85,097,700.16 | 4.088 | 5.258 | 06/30/2026 |
| 6 | Vestal Point Capital LP | 1,800,000 | -966,868 | 57,816,000 | 1.5465 | 3.5723 | 06/30/2026 |
| 7 | Fidelity Management & Research Co. LLC | 1,736,979 | -3,058,487 | 55,791,765.48 | 0.0027 | 3.4473 | 09/30/2026 |
| 8 | Two Sigma Investments LP | 1,648,983 | 627,718 | 52,965,333.96 | 0.0405 | 3.2726 | 06/30/2026 |
| 9 | Millennium Management LLC | 1,597,037 | 359,634 | 51,296,828.44 | 0.0357 | 3.1695 | 06/30/2026 |
| 10 | Armistice Capital LLC | 1,428,000 | 240,000 | 45,867,360 | 1.2494 | 2.8341 | 06/30/2026 |
| 11 | Caligan Partners LP | 1,381,317 | 1,381,317 | 44,367,902.04 | 2.6722 | 2.7414 | 06/30/2026 |
| 12 | Kynam Capital Management LP | 1,375,000 | 490,063 | 44,165,000 | 2.8929 | 2.7289 | 06/30/2026 |
| 13 | BVF Partners LP | 1,294,463 | 0 | 41,578,151.56 | 1.3376 | 2.569 | 06/30/2026 |
| 14 | Acadian Asset Management LLC | 1,209,894 | 708,803 | 38,861,795.28 | 0.0387 | 2.4012 | 06/30/2026 |
| 15 | Trails Edge Capital Partners LP | 1,063,234 | 380,637 | 34,151,076.08 | 5.7982 | 2.1101 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Health Care Fund | 4,246,274 | 588,466 | 136,390,320.88 | 0.3312 | 8.4273 | 07/31/2026 |
| 2 | BB Biotech AG | 2,788,245 | -8,558 | 89,558,429.4 | 2.5316 | 5.5337 | 06/30/2026 |
| 3 | Vanguard Capital Opportunity Fund | 2,335,650 | -90,000 | 75,021,078 | 0.2494 | 4.6354 | 06/30/2026 |
| 4 | PRIMECAP Odyssey Aggressive Growth Fund | 1,112,800 | -30,000 | 35,743,136 | 0.4763 | 2.2085 | 06/30/2026 |
| 5 | Fidelity Growth Company Commingled Pool | 792,382 | -879,402 | 25,451,309.84 | 0.02 | 1.5726 | 08/31/2026 |
| 6 | Fidelity Growth Company Fund | 635,923 | -526,369 | 20,425,846.76 | 0.0212 | 1.2621 | 08/31/2026 |
| 7 | Fidelity Select Port. - Health Care Portfolio | 500,000 | 0 | 16,060,000 | 0.2317 | 0.9923 | 08/31/2026 |
| 8 | BlackRock Health Sciences Trust II | 359,126 | 321,900 | 11,535,127.12 | 0.9701 | 0.7127 | 06/30/2026 |
| 9 | iShares Biotechnology ETF | 356,240 | 79,055 | 11,442,428.8 | 0.1026 | 0.707 | 09/30/2026 |
| 10 | T Rowe Price Health Sciences Fund | 339,668 | -375,400 | 10,910,136.16 | 0.0855 | 0.6741 | 09/30/2026 |
| 11 | MFS New Discovery Fund | 304,295 | 0 | 9,773,955.4 | 0.4663 | 0.6039 | 08/31/2026 |
| 12 | Fidelity Select Port. - Biotechnology Portfolio | 287,200 | -34,300 | 9,224,864 | 0.1558 | 0.57 | 08/31/2026 |
| 13 | Candriam Equities L - Oncology | 269,729 | 0 | 8,663,695.48 | 0.4749 | 0.5353 | 03/31/2026 |
| 14 | Fidelity Advisor Health Care Fund | 260,000 | 0 | 8,351,200 | 0.2432 | 0.516 | 08/31/2026 |
| 15 | Wellington Mgmt. Funds IE Plc - Global Health Care Eq. | 209,936 | 46,578 | 6,743,144.32 | 0.5692 | 0.4166 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Caligan Partners LP | 1,381,317 | 1,381,317 | 44,367,902.04 | 2.6722 | 2.7414 | 06/30/2026 |
| 2 | Wellington Management Co. LLP | 5,641,222 | 1,005,315 | 181,196,050.64 | 0.0292 | 11.1958 | 06/30/2026 |
| 3 | Acadian Asset Management LLC | 1,209,894 | 708,803 | 38,861,795.28 | 0.0387 | 2.4012 | 06/30/2026 |
| 4 | Two Sigma Investments LP | 1,648,983 | 627,718 | 52,965,333.96 | 0.0405 | 3.2726 | 06/30/2026 |
| 5 | Braidwell LP | 521,327 | 521,327 | 16,745,023.24 | 0.5783 | 1.0346 | 06/30/2026 |
| 6 | Jones Hill Capital LP | 512,856 | 512,856 | 16,472,934.72 | 4.081 | 1.0178 | 06/30/2026 |
| 7 | Kynam Capital Management LP | 1,375,000 | 490,063 | 44,165,000 | 2.8929 | 2.7289 | 06/30/2026 |
| 8 | Fulcrum Asset Management LLP | 470,025 | 470,025 | 15,097,203 | 1.1673 | 0.9328 | 06/30/2026 |
| 9 | Marshall Wace LLP | 590,941 | 410,601 | 18,981,024.92 | 0.0159 | 1.1728 | 06/30/2026 |
| 10 | Trails Edge Capital Partners LP | 1,063,234 | 380,637 | 34,151,076.08 | 5.7982 | 2.1101 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 1,736,979 | -3,058,487 | 55,791,765.48 | 0.0027 | 3.4473 | 09/30/2026 |
| 2 | T. Rowe Price Investment Management, Inc. | 0 | -1,891,600 | 0 | 0 | 0 | |
| 3 | Deep Track Capital LP | 311,218 | -1,620,666 | 9,996,322.16 | 0.1616 | 0.6177 | 06/30/2026 |
| 4 | Vestal Point Capital LP | 1,800,000 | -966,868 | 57,816,000 | 1.5465 | 3.5723 | 06/30/2026 |
| 5 | Logos Global Management LP | 600,000 | -900,000 | 19,272,000 | 1.0149 | 1.1908 | 06/30/2026 |
| 6 | Baker Bros. Advisors LP | 0 | -734,397 | 0 | 0 | 0 | |
| 7 | Fiera Capital, Inc. | 0 | -657,734 | 0 | 0 | 0 | |
| 8 | Caption Management LLC | 172,503 | -489,283 | 5,540,796.36 | 0.2041 | 0.3424 | 06/30/2026 |
| 9 | Fiera Capital Corp. (Investment Management) | 0 | -422,365 | 0 | 0 | 0 | |
| 10 | New York State Common Retirement Fund (Invt Mgmt) | 33,982 | -177,158 | 1,091,501.84 | 0.0013 | 0.0674 | 06/30/2026 |
Data provided by FactSet Research Systems Inc.