| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Caligan Partners LP | 4,974,906 | 4,974,906 | 27,063,488.64 | 1.6195 | 2.3952 | 03/31/2026 |
| 2 | Paradigm BioCapital Advisors LP | 4,000,000 | 4,000,000 | 21,760,000 | 0.4893 | 1.9258 | 03/31/2026 |
| 3 | Millennium Management LLC | 2,987,613 | 2,875,583 | 16,252,614.72 | 0.0115 | 1.4384 | 03/31/2026 |
| 4 | Adar1 Capital Management LLC | 2,709,846 | 2,709,846 | 14,741,562.24 | 1.1209 | 1.3046 | 12/31/2025 |
| 5 | Trails Edge Capital Partners LP | 2,657,997 | 2,657,997 | 14,459,503.68 | 3.1336 | 1.2797 | 03/31/2026 |
| 6 | Franklin Advisers, Inc. | 2,461,565 | 2,461,565 | 13,390,913.6 | 0.0059 | 1.1851 | 03/31/2026 |
| 7 | UBS Securities LLC | 2,300,256 | 2,300,074 | 12,513,392.64 | 0.0046 | 1.1074 | 03/31/2026 |
| 8 | Polar Capital LLP | 2,132,138 | 2,132,138 | 11,598,830.72 | 0.0235 | 1.0265 | 03/31/2026 |
| 9 | Boothbay Fund Management LLC | 1,470,407 | 1,470,407 | 7,999,014.08 | 0.1714 | 0.7079 | 03/31/2026 |
| 10 | Ikarian Capital LLC | 1,429,101 | 1,429,101 | 7,774,309.44 | 1.0513 | 0.688 | 03/31/2026 |
| 11 | NEXTBio Capital Management LP | 1,333,484 | 1,333,484 | 7,254,152.96 | 3.4161 | 0.642 | 03/31/2026 |
| 12 | RTW Investments LP | 1,298,702 | 1,298,702 | 7,064,938.88 | 0.0675 | 0.6253 | 03/31/2026 |
| 13 | Deep Track Capital LP | 1,222,453 | 1,222,453 | 6,650,144.32 | 0.1177 | 0.5885 | 03/31/2026 |
| 14 | Point72 Asset Management LP | 956,221 | 956,221 | 5,201,842.24 | 0.0081 | 0.4604 | 03/31/2026 |
| 15 | Columbia Management Investment Advisers LLC | 844,215 | 844,215 | 4,592,529.6 | 0.001 | 0.4064 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Polar Capital Funds Plc - Biotechnology Fund | 2,024,543 | 2,024,543 | 11,013,513.92 | 0.3499 | 0.9747 | 03/31/2026 |
| 2 | FTIF SICAV - Biotechnology Discovery Fund | 1,553,424 | 1,553,424 | 8,450,626.56 | 0.4811 | 0.7479 | 03/31/2026 |
| 3 | Franklin Biotechnology Discovery Fund | 908,000 | 908,000 | 4,939,520 | 0.4732 | 0.4372 | 03/31/2026 |
| 4 | Simplify Propel Opportunities ETF | 227,923 | 227,923 | 1,239,901.12 | 1.5816 | 0.1097 | 04/30/2026 |
| 5 | Artisan International Small-Mid Fund | 195,745 | 195,745 | 1,064,852.8 | 0.0381 | 0.0942 | 03/31/2026 |
| 6 | Fidelity Nasdaq Composite Index Fund | 31,482 | 26,787 | 171,262.08 | 0.0006 | 0.0152 | 03/31/2026 |
| 7 | Artisan Multiple Invt. Tr. - International Small-Mid Tr. | 2,821 | 2,821 | 15,346.24 | 0.0441 | 0.0014 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Caligan Partners LP | 4,974,906 | 4,974,906 | 27,063,488.64 | 1.6195 | 2.3952 | 03/31/2026 |
| 2 | Paradigm BioCapital Advisors LP | 4,000,000 | 4,000,000 | 21,760,000 | 0.4893 | 1.9258 | 03/31/2026 |
| 3 | Millennium Management LLC | 2,987,613 | 2,875,583 | 16,252,614.72 | 0.0115 | 1.4384 | 03/31/2026 |
| 4 | Adar1 Capital Management LLC | 2,709,846 | 2,709,846 | 14,741,562.24 | 1.1209 | 1.3046 | 12/31/2025 |
| 5 | Trails Edge Capital Partners LP | 2,657,997 | 2,657,997 | 14,459,503.68 | 3.1336 | 1.2797 | 03/31/2026 |
| 6 | Franklin Advisers, Inc. | 2,461,565 | 2,461,565 | 13,390,913.6 | 0.0059 | 1.1851 | 03/31/2026 |
| 7 | UBS Securities LLC | 2,300,256 | 2,300,074 | 12,513,392.64 | 0.0046 | 1.1074 | 03/31/2026 |
| 8 | Polar Capital LLP | 2,132,138 | 2,132,138 | 11,598,830.72 | 0.0235 | 1.0265 | 03/31/2026 |
| 9 | Boothbay Fund Management LLC | 1,470,407 | 1,470,407 | 7,999,014.08 | 0.1714 | 0.7079 | 03/31/2026 |
| 10 | Ikarian Capital LLC | 1,429,101 | 1,429,101 | 7,774,309.44 | 1.0513 | 0.688 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Yiheng Capital Management LP | 0 | -2,644,926 | 0 | 0 | 0 | |
| 2 | StemPoint Capital LP | 0 | -30,824 | 0 | 0 | 0 | |
| 3 | AQR Capital Management LLC | 0 | -10,000 | 0 | 0 | 0 | |
| 4 | Creative Planning LLC | 0 | -10,000 | 0 | 0 | 0 | |
| 5 | Morgan Stanley Smith Barney LLC (Investment Management) | 0 | -1,080 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.