| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Caligan Partners LP | 8,163,191 | 6,163,191 | 38,203,733.88 | 1.8357 | 3.4549 | 06/30/2026 |
| 2 | Paradigm BioCapital Advisors LP | 4,000,000 | 0 | 18,720,000 | 0.376 | 1.6929 | 06/30/2026 |
| 3 | Adar1 Capital Management LLC | 3,606,656 | 896,810 | 16,879,150.08 | 0.7391 | 1.5264 | 06/30/2026 |
| 4 | Millennium Management LLC | 3,512,174 | 859,604 | 16,436,974.32 | 0.011 | 1.4864 | 06/30/2026 |
| 5 | Nantahala Capital Management LLC | 2,686,393 | 2,686,393 | 12,572,319.24 | 0.6955 | 1.137 | 06/30/2026 |
| 6 | Trails Edge Capital Partners LP | 2,657,997 | 0 | 12,439,425.96 | 1.6611 | 1.1249 | 06/30/2026 |
| 7 | Franklin Advisers, Inc. | 2,642,611 | 142,470 | 12,367,419.48 | 0.0053 | 1.1184 | 06/30/2026 |
| 8 | Squadron Capital Management LLC | 2,435,000 | 2,135,000 | 11,395,800 | 3.9813 | 1.0306 | 06/30/2026 |
| 9 | Woodline Partners LP | 2,323,149 | 2,323,149 | 10,872,337.32 | 0.0327 | 0.9832 | 06/30/2026 |
| 10 | abrdn, Inc. | 2,307,773 | 2,307,773 | 10,800,377.64 | 0.0935 | 0.9767 | 06/30/2026 |
| 11 | UBS Securities LLC | 2,284,905 | -349,857 | 10,693,355.4 | 0.0039 | 0.967 | 06/30/2026 |
| 12 | Boothbay Fund Management LLC | 2,003,782 | 1,344,811 | 9,377,699.76 | 0.1818 | 0.8481 | 06/30/2026 |
| 13 | NEXTBio Capital Management LP | 1,787,984 | 489,283 | 8,367,765.12 | 3.4951 | 0.7567 | 06/30/2026 |
| 14 | Columbia Management Investment Advisers LLC | 1,697,148 | 1,081,675 | 7,942,652.64 | 0.0017 | 0.7183 | 06/30/2026 |
| 15 | Point72 Asset Management LP | 1,683,012 | 1,683,012 | 7,876,496.16 | 0.012 | 0.7123 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | FTIF SICAV - Biotechnology Discovery Fund | 1,672,877 | 80,877 | 7,829,064.36 | 0.36 | 0.708 | 06/30/2026 |
| 2 | abrdn World Healthcare Fund | 1,214,281 | 1,214,281 | 5,682,835.08 | 0.8466 | 0.5139 | 06/30/2026 |
| 3 | Polar Capital Funds Plc - Biotechnology Fund | 976,208 | -913,792 | 4,568,653.44 | 0.1148 | 0.4132 | 06/30/2026 |
| 4 | Franklin Biotechnology Discovery Fund | 969,588 | 61,588 | 4,537,671.84 | 0.3666 | 0.4104 | 06/30/2026 |
| 5 | Fidelity Advisor Series VII - Biotechnology Fund | 685,400 | 685,400 | 3,207,672 | 0.1307 | 0.2901 | 06/30/2026 |
| 6 | Simplify Propel Opportunities ETF | 313,483 | -24,179 | 1,467,100.44 | 1.7845 | 0.1327 | 07/31/2026 |
| 7 | Artisan International Small-Mid Fund | 144,292 | 144,292 | 675,286.56 | 0.0251 | 0.0611 | 06/30/2026 |
| 8 | Fidelity Nasdaq Composite Index Fund | 34,355 | 29,660 | 160,781.4 | 0.0006 | 0.0145 | 06/30/2026 |
| 9 | Harbor Health Care ETF | 33,996 | 33,996 | 159,101.28 | 0.3558 | 0.0144 | 07/31/2026 |
| 10 | Harbor Health Care UCITS ETF | 11,822 | 11,822 | 55,326.96 | 0.3547 | 0.005 | 07/31/2026 |
| 11 | ActivePassive International Equity ETF | 10,009 | 10,009 | 46,842.12 | 0.0041 | 0.0042 | 07/31/2026 |
| 12 | Russell Investment Funds - Investment US Small Cap Equity Fund | 9,220 | 9,220 | 43,149.6 | 0.0177 | 0.0039 | 03/31/2026 |
| 13 | Artisan Multiple Invt. Tr. - International Small-Mid Tr. | 2,073 | 2,073 | 9,701.64 | 0.0281 | 0.0009 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Caligan Partners LP | 8,163,191 | 6,163,191 | 38,203,733.88 | 1.8357 | 3.4549 | 06/30/2026 |
| 2 | Nantahala Capital Management LLC | 2,686,393 | 2,686,393 | 12,572,319.24 | 0.6955 | 1.137 | 06/30/2026 |
| 3 | Woodline Partners LP | 2,323,149 | 2,323,149 | 10,872,337.32 | 0.0327 | 0.9832 | 06/30/2026 |
| 4 | abrdn, Inc. | 2,307,773 | 2,307,773 | 10,800,377.64 | 0.0935 | 0.9767 | 06/30/2026 |
| 5 | Squadron Capital Management LLC | 2,435,000 | 2,135,000 | 11,395,800 | 3.9813 | 1.0306 | 06/30/2026 |
| 6 | Point72 Asset Management LP | 1,683,012 | 1,683,012 | 7,876,496.16 | 0.012 | 0.7123 | 06/30/2026 |
| 7 | Citadel Advisors LLC | 1,540,000 | 1,540,000 | 7,207,200 | 0.0053 | 0.6518 | 06/30/2026 |
| 8 | Integral Health Asset Management LLC | 1,520,000 | 1,520,000 | 7,113,600 | 0.2801 | 0.6433 | 06/30/2026 |
| 9 | Boothbay Fund Management LLC | 2,003,782 | 1,344,811 | 9,377,699.76 | 0.1818 | 0.8481 | 06/30/2026 |
| 10 | JPMorgan Securities LLC (Investment Management) | 1,309,100 | 1,309,100 | 6,126,588 | 0.0028 | 0.554 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RTW Investments LP | 0 | -1,298,701 | 0 | 0 | 0 | |
| 2 | Polar Capital LLP | 1,074,214 | -924,666 | 5,027,321.52 | 0.0095 | 0.4546 | 06/30/2026 |
| 3 | UBS Securities LLC | 2,284,905 | -349,857 | 10,693,355.4 | 0.0039 | 0.967 | 06/30/2026 |
| 4 | Saturn V Capital Management LP | 0 | -283,166 | 0 | 0 | 0 | |
| 5 | Yiheng Capital Management LP | 0 | -255,915 | 0 | 0 | 0 | |
| 6 | Eventide Asset Management LLC | 0 | -250,000 | 0 | 0 | 0 | |
| 7 | Goldman Sachs & Co. LLC (Private Banking) | 224,499 | -205,096 | 1,050,655.32 | 0.0003 | 0.095 | 06/30/2026 |
| 8 | J. Goldman & Co. LP | 337,500 | -178,945 | 1,579,500 | 0.0552 | 0.1428 | 06/30/2026 |
| 9 | Morgan Stanley & Co. LLC | 280,191 | -132,556 | 1,311,293.88 | 0.0004 | 0.1186 | 06/30/2026 |
| 10 | Superstring Capital Management LP | 0 | -100,000 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.