| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Caligan Partners LP | 8,163,191 | 3,188,285 | 25,795,683.56 | 1.6484 | 3.4549 | 06/30/2026 |
| 2 | Paradigm BioCapital Advisors LP | 4,000,000 | 0 | 12,640,000 | 0.2729 | 1.6929 | 06/30/2026 |
| 3 | Adar1 Capital Management LLC | 3,606,656 | 1,432,258 | 11,397,032.96 | 0.5747 | 1.5264 | 06/30/2026 |
| 4 | Millennium Management LLC | 3,512,174 | 524,561 | 11,098,469.84 | 0.0076 | 1.4864 | 06/30/2026 |
| 5 | Nantahala Capital Management LLC | 2,686,393 | 2,686,393 | 8,489,001.88 | 0.5281 | 1.137 | 06/30/2026 |
| 6 | Trails Edge Capital Partners LP | 2,657,997 | 0 | 8,399,270.52 | 1.4674 | 1.1249 | 06/30/2026 |
| 7 | Franklin Advisers, Inc. | 2,642,611 | 181,046 | 8,350,650.76 | 0.0036 | 1.1184 | 06/30/2026 |
| 8 | Squadron Capital Management LLC | 2,435,000 | 1,900,000 | 7,694,600 | 3.0573 | 1.0306 | 06/30/2026 |
| 9 | Woodline Partners LP | 2,323,149 | 2,323,149 | 7,341,150.84 | 0.0227 | 0.9832 | 06/30/2026 |
| 10 | abrdn, Inc. | 2,307,773 | 2,307,773 | 7,292,562.68 | 0.0667 | 0.9767 | 06/30/2026 |
| 11 | UBS Securities LLC | 2,284,905 | -15,351 | 7,220,299.8 | 0.0027 | 0.967 | 06/30/2026 |
| 12 | Boothbay Fund Management LLC | 2,003,782 | 533,375 | 6,331,951.12 | 0.1292 | 0.8481 | 06/30/2026 |
| 13 | NEXTBio Capital Management LP | 1,787,984 | 454,500 | 5,650,029.44 | 2.7988 | 0.7567 | 06/30/2026 |
| 14 | Columbia Management Investment Advisers LLC | 1,697,148 | 852,933 | 5,362,987.68 | 0.0011 | 0.7183 | 06/30/2026 |
| 15 | Point72 Asset Management LP | 1,683,012 | 726,791 | 5,318,317.92 | 0.0083 | 0.7123 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | FTIF SICAV - Biotechnology Discovery Fund | 1,929,112 | 375,688 | 6,095,993.92 | 0.3135 | 0.8165 | 08/31/2026 |
| 2 | abrdn World Healthcare Fund | 1,380,877 | 1,380,877 | 4,363,571.32 | 0.7316 | 0.5844 | 08/31/2026 |
| 3 | abrdn Life Sciences Investors | 1,093,492 | 1,093,492 | 3,455,434.72 | 0.5771 | 0.4628 | 06/30/2026 |
| 4 | Franklin Biotechnology Discovery Fund | 1,042,549 | 134,549 | 3,294,454.84 | 0.3049 | 0.4412 | 08/31/2026 |
| 5 | Fidelity Advisor Series VII - Biotechnology Fund | 685,400 | 685,400 | 2,165,864 | 0.0941 | 0.2901 | 08/31/2026 |
| 6 | Helium Fund - Selection | 589,277 | 589,277 | 1,862,115.32 | 0.1031 | 0.2494 | 06/30/2026 |
| 7 | FIAM Small Capitalization Core Commingled Pool | 474,345 | 474,345 | 1,498,930.2 | 0.0341 | 0.2008 | 07/31/2026 |
| 8 | Simplify Propel Opportunities ETF | 313,483 | 85,560 | 990,606.28 | 8.7636 | 0.1327 | 09/30/2026 |
| 9 | Strategic Advisers Fidelity US Total Stock Fund | 220,400 | 220,400 | 696,464 | 0.0003 | 0.0933 | 08/31/2026 |
| 10 | Helium Fund - Performance | 184,714 | 184,714 | 583,696.24 | 0.0464 | 0.0782 | 06/30/2026 |
| 11 | Fidelity Small Cap Stock Fund | 154,400 | 154,400 | 487,904 | 0.0375 | 0.0653 | 07/31/2026 |
| 12 | Artisan International Small-Mid Fund | 144,292 | -51,453 | 455,962.72 | 0.0173 | 0.0611 | 06/30/2026 |
| 13 | Fidelity Series Small Cap Core Fund | 136,161 | 136,161 | 430,268.76 | 0.0288 | 0.0576 | 07/31/2026 |
| 14 | Helium Fund - Helium Fund | 52,527 | 52,527 | 165,985.32 | 0.0236 | 0.0222 | 06/30/2026 |
| 15 | Blackstone Alternative Multi Strategy Fund | 42,752 | 42,752 | 135,096.32 | 0.0085 | 0.0181 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Caligan Partners LP | 8,163,191 | 3,188,285 | 25,795,683.56 | 1.6484 | 3.4549 | 06/30/2026 |
| 2 | Nantahala Capital Management LLC | 2,686,393 | 2,686,393 | 8,489,001.88 | 0.5281 | 1.137 | 06/30/2026 |
| 3 | Woodline Partners LP | 2,323,149 | 2,323,149 | 7,341,150.84 | 0.0227 | 0.9832 | 06/30/2026 |
| 4 | abrdn, Inc. | 2,307,773 | 2,307,773 | 7,292,562.68 | 0.0667 | 0.9767 | 06/30/2026 |
| 5 | Squadron Capital Management LLC | 2,435,000 | 1,900,000 | 7,694,600 | 3.0573 | 1.0306 | 06/30/2026 |
| 6 | Citadel Advisors LLC | 1,540,000 | 1,540,000 | 4,866,400 | 0.0037 | 0.6518 | 06/30/2026 |
| 7 | Adar1 Capital Management LLC | 3,606,656 | 1,432,258 | 11,397,032.96 | 0.5747 | 1.5264 | 06/30/2026 |
| 8 | StemPoint Capital LP | 1,426,320 | 1,426,320 | 4,507,171.2 | 0.9467 | 0.6037 | 06/30/2026 |
| 9 | JPMorgan Securities LLC (Investment Management) | 1,309,100 | 1,309,100 | 4,136,756 | 0.0019 | 0.554 | 06/30/2026 |
| 10 | Kingdon Capital Management LLC | 1,270,000 | 1,270,000 | 4,013,200 | 0.5748 | 0.5375 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RTW Investments LP | 0 | -1,298,702 | 0 | 0 | 0 | |
| 2 | Polar Capital LLP | 1,074,214 | -1,057,924 | 3,394,516.24 | 0.0064 | 0.4546 | 06/30/2026 |
| 3 | Deep Track Capital LP | 800,000 | -422,453 | 2,528,000 | 0.04 | 0.3386 | 06/30/2026 |
| 4 | Ikarian Capital LLC | 1,129,101 | -300,000 | 3,567,959.16 | 0.6486 | 0.4779 | 06/30/2026 |
| 5 | Russell Investment Management LLC | 0 | -205,639 | 0 | 0 | 0 | |
| 6 | Artisan Partners LP | 263,538 | -59,468 | 832,780.08 | 0.0007 | 0.1115 | 06/30/2026 |
| 7 | Prelude Capital Management LLC | 0 | -40,000 | 0 | 0 | 0 | |
| 8 | ExodusPoint Capital Management LP | 0 | -38,256 | 0 | 0 | 0 | |
| 9 | Hudson Bay Capital Management LP | 115,000 | -30,459 | 363,400 | 0.0018 | 0.0487 | 06/30/2026 |
| 10 | Virtu Americas LLC | 0 | -18,729 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.