| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Caligan Partners LP | 4,974,906 | 2,974,906 | 18,357,403.14 | 0.91 | 2.3803 | 03/31/2026 |
| 2 | Paradigm BioCapital Advisors LP | 4,000,000 | 0 | 14,760,000 | 0.2771 | 1.9138 | 03/31/2026 |
| 3 | Millennium Management LLC | 2,987,613 | 335,043 | 11,024,291.97 | 0.0075 | 1.4294 | 03/31/2026 |
| 4 | Trails Edge Capital Partners LP | 2,657,997 | 0 | 9,808,008.93 | 1.7203 | 1.2717 | 03/31/2026 |
| 5 | Franklin Advisers, Inc. | 2,461,565 | -38,576 | 9,083,174.85 | 0.0039 | 1.1777 | 03/31/2026 |
| 6 | UBS Securities LLC | 2,300,256 | -334,506 | 8,487,944.64 | 0.003 | 1.1006 | 03/31/2026 |
| 7 | Adar1 Capital Management LLC | 2,174,398 | -535,448 | 8,023,528.62 | 0.4229 | 1.0403 | 03/31/2026 |
| 8 | Polar Capital LLP | 2,132,138 | 133,258 | 7,867,589.22 | 0.0148 | 1.0201 | 03/31/2026 |
| 9 | Boothbay Fund Management LLC | 1,470,407 | 811,436 | 5,425,801.83 | 0.1112 | 0.7035 | 03/31/2026 |
| 10 | Ikarian Capital LLC | 1,429,101 | 926,500 | 5,273,382.69 | 0.7621 | 0.6838 | 03/31/2026 |
| 11 | NEXTBio Capital Management LP | 1,333,484 | 34,783 | 4,920,555.96 | 2.4307 | 0.638 | 03/31/2026 |
| 12 | RTW Investments LP | 1,298,702 | 1 | 4,792,210.38 | 0.0404 | 0.6214 | 03/31/2026 |
| 13 | Deep Track Capital LP | 1,222,453 | 732,453 | 4,510,851.57 | 0.0675 | 0.5849 | 03/31/2026 |
| 14 | Point72 Asset Management LP | 956,221 | 956,221 | 3,528,455.49 | 0.0051 | 0.4575 | 03/31/2026 |
| 15 | Columbia Management Investment Advisers LLC | 844,215 | 228,742 | 3,115,153.35 | 0.0007 | 0.4039 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Polar Capital Funds Plc - Biotechnology Fund | 2,024,543 | 134,543 | 7,470,563.67 | 0.2086 | 0.9686 | 04/30/2026 |
| 2 | FTIF SICAV - Biotechnology Discovery Fund | 1,672,877 | 80,877 | 6,172,916.13 | 0.3105 | 0.8004 | 05/31/2026 |
| 3 | Franklin Biotechnology Discovery Fund | 969,588 | 61,588 | 3,577,779.72 | 0.3092 | 0.4639 | 05/31/2026 |
| 4 | Fidelity Advisor Series VII - Biotechnology Fund | 685,400 | 685,400 | 2,529,126 | 0.1176 | 0.3279 | 05/31/2026 |
| 5 | Simplify Propel Opportunities ETF | 313,483 | -24,179 | 1,156,752.27 | 7.1013 | 0.15 | 06/30/2026 |
| 6 | Artisan International Small-Mid Fund | 195,745 | 195,745 | 722,299.05 | 0.0249 | 0.0937 | 03/31/2026 |
| 7 | Fidelity Nasdaq Composite Index Fund | 34,355 | 29,660 | 126,769.95 | 0.0005 | 0.0164 | 04/30/2026 |
| 8 | Russell Investment Funds - Investment US Small Cap Equity Fund | 9,220 | 9,220 | 34,021.8 | 0.0136 | 0.0044 | 03/31/2026 |
| 9 | ActivePassive International Equity ETF | 8,222 | 8,222 | 30,339.18 | 0.0029 | 0.0039 | 06/29/2026 |
| 10 | Artisan Multiple Invt. Tr. - International Small-Mid Tr. | 2,821 | 2,821 | 10,409.49 | 0.0288 | 0.0013 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Caligan Partners LP | 4,974,906 | 2,974,906 | 18,357,403.14 | 0.91 | 2.3803 | 03/31/2026 |
| 2 | Point72 Asset Management LP | 956,221 | 956,221 | 3,528,455.49 | 0.0051 | 0.4575 | 03/31/2026 |
| 3 | Ikarian Capital LLC | 1,429,101 | 926,500 | 5,273,382.69 | 0.7621 | 0.6838 | 03/31/2026 |
| 4 | Boothbay Fund Management LLC | 1,470,407 | 811,436 | 5,425,801.83 | 0.1112 | 0.7035 | 03/31/2026 |
| 5 | Deep Track Capital LP | 1,222,453 | 732,453 | 4,510,851.57 | 0.0675 | 0.5849 | 03/31/2026 |
| 6 | HighVista Strategies LLC | 615,666 | 615,666 | 2,271,807.54 | 0.5357 | 0.2946 | 03/31/2026 |
| 7 | Marshall Wace LLP | 654,211 | 482,118 | 2,414,038.59 | 0.0022 | 0.313 | 03/31/2026 |
| 8 | Integral Health Asset Management LLC | 400,000 | 400,000 | 1,476,000 | 0.0668 | 0.1914 | 03/31/2026 |
| 9 | Millennium Management LLC | 2,987,613 | 335,043 | 11,024,291.97 | 0.0075 | 1.4294 | 03/31/2026 |
| 10 | Artisan Partners LP | 323,006 | 323,006 | 1,191,892.14 | 0.0009 | 0.1545 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Adar1 Capital Management LLC | 2,174,398 | -535,448 | 8,023,528.62 | 0.4229 | 1.0403 | 03/31/2026 |
| 2 | Alyeska Investment Group LP | 0 | -500,000 | 0 | 0 | 0 | |
| 3 | StemPoint Capital LP | 0 | -467,242 | 0 | 0 | 0 | |
| 4 | J. Goldman & Co. LP | 103,518 | -412,927 | 381,981.42 | 0.0154 | 0.0495 | 03/31/2026 |
| 5 | UBS Securities LLC | 2,300,256 | -334,506 | 8,487,944.64 | 0.003 | 1.1006 | 03/31/2026 |
| 6 | Saturn V Capital Management LP | 0 | -283,166 | 0 | 0 | 0 | |
| 7 | Propel Bio Management LLC | 724,678 | -275,322 | 2,674,061.82 | 1.3647 | 0.3467 | 03/31/2026 |
| 8 | Yiheng Capital Management LP | 0 | -255,915 | 0 | 0 | 0 | |
| 9 | Eventide Asset Management LLC | 0 | -250,000 | 0 | 0 | 0 | |
| 10 | Goldman Sachs & Co. LLC (Private Banking) | 184,907 | -244,688 | 682,306.83 | 0.0002 | 0.0885 | 03/31/2026 |
Data provided by FactSet Research Systems Inc.