| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Paradigm BioCapital Advisors LP | 4,000,000 | 4,000,000 | 21,720,000 | 0.5143 | 1.9379 | 12/31/2025 |
| 2 | Adar1 Capital Management LLC | 2,709,846 | 2,709,846 | 14,714,463.78 | 1.0891 | 1.3129 | 12/31/2025 |
| 3 | Trails Edge Capital Partners LP | 2,657,997 | 2,657,997 | 14,432,923.71 | 3.1326 | 1.2877 | 12/31/2025 |
| 4 | Millennium Management LLC | 2,652,570 | 2,540,540 | 14,403,455.1 | 0.0106 | 1.2851 | 12/31/2025 |
| 5 | UBS Securities LLC | 2,634,762 | 2,634,580 | 14,306,757.66 | 0.006 | 1.2765 | 12/31/2025 |
| 6 | Franklin Advisers, Inc. | 2,500,141 | 2,500,141 | 13,575,765.63 | 0.0062 | 1.2113 | 12/31/2025 |
| 7 | Caligan Partners LP | 2,000,000 | 2,000,000 | 10,860,000 | 0.9367 | 0.969 | 12/31/2025 |
| 8 | Polar Capital LLP | 1,998,880 | 1,998,880 | 10,853,918.4 | 0.0283 | 0.9684 | 12/31/2025 |
| 9 | NEXTBio Capital Management LP | 1,298,701 | 1,298,701 | 7,051,946.43 | 3.6358 | 0.6292 | 12/31/2025 |
| 10 | RTW Investments LP | 1,298,701 | 1,298,701 | 7,051,946.43 | 0.0716 | 0.6292 | 12/31/2025 |
| 11 | Propel Bio Management LLC | 1,000,000 | 1,000,000 | 5,430,000 | 5.0453 | 0.4845 | 12/31/2025 |
| 12 | BVF Partners LP | 686,040 | 0 | 3,725,197.2 | 0.1118 | 0.3324 | 12/31/2025 |
| 13 | Boothbay Fund Management LLC | 658,971 | 658,971 | 3,578,212.53 | 0.0929 | 0.3193 | 12/31/2025 |
| 14 | Columbia Management Investment Advisers LLC | 615,473 | 615,473 | 3,342,018.39 | 0.0008 | 0.2982 | 12/31/2025 |
| 15 | J. Goldman & Co. LP | 516,445 | 516,445 | 2,804,296.35 | 0.1098 | 0.2502 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Polar Capital Funds Plc - Biotechnology Fund | 1,890,000 | 1,890,000 | 10,262,700 | 0.3322 | 0.9157 | 02/27/2026 |
| 2 | FTIF SICAV - Biotechnology Discovery Fund | 1,592,000 | 1,592,000 | 8,644,560 | 0.4818 | 0.7713 | 02/28/2026 |
| 3 | Franklin Biotechnology Discovery Fund | 908,000 | 908,000 | 4,930,440 | 0.4761 | 0.4399 | 02/28/2026 |
| 4 | Simplify Propel Opportunities ETF | 227,923 | 227,923 | 1,237,621.89 | 1.7269 | 0.1104 | 03/30/2026 |
| 5 | Fidelity Nasdaq Composite Index Fund | 4,695 | 0 | 25,493.85 | 0.0001 | 0.0023 | 02/28/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Paradigm BioCapital Advisors LP | 4,000,000 | 4,000,000 | 21,720,000 | 0.5143 | 1.9379 | 12/31/2025 |
| 2 | Adar1 Capital Management LLC | 2,709,846 | 2,709,846 | 14,714,463.78 | 1.0891 | 1.3129 | 12/31/2025 |
| 3 | Trails Edge Capital Partners LP | 2,657,997 | 2,657,997 | 14,432,923.71 | 3.1326 | 1.2877 | 12/31/2025 |
| 4 | UBS Securities LLC | 2,634,762 | 2,634,580 | 14,306,757.66 | 0.006 | 1.2765 | 12/31/2025 |
| 5 | Millennium Management LLC | 2,652,570 | 2,540,540 | 14,403,455.1 | 0.0106 | 1.2851 | 12/31/2025 |
| 6 | Franklin Advisers, Inc. | 2,500,141 | 2,500,141 | 13,575,765.63 | 0.0062 | 1.2113 | 12/31/2025 |
| 7 | Caligan Partners LP | 2,000,000 | 2,000,000 | 10,860,000 | 0.9367 | 0.969 | 12/31/2025 |
| 8 | Polar Capital LLP | 1,998,880 | 1,998,880 | 10,853,918.4 | 0.0283 | 0.9684 | 12/31/2025 |
| 9 | NEXTBio Capital Management LP | 1,298,701 | 1,298,701 | 7,051,946.43 | 3.6358 | 0.6292 | 12/31/2025 |
| 10 | RTW Investments LP | 1,298,701 | 1,298,701 | 7,051,946.43 | 0.0716 | 0.6292 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Yiheng Capital Management LP | 255,915 | -2,389,011 | 1,389,618.45 | 0.3928 | 0.124 | 12/31/2025 |
| 2 | Morgan Stanley Smith Barney LLC (Investment Management) | 540 | -540 | 2,932.2 | 0 | 0.0003 | 12/31/2025 |
Data provided by FactSet Research Systems Inc.