| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 22,757,490 | -2,203,109 | 666,794,457 | 0.0333 | 12.2524 | 03/31/2026 |
| 2 | Suvretta Capital Management LLC | 7,581,029 | 3,763,020 | 222,124,149.7 | 5.0066 | 4.0815 | 03/31/2026 |
| 3 | HHLR Advisors Ltd. | 6,065,950 | -233,100 | 177,732,335 | 1.4602 | 3.2658 | 03/31/2026 |
| 4 | Westfield Capital Management Co. LP | 5,763,475 | -331,011 | 168,869,817.5 | 0.6019 | 3.103 | 03/31/2026 |
| 5 | Point72 Asset Management LP | 3,886,017 | 3,886,017 | 113,860,298.1 | 0.1669 | 2.0922 | 03/31/2026 |
| 6 | BlackRock Fund Advisors | 3,326,334 | 284,796 | 97,461,586.2 | 0.0019 | 1.7909 | 03/31/2026 |
| 7 | FIAM LLC | 2,708,779 | 208,384 | 79,367,224.7 | 0.0327 | 1.4584 | 03/31/2026 |
| 8 | First Beijing Investment Ltd. | 2,296,335 | 2,296,335 | 67,282,615.5 | 2.0437 | 1.2363 | 03/31/2026 |
| 9 | Artisan Partners LP | 2,254,488 | -293,464 | 66,056,498.4 | 0.0499 | 1.2138 | 03/31/2026 |
| 10 | Two Sigma Investments LP | 1,890,396 | 1,530,461 | 55,388,602.8 | 0.0415 | 1.0178 | 03/31/2026 |
| 11 | Fidelity Management & Research (Hong Kong) Ltd. | 1,850,839 | 1,401,500 | 54,229,582.7 | 0.3012 | 0.9965 | 04/30/2026 |
| 12 | Kynam Capital Management LP | 1,576,295 | 1,576,295 | 46,185,443.5 | 2.8425 | 0.8487 | 03/31/2026 |
| 13 | Acadian Asset Management LLC | 1,527,336 | 1,527,336 | 44,750,944.8 | 0.0481 | 0.8223 | 03/31/2026 |
| 14 | SSgA Funds Management, Inc. | 1,498,372 | 341,250 | 43,902,299.6 | 0.0013 | 0.8067 | 03/31/2026 |
| 15 | Goldman Sachs & Co. LLC (Private Banking) | 1,464,112 | 435,856 | 42,898,481.6 | 0.0133 | 0.7883 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity OTC Portfolio | 3,709,610 | -974,200 | 108,691,573 | 0.2533 | 1.9972 | 04/30/2026 |
| 2 | Fidelity Select Pharmaceuticals Portfolio | 2,522,300 | 1,689,600 | 73,903,390 | 4.8603 | 1.358 | 04/30/2026 |
| 3 | Fidelity Select Port. - Health Care Portfolio | 2,280,000 | -570,000 | 66,804,000 | 1.1063 | 1.2275 | 04/30/2026 |
| 4 | Fidelity VIP - Contrafund Portfolio | 1,855,400 | -335,486 | 54,363,220 | 0.1829 | 0.9989 | 04/30/2026 |
| 5 | Artisan International Small-Mid Fund | 1,431,575 | -147,088 | 41,945,147.5 | 1.4971 | 0.7707 | 03/31/2026 |
| 6 | Strategic Advisers Fidelity US Total Stock Fund | 1,352,980 | -32,700 | 39,642,314 | 0.016 | 0.7284 | 04/30/2026 |
| 7 | Fidelity Advisor Health Care Fund | 1,160,000 | -340,000 | 33,988,000 | 1.1066 | 0.6245 | 04/30/2026 |
| 8 | Fidelity Emerging Markets Fund | 1,088,900 | 1,088,900 | 31,904,770 | 0.2751 | 0.5863 | 04/30/2026 |
| 9 | iShares Biotechnology ETF | 959,757 | 29,051 | 28,120,880.1 | 0.3428 | 0.5167 | 05/29/2026 |
| 10 | Fidelity US Equity Central Fund | 850,000 | -170,000 | 24,905,000 | 0.1065 | 0.4576 | 03/31/2026 |
| 11 | iShares Core MSCI Emerging Markets ETF | 825,168 | 99,919 | 24,177,422.4 | 0.0151 | 0.4443 | 05/29/2026 |
| 12 | Harbor Small Cap Growth Fund | 760,321 | 173,920 | 22,277,405.3 | 0.8635 | 0.4093 | 01/31/2026 |
| 13 | Fidelity VIP - Mid Cap Portfolio | 695,600 | 302,100 | 20,381,080 | 0.2164 | 0.3745 | 04/30/2026 |
| 14 | Fidelity Insights Investment Trust | 692,538 | 0 | 20,291,363.4 | 0.1214 | 0.3729 | 03/31/2026 |
| 15 | Fidelity China Region Fund | 653,039 | 403,500 | 19,134,042.7 | 0.7206 | 0.3516 | 04/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Point72 Asset Management LP | 3,886,017 | 3,886,017 | 113,860,298.1 | 0.1669 | 2.0922 | 03/31/2026 |
| 2 | Suvretta Capital Management LLC | 7,581,029 | 3,763,020 | 222,124,149.7 | 5.0066 | 4.0815 | 03/31/2026 |
| 3 | First Beijing Investment Ltd. | 2,296,335 | 2,296,335 | 67,282,615.5 | 2.0437 | 1.2363 | 03/31/2026 |
| 4 | Kynam Capital Management LP | 1,576,295 | 1,576,295 | 46,185,443.5 | 2.8425 | 0.8487 | 03/31/2026 |
| 5 | Two Sigma Investments LP | 1,890,396 | 1,530,461 | 55,388,602.8 | 0.0415 | 1.0178 | 03/31/2026 |
| 6 | Acadian Asset Management LLC | 1,527,336 | 1,527,336 | 44,750,944.8 | 0.0481 | 0.8223 | 03/31/2026 |
| 7 | Fidelity Management & Research (Hong Kong) Ltd. | 1,850,839 | 1,401,500 | 54,229,582.7 | 0.3012 | 0.9965 | 04/30/2026 |
| 8 | Davern Capital Partners LP | 1,314,748 | 1,314,748 | 38,522,116.4 | 10.2242 | 0.7078 | 03/31/2026 |
| 9 | Hudson Bay Capital Management LP | 876,351 | 656,351 | 25,677,084.3 | 0.1437 | 0.4718 | 03/31/2026 |
| 10 | SG Americas Securities LLC | 535,658 | 530,251 | 15,694,779.4 | 0.0145 | 0.2884 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 22,757,490 | -2,203,109 | 666,794,457 | 0.0333 | 12.2524 | 03/31/2026 |
| 2 | Janus Henderson Investors US LLC | 0 | -2,121,691 | 0 | 0 | 0 | |
| 3 | Braidwell LP | 0 | -1,826,155 | 0 | 0 | 0 | |
| 4 | AllianceBernstein LP | 0 | -1,632,967 | 0 | 0 | 0 | |
| 5 | Federated Global Investment Management Corp. | 18,000 | -1,042,903 | 527,400 | 0.0044 | 0.0097 | 03/31/2026 |
| 6 | Tang Capital Management LLC | 0 | -830,000 | 0 | 0 | 0 | |
| 7 | Two Sigma Advisers LP | 0 | -723,700 | 0 | 0 | 0 | |
| 8 | UBS Securities LLC | 237,931 | -704,771 | 6,971,378.3 | 0.0025 | 0.1281 | 03/31/2026 |
| 9 | Millennium Management LLC | 284,911 | -507,574 | 8,347,892.3 | 0.0058 | 0.1534 | 03/31/2026 |
| 10 | Columbia Management Investment Advisers LLC | 64,001 | -467,270 | 1,875,229.3 | 0.0004 | 0.0345 | 03/31/2026 |
Data provided by FactSet Research Systems Inc.