| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 24,960,599 | 13,954,626 | 702,141,649.87 | 0.0388 | 13.5236 | 09/30/2025 |
| 2 | HHLR Advisors Ltd. | 6,299,050 | 314,500 | 177,192,276.5 | 1.2712 | 3.4128 | 09/30/2025 |
| 3 | Westfield Capital Management Co. LP | 6,094,486 | -823,081 | 171,437,891.18 | 0.6984 | 3.302 | 09/30/2025 |
| 4 | Suvretta Capital Management LLC | 3,818,009 | 68,044 | 107,400,593.17 | 2.9618 | 2.0686 | 09/30/2025 |
| 5 | BlackRock Fund Advisors | 3,041,538 | -67,455 | 85,558,463.94 | 0.0019 | 1.6479 | 09/30/2025 |
| 6 | Artisan Partners LP | 2,547,952 | 1,416,184 | 71,673,889.76 | 0.0564 | 1.3805 | 09/30/2025 |
| 7 | FIAM LLC | 2,500,395 | 551,593 | 70,336,111.35 | 0.0362 | 1.3547 | 09/30/2025 |
| 8 | Janus Henderson Investors US LLC | 2,121,691 | 102,387 | 59,683,167.83 | 0.0279 | 1.1495 | 09/30/2025 |
| 9 | Braidwell LP | 1,826,155 | -1,151,796 | 51,369,740.15 | 1.3338 | 0.9894 | 09/30/2025 |
| 10 | AllianceBernstein LP | 1,632,967 | 124,715 | 45,935,361.71 | 0.0134 | 0.8847 | 09/30/2025 |
| 11 | SSgA Funds Management, Inc. | 1,157,122 | 18,933 | 32,549,841.86 | 0.0011 | 0.6269 | 09/30/2025 |
| 12 | Federated Global Investment Management Corp. | 1,060,903 | -326,768 | 29,843,201.39 | 0.2387 | 0.5748 | 09/30/2025 |
| 13 | Matthews International Capital Management LLC | 1,028,447 | -73,440 | 28,930,214.11 | 0.5014 | 0.5572 | 09/30/2025 |
| 14 | Goldman Sachs & Co. LLC (Private Banking) | 1,028,256 | 74,425 | 28,924,841.28 | 0.0126 | 0.5571 | 09/30/2025 |
| 15 | UBS Securities LLC | 942,702 | -1,623 | 26,518,207.26 | 0.0108 | 0.5108 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity OTC Portfolio | 4,683,810 | 2,070,123 | 131,755,575.3 | 0.3651 | 2.5377 | 10/31/2025 |
| 2 | Fidelity Select Port. - Health Care Portfolio | 3,670,000 | 218,176 | 103,237,100 | 1.5584 | 1.9884 | 10/31/2025 |
| 3 | Fidelity Advisor Health Care Fund | 2,080,000 | 116,307 | 58,510,400 | 1.6632 | 1.1269 | 10/31/2025 |
| 4 | Fidelity VIP - Contrafund Portfolio | 2,030,839 | 640,439 | 57,127,501.07 | 0.1997 | 1.1003 | 10/31/2025 |
| 5 | Fidelity Strategic Advisers US Total Stock Fund | 1,682,280 | -60,860 | 47,322,536.4 | 0.0245 | 0.9115 | 10/31/2025 |
| 6 | Artisan International Small-Mid Fund | 1,578,663 | 809,401 | 44,407,790.19 | 1.4357 | 0.8553 | 09/30/2025 |
| 7 | Fidelity Puritan Fund | 1,492,282 | 610,942 | 41,977,892.66 | 0.192 | 0.8085 | 09/30/2025 |
| 8 | Fidelity Advisor New Insights Fund | 1,307,271 | 1,061,771 | 36,773,533.23 | 0.1492 | 0.7083 | 10/31/2025 |
| 9 | Fidelity US Equity Central Fund | 1,020,000 | 220,000 | 28,692,600 | 0.1512 | 0.5526 | 09/30/2025 |
| 10 | American Funds Small Cap World Fund | 899,946 | -367,219 | 25,315,480.98 | 0.0316 | 0.4876 | 09/30/2025 |
| 11 | Fidelity Select Pharmaceuticals Portfolio | 832,700 | 69,600 | 23,423,851 | 1.8309 | 0.4512 | 10/31/2025 |
| 12 | Fidelity OTC Commingled Pool | 793,863 | 229,062 | 22,331,366.19 | 0.3659 | 0.4301 | 10/31/2025 |
| 13 | iShares Biotechnology ETF | 760,109 | -8,617 | 21,381,866.17 | 0.303 | 0.4118 | 10/31/2025 |
| 14 | Fidelity VIP - Health Care Portfolio | 610,700 | 54,163 | 17,178,991 | 1.5248 | 0.3309 | 10/31/2025 |
| 15 | Federated Hermes Kaufmann Small Cap Fund | 527,700 | -156,900 | 14,844,201 | 0.4292 | 0.2859 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 24,960,599 | 13,954,626 | 702,141,649.87 | 0.0388 | 13.5236 | 09/30/2025 |
| 2 | Artisan Partners LP | 2,547,952 | 1,416,184 | 71,673,889.76 | 0.0564 | 1.3805 | 09/30/2025 |
| 3 | FIAM LLC | 2,500,395 | 551,593 | 70,336,111.35 | 0.0362 | 1.3547 | 09/30/2025 |
| 4 | Leap Investments LP | 402,089 | 357,689 | 11,310,763.57 | 0.196 | 0.2179 | 09/30/2025 |
| 5 | HHLR Advisors Ltd. | 6,299,050 | 314,500 | 177,192,276.5 | 1.2712 | 3.4128 | 09/30/2025 |
| 6 | Rakuten Investment Management, Inc. | 232,468 | 230,699 | 6,539,324.84 | 0.0208 | 0.126 | 09/30/2025 |
| 7 | Two Sigma Advisers LP | 723,700 | 219,600 | 20,357,681 | 0.0399 | 0.3921 | 09/30/2025 |
| 8 | Citadel Advisors LLC | 176,448 | 163,287 | 4,963,482.24 | 0.0054 | 0.0956 | 09/30/2025 |
| 9 | Triata Capital Ltd. | 161,800 | 161,800 | 4,551,434 | 0.5931 | 0.0877 | 09/30/2025 |
| 10 | Empire Life Investments, Inc. | 325,008 | 159,347 | 9,142,475.04 | 0.2485 | 0.1761 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Associates, Inc. (IM) | 0 | -6,725,464 | 0 | 0 | 0 | |
| 2 | Invesco Advisers, Inc. | 7,908 | -2,905,351 | 222,452.04 | 0.0001 | 0.0043 | 09/30/2025 |
| 3 | Massachusetts Financial Services Co. | 521,811 | -1,648,540 | 14,678,543.43 | 0.0045 | 0.2827 | 09/30/2025 |
| 4 | Wellington Management Co. LLP | 0 | -1,609,047 | 0 | 0 | 0 | |
| 5 | Braidwell LP | 1,826,155 | -1,151,796 | 51,369,740.15 | 1.3338 | 0.9894 | 09/30/2025 |
| 6 | Westfield Capital Management Co. LP | 6,094,486 | -823,081 | 171,437,891.18 | 0.6984 | 3.302 | 09/30/2025 |
| 7 | Capital Research & Management Co. (International Investors) | 941,600 | -735,660 | 26,487,208 | 0.004 | 0.5102 | 09/30/2025 |
| 8 | Morgan Stanley & Co. LLC | 214,085 | -700,661 | 6,022,211.05 | 0.002 | 0.116 | 09/30/2025 |
| 9 | Kynam Capital Management LP | 0 | -610,000 | 0 | 0 | 0 | |
| 10 | Rock Springs Capital Management LP | 0 | -512,932 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.