| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 22,866,256 | 11,860,283 | 752,528,484.96 | 0.0419 | 12.4079 | 06/30/2025 |
| 2 | Westfield Capital Management Co. LP | 6,472,547 | -445,020 | 213,011,521.77 | 0.8382 | 3.5122 | 06/30/2025 |
| 3 | HHLR Advisors Ltd. | 6,203,250 | 218,700 | 204,148,957.5 | 1.6538 | 3.3661 | 06/30/2025 |
| 4 | Suvretta Capital Management LLC | 3,774,009 | 24,044 | 124,202,636.19 | 3.5926 | 2.0479 | 06/30/2025 |
| 5 | BlackRock Fund Advisors | 2,853,115 | -255,878 | 93,896,014.65 | 0.0021 | 1.5482 | 06/30/2025 |
| 6 | Braidwell LP | 2,542,104 | -435,847 | 83,660,642.64 | 2.4703 | 1.3794 | 06/30/2025 |
| 7 | FIAM LLC | 2,541,920 | 593,118 | 83,654,587.2 | 0.0456 | 1.3793 | 06/30/2025 |
| 8 | Artisan Partners LP | 2,122,268 | 990,500 | 69,843,839.88 | 0.0531 | 1.1516 | 06/30/2025 |
| 9 | Janus Henderson Investors US LLC | 2,053,994 | 34,690 | 67,596,942.54 | 0.032 | 1.1146 | 06/30/2025 |
| 10 | AllianceBernstein LP | 1,560,596 | 52,344 | 51,359,214.36 | 0.0149 | 0.8468 | 06/30/2025 |
| 11 | SSgA Funds Management, Inc. | 1,119,691 | -18,498 | 36,849,030.81 | 0.0012 | 0.6076 | 06/30/2025 |
| 12 | Capital Research & Management Co. (International Investors) | 1,082,473 | -594,787 | 35,624,186.43 | 0.0055 | 0.5874 | 06/30/2025 |
| 13 | Federated Global Investment Management Corp. | 1,059,724 | -327,947 | 34,875,516.84 | 0.2777 | 0.575 | 06/30/2025 |
| 14 | Matthews International Capital Management LLC | 1,028,447 | -73,440 | 33,846,190.77 | 0.51 | 0.5581 | 09/30/2025 |
| 15 | UBS Securities LLC | 1,002,956 | 58,631 | 33,007,281.96 | 0.0135 | 0.5442 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity OTC Portfolio | 4,683,810 | 4,581,791 | 154,144,187.1 | 0.4333 | 2.5416 | 08/31/2025 |
| 2 | Fidelity Select Port. - Health Care Portfolio | 3,670,000 | 870,000 | 120,779,700 | 1.8852 | 1.9914 | 08/31/2025 |
| 3 | Fidelity Advisor Health Care Fund | 2,080,000 | 430,000 | 68,452,800 | 1.924 | 1.1287 | 08/31/2025 |
| 4 | Fidelity VIP - Contrafund Portfolio | 1,771,433 | 1,383,533 | 58,297,860.03 | 0.2046 | 0.9612 | 08/31/2025 |
| 5 | Fidelity Strategic Advisers US Total Stock Fund | 1,682,280 | 402,280 | 55,363,834.8 | 0.0307 | 0.9129 | 08/31/2025 |
| 6 | Artisan International Small-Mid Fund | 1,578,663 | 809,401 | 51,953,799.33 | 1.714 | 0.8566 | 09/30/2025 |
| 7 | Fidelity Puritan Fund | 1,412,282 | 1,412,282 | 46,478,200.62 | 0.2106 | 0.7663 | 07/31/2025 |
| 8 | Fidelity Advisor New Insights Fund | 1,275,564 | 1,030,064 | 41,978,811.24 | 0.1702 | 0.6922 | 08/31/2025 |
| 9 | Fidelity US Equity Central Fund | 1,050,000 | 250,000 | 34,555,500 | 0.1859 | 0.5698 | 06/30/2025 |
| 10 | American Funds Small Cap World Fund | 899,946 | -367,219 | 29,617,222.86 | 0.0376 | 0.4883 | 09/30/2025 |
| 11 | Fidelity Select Pharmaceuticals Portfolio | 832,700 | 69,600 | 27,404,157 | 2.2571 | 0.4518 | 08/31/2025 |
| 12 | Fidelity OTC Commingled Pool | 793,863 | 776,857 | 26,126,031.33 | 0.4351 | 0.4308 | 08/31/2025 |
| 13 | iShares Biotechnology ETF | 752,421 | -67,889 | 24,762,175.11 | 0.3844 | 0.4083 | 09/30/2025 |
| 14 | iShares Core MSCI Emerging Markets ETF | 677,319 | 28,253 | 22,290,568.29 | 0.0197 | 0.3675 | 09/30/2025 |
| 15 | Fidelity VIP - Health Care Portfolio | 600,000 | 160,000 | 19,746,000 | 1.8342 | 0.3256 | 08/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 22,866,256 | 11,860,283 | 752,528,484.96 | 0.0419 | 12.4079 | 06/30/2025 |
| 2 | Artisan Partners LP | 2,122,268 | 990,500 | 69,843,839.88 | 0.0531 | 1.1516 | 06/30/2025 |
| 3 | Balyasny Asset Management LP | 947,633 | 746,642 | 31,186,602.03 | 0.0671 | 0.5142 | 06/30/2025 |
| 4 | FIAM LLC | 2,541,920 | 593,118 | 83,654,587.2 | 0.0456 | 1.3793 | 06/30/2025 |
| 5 | Canada Pension Plan Investment Board | 444,900 | 444,900 | 14,641,659 | 0.0071 | 0.2414 | 06/30/2025 |
| 6 | Point72 Asset Management LP | 362,317 | 362,317 | 11,923,852.47 | 0.0222 | 0.1966 | 06/30/2025 |
| 7 | StemPoint Capital LP | 270,144 | 270,144 | 8,890,439.04 | 1.8269 | 0.1466 | 06/30/2025 |
| 8 | Logos Global Management LP | 250,000 | 250,000 | 8,227,500 | 0.7557 | 0.1357 | 06/30/2025 |
| 9 | HHLR Advisors Ltd. | 6,203,250 | 218,700 | 204,148,957.5 | 1.6538 | 3.3661 | 06/30/2025 |
| 10 | Two Sigma Advisers LP | 716,100 | 212,000 | 23,566,851 | 0.0447 | 0.3886 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Associates, Inc. (IM) | 795,802 | -5,929,662 | 26,189,843.82 | 0.003 | 0.4318 | 06/30/2025 |
| 2 | Invesco Advisers, Inc. | 6,939 | -2,906,320 | 228,362.49 | 0.0001 | 0.0038 | 06/30/2025 |
| 3 | Massachusetts Financial Services Co. | 445,529 | -1,724,822 | 14,662,359.39 | 0.0045 | 0.2418 | 06/30/2025 |
| 4 | Wellington Management Co. LLP | 0 | -1,609,047 | 0 | 0 | 0 | |
| 5 | Kynam Capital Management LP | 0 | -610,000 | 0 | 0 | 0 | |
| 6 | Morgan Stanley & Co. LLC | 310,599 | -604,147 | 10,221,813.09 | 0.0034 | 0.1685 | 06/30/2025 |
| 7 | Capital Research & Management Co. (International Investors) | 1,082,473 | -594,787 | 35,624,186.43 | 0.0055 | 0.5874 | 06/30/2025 |
| 8 | Two Sigma Investments LP | 269,701 | -532,080 | 8,875,859.91 | 0.0148 | 0.1463 | 06/30/2025 |
| 9 | Rock Springs Capital Management LP | 0 | -512,932 | 0 | 0 | 0 | |
| 10 | Westfield Capital Management Co. LP | 6,472,547 | -445,020 | 213,011,521.77 | 0.8382 | 3.5122 | 06/30/2025 |
Data provided by FactSet Research Systems Inc.