| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 16,290,130 | -1,398,462 | 6,059,928.36 | 0.0029 | 10.2369 | 09/30/2025 |
| 2 | Rubric Capital Management LP | 15,307,347 | 0 | 5,694,333.08 | 0.0619 | 9.6193 | 12/31/2025 |
| 3 | EcoR1 Capital, LLC | 14,900,000 | 14,900,000 | 5,542,800 | 0.2025 | 9.3633 | 01/02/2026 |
| 4 | 683 Capital Management LLC | 13,016,763 | 8,666,763 | 4,842,235.84 | 0.3655 | 8.1799 | 01/06/2026 |
| 5 | Mangrove Partners IM LLC | 7,790,580 | -845,905 | 2,898,095.76 | 0.222 | 4.8957 | 09/30/2025 |
| 6 | Rock Springs Capital Management LP | 4,570,649 | 105,357 | 1,700,281.43 | 0.0948 | 2.8722 | 09/30/2025 |
| 7 | Clearline Capital LP | 3,834,163 | 216,000 | 1,426,308.64 | 0.1059 | 2.4094 | 09/30/2025 |
| 8 | Alkeon Capital Management LLC | 3,698,100 | -1,000,000 | 1,375,693.2 | 0.0051 | 2.3239 | 09/30/2025 |
| 9 | Citadel Securities LLC | 2,318,074 | 2,203,675 | 862,323.53 | 0.0023 | 1.4567 | 09/30/2025 |
| 10 | Tejara Capital Ltd. | 2,159,681 | -270,756 | 803,401.33 | 0.3113 | 1.3572 | 12/31/2025 |
| 11 | UBS Asset Management Switzerland AG | 1,763,666 | 1,763,666 | 656,083.75 | 0.0002 | 1.1083 | 12/31/2025 |
| 12 | Schonfeld Strategic Advisors LLC | 1,732,724 | 823,084 | 644,573.33 | 0.0043 | 1.0889 | 09/30/2025 |
| 13 | Adage Capital Management LP | 1,700,756 | 0 | 632,681.23 | 0.001 | 1.0688 | 03/31/2025 |
| 14 | Monaco Asset Management SAM | 1,585,214 | 1,190,214 | 589,699.61 | 0.1504 | 0.9962 | 12/31/2025 |
| 15 | Fidelity Management & Research Co. LLC | 1,454,900 | -23,600 | 541,222.8 | 0 | 0.9143 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | abrdn Life Sciences Investors | 2,076,408 | 0 | 772,423.78 | 0.1429 | 1.3048 | 09/30/2025 |
| 2 | UBS (Lux) Equity Fund - Biotech (USD) | 1,840,965 | 153,565 | 684,838.98 | 0.1381 | 1.1569 | 10/31/2025 |
| 3 | HealthInvest Sustainable Healthcare | 270,000 | 0 | 100,440 | 0.0338 | 0.1697 | 12/31/2024 |
| 4 | iShares Genomics Immunology & Healthcare ETF | 213,432 | -155,610 | 79,396.7 | 0.0549 | 0.1341 | 01/30/2026 |
| 5 | State Street SPDR S&P International Small Cap ETF | 130,643 | 85,225 | 48,599.2 | 0.0055 | 0.0821 | 01/30/2026 |
| 6 | Virtus LifeSci Biotech Clinical Trials ETF | 129,828 | 86,059 | 48,296.02 | 0.1345 | 0.0816 | 01/30/2026 |
| 7 | HealthInvest Small & Micro Cap Fund | 120,000 | 0 | 44,640 | 0.0447 | 0.0754 | 12/31/2024 |
| 8 | Fidelity Nasdaq Composite Index Fund | 92,534 | 0 | 34,422.65 | 0.0002 | 0.0581 | 12/31/2025 |
| 9 | Fubon NYSE FactSet Global Genomics and Immuno Biopharma ETF | 78,899 | -69,666 | 29,350.43 | 0.0541 | 0.0496 | 01/30/2026 |
| 10 | Avanza Healthcare By Samuelsson & Hult | 38,235 | 0 | 14,223.42 | 0.065 | 0.024 | 06/30/2025 |
| 11 | iShares Genomics Immunology and Healthcare Index ETF | 6,658 | -4,331 | 2,476.78 | 0.0552 | 0.0042 | 01/30/2026 |
| 12 | Blackstone Alternative Multi Strategy Fund | 3,300 | 1,100 | 1,227.6 | 0.0001 | 0.0021 | 09/30/2025 |
| 13 | Northern Small Cap Core Fund | 1,007 | 0 | 374.6 | 0.0001 | 0.0006 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | EcoR1 Capital, LLC | 14,900,000 | 14,900,000 | 5,542,800 | 0.2025 | 9.3633 | 01/02/2026 |
| 2 | 683 Capital Management LLC | 13,016,763 | 8,666,763 | 4,842,235.84 | 0.3655 | 8.1799 | 01/06/2026 |
| 3 | Citadel Securities LLC | 2,318,074 | 2,203,675 | 862,323.53 | 0.0023 | 1.4567 | 09/30/2025 |
| 4 | UBS Asset Management Switzerland AG | 1,763,666 | 1,763,666 | 656,083.75 | 0.0002 | 1.1083 | 12/31/2025 |
| 5 | Monaco Asset Management SAM | 1,585,214 | 1,190,214 | 589,699.61 | 0.1504 | 0.9962 | 12/31/2025 |
| 6 | UBS Switzerland AG (Investment Management) | 1,321,648 | 1,124,365 | 491,653.06 | 0.001 | 0.8305 | 12/31/2025 |
| 7 | Schonfeld Strategic Advisors LLC | 1,732,724 | 823,084 | 644,573.33 | 0.0043 | 1.0889 | 09/30/2025 |
| 8 | Logos Global Management LP | 500,000 | 500,000 | 186,000 | 0.0136 | 0.3142 | 09/30/2025 |
| 9 | Morgan Stanley & Co. LLC | 1,270,766 | 487,409 | 472,724.95 | 0.0002 | 0.7986 | 12/31/2025 |
| 10 | Two Sigma Investments LP | 1,088,096 | 428,938 | 404,771.71 | 0.0006 | 0.6838 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Goldman Sachs & Co. LLC (Private Banking) | 28,026 | -3,062,042 | 10,425.67 | 0 | 0.0176 | 12/31/2025 |
| 2 | abrdn, Inc. | 0 | -3,028,872 | 0 | 0 | 0 | |
| 3 | Janus Henderson Investors US LLC | 16,290,130 | -1,398,462 | 6,059,928.36 | 0.0029 | 10.2369 | 09/30/2025 |
| 4 | Renaissance Technologies LLC | 194,371 | -1,286,100 | 72,306.01 | 0.0001 | 0.1221 | 12/31/2025 |
| 5 | Alkeon Capital Management LLC | 3,698,100 | -1,000,000 | 1,375,693.2 | 0.0051 | 2.3239 | 09/30/2025 |
| 6 | Mangrove Partners IM LLC | 7,790,580 | -845,905 | 2,898,095.76 | 0.222 | 4.8957 | 09/30/2025 |
| 7 | Marshall Wace LLP | 0 | -767,744 | 0 | 0 | 0 | |
| 8 | Atle Fund Management AB | 0 | -764,901 | 0 | 0 | 0 | |
| 9 | Soleus Capital Management LP (Investment Management) | 0 | -599,711 | 0 | 0 | 0 | |
| 10 | Hudson Bay Capital Management LP | 0 | -450,000 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.