| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 17,688,592 | -5,046,529 | 35,377,184 | 0.0169 | 11.4013 | 06/30/2025 |
| 2 | Rubric Capital Management LP | 15,307,347 | 0 | 30,614,694 | 0.3952 | 9.8664 | 06/30/2025 |
| 3 | Mangrove Partners IM LLC | 8,636,485 | 0 | 17,272,970 | 1.5138 | 5.5667 | 06/30/2025 |
| 4 | Alkeon Capital Management LLC | 4,698,100 | 0 | 9,396,200 | 0.0389 | 3.0282 | 06/30/2025 |
| 5 | Rock Springs Capital Management LP | 4,465,292 | -2,218,955 | 8,930,584 | 0.4564 | 2.8781 | 06/30/2025 |
| 6 | 683 Capital Management LLC | 4,350,000 | -285,000 | 8,700,000 | 0.7094 | 2.8038 | 06/30/2025 |
| 7 | Clearline Capital LP | 3,618,163 | 400,269 | 7,236,326 | 0.596 | 2.3321 | 06/30/2025 |
| 8 | Goldman Sachs & Co. LLC (Private Banking) | 3,090,068 | 964,148 | 6,180,136 | 0.0025 | 1.9917 | 06/30/2025 |
| 9 | abrdn, Inc. | 3,028,872 | 840,518 | 6,057,744 | 0.0588 | 1.9523 | 06/30/2025 |
| 10 | Tejara Capital Ltd. | 2,430,437 | -90,887 | 4,860,874 | 1.9604 | 1.5666 | 06/30/2025 |
| 11 | Renaissance Technologies LLC | 1,480,471 | 130,000 | 2,960,942 | 0.0037 | 0.9542 | 06/30/2025 |
| 12 | Fidelity Management & Research Co. LLC | 1,478,500 | 719,400 | 2,957,000 | 0.0002 | 0.953 | 06/30/2025 |
| 13 | Schonfeld Strategic Advisors LLC | 909,640 | -681,416 | 1,819,280 | 0.0126 | 0.5863 | 06/30/2025 |
| 14 | Morgan Stanley & Co. LLC | 783,357 | -1,392,248 | 1,566,714 | 0.0005 | 0.5049 | 06/30/2025 |
| 15 | Marshall Wace LLP | 767,744 | 0 | 1,535,488 | 0.0017 | 0.4949 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | abrdn World Healthcare Fund | 3,462,291 | 2,117,828 | 6,924,582 | 1.1763 | 2.2316 | 08/31/2025 |
| 2 | abrdn Life Sciences Investors | 2,076,408 | 1,264,355 | 4,152,816 | 0.7529 | 1.3384 | 07/31/2025 |
| 3 | UBS (Lux) Equity Fund - Biotech (USD) | 1,677,900 | 108,800 | 3,355,800 | 0.7377 | 1.0815 | 06/30/2025 |
| 4 | Fidelity Select Port. - Biotechnology Portfolio | 838,700 | 838,700 | 1,677,400 | 0.035 | 0.5406 | 08/31/2025 |
| 5 | Fidelity Advisor Series VII - Biotechnology Fund | 759,100 | 0 | 1,518,200 | 0.0899 | 0.4893 | 08/31/2025 |
| 6 | iShares Genomics Immunology & Healthcare ETF | 358,296 | 116,257 | 716,592 | 0.5917 | 0.2309 | 09/30/2025 |
| 7 | HealthInvest Sustainable Healthcare | 270,000 | 0 | 540,000 | 0.1918 | 0.174 | 12/31/2024 |
| 8 | BIT Biotech Opportunities | 190,059 | 0 | 380,118 | 1.0746 | 0.1225 | 02/28/2025 |
| 9 | Fubon NYSE FactSet Global Genomics and Immuno Biopharma ETF | 145,321 | 47,698 | 290,642 | 0.584 | 0.0937 | 09/30/2025 |
| 10 | SPDR S&P International Small Cap ETF | 132,701 | 87,042 | 265,402 | 0.034 | 0.0855 | 09/30/2025 |
| 11 | HealthInvest Small & Micro Cap Fund | 120,000 | 0 | 240,000 | 0.2596 | 0.0773 | 12/31/2024 |
| 12 | Fidelity Nasdaq Composite Index Fund | 92,534 | 378 | 185,068 | 0.0008 | 0.0596 | 08/31/2025 |
| 13 | ActivePassive International Equity ETF | 58,445 | 58,445 | 116,890 | 0.0125 | 0.0377 | 09/30/2025 |
| 14 | Arctic Funds Plc - Aurora LifeScience | 55,551 | 55,551 | 111,102 | 0.2943 | 0.0358 | 07/31/2025 |
| 15 | Virtus LifeSci Biotech Clinical Trials ETF | 40,930 | -3,077 | 81,860 | 0.4305 | 0.0264 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Goldman Sachs & Co. LLC (Private Banking) | 3,090,068 | 964,148 | 6,180,136 | 0.0025 | 1.9917 | 06/30/2025 |
| 2 | abrdn, Inc. | 3,028,872 | 840,518 | 6,057,744 | 0.0588 | 1.9523 | 06/30/2025 |
| 3 | Fidelity Management & Research Co. LLC | 1,478,500 | 719,400 | 2,957,000 | 0.0002 | 0.953 | 06/30/2025 |
| 4 | Two Sigma Investments LP | 659,158 | 413,952 | 1,318,316 | 0.0022 | 0.4249 | 06/30/2025 |
| 5 | Clearline Capital LP | 3,618,163 | 400,269 | 7,236,326 | 0.596 | 2.3321 | 06/30/2025 |
| 6 | Atle Fund Management AB | 764,901 | 374,901 | 1,529,802 | 0.391 | 0.493 | 06/30/2025 |
| 7 | Citadel Advisors LLC | 646,260 | 302,607 | 1,292,520 | 0.0015 | 0.4166 | 06/30/2025 |
| 8 | Paloma Partners Management Co. | 296,659 | 296,659 | 593,318 | 0.1071 | 0.1912 | 06/30/2025 |
| 9 | Millennium Management LLC | 595,673 | 201,242 | 1,191,346 | 0.001 | 0.3839 | 06/30/2025 |
| 10 | Simplex Trading LLC | 201,141 | 197,024 | 402,282 | 0.0089 | 0.1296 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 17,688,592 | -5,046,529 | 35,377,184 | 0.0169 | 11.4013 | 06/30/2025 |
| 2 | Rock Springs Capital Management LP | 4,465,292 | -2,218,955 | 8,930,584 | 0.4564 | 2.8781 | 06/30/2025 |
| 3 | Adage Capital Management LP | 0 | -1,700,756 | 0 | 0 | 0 | |
| 4 | UBS Asset Management Switzerland AG | 0 | -1,569,100 | 0 | 0 | 0 | |
| 5 | Morgan Stanley & Co. LLC | 783,357 | -1,392,248 | 1,566,714 | 0.0005 | 0.5049 | 06/30/2025 |
| 6 | Great Point Partners LLC | 0 | -1,275,000 | 0 | 0 | 0 | |
| 7 | Woodline Partners LP | 0 | -947,986 | 0 | 0 | 0 | |
| 8 | Perceptive Advisors LLC | 0 | -876,961 | 0 | 0 | 0 | |
| 9 | Integral Health Asset Management LLC | 0 | -800,000 | 0 | 0 | 0 | |
| 10 | Acuta Capital Partners LLC | 0 | -791,815 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.