| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Rubric Capital Management LP | 15,307,347 | 0 | 4,286,057.16 | 0.0471 | 9.5901 | 12/31/2025 |
| 2 | EcoR1 Capital, LLC | 14,900,000 | 14,900,000 | 4,172,000 | 0.1596 | 9.3349 | 01/02/2026 |
| 3 | 683 Capital Management LLC | 13,016,763 | 8,141,763 | 3,644,693.64 | 0.2918 | 8.1551 | 01/06/2026 |
| 4 | Schonfeld Strategic Advisors LLC | 6,090,381 | 4,357,657 | 1,705,306.68 | 0.0082 | 3.8157 | 12/31/2025 |
| 5 | Tejara Capital Ltd. | 2,159,681 | 252,837 | 604,710.68 | 0.1933 | 1.353 | 12/31/2025 |
| 6 | Logos Global Management LP | 1,850,000 | 1,350,000 | 518,000 | 0.0283 | 1.159 | 12/31/2025 |
| 7 | UBS Asset Management Switzerland AG | 1,763,666 | -143,109 | 493,826.48 | 0.0001 | 1.1049 | 12/31/2025 |
| 8 | Monaco Asset Management SAM | 1,585,214 | 639,299 | 443,859.92 | 0.1058 | 0.9931 | 12/31/2025 |
| 9 | UBS Switzerland AG (Investment Management) | 1,321,648 | 680,348 | 370,061.44 | 0.0009 | 0.828 | 12/31/2025 |
| 10 | Balyasny Asset Management LP | 1,280,275 | 1,280,275 | 358,477 | 0.0007 | 0.8021 | 12/31/2025 |
| 11 | Morgan Stanley & Co. LLC | 1,270,766 | -2,074,961 | 355,814.48 | 0.0001 | 0.7961 | 12/31/2025 |
| 12 | Two Sigma Investments LP | 525,125 | -562,971 | 147,035 | 0.0002 | 0.329 | 12/31/2025 |
| 13 | Group One Trading LLC | 441,636 | 305,048 | 123,658.08 | 0.0033 | 0.2767 | 12/31/2025 |
| 14 | Simplex Trading LLC | 419,477 | 223,208 | 117,453.56 | 0.0028 | 0.2628 | 12/31/2025 |
| 15 | Entrypoint Capital LLC | 400,700 | 400,700 | 112,196 | 0.0395 | 0.251 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | UBS (Lux) Equity Fund - Biotech (USD) | 1,763,666 | -143,109 | 493,826.48 | 0.1031 | 1.1049 | 12/31/2025 |
| 2 | HealthInvest Sustainable Healthcare | 270,000 | 0 | 75,600 | 0.0274 | 0.1692 | 12/31/2024 |
| 3 | iShares Genomics Immunology & Healthcare ETF | 221,968 | -136,328 | 62,151.04 | 0.0404 | 0.1391 | 03/31/2026 |
| 4 | State Street SPDR S&P International Small Cap ETF | 133,379 | 678 | 37,346.12 | 0.0042 | 0.0836 | 03/31/2026 |
| 5 | Virtus Biotech Clinical Trials ETF | 125,662 | 84,732 | 35,185.36 | 0.0911 | 0.0787 | 03/31/2026 |
| 6 | HealthInvest Small & Mid Cap Healthcare | 120,000 | 0 | 33,600 | 0.0348 | 0.0752 | 12/31/2024 |
| 7 | Fidelity Nasdaq Composite Index Fund | 92,534 | 0 | 25,909.52 | 0.0001 | 0.058 | 02/28/2026 |
| 8 | Fubon NYSE FactSet Global Genomics and Immuno Biopharma ETF | 74,727 | -70,594 | 20,923.56 | 0.0406 | 0.0468 | 03/31/2026 |
| 9 | Avanza Healthcare By Samuelsson & Hult | 38,235 | 0 | 10,705.8 | 0.0531 | 0.024 | 06/30/2025 |
| 10 | iShares Genomics Immunology and Healthcare Index ETF | 6,658 | -4,331 | 1,864.24 | 0.0406 | 0.0042 | 03/31/2026 |
| 11 | Blackstone Alternative Multi Strategy Fund | 4,600 | 1,300 | 1,288 | 0.0001 | 0.0029 | 12/31/2025 |
| 12 | Northern Small Cap Core Fund | 1,007 | 0 | 281.96 | 0.0001 | 0.0006 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | EcoR1 Capital, LLC | 14,900,000 | 14,900,000 | 4,172,000 | 0.1596 | 9.3349 | 01/02/2026 |
| 2 | 683 Capital Management LLC | 13,016,763 | 8,141,763 | 3,644,693.64 | 0.2918 | 8.1551 | 01/06/2026 |
| 3 | Schonfeld Strategic Advisors LLC | 6,090,381 | 4,357,657 | 1,705,306.68 | 0.0082 | 3.8157 | 12/31/2025 |
| 4 | Logos Global Management LP | 1,850,000 | 1,350,000 | 518,000 | 0.0283 | 1.159 | 12/31/2025 |
| 5 | Balyasny Asset Management LP | 1,280,275 | 1,280,275 | 358,477 | 0.0007 | 0.8021 | 12/31/2025 |
| 6 | UBS Switzerland AG (Investment Management) | 1,321,648 | 680,348 | 370,061.44 | 0.0009 | 0.828 | 12/31/2025 |
| 7 | Monaco Asset Management SAM | 1,585,214 | 639,299 | 443,859.92 | 0.1058 | 0.9931 | 12/31/2025 |
| 8 | Entrypoint Capital LLC | 400,700 | 400,700 | 112,196 | 0.0395 | 0.251 | 12/31/2025 |
| 9 | Luminus Management LLC | 395,000 | 395,000 | 110,600 | 0.0872 | 0.2475 | 12/31/2025 |
| 10 | Rangeley Capital LLC | 364,000 | 364,000 | 101,920 | 0.0819 | 0.228 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 0 | -16,290,130 | 0 | 0 | 0 | |
| 2 | Mangrove Partners IM LLC | 0 | -7,790,580 | 0 | 0 | 0 | |
| 3 | abrdn, Inc. | 0 | -5,538,699 | 0 | 0 | 0 | |
| 4 | Rock Springs Capital Management LP | 0 | -4,570,649 | 0 | 0 | 0 | |
| 5 | Clearline Capital LP | 0 | -3,834,163 | 0 | 0 | 0 | |
| 6 | Alkeon Capital Management LLC | 0 | -3,698,100 | 0 | 0 | 0 | |
| 7 | Goldman Sachs & Co. LLC (Private Banking) | 28,026 | -2,335,998 | 7,847.28 | 0 | 0.0176 | 12/31/2025 |
| 8 | Citadel Securities LLC | 0 | -2,318,074 | 0 | 0 | 0 | |
| 9 | Morgan Stanley & Co. LLC | 1,270,766 | -2,074,961 | 355,814.48 | 0.0001 | 0.7961 | 12/31/2025 |
| 10 | Adage Capital Management LP | 0 | -1,700,756 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.