| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 16,290,130 | -6,444,991 | 28,507,727.5 | 0.0134 | 10.2391 | 09/30/2025 |
| 2 | Rubric Capital Management LP | 15,307,347 | 0 | 26,787,857.25 | 0.3414 | 9.6214 | 09/30/2025 |
| 3 | Mangrove Partners IM LLC | 7,790,580 | -845,905 | 13,633,515 | 1.0637 | 4.8968 | 09/30/2025 |
| 4 | abrdn, Inc. | 5,538,699 | 3,350,345 | 9,692,723.25 | 0.0907 | 3.4813 | 09/30/2025 |
| 5 | 683 Capital Management LLC | 4,875,000 | 240,000 | 8,531,250 | 0.7334 | 3.0642 | 09/30/2025 |
| 6 | Rock Springs Capital Management LP | 4,570,649 | -2,113,598 | 7,998,635.75 | 0.4005 | 2.8729 | 09/30/2025 |
| 7 | Clearline Capital LP | 3,834,163 | 616,269 | 6,709,785.25 | 0.5645 | 2.41 | 09/30/2025 |
| 8 | Alkeon Capital Management LLC | 3,698,100 | -1,000,000 | 6,471,675 | 0.0275 | 2.3244 | 09/30/2025 |
| 9 | Morgan Stanley & Co. LLC | 3,345,727 | 1,170,122 | 5,855,022.25 | 0.002 | 2.1029 | 09/30/2025 |
| 10 | Goldman Sachs & Co. LLC (Private Banking) | 2,364,024 | 238,104 | 4,137,042 | 0.0018 | 1.4859 | 09/30/2025 |
| 11 | Citadel Securities LLC | 2,318,074 | 2,318,074 | 4,056,629.5 | 0.0116 | 1.457 | 09/30/2025 |
| 12 | Tejara Capital Ltd. | 1,906,844 | -614,480 | 3,336,977 | 1.6606 | 1.1985 | 09/30/2025 |
| 13 | UBS Asset Management Switzerland AG | 1,906,775 | 337,675 | 3,336,856.25 | 0.0007 | 1.1985 | 09/30/2025 |
| 14 | Schonfeld Strategic Advisors LLC | 1,732,724 | 141,668 | 3,032,267 | 0.0209 | 1.0891 | 09/30/2025 |
| 15 | Fidelity Management & Research Co. LLC | 1,454,900 | 695,800 | 2,546,075 | 0.0001 | 0.9145 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | abrdn World Healthcare Fund | 3,462,291 | 1,780,487 | 6,059,009.25 | 1.0199 | 2.1762 | 10/31/2025 |
| 2 | abrdn Life Sciences Investors | 2,076,408 | 1,264,355 | 3,633,714 | 0.6218 | 1.3051 | 07/31/2025 |
| 3 | UBS (Lux) Equity Fund - Biotech (USD) | 1,906,776 | 201,476 | 3,336,858 | 0.6701 | 1.1985 | 08/29/2025 |
| 4 | Fidelity Advisor Series VII - Biotechnology Fund | 759,100 | 0 | 1,328,425 | 0.0721 | 0.4771 | 10/31/2025 |
| 5 | Fidelity Select Port. - Biotechnology Portfolio | 520,612 | 520,612 | 911,071 | 0.0179 | 0.3272 | 10/31/2025 |
| 6 | iShares Genomics Immunology & Healthcare ETF | 361,878 | 118,080 | 633,286.5 | 0.4817 | 0.2275 | 10/31/2025 |
| 7 | HealthInvest Sustainable Healthcare | 270,000 | 0 | 472,500 | 0.1593 | 0.1697 | 12/31/2024 |
| 8 | BIT Biotech Opportunities | 190,059 | 0 | 332,603.25 | 0.9154 | 0.1195 | 02/28/2025 |
| 9 | Fubon NYSE FactSet Global Genomics and Immuno Biopharma ETF | 142,605 | 46,230 | 249,558.75 | 0.4761 | 0.0896 | 10/31/2025 |
| 10 | SPDR S&P International Small Cap ETF | 130,643 | 84,984 | 228,625.25 | 0.0295 | 0.0821 | 11/28/2025 |
| 11 | HealthInvest Small & Micro Cap Fund | 120,000 | 0 | 210,000 | 0.2152 | 0.0754 | 12/31/2024 |
| 12 | Fidelity Nasdaq Composite Index Fund | 92,534 | 378 | 161,934.5 | 0.0007 | 0.0582 | 10/31/2025 |
| 13 | Arctic Funds Plc - Aurora LifeScience | 55,551 | -120,482 | 97,214.25 | 0.2381 | 0.0349 | 07/31/2025 |
| 14 | Virtus LifeSci Biotech Clinical Trials ETF | 42,979 | 12,588 | 75,213.25 | 0.3267 | 0.027 | 10/31/2025 |
| 15 | Avanza Healthcare By Samuelsson & Hult | 38,235 | 18,635 | 66,911.25 | 0.3044 | 0.024 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | abrdn, Inc. | 5,538,699 | 3,350,345 | 9,692,723.25 | 0.0907 | 3.4813 | 09/30/2025 |
| 2 | Citadel Securities LLC | 2,318,074 | 2,318,074 | 4,056,629.5 | 0.0116 | 1.457 | 09/30/2025 |
| 3 | Morgan Stanley & Co. LLC | 3,345,727 | 1,170,122 | 5,855,022.25 | 0.002 | 2.1029 | 09/30/2025 |
| 4 | Two Sigma Investments LP | 1,088,096 | 842,890 | 1,904,168 | 0.003 | 0.6839 | 09/30/2025 |
| 5 | Fidelity Management & Research Co. LLC | 1,454,900 | 695,800 | 2,546,075 | 0.0001 | 0.9145 | 09/30/2025 |
| 6 | Clearline Capital LP | 3,834,163 | 616,269 | 6,709,785.25 | 0.5645 | 2.41 | 09/30/2025 |
| 7 | Monaco Asset Management SAM | 945,915 | 529,447 | 1,655,351.25 | 0.5792 | 0.5946 | 09/30/2025 |
| 8 | Citadel Advisors LLC | 853,558 | 509,905 | 1,493,726.5 | 0.0016 | 0.5365 | 09/30/2025 |
| 9 | Logos Global Management LP | 500,000 | 500,000 | 875,000 | 0.066 | 0.3143 | 09/30/2025 |
| 10 | Atle Fund Management AB | 764,901 | 374,901 | 1,338,576.75 | 0.3123 | 0.4808 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 16,290,130 | -6,444,991 | 28,507,727.5 | 0.0134 | 10.2391 | 09/30/2025 |
| 2 | Rock Springs Capital Management LP | 4,570,649 | -2,113,598 | 7,998,635.75 | 0.4005 | 2.8729 | 09/30/2025 |
| 3 | Adage Capital Management LP | 0 | -1,700,756 | 0 | 0 | 0 | |
| 4 | Great Point Partners LLC | 0 | -1,275,000 | 0 | 0 | 0 | |
| 5 | Alkeon Capital Management LLC | 3,698,100 | -1,000,000 | 6,471,675 | 0.0275 | 2.3244 | 09/30/2025 |
| 6 | Woodline Partners LP | 0 | -947,986 | 0 | 0 | 0 | |
| 7 | Perceptive Advisors LLC | 0 | -876,961 | 0 | 0 | 0 | |
| 8 | Mangrove Partners IM LLC | 7,790,580 | -845,905 | 13,633,515 | 1.0637 | 4.8968 | 09/30/2025 |
| 9 | Integral Health Asset Management LLC | 0 | -800,000 | 0 | 0 | 0 | |
| 10 | Acuta Capital Partners LLC | 0 | -791,815 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.