# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Rubric Capital Management LP 15,307,347 0 4,775,892.26 0.0528 9.59 03/31/2026
2 EcoR1 Capital, LLC 13,368,855 13,368,855 4,171,082.76 0.1578 8.3755 03/31/2026
3 683 Capital Management LLC 12,000,000 7,125,000 3,744,000 0.3165 7.5179 03/31/2026
4 BofA Securities, Inc. 8,195,287 8,194,267 2,556,929.54 0.0035 5.1343 03/31/2026
5 Defilade Capital Management LP 7,558,756 7,558,756 2,358,331.87 0.3221 4.7355 03/31/2026
6 Newtyn Management LLC 7,079,056 7,079,056 2,208,665.47 0.195 4.435 03/31/2026
7 Millennium Management LLC 3,559,103 3,221,600 1,110,440.14 0.0008 2.2298 03/31/2026
8 Tejara Capital Ltd. 2,037,520 130,676 635,706.24 0.178 1.2765 03/31/2026
9 UBS Securities LLC 1,481,151 1,160,784 462,119.11 0.0002 0.9279 03/31/2026
10 Truvalue Asset Management Co. Ltd. 992,095 992,095 309,533.64 0.0137 0.6215 12/31/2025
11 Wealthspire Advisors LLC 796,036 795,010 248,363.23 0.0018 0.4987 03/31/2026
12 Marshall Wace LLP 686,987 -80,757 214,339.94 0.0002 0.4304 03/31/2026
13 Group One Trading LLC 335,827 199,239 104,778.02 0.003 0.2104 03/31/2026
14 Rangeley Capital LLC 329,200 329,200 102,710.4 0.0819 0.2062 03/31/2026
15 David M. Knott Partnership 300,337 0 93,705.14 0.0501 0.1882 03/31/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 CSOP Glb Pharmaceutical and Biological Stock Initiation QDII 992,095 992,095 309,533.64 0.2259 0.6215 12/31/2025
2 HealthInvest Sustainable Healthcare 270,000 0 84,240 0.0293 0.1692 12/31/2024
3 iShares Genomics Immunology & Healthcare ETF 259,520 -88,030 80,970.24 0.0506 0.1626 05/29/2026
4 Virtus Biotech Clinical Trials ETF 152,070 105,766 47,445.84 0.1125 0.0953 05/29/2026
5 State Street SPDR S&P International Small Cap ETF 132,696 2,053 41,401.15 0.0048 0.0831 05/29/2026
6 HealthInvest Small & Mid Cap Healthcare 120,000 0 37,440 0.0383 0.0752 12/31/2024
7 Fidelity Nasdaq Composite Index Fund 92,534 0 28,870.61 0.0001 0.058 04/30/2026
8 Fubon NYSE FactSet Global Genomics and Immuno Biopharma ETF 70,728 -67,179 22,067.14 0.0466 0.0443 05/29/2026
9 iShares Genomics Immunology and Healthcare Index ETF 9,056 -1,933 2,825.47 0.0532 0.0057 05/29/2026
10 Blackstone Alternative Multi Strategy Fund 1,200 -2,100 374.4 0 0.0008 03/31/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 EcoR1 Capital, LLC 13,368,855 13,368,855 4,171,082.76 0.1578 8.3755 03/31/2026
2 BofA Securities, Inc. 8,195,287 8,194,267 2,556,929.54 0.0035 5.1343 03/31/2026
3 Defilade Capital Management LP 7,558,756 7,558,756 2,358,331.87 0.3221 4.7355 03/31/2026
4 683 Capital Management LLC 12,000,000 7,125,000 3,744,000 0.3165 7.5179 03/31/2026
5 Newtyn Management LLC 7,079,056 7,079,056 2,208,665.47 0.195 4.435 03/31/2026
6 Millennium Management LLC 3,559,103 3,221,600 1,110,440.14 0.0008 2.2298 03/31/2026
7 UBS Securities LLC 1,481,151 1,160,784 462,119.11 0.0002 0.9279 03/31/2026
8 Truvalue Asset Management Co. Ltd. 992,095 992,095 309,533.64 0.0137 0.6215 12/31/2025
9 Wealthspire Advisors LLC 796,036 795,010 248,363.23 0.0018 0.4987 03/31/2026
10 Rangeley Capital LLC 329,200 329,200 102,710.4 0.0819 0.2062 03/31/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Janus Henderson Investors US LLC 0 -16,290,130 0 0 0
2 Mangrove Partners IM LLC 0 -7,790,580 0 0 0
3 abrdn, Inc. 0 -5,538,699 0 0 0
4 Rock Springs Capital Management LP 0 -4,570,649 0 0 0
5 Clearline Capital LP 0 -3,834,163 0 0 0
6 Alkeon Capital Management LLC 0 -3,698,100 0 0 0
7 Morgan Stanley & Co. LLC 14,006 -3,331,721 4,369.87 0 0.0088 03/31/2026
8 Goldman Sachs & Co. LLC (Private Banking) 0 -2,364,024 0 0 0
9 Citadel Securities LLC 0 -2,318,074 0 0 0
10 UBS Asset Management Switzerland AG 0 -1,906,775 0 0 0

Data provided by FactSet Research Systems Inc.