# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 BlackRock Fund Advisors 565,887 -18,404 8,839,154.94 0.0002 0.4454 03/31/2025
2 Citadel Securities LLC 486,793 486,793 7,603,706.66 0.0231 0.3831 03/31/2025
3 Morgan Stanley & Co. International Plc 313,522 150,022 4,897,213.64 0.0482 0.2468 03/31/2025
4 Susquehanna Financial Group LLLP 260,941 106,962 4,075,898.42 0.006 0.2054 03/31/2025
5 Goldman Sachs & Co. LLC (Private Banking) 257,143 257,143 4,016,573.66 0.0021 0.2024 03/31/2025
6 Morgan Stanley & Co. LLC 224,259 -994 3,502,925.58 0.0012 0.1765 03/31/2025
7 Summit X LLC 198,163 52,508 3,095,306.06 0.5864 0.156 03/31/2025
8 Group One Trading LLC 151,231 151,231 2,362,228.22 0.0745 0.119 03/31/2025
9 TD Securities (USA) LLC 150,000 150,000 2,343,000 0.0727 0.1181 03/31/2025
10 UBS Securities LLC 137,335 -27,818 2,145,172.7 0.0009 0.1081 03/31/2025
11 Aperio Group LLC 132,489 4,898 2,069,478.18 0.0018 0.1043 03/31/2025
12 Penbrook Management LLC 87,675 -3,400 1,369,483.5 0.9563 0.069 03/31/2025
13 Cubist Systematic Strategies LLC 71,891 36,700 1,122,937.42 0.0133 0.0566 03/31/2025
14 Marshall Wace LLP 71,651 71,651 1,119,188.62 0.0013 0.0564 03/31/2025
15 Rockbridge Investment Management LLC 49,150 0 767,723 0.085 0.0387 03/31/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 iShares Biotechnology ETF 500,796 -87,709 7,822,433.52 0.1446 0.3942 06/30/2025
2 iShares IV Plc - NASDAQ US Biotechnology UCITS ETF 22,671 7,301 354,121.02 0.0759 0.0178 06/30/2025
3 Fidelity Nasdaq Composite Index Fund 18,245 0 284,986.9 0.0014 0.0144 05/31/2025
4 Invesco Markets Plc - NASDAQ Biotech UCITS ETF 13,266 4,077 207,214.92 0.0761 0.0104 06/30/2025
5 China Universal Nasdaq Biotechnology Index ETF 6,776 0 105,841.12 0.0495 0.0053 12/31/2024
6 Quantified Global Fund 4,578 3,169 71,508.36 0.388 0.0036 03/31/2025
7 ActivePassive International Equity ETF 4,199 -7,920 65,588.38 0.0069 0.0033 06/30/2025
8 Mirae Asset Tiger NASDAQ Bio ETF 1,953 878 30,505.86 0.0756 0.0015 06/30/2025
9 Invesco Nasdaq Biotechnology ETF 1,870 653 29,209.4 0.076 0.0015 06/30/2025
10 ProShares Ultra NASDAQ Biotechnology 1,696 181 26,491.52 0.0634 0.0013 06/30/2025
11 Xtrackers IE Plc - MSCI Genomic Healthcare Innov UCITS ETF 1,402 1,402 21,899.24 0.3953 0.0011 06/30/2025
12 Gestion Boutique VI, FI - Kaldi 1,000 0 15,620 0.2071 0.0008 12/31/2024
13 DFA International Core Equity 2 Portfolio 796 0 12,433.52 0 0.0006 03/31/2025
14 GF Nasdaq Biotechnology Index Fund 671 0 10,481.02 0.0422 0.0005 12/31/2024
15 Capital Nasdaq Biotechnology Index ETF 135 0 2,108.7 0.0275 0.0001 06/30/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Citadel Securities LLC 486,793 486,793 7,603,706.66 0.0231 0.3831 03/31/2025
2 Goldman Sachs & Co. LLC (Private Banking) 257,143 257,143 4,016,573.66 0.0021 0.2024 03/31/2025
3 Group One Trading LLC 151,231 151,231 2,362,228.22 0.0745 0.119 03/31/2025
4 Morgan Stanley & Co. International Plc 313,522 150,022 4,897,213.64 0.0482 0.2468 03/31/2025
5 TD Securities (USA) LLC 150,000 150,000 2,343,000 0.0727 0.1181 03/31/2025
6 Susquehanna Financial Group LLLP 260,941 106,962 4,075,898.42 0.006 0.2054 03/31/2025
7 Marshall Wace LLP 71,651 71,651 1,119,188.62 0.0013 0.0564 03/31/2025
8 Summit X LLC 198,163 52,508 3,095,306.06 0.5864 0.156 03/31/2025
9 Oasis Management (Hong Kong) LLC 41,450 41,450 647,449 0.1467 0.0326 03/31/2025
10 Cubist Systematic Strategies LLC 71,891 36,700 1,122,937.42 0.0133 0.0566 03/31/2025
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Merrill Lynch International (Investment Management) 0 -200,000 0 0 0
2 Oaktree Capital Management LP 0 -179,593 0 0 0
3 Citigroup Global Markets, Inc. (Investment Management) 25,497 -74,503 398,263.14 0.0003 0.0201 03/31/2025
4 BofA Securities, Inc. 4,517 -66,483 70,555.54 0.0001 0.0036 03/31/2025
5 Jane Street Capital LLC 48,601 -53,574 759,147.62 0.0011 0.0383 03/31/2025
6 Oaktree Fund Advisors LLC 0 -47,909 0 0 0
7 Prosperity Wealth Management, Inc. 48,700 -44,545 760,694 0.2997 0.0383 03/31/2025
8 UBS Securities LLC 137,335 -27,818 2,145,172.7 0.0009 0.1081 03/31/2025
9 Creative Planning LLC 0 -24,873 0 0 0
10 BlackRock Fund Advisors 565,887 -18,404 8,839,154.94 0.0002 0.4454 03/31/2025

Data provided by FactSet Research Systems Inc.