| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Dauntless Investment Group LLC | 214,987 | 18,395 | 967,441.5 | 1.7351 | 10.7043 | 06/30/2026 |
| 2 | Ikarian Capital LLC | 211,538 | 0 | 951,921 | 0.1731 | 10.5326 | 09/30/2026 |
| 3 | Stonepine Capital Management LLC | 199,486 | 146,026 | 897,687 | 0.3946 | 9.9325 | 06/30/2026 |
| 4 | Millennium Management LLC | 112,323 | 36,076 | 505,453.5 | 0.0003 | 5.5926 | 06/30/2026 |
| 5 | Adar1 Capital Management LLC | 102,883 | 0 | 462,973.5 | 0.0233 | 5.1226 | 03/31/2026 |
| 6 | Summittx Capital LP | 100,300 | 0 | 451,350 | 0.0126 | 4.994 | 06/30/2026 |
| 7 | Woodline Partners LP | 76,446 | -3,136 | 344,007 | 0.0011 | 3.8063 | 06/30/2026 |
| 8 | abrdn, Inc. | 75,000 | 0 | 337,500 | 0.0031 | 3.7343 | 06/30/2026 |
| 9 | Soleus Capital Management LP (Investment Management) | 72,730 | 0 | 327,285 | 0.0123 | 3.6213 | 06/30/2026 |
| 10 | AIGH Capital Management LLC | 70,000 | 19,000 | 315,000 | 0.0347 | 3.4853 | 06/30/2026 |
| 11 | Boothbay Fund Management LLC | 59,838 | 0 | 269,271 | 0.0055 | 2.9794 | 06/30/2026 |
| 12 | Velan Capital Investment Management LP | 32,372 | -52,477 | 145,674 | 0.1328 | 1.6118 | 06/30/2026 |
| 13 | Barclays Bank Plc (Private Banking) | 21,469 | 20,169 | 96,610.5 | 0.0001 | 1.069 | 06/30/2026 |
| 14 | Birchview Capital LP | 20,000 | 0 | 90,000 | 0.0519 | 0.9958 | 06/30/2026 |
| 15 | XTX Markets LLC | 15,006 | 15,006 | 67,527 | 0.0009 | 0.7472 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | abrdn World Healthcare Fund | 40,400 | 0 | 181,800 | 0.0305 | 2.0115 | 08/31/2026 |
| 2 | abrdn Life Sciences Investors | 34,600 | 0 | 155,700 | 0.026 | 1.7227 | 06/30/2026 |
| 3 | Abante Quant Value Small Caps | 10,491 | 10,491 | 47,209.5 | 0.2384 | 0.5224 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Stonepine Capital Management LLC | 199,486 | 146,026 | 897,687 | 0.3946 | 9.9325 | 06/30/2026 |
| 2 | Millennium Management LLC | 112,323 | 36,076 | 505,453.5 | 0.0003 | 5.5926 | 06/30/2026 |
| 3 | Barclays Bank Plc (Private Banking) | 21,469 | 20,169 | 96,610.5 | 0.0001 | 1.069 | 06/30/2026 |
| 4 | AIGH Capital Management LLC | 70,000 | 19,000 | 315,000 | 0.0347 | 3.4853 | 06/30/2026 |
| 5 | Dauntless Investment Group LLC | 214,987 | 18,395 | 967,441.5 | 1.7351 | 10.7043 | 06/30/2026 |
| 6 | XTX Markets LLC | 15,006 | 15,006 | 67,527 | 0.0009 | 0.7472 | 06/30/2026 |
| 7 | Abante Asesores Gestion SGIIC SA | 10,491 | 10,491 | 47,209.5 | 0.0034 | 0.5224 | 06/30/2026 |
| 8 | UBS Securities LLC | 6,772 | 4,260 | 30,474 | 0 | 0.3372 | 06/30/2026 |
| 9 | Morgan Stanley Smith Barney LLC (Investment Management) | 8,000 | 4,000 | 36,000 | 0 | 0.3983 | 06/30/2026 |
| 10 | GAMMA Investing LLC | 3,116 | 1,396 | 14,022 | 0.0005 | 0.1551 | 09/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Centiva Capital LP | 0 | -60,000 | 0 | 0 | 0 | |
| 2 | Velan Capital Investment Management LP | 32,372 | -52,477 | 145,674 | 0.1328 | 1.6118 | 06/30/2026 |
| 3 | Citadel Advisors LLC | 0 | -32,519 | 0 | 0 | 0 | |
| 4 | Woodline Partners LP | 76,446 | -3,136 | 344,007 | 0.0011 | 3.8063 | 06/30/2026 |
| 5 | RBC Dominion Securities, Inc. (Investment Management) | 0 | -11 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.