| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Ikarian Capital LLC | 211,538 | 211,538 | 1,848,842.12 | 0.2418 | 25.2138 | 01/31/2026 |
| 2 | Stonepine Capital Management LLC | 93,460 | 93,460 | 816,840.4 | 0.377 | 11.1398 | 01/29/2026 |
| 3 | Woodline Partners LP | 79,582 | 79,582 | 695,546.68 | 0.0026 | 9.4856 | 12/31/2025 |
| 4 | abrdn, Inc. | 75,000 | 75,000 | 655,500 | 0.0059 | 8.9395 | 12/31/2025 |
| 5 | Millennium Management LLC | 74,817 | 74,817 | 653,900.58 | 0.0005 | 8.9177 | 12/31/2025 |
| 6 | Summittx Capital LP | 64,795 | 64,795 | 566,308.3 | 0.016 | 7.7231 | 12/31/2025 |
| 7 | Boothbay Fund Management LLC | 59,838 | 59,838 | 522,984.12 | 0.0129 | 7.1323 | 12/31/2025 |
| 8 | Adar1 Capital Management LLC | 58,230 | 58,230 | 508,930.2 | 0.0365 | 6.9406 | 12/31/2025 |
| 9 | AIGH Capital Management LLC | 49,323 | 49,323 | 431,083.02 | 0.092 | 5.879 | 12/31/2025 |
| 10 | Resolute Capital Asset Partners LLC | 30,000 | 30,000 | 262,200 | 0.118 | 3.5758 | 12/31/2025 |
| 11 | Soleus Capital Management LP (Investment Management) | 25,000 | 25,000 | 218,500 | 0.0088 | 2.9798 | 12/31/2025 |
| 12 | Simplify Asset Management, Inc. | 17,448 | 17,448 | 152,495.52 | 0.0025 | 2.0797 | 12/31/2025 |
| 13 | Centiva Capital LP | 12,053 | 12,053 | 105,343.22 | 0.0062 | 1.4366 | 12/31/2025 |
| 14 | Morgan Stanley Smith Barney LLC (Investment Management) | 3,000 | 3,000 | 26,220 | 0 | 0.3576 | 12/31/2025 |
| 15 | GAMMA Investing LLC | 2,084 | 1,844 | 18,214.16 | 0.0009 | 0.2484 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | abrdn World Healthcare Fund | 40,400 | 40,400 | 353,096 | 0.0624 | 4.8154 | 01/31/2026 |
| 2 | Simplify Propel Opportunities ETF | 13,753 | 13,753 | 120,201.22 | 0.1589 | 1.6393 | 01/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Ikarian Capital LLC | 211,538 | 211,538 | 1,848,842.12 | 0.2418 | 25.2138 | 01/31/2026 |
| 2 | Stonepine Capital Management LLC | 93,460 | 93,460 | 816,840.4 | 0.377 | 11.1398 | 01/29/2026 |
| 3 | Woodline Partners LP | 79,582 | 79,582 | 695,546.68 | 0.0026 | 9.4856 | 12/31/2025 |
| 4 | abrdn, Inc. | 75,000 | 75,000 | 655,500 | 0.0059 | 8.9395 | 12/31/2025 |
| 5 | Millennium Management LLC | 74,817 | 74,817 | 653,900.58 | 0.0005 | 8.9177 | 12/31/2025 |
| 6 | Summittx Capital LP | 64,795 | 64,795 | 566,308.3 | 0.016 | 7.7231 | 12/31/2025 |
| 7 | Boothbay Fund Management LLC | 59,838 | 59,838 | 522,984.12 | 0.0129 | 7.1323 | 12/31/2025 |
| 8 | Adar1 Capital Management LLC | 58,230 | 58,230 | 508,930.2 | 0.0365 | 6.9406 | 12/31/2025 |
| 9 | AIGH Capital Management LLC | 49,323 | 49,323 | 431,083.02 | 0.092 | 5.879 | 12/31/2025 |
| 10 | Resolute Capital Asset Partners LLC | 30,000 | 30,000 | 262,200 | 0.118 | 3.5758 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Raymond James Financial Services Advisors, Inc. | 0 | -717 | 0 | 0 | 0 | |
| 2 | Morgan Stanley & Co. LLC | 0 | -206 | 0 | 0 | 0 | |
| 3 | UBS Securities LLC | 17 | -113 | 148.58 | 0 | 0.002 | 12/31/2025 |
Data provided by FactSet Research Systems Inc.