| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Redmile Group LLC | 2,164,777 | 0 | 10,780,589.46 | 0.7425 | 4.5831 | 12/31/2025 |
| 2 | Nantahala Capital Management LLC | 1,542,427 | 500,000 | 7,681,286.46 | 0.4943 | 3.2655 | 12/31/2025 |
| 3 | Ikarian Capital LLC | 865,784 | -7,784 | 4,311,604.32 | 0.602 | 1.833 | 12/31/2025 |
| 4 | Great Point Partners LLC | 808,032 | 808,032 | 4,023,999.36 | 1.1185 | 1.7107 | 12/31/2025 |
| 5 | Millennium Management LLC | 659,592 | 460,945 | 3,284,768.16 | 0.0025 | 1.3964 | 12/31/2025 |
| 6 | Medical Strategy GmbH | 528,006 | 528,006 | 2,629,469.88 | 0.2922 | 1.1179 | 12/30/2025 |
| 7 | Tetragon Partners UK LLP | 365,369 | 365,369 | 1,819,537.62 | 0.2864 | 0.7735 | 12/31/2025 |
| 8 | Morgan Stanley & Co. LLC | 298,780 | -830,619 | 1,487,924.4 | 0.0006 | 0.6326 | 12/31/2025 |
| 9 | SG Americas Securities LLC | 256,340 | -51,991 | 1,276,573.2 | 0.0018 | 0.5427 | 12/31/2025 |
| 10 | Lombard Odier Asset Management (USA) Corp. | 255,901 | -1,593,833 | 1,274,386.98 | 0.3675 | 0.5418 | 12/31/2025 |
| 11 | Ishara Investments LP | 240,000 | 240,000 | 1,195,200 | 1.4931 | 0.5081 | 12/31/2025 |
| 12 | Boothbay Fund Management LLC | 209,088 | -43,333 | 1,041,258.24 | 0.0283 | 0.4427 | 12/31/2025 |
| 13 | UBS Securities LLC | 200,149 | -17,063 | 996,742.02 | 0.0004 | 0.4237 | 12/31/2025 |
| 14 | M28 Capital Management LP | 185,100 | 0 | 921,798 | 1.4789 | 0.3919 | 12/31/2025 |
| 15 | HSBC Bank Plc (Broker) | 172,834 | 0 | 860,713.32 | 0.002 | 0.3659 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | FCP Medical - BioHealth | 528,006 | 528,006 | 2,629,469.88 | 0.283 | 1.1179 | 12/30/2025 |
| 2 | iShares Biotechnology ETF | 145,979 | 4,260 | 726,975.42 | 0.009 | 0.3091 | 02/27/2026 |
| 3 | RIM Global - Bioscience | 94,158 | 36,300 | 468,906.84 | 0.4503 | 0.1993 | 11/28/2025 |
| 4 | Galileo - Biotech Innovation Fund | 58,645 | 0 | 292,052.1 | 0.8378 | 0.1242 | 06/30/2025 |
| 5 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 32,066 | 2,646 | 159,688.68 | 0.0174 | 0.0679 | 02/27/2026 |
| 6 | Vifag 2002, SICAV | 29,983 | 29,983 | 149,315.34 | 0.1726 | 0.0635 | 12/31/2025 |
| 7 | Fidelity Nasdaq Composite Index Fund | 29,538 | 0 | 147,099.24 | 0.0007 | 0.0625 | 01/31/2026 |
| 8 | Lumyna - MW TOPS UCITS Fund | 19,672 | 0 | 97,966.56 | 0.0039 | 0.0416 | 03/31/2025 |
| 9 | Invesco Markets Plc - NASDAQ Biotech UCITS ETF | 15,481 | -514 | 77,095.38 | 0.0189 | 0.0328 | 02/27/2026 |
| 10 | China Universal Nasdaq Biotechnology Index ETF | 9,446 | 0 | 47,041.08 | 0.0216 | 0.02 | 06/30/2025 |
| 11 | State Street SPDR S&P International Small Cap ETF | 9,434 | 1,521 | 46,981.32 | 0.0059 | 0.02 | 02/27/2026 |
| 12 | Steward Values Enhanced International Fund | 5,800 | 0 | 28,884 | 0.0092 | 0.0123 | 02/28/2026 |
| 13 | Invesco Nasdaq Biotechnology ETF | 2,621 | 927 | 13,052.58 | 0.0187 | 0.0055 | 02/27/2026 |
| 14 | Mirae Asset Tiger NASDAQ Bio ETF | 2,491 | 314 | 12,405.18 | 0.0184 | 0.0053 | 02/26/2026 |
| 15 | ProShares Ultra NASDAQ Biotechnology | 2,169 | 517 | 10,801.62 | 0.0124 | 0.0046 | 02/27/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Great Point Partners LLC | 808,032 | 808,032 | 4,023,999.36 | 1.1185 | 1.7107 | 12/31/2025 |
| 2 | Medical Strategy GmbH | 528,006 | 528,006 | 2,629,469.88 | 0.2922 | 1.1179 | 12/30/2025 |
| 3 | Nantahala Capital Management LLC | 1,542,427 | 500,000 | 7,681,286.46 | 0.4943 | 3.2655 | 12/31/2025 |
| 4 | Millennium Management LLC | 659,592 | 460,945 | 3,284,768.16 | 0.0025 | 1.3964 | 12/31/2025 |
| 5 | Tetragon Partners UK LLP | 365,369 | 365,369 | 1,819,537.62 | 0.2864 | 0.7735 | 12/31/2025 |
| 6 | Ishara Investments LP | 240,000 | 240,000 | 1,195,200 | 1.4931 | 0.5081 | 12/31/2025 |
| 7 | Seven Fleet Capital Management LP | 147,600 | 147,600 | 735,048 | 0.3041 | 0.3125 | 12/31/2025 |
| 8 | Citadel Advisors LLC | 140,870 | 140,870 | 701,532.6 | 0.0007 | 0.2982 | 12/31/2025 |
| 9 | Point72 Asset Management LP | 114,070 | 114,070 | 568,068.6 | 0.0009 | 0.2415 | 12/31/2025 |
| 10 | Citadel Securities LLC | 103,191 | 103,191 | 513,891.18 | 0.0012 | 0.2185 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Lombard Odier Asset Management (USA) Corp. | 255,901 | -1,593,833 | 1,274,386.98 | 0.3675 | 0.5418 | 12/31/2025 |
| 2 | Morgan Stanley & Co. LLC | 298,780 | -830,619 | 1,487,924.4 | 0.0006 | 0.6326 | 12/31/2025 |
| 3 | Cantor Fitzgerald Europe | 0 | -789,039 | 0 | 0 | 0 | |
| 4 | BlackRock Fund Advisors | 42,748 | -104,104 | 212,885.04 | 0 | 0.0905 | 12/31/2025 |
| 5 | Osaic Wealth, Inc. (Investment Management) | 3 | -69,378 | 14.94 | 0 | 0 | 12/31/2025 |
| 6 | Woodline Partners LP | 0 | -62,459 | 0 | 0 | 0 | |
| 7 | Morgan Stanley Smith Barney LLC (Investment Management) | 25,473 | -56,855 | 126,855.54 | 0 | 0.0539 | 12/31/2025 |
| 8 | SG Americas Securities LLC | 256,340 | -51,991 | 1,276,573.2 | 0.0018 | 0.5427 | 12/31/2025 |
| 9 | Boothbay Fund Management LLC | 209,088 | -43,333 | 1,041,258.24 | 0.0283 | 0.4427 | 12/31/2025 |
| 10 | Saturn V Capital Management LP | 0 | -34,737 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.