# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Redmile Group LLC 2,164,777 0 22,730,158.5 1.1168 4.5831 03/31/2026
2 Nantahala Capital Management LLC 2,146,731 604,304 22,540,675.5 1.2532 4.5449 03/31/2026
3 Citadel Advisors LLC 1,166,473 1,025,603 12,247,966.5 0.0109 2.4696 03/31/2026
4 Millennium Management LLC 1,074,191 414,599 11,279,005.5 0.0077 2.2742 03/31/2026
5 Great Point Partners LLC 1,020,489 212,457 10,715,134.5 2.1337 2.1605 03/31/2026
6 Ikarian Capital LLC 865,784 0 9,090,732 1.3137 1.833 03/31/2026
7 Tetragon Partners UK LLP 630,161 264,792 6,616,690.5 0.8049 1.3341 03/31/2026
8 Medical Strategy GmbH 551,856 23,850 5,794,488 0.5439 1.1683 03/31/2026
9 Jones Hill Capital LP 301,604 301,604 3,166,842 0.6319 0.6385 03/31/2026
10 SG Americas Securities LLC 286,698 30,358 3,010,329 0.0027 0.607 03/31/2026
11 UBS Securities LLC 245,737 45,588 2,580,238.5 0.0009 0.5203 03/31/2026
12 Boothbay Fund Management LLC 209,088 0 2,195,424 0.045 0.4427 03/31/2026
13 BMO Asset Management, Inc. 197,901 42,427 2,077,960.5 0.001 0.419 03/31/2026
14 Reichmuth & Co. Integrale Vermogensverwaltung AG 174,295 38,334 1,830,097.5 1.0931 0.369 02/27/2026
15 BlackRock Fund Advisors 173,673 130,925 1,823,566.5 0 0.3677 03/31/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 FCP Medical - BioHealth 551,856 23,850 5,794,488 0.527 1.1683 03/31/2026
2 iShares Biotechnology ETF 185,777 9,171 1,950,658.5 0.0215 0.3933 06/30/2026
3 RIM Global - Bioscience 174,295 38,334 1,830,097.5 1.4547 0.369 02/27/2026
4 Galileo - Biotech Innovation Fund 58,645 0 615,772.5 1.3685 0.1242 12/31/2025
5 iShares IV Plc - NASDAQ US Biotechnology UCITS ETF 31,757 1,352 333,448.5 0.0316 0.0672 06/26/2026
6 Vifag 2002, SICAV 29,983 0 314,821.5 0.2762 0.0635 12/31/2025
7 Fidelity Nasdaq Composite Index Fund 29,538 0 310,149 0.0012 0.0625 04/30/2026
8 Lumyna - MW TOPS UCITS Fund 19,672 0 206,556 0.0074 0.0416 03/31/2025
9 Invesco Markets Plc - NASDAQ Biotech UCITS ETF 15,267 310 160,303.5 0.0345 0.0323 06/29/2026
10 State Street SPDR S&P International Small Cap ETF 9,532 290 100,086 0.0115 0.0202 06/29/2026
11 ActivePassive International Equity ETF 8,772 8,772 92,106 0.0088 0.0186 06/29/2026
12 China Universal Nasdaq Biotechnology Index ETF 7,653 0 80,356.5 0.0354 0.0162 12/31/2025
13 China Universal Global Healthcare Mixed Fund 6,000 0 63,000 0.0755 0.0127 12/31/2025
14 Steward Values Enhanced International Fund 5,800 0 60,900 0.0196 0.0123 05/31/2026
15 Invesco Nasdaq Biotechnology ETF 2,379 128 24,979.5 0.0343 0.005 06/30/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Citadel Advisors LLC 1,166,473 1,025,603 12,247,966.5 0.0109 2.4696 03/31/2026
2 Nantahala Capital Management LLC 2,146,731 604,304 22,540,675.5 1.2532 4.5449 03/31/2026
3 Millennium Management LLC 1,074,191 414,599 11,279,005.5 0.0077 2.2742 03/31/2026
4 Jones Hill Capital LP 301,604 301,604 3,166,842 0.6319 0.6385 03/31/2026
5 Tetragon Partners UK LLP 630,161 264,792 6,616,690.5 0.8049 1.3341 03/31/2026
6 Great Point Partners LLC 1,020,489 212,457 10,715,134.5 2.1337 2.1605 03/31/2026
7 Adar1 Capital Management LLC 172,157 148,514 1,807,648.5 0.0953 0.3645 03/31/2026
8 BNP Paribas Financial Markets SNC 147,668 135,641 1,550,514 0.0008 0.3126 03/31/2026
9 BlackRock Fund Advisors 173,673 130,925 1,823,566.5 0 0.3677 03/31/2026
10 Susquehanna Financial Group LLLP 115,281 98,415 1,210,450.5 0.0013 0.2441 03/31/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Morgan Stanley & Co. LLC 41,871 -256,909 439,645.5 0.0001 0.0886 03/31/2026
2 Lombard Odier Asset Management (USA) Corp. 0 -255,901 0 0 0
3 Ishara Investments LP 140,500 -99,500 1,475,250 1.3146 0.2975 03/31/2026
4 M28 Capital Management LP 101,203 -83,897 1,062,631.5 2.2699 0.2143 03/31/2026
5 Opaleye Management, Inc. 0 -78,926 0 0 0
6 Quadrature Capital Ltd. 0 -54,380 0 0 0
7 HSBC Bank Plc (Broker) 122,834 -50,000 1,289,757 0.0025 0.2601 03/31/2026
8 Citadel Securities LLC 68,334 -34,857 717,507 0.0015 0.1447 03/31/2026
9 Two Sigma Investments LP 16,203 -23,141 170,131.5 0.0001 0.0343 03/31/2026
10 Two Sigma Advisers LP 0 -15,900 0 0 0

Data provided by FactSet Research Systems Inc.