| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Redmile Group LLC | 2,164,777 | 0 | 21,344,701.22 | 1.431 | 4.5831 | 06/30/2026 |
| 2 | Nantahala Capital Management LLC | 1,346,731 | -800,000 | 13,278,767.66 | 0.826 | 2.8512 | 06/30/2026 |
| 3 | Citadel Advisors LLC | 1,230,386 | 63,913 | 12,131,605.96 | 0.0091 | 2.6049 | 06/30/2026 |
| 4 | Millennium Management LLC | 909,279 | -164,912 | 8,965,490.94 | 0.0061 | 1.9251 | 06/30/2026 |
| 5 | Ikarian Capital LLC | 830,784 | -35,000 | 8,191,530.24 | 1.4891 | 1.7589 | 06/30/2026 |
| 6 | Tetragon Partners UK LLP | 764,256 | 134,095 | 7,535,564.16 | 0.7801 | 1.618 | 06/30/2026 |
| 7 | Soleus Capital Management LP (Investment Management) | 630,000 | 630,000 | 6,211,800 | 0.2327 | 1.3338 | 06/30/2026 |
| 8 | Balyasny Asset Management LP | 610,980 | 610,980 | 6,024,262.8 | 0.0114 | 1.2935 | 06/30/2026 |
| 9 | Medical Strategy GmbH | 543,561 | -8,295 | 5,359,511.46 | 0.5623 | 1.1508 | 06/30/2026 |
| 10 | Great Point Partners LLC | 450,000 | -570,489 | 4,437,000 | 1.1935 | 0.9527 | 06/30/2026 |
| 11 | Columbia Management Investment Advisers LLC | 370,052 | 370,052 | 3,648,712.72 | 0.0008 | 0.7834 | 06/30/2026 |
| 12 | Jane Street Capital LLC | 369,151 | 268,224 | 3,639,828.86 | 0.0022 | 0.7815 | 06/30/2026 |
| 13 | Adar1 Capital Management LLC | 338,373 | 166,216 | 3,336,357.78 | 0.1682 | 0.7164 | 06/30/2026 |
| 14 | Summittx Capital LP | 326,648 | 326,648 | 3,220,749.28 | 0.0901 | 0.6916 | 06/30/2026 |
| 15 | Schonfeld Strategic Advisors LLC | 269,348 | 269,348 | 2,655,771.28 | 0.0138 | 0.5702 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Select Port. - Biotechnology Portfolio | 2,042,900 | 2,042,900 | 20,142,994 | 0.3414 | 4.3251 | 08/31/2026 |
| 2 | FCP Medical - BioHealth | 543,561 | -8,295 | 5,359,511.46 | 0.5319 | 1.1508 | 06/30/2026 |
| 3 | Fidelity Advisor Series VII - Biotechnology Fund | 531,788 | 531,788 | 5,243,429.68 | 0.2279 | 1.1259 | 08/31/2026 |
| 4 | Fidelity Select Port. - Health Care Portfolio | 500,000 | 500,000 | 4,930,000 | 0.0731 | 1.0586 | 08/31/2026 |
| 5 | iShares Biotechnology ETF | 292,172 | 118,859 | 2,880,815.92 | 0.0262 | 0.6186 | 09/30/2026 |
| 6 | APO Medical Opportunities | 231,193 | 0 | 2,279,562.98 | 0.3188 | 0.4895 | 03/31/2026 |
| 7 | Fidelity Advisor Health Care Fund | 228,000 | 228,000 | 2,248,080 | 0.0672 | 0.4827 | 08/31/2026 |
| 8 | Alger Small Cap Growth Fund | 105,679 | 105,679 | 1,041,994.94 | 0.5306 | 0.2237 | 07/31/2026 |
| 9 | abrdn World Healthcare Fund | 105,000 | 105,000 | 1,035,300 | 0.1736 | 0.2223 | 08/31/2026 |
| 10 | RIM Global - Bioscience | 101,055 | -47,000 | 996,402.3 | 0.8794 | 0.2139 | 05/29/2026 |
| 11 | Fidelity VIP - Health Care Portfolio | 85,000 | 85,000 | 838,100 | 0.0685 | 0.18 | 08/31/2026 |
| 12 | Alger Small Cap Growth Portfolio | 83,412 | 83,412 | 822,442.32 | 0.536 | 0.1766 | 07/31/2026 |
| 13 | Galileo - Biotech Innovation Fund | 58,645 | 0 | 578,239.7 | 1.3037 | 0.1242 | 12/31/2025 |
| 14 | Alger Institutional Funds - Small Cap Growth Inst. Fund | 41,292 | 41,292 | 407,139.12 | 0.5229 | 0.0874 | 07/31/2026 |
| 15 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 39,823 | 8,719 | 392,654.78 | 0.0322 | 0.0843 | 09/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Soleus Capital Management LP (Investment Management) | 630,000 | 630,000 | 6,211,800 | 0.2327 | 1.3338 | 06/30/2026 |
| 2 | Balyasny Asset Management LP | 610,980 | 610,980 | 6,024,262.8 | 0.0114 | 1.2935 | 06/30/2026 |
| 3 | Columbia Management Investment Advisers LLC | 370,052 | 370,052 | 3,648,712.72 | 0.0008 | 0.7834 | 06/30/2026 |
| 4 | Summittx Capital LP | 326,648 | 326,648 | 3,220,749.28 | 0.0901 | 0.6916 | 06/30/2026 |
| 5 | Schonfeld Strategic Advisors LLC | 269,348 | 269,348 | 2,655,771.28 | 0.0138 | 0.5702 | 06/30/2026 |
| 6 | Jane Street Capital LLC | 369,151 | 268,224 | 3,639,828.86 | 0.0022 | 0.7815 | 06/30/2026 |
| 7 | Propel Bio Management LLC | 191,733 | 191,733 | 1,890,487.38 | 1.0477 | 0.4059 | 06/30/2026 |
| 8 | Fred Alger Management LLC | 177,000 | 177,000 | 1,745,220 | 0.0058 | 0.3747 | 06/30/2026 |
| 9 | Morgan Stanley Smith Barney LLC (Investment Management) | 200,200 | 176,962 | 1,973,972 | 0.0002 | 0.4238 | 06/30/2026 |
| 10 | Adar1 Capital Management LLC | 338,373 | 166,216 | 3,336,357.78 | 0.1682 | 0.7164 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Nantahala Capital Management LLC | 1,346,731 | -800,000 | 13,278,767.66 | 0.826 | 2.8512 | 06/30/2026 |
| 2 | Great Point Partners LLC | 450,000 | -570,489 | 4,437,000 | 1.1935 | 0.9527 | 06/30/2026 |
| 3 | Jones Hill Capital LP | 0 | -301,604 | 0 | 0 | 0 | |
| 4 | SG Americas Securities LLC | 12,056 | -274,642 | 118,872.16 | 0.0001 | 0.0255 | 06/30/2026 |
| 5 | Millennium Management LLC | 909,279 | -164,912 | 8,965,490.94 | 0.0061 | 1.9251 | 06/30/2026 |
| 6 | Point72 Asset Management LP | 0 | -119,711 | 0 | 0 | 0 | |
| 7 | Marshall Wace LLP | 72,039 | -97,577 | 710,304.54 | 0.0006 | 0.1525 | 06/30/2026 |
| 8 | Seven Fleet Capital Management LP | 60,107 | -96,652 | 592,655.02 | 0.1132 | 0.1273 | 06/30/2026 |
| 9 | Ishara Investments LP | 55,350 | -85,150 | 545,751 | 0.454 | 0.1172 | 06/30/2026 |
| 10 | Reichmuth & Co. Integrale Vermogensverwaltung AG | 101,055 | -47,000 | 996,402.3 | 0.6352 | 0.2139 | 05/29/2026 |
Data provided by FactSet Research Systems Inc.