| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Redmile Group LLC | 2,164,777 | 0 | 13,205,139.7 | 0.7447 | 4.5831 | 03/31/2026 |
| 2 | Nantahala Capital Management LLC | 2,146,731 | 1,104,304 | 13,095,059.1 | 0.7407 | 4.5449 | 03/31/2026 |
| 3 | Citadel Advisors LLC | 1,166,473 | 1,166,473 | 7,115,485.3 | 0.0067 | 2.4696 | 03/31/2026 |
| 4 | Millennium Management LLC | 1,074,191 | 775,679 | 6,552,565.1 | 0.0046 | 2.2742 | 03/31/2026 |
| 5 | Great Point Partners LLC | 1,020,489 | 1,020,489 | 6,224,982.9 | 1.3838 | 2.1605 | 03/31/2026 |
| 6 | Ikarian Capital LLC | 865,784 | -35,000 | 5,281,282.4 | 0.7142 | 1.833 | 03/31/2026 |
| 7 | Tetragon Partners UK LLP | 630,161 | 630,161 | 3,843,982.1 | 0.5057 | 1.3341 | 03/31/2026 |
| 8 | Medical Strategy GmbH | 603,691 | 603,691 | 3,682,515.1 | 0.3683 | 1.2781 | 02/27/2026 |
| 9 | Jones Hill Capital LP | 301,604 | 301,604 | 1,839,784.4 | 0.3955 | 0.6385 | 03/31/2026 |
| 10 | SG Americas Securities LLC | 286,698 | -21,591 | 1,748,857.8 | 0.0017 | 0.607 | 03/31/2026 |
| 11 | UBS Securities LLC | 245,737 | -45,462 | 1,498,995.7 | 0.0006 | 0.5203 | 03/31/2026 |
| 12 | Boothbay Fund Management LLC | 209,088 | -70,549 | 1,275,436.8 | 0.0273 | 0.4427 | 03/31/2026 |
| 13 | BMO Asset Management, Inc. | 197,901 | 49,119 | 1,207,196.1 | 0.0006 | 0.419 | 03/31/2026 |
| 14 | BlackRock Fund Advisors | 173,673 | 141,896 | 1,059,405.3 | 0 | 0.3677 | 03/31/2026 |
| 15 | Marshall Wace LLP | 169,616 | 86,397 | 1,034,657.6 | 0.001 | 0.3591 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | FCP Medical - BioHealth | 603,691 | 603,691 | 3,682,515.1 | 0.3591 | 1.2781 | 02/27/2026 |
| 2 | iShares Biotechnology ETF | 169,713 | 137,096 | 1,035,249.3 | 0.0132 | 0.3593 | 04/30/2026 |
| 3 | RIM Global - Bioscience | 147,961 | 53,803 | 902,562.1 | 0.7709 | 0.3133 | 01/30/2026 |
| 4 | Galileo - Biotech Innovation Fund | 58,645 | 0 | 357,734.5 | 0.8887 | 0.1242 | 12/31/2025 |
| 5 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 37,490 | 3,837 | 228,689 | 0.0262 | 0.0794 | 04/30/2026 |
| 6 | Vifag 2002, SICAV | 29,983 | 29,983 | 182,896.3 | 0.1673 | 0.0635 | 12/31/2025 |
| 7 | Fidelity Nasdaq Composite Index Fund | 29,538 | 0 | 180,181.8 | 0.0007 | 0.0625 | 03/31/2026 |
| 8 | Lumyna - MW TOPS UCITS Fund | 19,672 | 0 | 119,999.2 | 0.0044 | 0.0416 | 03/31/2025 |
| 9 | Invesco Markets Plc - NASDAQ Biotech UCITS ETF | 15,074 | -1,517 | 91,951.4 | 0.0232 | 0.0319 | 04/30/2026 |
| 10 | State Street SPDR S&P International Small Cap ETF | 9,581 | 192 | 58,444.1 | 0.0064 | 0.0203 | 04/30/2026 |
| 11 | China Universal Nasdaq Biotechnology Index ETF | 7,653 | -1,793 | 46,683.3 | 0.0228 | 0.0162 | 12/31/2025 |
| 12 | China Universal Global Healthcare Mixed Fund | 6,000 | 6,000 | 36,600 | 0.0462 | 0.0127 | 12/31/2025 |
| 13 | Steward Values Enhanced International Fund | 5,800 | 0 | 35,380 | 0.0117 | 0.0123 | 03/31/2026 |
| 14 | Invesco Nasdaq Biotechnology ETF | 2,476 | 639 | 15,103.6 | 0.0231 | 0.0052 | 04/30/2026 |
| 15 | Mirae Asset Tiger NASDAQ Bio ETF | 2,294 | 211 | 13,993.4 | 0.0229 | 0.0049 | 04/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Citadel Advisors LLC | 1,166,473 | 1,166,473 | 7,115,485.3 | 0.0067 | 2.4696 | 03/31/2026 |
| 2 | Nantahala Capital Management LLC | 2,146,731 | 1,104,304 | 13,095,059.1 | 0.7407 | 4.5449 | 03/31/2026 |
| 3 | Great Point Partners LLC | 1,020,489 | 1,020,489 | 6,224,982.9 | 1.3838 | 2.1605 | 03/31/2026 |
| 4 | Millennium Management LLC | 1,074,191 | 775,679 | 6,552,565.1 | 0.0046 | 2.2742 | 03/31/2026 |
| 5 | Tetragon Partners UK LLP | 630,161 | 630,161 | 3,843,982.1 | 0.5057 | 1.3341 | 03/31/2026 |
| 6 | Medical Strategy GmbH | 603,691 | 603,691 | 3,682,515.1 | 0.3683 | 1.2781 | 02/27/2026 |
| 7 | Jones Hill Capital LP | 301,604 | 301,604 | 1,839,784.4 | 0.3955 | 0.6385 | 03/31/2026 |
| 8 | Seven Fleet Capital Management LP | 156,759 | 156,759 | 956,229.9 | 0.2881 | 0.3319 | 03/31/2026 |
| 9 | BNP Paribas Financial Markets | 147,668 | 147,068 | 900,774.8 | 0.0005 | 0.3126 | 03/31/2026 |
| 10 | BlackRock Fund Advisors | 173,673 | 141,896 | 1,059,405.3 | 0 | 0.3677 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Lombard Odier Asset Management (USA) Corp. | 0 | -1,844,948 | 0 | 0 | 0 | |
| 2 | Morgan Stanley & Co. LLC | 41,871 | -1,079,136 | 255,413.1 | 0.0001 | 0.0886 | 03/31/2026 |
| 3 | Cantor Fitzgerald Europe | 0 | -801,306 | 0 | 0 | 0 | |
| 4 | M28 Capital Management LP | 101,203 | -83,897 | 617,338.3 | 1.1745 | 0.2143 | 03/31/2026 |
| 5 | Boothbay Fund Management LLC | 209,088 | -70,549 | 1,275,436.8 | 0.0273 | 0.4427 | 03/31/2026 |
| 6 | Morgan Stanley Smith Barney LLC (Investment Management) | 23,238 | -63,101 | 141,751.8 | 0 | 0.0492 | 03/31/2026 |
| 7 | Woodline Partners LP | 0 | -62,459 | 0 | 0 | 0 | |
| 8 | Osaic Wealth, Inc. (Investment Management) | 0 | -62,171 | 0 | 0 | 0 | |
| 9 | HSBC Bank Plc (Broker) | 122,834 | -50,039 | 749,287.4 | 0.0015 | 0.2601 | 03/31/2026 |
| 10 | Two Sigma Investments LP | 16,203 | -47,044 | 98,838.3 | 0.0001 | 0.0343 | 03/31/2026 |
Data provided by FactSet Research Systems Inc.