| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Redmile Group LLC | 2,164,777 | -50,170 | 13,291,730.78 | 0.8369 | 4.5831 | 09/30/2025 |
| 2 | Lombard Odier Asset Management (USA) Corp. | 1,844,948 | -4,786 | 11,327,980.72 | 2.0356 | 3.906 | 09/30/2025 |
| 3 | Morgan Stanley & Co. LLC | 1,121,007 | -863,304 | 6,882,982.98 | 0.0023 | 2.3733 | 09/30/2025 |
| 4 | Nantahala Capital Management LLC | 1,042,427 | 0 | 6,400,501.78 | 0.3424 | 2.2069 | 09/30/2025 |
| 5 | Ikarian Capital LLC | 900,784 | 900,784 | 5,530,813.76 | 0.8319 | 1.9071 | 09/30/2025 |
| 6 | Cantor Fitzgerald Europe | 801,306 | 27,461 | 4,920,018.84 | 0.6636 | 1.6965 | 09/30/2025 |
| 7 | SG Americas Securities LLC | 308,289 | 0 | 1,892,894.46 | 0.0067 | 0.6527 | 09/30/2025 |
| 8 | Millennium Management LLC | 298,512 | -98,350 | 1,832,863.68 | 0.0014 | 0.632 | 09/30/2025 |
| 9 | UBS Securities LLC | 291,199 | -27,115 | 1,787,961.86 | 0.0007 | 0.6165 | 09/30/2025 |
| 10 | Boothbay Fund Management LLC | 279,637 | 29,625 | 1,716,971.18 | 0.0418 | 0.592 | 09/30/2025 |
| 11 | M28 Capital Management LP | 185,100 | 0 | 1,136,514 | 0.7651 | 0.3919 | 09/30/2025 |
| 12 | HSBC Bank Plc (Broker) | 172,873 | 39 | 1,061,440.22 | 0.0019 | 0.366 | 09/30/2025 |
| 13 | BMO Asset Management, Inc. | 148,782 | -6,811 | 913,521.48 | 0.0005 | 0.315 | 09/30/2025 |
| 14 | Morgan Stanley Smith Barney LLC (Investment Management) | 86,339 | 70,576 | 530,121.46 | 0.0001 | 0.1828 | 09/30/2025 |
| 15 | Marshall Wace LLP | 83,219 | -145,199 | 510,964.66 | 0.0005 | 0.1762 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Galileo - Biotech Innovation Fund | 58,645 | 0 | 360,080.3 | 1.0045 | 0.1242 | 06/30/2025 |
| 2 | RIM Global - Bioscience | 57,858 | 0 | 355,248.12 | 0.3019 | 0.1225 | 08/29/2025 |
| 3 | iShares Biotechnology ETF | 40,137 | -127,313 | 246,441.18 | 0.0028 | 0.085 | 11/28/2025 |
| 4 | iShares IV Plc - NASDAQ US Biotechnology UCITS ETF | 35,358 | 14,355 | 217,098.12 | 0.0252 | 0.0749 | 11/28/2025 |
| 5 | Fidelity Nasdaq Composite Index Fund | 29,538 | 121 | 181,363.32 | 0.0008 | 0.0625 | 10/31/2025 |
| 6 | Virtus LifeSci Biotech Clinical Trials ETF | 23,048 | 5,872 | 141,514.72 | 0.5047 | 0.0488 | 11/28/2025 |
| 7 | Lumyna - MW TOPS UCITS Fund | 19,672 | 0 | 120,786.08 | 0.0046 | 0.0416 | 03/31/2025 |
| 8 | Invesco Markets Plc - NASDAQ Biotech UCITS ETF | 16,592 | 3,501 | 101,874.88 | 0.0227 | 0.0351 | 11/28/2025 |
| 9 | China Universal Nasdaq Biotechnology Index ETF | 9,446 | -517 | 57,998.44 | 0.0241 | 0.02 | 06/30/2025 |
| 10 | SPDR S&P International Small Cap ETF | 9,242 | 1,411 | 56,745.88 | 0.0071 | 0.0196 | 11/28/2025 |
| 11 | Steward Values Enhanced International Fund | 5,800 | 0 | 35,612 | 0.0121 | 0.0123 | 11/30/2025 |
| 12 | Mirae Asset Tiger NASDAQ Bio ETF | 2,326 | 332 | 14,281.64 | 0.0229 | 0.0049 | 11/28/2025 |
| 13 | Invesco Nasdaq Biotechnology ETF | 2,222 | 376 | 13,643.08 | 0.0234 | 0.0047 | 11/28/2025 |
| 14 | ProShares Ultra NASDAQ Biotechnology | 2,207 | 477 | 13,550.98 | 0.0154 | 0.0047 | 11/28/2025 |
| 15 | Blackstone Alternative Multi Strategy Fund | 1,500 | 300 | 9,210 | 0.0006 | 0.0032 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Ikarian Capital LLC | 900,784 | 900,784 | 5,530,813.76 | 0.8319 | 1.9071 | 09/30/2025 |
| 2 | Morgan Stanley Smith Barney LLC (Investment Management) | 86,339 | 70,576 | 530,121.46 | 0.0001 | 0.1828 | 09/30/2025 |
| 3 | Boothbay Fund Management LLC | 279,637 | 29,625 | 1,716,971.18 | 0.0418 | 0.592 | 09/30/2025 |
| 4 | Cantor Fitzgerald Europe | 801,306 | 27,461 | 4,920,018.84 | 0.6636 | 1.6965 | 09/30/2025 |
| 5 | UBS Switzerland AG (Investment Management) | 14,964 | 14,964 | 91,878.96 | 0.0002 | 0.0317 | 09/30/2025 |
| 6 | HRT Financial LP | 10,887 | 10,887 | 66,846.18 | 0.0003 | 0.023 | 09/30/2025 |
| 7 | EHP Funds, Inc. | 10,673 | 10,673 | 65,532.22 | 0.0839 | 0.0226 | 09/30/2025 |
| 8 | Cambridge Investment Research Advisors, Inc. | 10,194 | 10,194 | 62,591.16 | 0.0002 | 0.0216 | 09/30/2025 |
| 9 | BlackRock Advisors (UK) Ltd. | 30,055 | 8,292 | 184,537.7 | 0 | 0.0636 | 09/30/2025 |
| 10 | Wexford Capital LP | 7,708 | 7,708 | 47,327.12 | 0.0067 | 0.0163 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Morgan Stanley & Co. LLC | 1,121,007 | -863,304 | 6,882,982.98 | 0.0023 | 2.3733 | 09/30/2025 |
| 2 | Saturn V Capital Management LP | 0 | -732,463 | 0 | 0 | 0 | |
| 3 | Parkman Healthcare Partners LLC | 0 | -401,746 | 0 | 0 | 0 | |
| 4 | Schonfeld Strategic Advisors LLC | 0 | -149,996 | 0 | 0 | 0 | |
| 5 | Marshall Wace LLP | 83,219 | -145,199 | 510,964.66 | 0.0005 | 0.1762 | 09/30/2025 |
| 6 | Walleye Capital LLC | 0 | -136,150 | 0 | 0 | 0 | |
| 7 | BlackRock Fund Advisors | 31,777 | -126,895 | 195,110.78 | 0 | 0.0673 | 09/30/2025 |
| 8 | Millennium Management LLC | 298,512 | -98,350 | 1,832,863.68 | 0.0014 | 0.632 | 09/30/2025 |
| 9 | Woodline Partners LP | 62,459 | -72,033 | 383,498.26 | 0.0017 | 0.1322 | 09/30/2025 |
| 10 | Bank of America, NA (Private Banking) | 546 | -63,790 | 3,352.44 | 0 | 0.0012 | 09/30/2025 |
Data provided by FactSet Research Systems Inc.