| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 7,601,220 | -374,076 | 419,131,270.8 | 0.0206 | 4.399 | 03/31/2026 |
| 2 | Wellington Management Co. LLP | 6,848,399 | 100,019 | 377,620,720.86 | 0.0595 | 3.9633 | 03/31/2026 |
| 3 | Avoro Capital Advisor LLC | 6,555,555 | 0 | 361,473,302.7 | 3.1554 | 3.7939 | 03/31/2026 |
| 4 | Janus Henderson Investors US LLC | 5,211,393 | 258,092 | 287,356,210.02 | 0.1248 | 3.016 | 03/31/2026 |
| 5 | Deep Track Capital LP | 4,279,848 | 168,066 | 235,990,818.72 | 3.3734 | 2.4769 | 03/31/2026 |
| 6 | BVF Partners LP | 3,459,358 | -19,664 | 190,749,000.12 | 4.523 | 2.002 | 03/31/2026 |
| 7 | Morgan Stanley & Co. LLC | 2,034,527 | 307,253 | 112,183,818.78 | 0.0329 | 1.1774 | 03/31/2026 |
| 8 | T. Rowe Price Associates, Inc. (IM) | 2,000,696 | 329,558 | 110,318,377.44 | 0.0122 | 1.1579 | 03/31/2026 |
| 9 | Principal Global Investors LLC | 1,753,764 | 469,554 | 96,702,546.96 | 0.0414 | 1.0149 | 03/31/2026 |
| 10 | Driehaus Capital Management LLC | 1,577,356 | -65,088 | 86,975,409.84 | 0.387 | 0.9129 | 03/31/2026 |
| 11 | American Century Investment Management, Inc. | 1,438,031 | 931,072 | 79,293,029.34 | 0.0266 | 0.8322 | 03/31/2026 |
| 12 | Baker Bros. Advisors LP | 1,432,529 | 0 | 78,989,649.06 | 0.328 | 0.829 | 03/31/2026 |
| 13 | Casdin Capital LLC | 1,175,000 | 0 | 64,789,500 | 3.128 | 0.68 | 03/31/2026 |
| 14 | Capitolis Liquid Global Markets LLC | 1,151,300 | 273,000 | 63,482,682 | 0.3527 | 0.6663 | 03/31/2026 |
| 15 | Pacific Heights Asset Management LLC | 750,000 | 50,000 | 41,355,000 | 1.3219 | 0.434 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Health Care Fund | 2,909,218 | -126,395 | 160,414,280.52 | 0.3964 | 1.6836 | 04/30/2026 |
| 2 | T Rowe Price Health Sciences Fund | 1,318,007 | 264,741 | 72,674,905.98 | 0.58 | 0.7628 | 03/31/2026 |
| 3 | Worldwide Healthcare Trust Plc | 1,312,400 | 780,700 | 72,365,736 | 3.578 | 0.7595 | 06/30/2026 |
| 4 | American Century Heritage Fund | 767,674 | 767,674 | 42,329,544.36 | 0.7138 | 0.4443 | 03/31/2026 |
| 5 | Fidelity Advisor Growth Opportunities Fund | 733,500 | -82,500 | 40,445,190 | 0.1162 | 0.4245 | 05/31/2026 |
| 6 | Principal Funds, Inc. - Global Emerging Markets Fund | 625,751 | 234,955 | 34,503,910.14 | 0.4379 | 0.3621 | 05/31/2026 |
| 7 | Vanguard Explorer Fund | 577,223 | -69,490 | 31,828,076.22 | 0.1368 | 0.3341 | 03/31/2026 |
| 8 | Janus Henderson Global Life Sciences Fund | 569,355 | -4,933 | 31,394,234.7 | 0.535 | 0.3295 | 03/31/2026 |
| 9 | Fidelity Select Port. - Biotechnology Portfolio | 542,038 | -90,600 | 29,887,975.32 | 0.4887 | 0.3137 | 05/31/2026 |
| 10 | Fidelity Select Port. - Health Care Portfolio | 540,000 | -210,000 | 29,775,600 | 0.4495 | 0.3125 | 05/31/2026 |
| 11 | Janus Henderson Capital Funds Plc - Global Life Sciences Fund | 526,487 | 33,716 | 29,030,493.18 | 0.5415 | 0.3047 | 03/31/2026 |
| 12 | Janus Henderson Horizon Fund - Biotechnology Fund | 482,023 | 0 | 26,578,748.22 | 1.376 | 0.279 | 03/31/2026 |
| 13 | Fidelity Advisor Series VII - Biotechnology Fund | 481,200 | 0 | 26,533,368 | 1.1728 | 0.2785 | 05/31/2026 |
| 14 | Janus Henderson Triton Fund | 459,487 | -11,279 | 25,336,113.18 | 0.4182 | 0.2659 | 03/31/2026 |
| 15 | Fidelity Contrafund | 450,605 | -429,295 | 24,846,359.7 | 0.014 | 0.2608 | 05/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | American Century Investment Management, Inc. | 1,438,031 | 931,072 | 79,293,029.34 | 0.0266 | 0.8322 | 03/31/2026 |
| 2 | Paradigm BioCapital Advisors LP | 545,287 | 545,287 | 30,067,125.18 | 0.5361 | 0.3156 | 03/31/2026 |
| 3 | Principal Global Investors LLC | 1,753,764 | 469,554 | 96,702,546.96 | 0.0414 | 1.0149 | 03/31/2026 |
| 4 | T. Rowe Price Associates, Inc. (IM) | 2,000,696 | 329,558 | 110,318,377.44 | 0.0122 | 1.1579 | 03/31/2026 |
| 5 | Morgan Stanley & Co. LLC | 2,034,527 | 307,253 | 112,183,818.78 | 0.0329 | 1.1774 | 03/31/2026 |
| 6 | Capitolis Liquid Global Markets LLC | 1,151,300 | 273,000 | 63,482,682 | 0.3527 | 0.6663 | 03/31/2026 |
| 7 | Janus Henderson Investors US LLC | 5,211,393 | 258,092 | 287,356,210.02 | 0.1248 | 3.016 | 03/31/2026 |
| 8 | SEB Asset Management AB | 245,043 | 245,043 | 13,511,671.02 | 0.0488 | 0.1418 | 03/31/2026 |
| 9 | Pentwater Capital Management LP | 245,000 | 245,000 | 13,509,300 | 0.1022 | 0.1418 | 03/31/2026 |
| 10 | JPMorgan Securities LLC (Investment Management) | 211,912 | 199,750 | 11,684,827.68 | 0.0054 | 0.1226 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Citadel Advisors LLC | 0 | -772,518 | 0 | 0 | 0 | |
| 2 | DWS Investments (UK) Ltd. | 331,867 | -509,295 | 18,299,146.38 | 0.0066 | 0.1921 | 03/31/2026 |
| 3 | Farallon Capital Management LLC | 0 | -454,000 | 0 | 0 | 0 | |
| 4 | Fidelity Management & Research Co. LLC | 7,601,220 | -374,076 | 419,131,270.8 | 0.0206 | 4.399 | 03/31/2026 |
| 5 | Franklin Advisers, Inc. | 531,172 | -339,274 | 29,288,824.08 | 0.0126 | 0.3074 | 03/31/2026 |
| 6 | EcoR1 Capital, LLC | 0 | -334,380 | 0 | 0 | 0 | |
| 7 | Capricorn Fund Managers Ltd. | 0 | -252,600 | 0 | 0 | 0 | |
| 8 | AllianceBernstein LP | 638,813 | -210,038 | 35,224,148.82 | 0.0098 | 0.3697 | 03/31/2026 |
| 9 | Monashee Investment Management LLC | 50,000 | -175,000 | 2,757,000 | 1.4027 | 0.0289 | 03/31/2026 |
| 10 | StemPoint Capital LP | 200,267 | -150,806 | 11,042,722.38 | 1.6039 | 0.1159 | 03/31/2026 |
Data provided by FactSet Research Systems Inc.