| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Wellington Management Co. LLP | 6,903,946 | 55,547 | 184,197,279.28 | 0.0297 | 3.9955 | 06/30/2026 |
| 2 | Fidelity Management & Research Co. LLC | 6,860,528 | -740,692 | 183,038,887.04 | 0.0086 | 3.9704 | 06/30/2026 |
| 3 | Avoro Capital Advisor LLC | 6,555,555 | 0 | 174,902,207.4 | 1.8404 | 3.7939 | 06/30/2026 |
| 4 | Janus Henderson Investors US LLC | 5,057,149 | -154,244 | 134,924,735.32 | 0.0593 | 2.9267 | 06/30/2026 |
| 5 | Deep Track Capital LP | 4,740,072 | 460,224 | 126,465,120.96 | 2.0413 | 2.7432 | 06/30/2026 |
| 6 | BVF Partners LP | 3,366,823 | -92,535 | 89,826,837.64 | 2.8761 | 1.9485 | 06/30/2026 |
| 7 | Morgan Stanley & Co. LLC | 2,461,083 | 426,556 | 65,661,694.44 | 0.0191 | 1.4243 | 06/30/2026 |
| 8 | Principal Global Investors LLC | 1,752,753 | -1,011 | 46,763,450.04 | 0.0207 | 1.0144 | 06/30/2026 |
| 9 | American Century Investment Management, Inc. | 1,682,179 | 244,148 | 44,880,535.72 | 0.0144 | 0.9735 | 06/30/2026 |
| 10 | RTW Investments LP | 1,607,507 | 1,607,507 | 42,888,286.76 | 0.3997 | 0.9303 | 06/30/2026 |
| 11 | Driehaus Capital Management LLC | 1,553,219 | -24,137 | 41,439,882.92 | 0.1931 | 0.8989 | 06/30/2026 |
| 12 | Baker Bros. Advisors LP | 1,432,529 | 0 | 38,219,873.72 | 0.1374 | 0.829 | 06/30/2026 |
| 13 | Casdin Capital LLC | 1,175,000 | 0 | 31,349,000 | 1.5177 | 0.68 | 06/30/2026 |
| 14 | Capitolis Liquid Global Markets LLC | 1,041,100 | -110,200 | 27,776,548 | 0.1174 | 0.6025 | 06/30/2026 |
| 15 | FIAM LLC | 914,871 | 165,001 | 24,408,758.28 | 0.0094 | 0.5295 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Health Care Fund | 3,278,237 | 466,983 | 87,463,363.16 | 0.2255 | 1.8972 | 07/31/2026 |
| 2 | American Century Heritage Fund | 967,353 | 199,679 | 25,808,978.04 | 0.4625 | 0.5598 | 06/30/2026 |
| 3 | Worldwide Healthcare Trust Plc | 778,500 | -22,800 | 20,770,380 | 1.1551 | 0.4505 | 09/30/2026 |
| 4 | Fidelity Advisor Growth Opportunities Fund | 733,500 | 0 | 19,569,780 | 0.0539 | 0.4245 | 08/31/2026 |
| 5 | Principal Funds, Inc. - Global Emerging Markets Fund | 625,751 | 0 | 16,695,036.68 | 0.2144 | 0.3621 | 07/31/2026 |
| 6 | Fidelity VIP - Contrafund Portfolio | 595,000 | 433,800 | 15,874,600 | 0.0525 | 0.3443 | 08/31/2026 |
| 7 | Janus Henderson Horizon Fund - Biotechnology Fund | 581,257 | 99,234 | 15,507,936.76 | 0.8204 | 0.3364 | 06/30/2026 |
| 8 | Janus Henderson Global Life Sciences Fund | 549,353 | -20,002 | 14,656,738.04 | 0.2554 | 0.3179 | 06/30/2026 |
| 9 | Fidelity Select Port. - Biotechnology Portfolio | 542,038 | -22,400 | 14,461,573.84 | 0.2488 | 0.3137 | 08/31/2026 |
| 10 | Fidelity Advisor New Insights Fund | 539,600 | 291,500 | 14,396,528 | 0.0515 | 0.3123 | 08/31/2026 |
| 11 | Janus Henderson Capital Funds Plc - Global Life Sciences Fund | 533,616 | 7,129 | 14,236,874.88 | 0.266 | 0.3088 | 06/30/2026 |
| 12 | Fidelity Advisor Series VII - Biotechnology Fund | 527,900 | 46,700 | 14,084,372 | 0.622 | 0.3055 | 08/31/2026 |
| 13 | Fidelity Select Port. - Health Care Portfolio | 500,000 | -100,000 | 13,340,000 | 0.1993 | 0.2894 | 08/31/2026 |
| 14 | iShares Biotechnology ETF | 485,119 | 103,443 | 12,942,974.92 | 0.1196 | 0.2808 | 09/30/2026 |
| 15 | Janus Henderson Triton Fund | 467,112 | 7,625 | 12,462,548.16 | 0.2276 | 0.2703 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RTW Investments LP | 1,607,507 | 1,607,507 | 42,888,286.76 | 0.3997 | 0.9303 | 06/30/2026 |
| 2 | Deep Track Capital LP | 4,740,072 | 460,224 | 126,465,120.96 | 2.0413 | 2.7432 | 06/30/2026 |
| 3 | Morgan Stanley & Co. LLC | 2,461,083 | 426,556 | 65,661,694.44 | 0.0191 | 1.4243 | 06/30/2026 |
| 4 | Davern Capital Partners LP | 446,059 | 319,598 | 11,900,854.12 | 2.2341 | 0.2581 | 06/30/2026 |
| 5 | Parkman Healthcare Partners LLC | 485,661 | 253,568 | 12,957,435.48 | 1.431 | 0.2811 | 06/30/2026 |
| 6 | BofA Securities, Inc. | 299,799 | 249,127 | 7,998,637.32 | 0.0118 | 0.1735 | 06/30/2026 |
| 7 | abrdn, Inc. | 639,915 | 248,106 | 17,072,932.2 | 0.1569 | 0.3703 | 06/30/2026 |
| 8 | American Century Investment Management, Inc. | 1,682,179 | 244,148 | 44,880,535.72 | 0.0144 | 0.9735 | 06/30/2026 |
| 9 | Marshall Wace LLP | 267,592 | 198,485 | 7,139,354.56 | 0.0059 | 0.1549 | 06/30/2026 |
| 10 | NEXTBio Capital Management LP | 312,496 | 179,257 | 8,337,393.28 | 4.2259 | 0.1808 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Associates, Inc. (IM) | 845,532 | -1,155,164 | 22,558,793.76 | 0.0024 | 0.4893 | 06/30/2026 |
| 2 | Fidelity Management & Research Co. LLC | 6,860,528 | -740,692 | 183,038,887.04 | 0.0086 | 3.9704 | 06/30/2026 |
| 3 | Paradigm BioCapital Advisors LP | 0 | -545,287 | 0 | 0 | 0 | |
| 4 | Balyasny Asset Management LP | 0 | -304,934 | 0 | 0 | 0 | |
| 5 | Pentwater Capital Management LP | 0 | -245,000 | 0 | 0 | 0 | |
| 6 | JPMorgan Securities LLC (Investment Management) | 2,634 | -209,278 | 70,275.12 | 0 | 0.0015 | 06/30/2026 |
| 7 | Sio Capital Management LLC | 0 | -209,093 | 0 | 0 | 0 | |
| 8 | StemPoint Capital LP | 38,178 | -162,089 | 1,018,589.04 | 0.2192 | 0.0221 | 06/30/2026 |
| 9 | Holocene Advisors, LP | 0 | -159,009 | 0 | 0 | 0 | |
| 10 | Janus Henderson Investors US LLC | 5,057,149 | -154,244 | 134,924,735.32 | 0.0593 | 2.9267 | 06/30/2026 |
Data provided by FactSet Research Systems Inc.