| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Wellington Management Co. LLP | 20,631,498 | 13,930,230 | 1,381,897,736.04 | 0.2148 | 11.94 | 10/31/2025 |
| 2 | Avoro Capital Advisor LLC | 5,155,555 | 5,155,555 | 345,319,073.9 | 3.7815 | 2.9836 | 09/30/2025 |
| 3 | Janus Henderson Investors US LLC | 4,321,392 | -127,775 | 289,446,836.16 | 0.1341 | 2.5009 | 09/30/2025 |
| 4 | Fidelity Management & Research Co. LLC | 4,271,011 | -437,950 | 286,072,316.78 | 0.0155 | 2.4717 | 09/30/2025 |
| 5 | Deep Track Capital LP | 4,215,811 | -918,106 | 282,375,020.78 | 5.0914 | 2.4398 | 09/30/2025 |
| 6 | BVF Partners LP | 3,203,917 | 1,432,500 | 214,598,360.66 | 5.4515 | 1.8542 | 09/30/2025 |
| 7 | Baker Bros. Advisors LP | 1,556,109 | -952,658 | 104,228,180.82 | 0.5469 | 0.9006 | 09/30/2025 |
| 8 | Casdin Capital LLC | 1,555,000 | 330,000 | 104,153,900 | 6.2807 | 0.8999 | 09/30/2025 |
| 9 | RA Capital Management LP | 1,517,418 | 0 | 101,636,657.64 | 1.0402 | 0.8782 | 09/30/2025 |
| 10 | Millennium Management LLC | 1,274,551 | 54,496 | 85,369,425.98 | 0.065 | 0.7376 | 09/30/2025 |
| 11 | Threadneedle Asset Management Ltd. | 1,126,034 | 1,907 | 75,421,757.32 | 0.0945 | 0.6517 | 09/30/2025 |
| 12 | FIAM LLC | 961,909 | 773,353 | 64,428,664.82 | 0.0323 | 0.5567 | 09/30/2025 |
| 13 | Rock Springs Capital Management LP | 951,154 | -184,725 | 63,708,294.92 | 3.1315 | 0.5505 | 09/30/2025 |
| 14 | Driehaus Capital Management LLC | 873,504 | 200,712 | 58,507,297.92 | 0.2832 | 0.5055 | 09/30/2025 |
| 15 | Logos Global Management LP | 850,000 | 0 | 56,933,000 | 3.9089 | 0.4919 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Health Care Fund | 3,035,613 | -1,378,960 | 203,325,358.74 | 0.4879 | 1.7568 | 10/31/2025 |
| 2 | Xtrackers SICAV - MSCI USA Swap UCITS ETF | 841,162 | 841,162 | 56,341,030.76 | 0.6749 | 0.4868 | 12/29/2025 |
| 3 | Fidelity Advisor Series I -Growth Opportunities Fund | 727,400 | 108,200 | 48,721,252 | 0.1605 | 0.421 | 11/30/2025 |
| 4 | Vanguard Explorer Fund | 582,447 | 0 | 39,012,300.06 | 0.1781 | 0.3371 | 09/30/2025 |
| 5 | Fidelity Select Port. - Health Care Portfolio | 560,000 | -290,000 | 37,508,800 | 0.5692 | 0.3241 | 11/30/2025 |
| 6 | Worldwide Healthcare Trust Plc | 531,700 | 531,700 | 35,613,266 | 1.6496 | 0.3077 | 12/31/2025 |
| 7 | Janus Henderson Triton Fund | 499,717 | -13,634 | 33,471,044.66 | 0.5678 | 0.2892 | 09/30/2025 |
| 8 | Janus Henderson Global Life Sciences Fund | 476,741 | -83,951 | 31,932,112.18 | 0.5884 | 0.2759 | 09/30/2025 |
| 9 | COLUMBIA THREADNEEDLE LUX I - American Smaller Companies | 452,557 | -253,675 | 30,312,267.86 | 1.6077 | 0.2619 | 11/30/2025 |
| 10 | Fidelity Small Cap Growth Fund | 427,449 | -1,261 | 28,630,534.02 | 0.3615 | 0.2474 | 10/31/2025 |
| 11 | Fidelity Select Port. - Biotechnology Portfolio | 422,564 | 32,900 | 28,303,336.72 | 0.5497 | 0.2445 | 11/30/2025 |
| 12 | FIAM Small Capitalization Core Commingled Pool | 412,300 | 412,300 | 27,615,854 | 0.56 | 0.2386 | 10/31/2025 |
| 13 | Principal Funds, Inc. - Small Cap Fund | 402,700 | 8,700 | 26,972,846 | 1.1309 | 0.2331 | 10/31/2025 |
| 14 | abrdn Healthcare Investors | 381,989 | 104,460 | 25,585,623.22 | 2.0484 | 0.2211 | 08/31/2025 |
| 15 | Janus Henderson Capital Funds Plc - Global Life Sciences Fund | 370,303 | -94,288 | 24,802,894.94 | 0.5369 | 0.2143 | 11/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Wellington Management Co. LLP | 20,631,498 | 13,930,230 | 1,381,897,736.04 | 0.2148 | 11.94 | 10/31/2025 |
| 2 | Avoro Capital Advisor LLC | 5,155,555 | 5,155,555 | 345,319,073.9 | 3.7815 | 2.9836 | 09/30/2025 |
| 3 | BVF Partners LP | 3,203,917 | 1,432,500 | 214,598,360.66 | 5.4515 | 1.8542 | 09/30/2025 |
| 4 | FIAM LLC | 961,909 | 773,353 | 64,428,664.82 | 0.0323 | 0.5567 | 09/30/2025 |
| 5 | Balyasny Asset Management LP | 461,553 | 461,553 | 30,914,819.94 | 0.0605 | 0.2671 | 09/30/2025 |
| 6 | Paradigm BioCapital Advisors LP | 372,869 | 372,869 | 24,974,765.62 | 0.5607 | 0.2158 | 09/30/2025 |
| 7 | Casdin Capital LLC | 1,555,000 | 330,000 | 104,153,900 | 6.2807 | 0.8999 | 09/30/2025 |
| 8 | Schroder Investment Management Ltd. | 300,947 | 300,947 | 20,157,430.06 | 0.008 | 0.1742 | 09/30/2025 |
| 9 | Goldman Sachs & Co. LLC (Private Banking) | 504,396 | 284,222 | 33,784,444.08 | 0.0144 | 0.2919 | 09/30/2025 |
| 10 | Alyeska Investment Group LP | 244,848 | 244,848 | 16,399,919.04 | 0.0478 | 0.1417 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Capital Research & Management Co. (International Investors) | 0 | -1,618,876 | 0 | 0 | 0 | |
| 2 | Vestal Point Capital LP | 0 | -1,200,000 | 0 | 0 | 0 | |
| 3 | Baker Bros. Advisors LP | 1,556,109 | -952,658 | 104,228,180.82 | 0.5469 | 0.9006 | 09/30/2025 |
| 4 | Deep Track Capital LP | 4,215,811 | -918,106 | 282,375,020.78 | 5.0914 | 2.4398 | 09/30/2025 |
| 5 | Citadel Advisors LLC | 384,201 | -760,574 | 25,733,782.98 | 0.0272 | 0.2223 | 09/30/2025 |
| 6 | Federated Global Investment Management Corp. | 2,500 | -463,300 | 167,450 | 0.0013 | 0.0014 | 09/30/2025 |
| 7 | Fidelity Management & Research Co. LLC | 4,271,011 | -437,950 | 286,072,316.78 | 0.0155 | 2.4717 | 09/30/2025 |
| 8 | Schonfeld Strategic Advisors LLC | 0 | -321,591 | 0 | 0 | 0 | |
| 9 | Monashee Investment Management LLC | 200,000 | -230,000 | 13,396,000 | 6.5654 | 0.1157 | 09/30/2025 |
| 10 | Morgan Stanley Investment Management, Inc. | 7,422 | -226,484 | 497,125.56 | 0.0005 | 0.0043 | 09/30/2025 |
Data provided by FactSet Research Systems Inc.