| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Wellington Management Co. LLP | 6,701,268 | -876,857 | 204,723,737.4 | 0.033 | 3.8782 | 06/30/2025 |
| 2 | Deep Track Capital LP | 5,133,917 | 1,033,917 | 156,841,164.35 | 3.023 | 2.9711 | 06/30/2025 |
| 3 | Fidelity Management & Research Co. LLC | 4,708,961 | -1,070,619 | 143,858,758.55 | 0.008 | 2.7252 | 06/30/2025 |
| 4 | Janus Henderson Investors US LLC | 4,449,167 | 157,542 | 135,922,051.85 | 0.0643 | 2.5748 | 06/30/2025 |
| 5 | BVF Partners LP | 3,139,712 | 1,368,295 | 95,918,201.6 | 3.0367 | 1.817 | 08/11/2025 |
| 6 | Baker Bros. Advisors LP | 2,508,767 | 2,147,202 | 76,642,831.85 | 0.4611 | 1.4519 | 06/30/2025 |
| 7 | Capital Research & Management Co. (International Investors) | 1,618,876 | -150 | 49,456,661.8 | 0.0077 | 0.9369 | 06/30/2025 |
| 8 | RA Capital Management LP | 1,517,418 | 0 | 46,357,119.9 | 0.5213 | 0.8782 | 06/30/2025 |
| 9 | Casdin Capital LLC | 1,225,000 | 525,000 | 37,423,750 | 2.7335 | 0.7089 | 06/30/2025 |
| 10 | Millennium Management LLC | 1,220,055 | 429,896 | 37,272,680.25 | 0.0309 | 0.7061 | 06/30/2025 |
| 11 | Vestal Point Capital LP | 1,200,000 | -588,990 | 36,660,000 | 1.3435 | 0.6945 | 06/30/2025 |
| 12 | Citadel Advisors LLC | 1,144,775 | 403,510 | 34,972,876.25 | 0.0389 | 0.6625 | 06/30/2025 |
| 13 | Rock Springs Capital Management LP | 1,135,879 | 2,900 | 34,701,103.45 | 1.7526 | 0.6574 | 06/30/2025 |
| 14 | Threadneedle Asset Management Ltd. | 1,124,127 | 47,310 | 34,342,079.85 | 0.043 | 0.6506 | 06/30/2025 |
| 15 | Principal Global Investors LLC | 853,202 | 96,495 | 26,065,321.1 | 0.0121 | 0.4938 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Health Care Fund | 1,990,460 | -2,258,682 | 60,808,553 | 0.1556 | 1.1519 | 07/31/2025 |
| 2 | American Funds Small Cap World Fund | 1,599,660 | -2,056,277 | 48,869,613 | 0.0625 | 0.9258 | 06/30/2025 |
| 3 | Fidelity Select Port. - Health Care Portfolio | 850,000 | 180,000 | 25,967,500 | 0.4119 | 0.4919 | 08/31/2025 |
| 4 | COLUMBIA THREADNEEDLE LUX I - American Smaller Companies | 705,536 | 44,624 | 21,554,124.8 | 1.0413 | 0.4083 | 08/31/2025 |
| 5 | Fidelity Advisor Series I -Growth Opportunities Fund | 619,200 | 356,100 | 18,916,560 | 0.0612 | 0.3583 | 08/31/2025 |
| 6 | Vanguard Explorer Fund | 582,447 | 0 | 17,793,755.85 | 0.0834 | 0.3371 | 06/30/2025 |
| 7 | Janus Henderson Global Life Sciences Fund | 560,692 | -25,653 | 17,129,140.6 | 0.3456 | 0.3245 | 06/30/2025 |
| 8 | Janus Henderson Triton Fund | 513,351 | 224,698 | 15,682,873.05 | 0.2622 | 0.2971 | 06/30/2025 |
| 9 | Fidelity Advisor Health Care Fund | 480,000 | 68,000 | 14,664,000 | 0.4186 | 0.2778 | 08/31/2025 |
| 10 | Fidelity Stock Selector Small Cap Fund | 477,600 | 271,200 | 14,590,680 | 0.2687 | 0.2764 | 07/31/2025 |
| 11 | Worldwide Healthcare Trust Plc | 476,000 | 476,000 | 14,541,800 | 0.7079 | 0.2755 | 09/30/2025 |
| 12 | Bellevue Healthcare Trust Plc | 466,550 | 0 | 14,253,102.5 | 2.7972 | 0.27 | 11/30/2024 |
| 13 | FIAM Small Capitalization Core Commingled Pool | 465,000 | 465,000 | 14,205,750 | 0.2938 | 0.2691 | 07/31/2025 |
| 14 | Janus Henderson Capital Funds Plc - Global Life Sciences Fund | 457,609 | -17,302 | 13,979,954.95 | 0.3495 | 0.2648 | 08/31/2025 |
| 15 | Federated Hermes Kaufmann Fund | 450,000 | 0 | 13,747,500 | 0.2663 | 0.2604 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 2,508,767 | 2,147,202 | 76,642,831.85 | 0.4611 | 1.4519 | 06/30/2025 |
| 2 | BVF Partners LP | 3,139,712 | 1,368,295 | 95,918,201.6 | 3.0367 | 1.817 | 08/11/2025 |
| 3 | Deep Track Capital LP | 5,133,917 | 1,033,917 | 156,841,164.35 | 3.023 | 2.9711 | 06/30/2025 |
| 4 | Casdin Capital LLC | 1,225,000 | 525,000 | 37,423,750 | 2.7335 | 0.7089 | 06/30/2025 |
| 5 | Pacific Heights Asset Management LLC | 460,000 | 460,000 | 14,053,000 | 0.6876 | 0.2662 | 06/30/2025 |
| 6 | Millennium Management LLC | 1,220,055 | 429,896 | 37,272,680.25 | 0.0309 | 0.7061 | 06/30/2025 |
| 7 | Logos Global Management LP | 850,000 | 425,000 | 25,967,500 | 2.4159 | 0.4919 | 06/30/2025 |
| 8 | Citadel Advisors LLC | 1,144,775 | 403,510 | 34,972,876.25 | 0.0389 | 0.6625 | 06/30/2025 |
| 9 | Schonfeld Strategic Advisors LLC | 321,591 | 321,591 | 9,824,605.05 | 0.0669 | 0.1861 | 06/30/2025 |
| 10 | Schroder Investment Management North America, Inc. | 187,805 | 187,805 | 5,737,442.75 | 0.006 | 0.1087 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Capital Research & Management Co. (Global Investors) | 0 | -2,164,145 | 0 | 0 | 0 | |
| 2 | FIL Investments International | 0 | -1,110,193 | 0 | 0 | 0 | |
| 3 | Fidelity Management & Research Co. LLC | 4,708,961 | -1,070,619 | 143,858,758.55 | 0.008 | 2.7252 | 06/30/2025 |
| 4 | Wellington Management Co. LLP | 6,701,268 | -876,857 | 204,723,737.4 | 0.033 | 3.8782 | 06/30/2025 |
| 5 | Federated Global Investment Management Corp. | 465,800 | -705,148 | 14,230,190 | 0.1134 | 0.2696 | 06/30/2025 |
| 6 | Driehaus Capital Management LLC | 672,792 | -599,951 | 20,553,795.6 | 0.1074 | 0.3894 | 06/30/2025 |
| 7 | Vestal Point Capital LP | 1,200,000 | -588,990 | 36,660,000 | 1.3435 | 0.6945 | 06/30/2025 |
| 8 | Schroder Investment Management Ltd. | 0 | -476,136 | 0 | 0 | 0 | |
| 9 | T. Rowe Price Associates, Inc. (IM) | 352,868 | -424,305 | 10,780,117.4 | 0.0012 | 0.2042 | 06/30/2025 |
| 10 | Readystate Asset Management LP | 178,612 | -302,629 | 5,456,596.6 | 0.2375 | 0.1034 | 06/30/2025 |
Data provided by FactSet Research Systems Inc.