| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Wellington Management Co. LLP | 6,903,946 | 155,566 | 338,914,709.14 | 0.0536 | 3.9955 | 06/30/2026 |
| 2 | Fidelity Management & Research Co. LLC | 6,860,528 | -1,114,768 | 336,783,319.52 | 0.0161 | 3.9704 | 06/30/2026 |
| 3 | Avoro Capital Advisor LLC | 6,555,555 | 0 | 321,812,194.95 | 2.8832 | 3.7939 | 06/30/2026 |
| 4 | Janus Henderson Investors US LLC | 5,057,149 | 103,848 | 248,255,444.41 | 0.1079 | 2.9267 | 06/30/2026 |
| 5 | Deep Track Capital LP | 4,740,072 | 628,290 | 232,690,134.48 | 3.1253 | 2.7432 | 06/30/2026 |
| 6 | BVF Partners LP | 3,366,823 | -112,199 | 165,277,341.07 | 4.3192 | 1.9485 | 06/30/2026 |
| 7 | Morgan Stanley & Co. LLC | 2,461,083 | 733,809 | 120,814,564.47 | 0.0349 | 1.4243 | 06/30/2026 |
| 8 | Principal Global Investors LLC | 1,752,753 | 468,543 | 86,042,644.77 | 0.0368 | 1.0144 | 06/30/2026 |
| 9 | American Century Investment Management, Inc. | 1,682,179 | 1,175,220 | 82,578,167.11 | 0.0263 | 0.9735 | 06/30/2026 |
| 10 | RTW Investments LP | 1,607,507 | 1,507,507 | 78,912,518.63 | 0.6336 | 0.9303 | 06/30/2026 |
| 11 | Driehaus Capital Management LLC | 1,553,219 | -89,225 | 76,247,520.71 | 0.3413 | 0.8989 | 06/30/2026 |
| 12 | Baker Bros. Advisors LP | 1,432,529 | 0 | 70,322,848.61 | 0.2435 | 0.829 | 06/30/2026 |
| 13 | Casdin Capital LLC | 1,175,000 | 0 | 57,680,750 | 2.5952 | 0.68 | 06/30/2026 |
| 14 | Capitolis Liquid Global Markets LLC | 1,041,100 | 162,800 | 51,107,599 | 0.2192 | 0.6025 | 06/30/2026 |
| 15 | FIAM LLC | 914,871 | 177,917 | 44,911,017.39 | 0.0172 | 0.5295 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Health Care Fund | 2,909,218 | 97,964 | 142,813,511.62 | 0.3387 | 1.6836 | 04/30/2026 |
| 2 | Worldwide Healthcare Trust Plc | 1,312,400 | 780,700 | 64,425,716 | 3.1337 | 0.7595 | 07/31/2026 |
| 3 | American Century Heritage Fund | 967,353 | 967,353 | 47,487,358.77 | 0.8471 | 0.5598 | 06/30/2026 |
| 4 | Fidelity Advisor Growth Opportunities Fund | 733,500 | -82,500 | 36,007,515 | 0.1056 | 0.4245 | 06/30/2026 |
| 5 | Principal Funds, Inc. - Global Emerging Markets Fund | 625,751 | 234,955 | 30,718,116.59 | 0.3804 | 0.3621 | 06/30/2026 |
| 6 | Janus Henderson Horizon Fund - Biotechnology Fund | 581,257 | 99,234 | 28,533,906.13 | 1.3105 | 0.3364 | 06/30/2026 |
| 7 | Janus Henderson Global Life Sciences Fund | 569,355 | -4,933 | 27,949,636.95 | 0.4619 | 0.3295 | 03/31/2026 |
| 8 | Fidelity Select Port. - Biotechnology Portfolio | 542,038 | -90,600 | 26,608,645.42 | 0.4229 | 0.3137 | 06/30/2026 |
| 9 | Fidelity Select Port. - Health Care Portfolio | 540,000 | -150,000 | 26,508,600 | 0.3796 | 0.3125 | 06/30/2026 |
| 10 | Fidelity Advisor Series VII - Biotechnology Fund | 527,900 | 46,700 | 25,914,611 | 1.056 | 0.3055 | 06/30/2026 |
| 11 | Janus Henderson Capital Funds Plc - Global Life Sciences Fund | 526,487 | 15,103 | 25,845,246.83 | 0.4678 | 0.3047 | 03/31/2026 |
| 12 | Janus Henderson Triton Fund | 459,487 | -11,279 | 22,556,216.83 | 0.3817 | 0.2659 | 03/31/2026 |
| 13 | iShares Biotechnology ETF | 430,126 | 40,298 | 21,114,885.34 | 0.2001 | 0.2489 | 07/31/2026 |
| 14 | T Rowe Price Health Sciences Fund | 419,407 | -633,859 | 20,588,689.63 | 0.1602 | 0.2427 | 06/30/2026 |
| 15 | Fidelity Small Cap Growth Fund | 414,389 | 0 | 20,342,356.01 | 0.2267 | 0.2398 | 05/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RTW Investments LP | 1,607,507 | 1,507,507 | 78,912,518.63 | 0.6336 | 0.9303 | 06/30/2026 |
| 2 | American Century Investment Management, Inc. | 1,682,179 | 1,175,220 | 82,578,167.11 | 0.0263 | 0.9735 | 06/30/2026 |
| 3 | Morgan Stanley & Co. LLC | 2,461,083 | 733,809 | 120,814,564.47 | 0.0349 | 1.4243 | 06/30/2026 |
| 4 | Deep Track Capital LP | 4,740,072 | 628,290 | 232,690,134.48 | 3.1253 | 2.7432 | 06/30/2026 |
| 5 | Principal Global Investors LLC | 1,752,753 | 468,543 | 86,042,644.77 | 0.0368 | 1.0144 | 06/30/2026 |
| 6 | Davern Capital Partners LP | 446,059 | 446,059 | 21,897,036.31 | 3.5939 | 0.2581 | 06/30/2026 |
| 7 | Parkman Healthcare Partners LLC | 485,661 | 430,661 | 23,841,098.49 | 2.2678 | 0.2811 | 06/30/2026 |
| 8 | abrdn, Inc. | 639,915 | 375,046 | 31,413,427.35 | 0.2718 | 0.3703 | 06/30/2026 |
| 9 | BofA Securities, Inc. | 299,799 | 295,387 | 14,717,132.91 | 0.0212 | 0.1735 | 06/30/2026 |
| 10 | SEB Asset Management AB | 245,043 | 245,043 | 12,029,160.87 | 0.0432 | 0.1418 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 6,860,528 | -1,114,768 | 336,783,319.52 | 0.0161 | 3.9704 | 06/30/2026 |
| 2 | T. Rowe Price Associates, Inc. (IM) | 845,532 | -825,606 | 41,507,165.88 | 0.0045 | 0.4893 | 06/30/2026 |
| 3 | Citadel Advisors LLC | 0 | -772,518 | 0 | 0 | 0 | |
| 4 | DWS Investments (UK) Ltd. | 331,867 | -509,295 | 16,291,351.03 | 0.0058 | 0.1921 | 06/30/2026 |
| 5 | Farallon Capital Management LLC | 0 | -454,000 | 0 | 0 | 0 | |
| 6 | EcoR1 Capital, LLC | 0 | -334,380 | 0 | 0 | 0 | |
| 7 | StemPoint Capital LP | 38,178 | -312,895 | 1,874,158.02 | 0.3211 | 0.0221 | 06/30/2026 |
| 8 | Franklin Advisers, Inc. | 578,497 | -291,949 | 28,398,417.73 | 0.0121 | 0.3348 | 06/30/2026 |
| 9 | Capricorn Fund Managers Ltd. | 0 | -252,600 | 0 | 0 | 0 | |
| 10 | AllianceBernstein LP | 611,708 | -237,143 | 30,028,745.72 | 0.0085 | 0.354 | 06/30/2026 |
Data provided by FactSet Research Systems Inc.