| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 7,975,296 | 3,704,285 | 439,757,821.44 | 0.024 | 4.6155 | 12/31/2025 |
| 2 | Wellington Management Co. LLP | 6,748,380 | 1,292,200 | 372,105,673.2 | 0.0603 | 3.9055 | 12/31/2025 |
| 3 | Avoro Capital Advisor LLC | 6,555,555 | 1,400,000 | 361,473,302.7 | 3.2871 | 3.7939 | 12/31/2025 |
| 4 | Janus Henderson Investors US LLC | 4,953,301 | 631,909 | 273,125,017.14 | 0.1321 | 2.8666 | 12/31/2025 |
| 5 | Deep Track Capital LP | 4,111,782 | -104,029 | 226,723,659.48 | 4.5693 | 2.3796 | 12/31/2025 |
| 6 | BVF Partners LP | 3,479,022 | 275,105 | 191,833,273.08 | 5.5595 | 2.0134 | 12/31/2025 |
| 7 | Morgan Stanley & Co. LLC | 1,727,274 | 1,492,341 | 95,241,888.36 | 0.0336 | 0.9996 | 12/31/2025 |
| 8 | T. Rowe Price Associates, Inc. (IM) | 1,671,138 | 1,381,745 | 92,146,549.32 | 0.011 | 0.9671 | 12/31/2025 |
| 9 | Driehaus Capital Management LLC | 1,642,444 | 768,940 | 90,564,362.16 | 0.4237 | 0.9505 | 12/31/2025 |
| 10 | Baker Bros. Advisors LP | 1,432,529 | -123,580 | 78,989,649.06 | 0.3855 | 0.829 | 12/31/2025 |
| 11 | Principal Global Investors LLC | 1,284,210 | 496,726 | 70,811,339.4 | 0.0323 | 0.7432 | 12/31/2025 |
| 12 | Casdin Capital LLC | 1,175,000 | -380,000 | 64,789,500 | 4.5587 | 0.68 | 12/31/2025 |
| 13 | Capitolis Liquid Global Markets LLC | 878,300 | 878,300 | 48,429,462 | 0.2929 | 0.5083 | 12/31/2025 |
| 14 | Franklin Advisers, Inc. | 870,446 | 124,805 | 47,996,392.44 | 0.0213 | 0.5037 | 12/31/2025 |
| 15 | AllianceBernstein LP | 848,851 | 819,292 | 46,805,644.14 | 0.014 | 0.4913 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Health Care Fund | 2,811,254 | 820,794 | 155,012,545.56 | 0.397 | 1.6269 | 01/31/2026 |
| 2 | T Rowe Price Health Sciences Fund | 1,053,266 | 840,209 | 58,077,087.24 | 0.5107 | 0.6096 | 12/31/2025 |
| 3 | Fidelity Contrafund | 851,525 | 851,525 | 46,953,088.5 | 0.0279 | 0.4928 | 02/28/2026 |
| 4 | Worldwide Healthcare Trust Plc | 801,300 | 325,300 | 44,183,682 | 2.3618 | 0.4637 | 03/31/2026 |
| 5 | Fidelity Advisor Series I -Growth Opportunities Fund | 733,500 | 114,300 | 40,445,190 | 0.1389 | 0.4245 | 02/28/2026 |
| 6 | Vanguard Explorer Fund | 646,713 | 64,266 | 35,659,754.82 | 0.1686 | 0.3743 | 12/31/2025 |
| 7 | Fidelity Select Port. - Health Care Portfolio | 620,000 | 20,000 | 34,186,800 | 0.5724 | 0.3588 | 02/28/2026 |
| 8 | Janus Henderson Global Life Sciences Fund | 574,288 | 97,547 | 31,666,240.32 | 0.5997 | 0.3324 | 12/31/2025 |
| 9 | Fidelity Select Port. - Biotechnology Portfolio | 564,438 | 180,674 | 31,123,111.32 | 0.5868 | 0.3267 | 02/28/2026 |
| 10 | Principal Funds, Inc. - Global Emerging Markets Fund | 562,416 | 562,416 | 31,011,618.24 | 0.4212 | 0.3255 | 02/28/2026 |
| 11 | Janus Henderson Capital Funds Plc - Global Life Sciences Fund | 511,384 | 115,917 | 28,197,713.76 | 0.5988 | 0.296 | 01/31/2026 |
| 12 | Janus Henderson Horizon Fund - Biotechnology Fund | 482,023 | 216,809 | 26,578,748.22 | 1.866 | 0.279 | 12/31/2025 |
| 13 | Fidelity Advisor Series VII - Biotechnology Fund | 481,200 | 179,500 | 26,533,368 | 1.3776 | 0.2785 | 02/28/2026 |
| 14 | Janus Henderson Triton Fund | 470,766 | -28,951 | 25,958,037.24 | 0.4506 | 0.2724 | 12/31/2025 |
| 15 | Fidelity Stock Selector Small Cap Fund | 418,100 | -59,500 | 23,054,034 | 0.3587 | 0.242 | 01/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 7,975,296 | 3,704,285 | 439,757,821.44 | 0.024 | 4.6155 | 12/31/2025 |
| 2 | Morgan Stanley & Co. LLC | 1,727,274 | 1,492,341 | 95,241,888.36 | 0.0336 | 0.9996 | 12/31/2025 |
| 3 | Avoro Capital Advisor LLC | 6,555,555 | 1,400,000 | 361,473,302.7 | 3.2871 | 3.7939 | 12/31/2025 |
| 4 | T. Rowe Price Associates, Inc. (IM) | 1,671,138 | 1,381,745 | 92,146,549.32 | 0.011 | 0.9671 | 12/31/2025 |
| 5 | Wellington Management Co. LLP | 6,748,380 | 1,292,200 | 372,105,673.2 | 0.0603 | 3.9055 | 12/31/2025 |
| 6 | Capitolis Liquid Global Markets LLC | 878,300 | 878,300 | 48,429,462 | 0.2929 | 0.5083 | 12/31/2025 |
| 7 | DWS Investments (UK) Ltd. | 841,162 | 841,162 | 46,381,672.68 | 0.0194 | 0.4868 | 12/31/2025 |
| 8 | AllianceBernstein LP | 848,851 | 819,292 | 46,805,644.14 | 0.014 | 0.4913 | 12/31/2025 |
| 9 | Driehaus Capital Management LLC | 1,642,444 | 768,940 | 90,564,362.16 | 0.4237 | 0.9505 | 12/31/2025 |
| 10 | Janus Henderson Investors US LLC | 4,953,301 | 631,909 | 273,125,017.14 | 0.1321 | 2.8666 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 0 | -1,517,418 | 0 | 0 | 0 | |
| 2 | Millennium Management LLC | 152,560 | -1,121,991 | 8,412,158.4 | 0.006 | 0.0883 | 12/31/2025 |
| 3 | Threadneedle Asset Management Ltd. | 206,121 | -919,913 | 11,365,511.94 | 0.0151 | 0.1193 | 12/31/2025 |
| 4 | Point72 Asset Management LP | 0 | -524,398 | 0 | 0 | 0 | |
| 5 | Invesco Advisers, Inc. | 0 | -434,277 | 0 | 0 | 0 | |
| 6 | Catalio Capital Management LP (Investment Management) | 252,901 | -398,909 | 13,944,961.14 | 2.5421 | 0.1464 | 12/31/2025 |
| 7 | Casdin Capital LLC | 1,175,000 | -380,000 | 64,789,500 | 4.5587 | 0.68 | 12/31/2025 |
| 8 | Paradigm BioCapital Advisors LP | 0 | -372,869 | 0 | 0 | 0 | |
| 9 | Nantahala Capital Management LLC | 0 | -368,553 | 0 | 0 | 0 | |
| 10 | abrdn, Inc. | 264,869 | -322,000 | 14,604,876.66 | 0.1345 | 0.1533 | 12/31/2025 |
Data provided by FactSet Research Systems Inc.