| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Wellington Management Co. LLP | 20,631,498 | 13,053,373 | 708,073,011.36 | 0.1161 | 11.94 | 10/31/2025 |
| 2 | Avoro Capital Advisor LLC | 5,155,555 | 5,155,555 | 176,938,647.6 | 2.1024 | 2.9836 | 09/30/2025 |
| 3 | Janus Henderson Investors US LLC | 4,321,392 | 29,767 | 148,310,173.44 | 0.0722 | 2.5009 | 09/30/2025 |
| 4 | Fidelity Management & Research Co. LLC | 4,271,011 | -1,508,569 | 146,581,097.52 | 0.0085 | 2.4717 | 09/30/2025 |
| 5 | Deep Track Capital LP | 4,215,811 | 115,811 | 144,686,633.52 | 2.9049 | 2.4398 | 09/30/2025 |
| 6 | BVF Partners LP | 3,203,917 | 1,432,500 | 109,958,431.44 | 3.0874 | 1.8542 | 09/30/2025 |
| 7 | Baker Bros. Advisors LP | 1,556,109 | 1,194,544 | 53,405,660.88 | 0.2769 | 0.9006 | 09/30/2025 |
| 8 | Casdin Capital LLC | 1,555,000 | 855,000 | 53,367,600 | 3.6034 | 0.8999 | 09/30/2025 |
| 9 | RA Capital Management LP | 1,517,418 | 0 | 52,077,785.76 | 0.5357 | 0.8782 | 09/30/2025 |
| 10 | Millennium Management LLC | 1,274,551 | 484,392 | 43,742,590.32 | 0.0357 | 0.7376 | 09/30/2025 |
| 11 | Threadneedle Asset Management Ltd. | 1,126,034 | 49,217 | 38,645,486.88 | 0.0519 | 0.6517 | 09/30/2025 |
| 12 | FIAM LLC | 961,909 | 875,230 | 33,012,716.88 | 0.0177 | 0.5567 | 09/30/2025 |
| 13 | Rock Springs Capital Management LP | 951,154 | -181,825 | 32,643,605.28 | 1.6538 | 0.5505 | 09/30/2025 |
| 14 | Driehaus Capital Management LLC | 873,504 | -399,239 | 29,978,657.28 | 0.1657 | 0.5055 | 09/30/2025 |
| 15 | Logos Global Management LP | 850,000 | 425,000 | 29,172,000 | 2.1983 | 0.4919 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Health Care Fund | 1,990,460 | -2,424,113 | 68,312,587.2 | 0.1638 | 1.1519 | 07/31/2025 |
| 2 | COLUMBIA THREADNEEDLE LUX I - American Smaller Companies | 695,093 | 15,850 | 23,855,591.76 | 1.3394 | 0.4023 | 10/31/2025 |
| 3 | Fidelity Advisor Series I -Growth Opportunities Fund | 619,200 | 109,300 | 21,250,944 | 0.0733 | 0.3583 | 09/30/2025 |
| 4 | Fidelity Select Port. - Health Care Portfolio | 600,000 | -100,000 | 20,592,000 | 0.3075 | 0.3472 | 09/30/2025 |
| 5 | Vanguard Explorer Fund | 582,447 | 0 | 19,989,581.04 | 0.0954 | 0.3371 | 06/30/2025 |
| 6 | FIAM Small Capitalization Core Commingled Pool | 503,900 | 503,900 | 17,293,848 | 0.3726 | 0.2916 | 08/31/2025 |
| 7 | Janus Henderson Triton Fund | 499,717 | 211,064 | 17,150,287.44 | 0.3084 | 0.2892 | 09/30/2025 |
| 8 | Fidelity Stock Selector Small Cap Fund | 477,600 | 271,200 | 16,391,232 | 0.3033 | 0.2764 | 08/31/2025 |
| 9 | Janus Henderson Global Life Sciences Fund | 476,741 | -109,604 | 16,361,751.12 | 0.3113 | 0.2759 | 09/30/2025 |
| 10 | Worldwide Healthcare Trust Plc | 476,000 | 476,000 | 16,336,320 | 0.7728 | 0.2755 | 10/31/2025 |
| 11 | Fidelity Small Cap Growth Fund | 427,449 | 115,669 | 14,670,049.68 | 0.1942 | 0.2474 | 08/31/2025 |
| 12 | Janus Henderson Capital Funds Plc - Global Life Sciences Fund | 395,467 | -64,180 | 13,572,427.44 | 0.3121 | 0.2289 | 09/30/2025 |
| 13 | CT Invt. Fds. UK ICVC - American Smaller Cos. Fund | 395,344 | -18,138 | 13,568,206.08 | 1.3512 | 0.2288 | 10/31/2025 |
| 14 | Principal Funds, Inc. - Small Cap Fund | 394,000 | -17,900 | 13,522,080 | 0.6132 | 0.228 | 09/30/2025 |
| 15 | Fidelity Select Port. - Biotechnology Portfolio | 383,764 | 93,388 | 13,170,780.48 | 0.2564 | 0.2221 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Wellington Management Co. LLP | 20,631,498 | 13,053,373 | 708,073,011.36 | 0.1161 | 11.94 | 10/31/2025 |
| 2 | Avoro Capital Advisor LLC | 5,155,555 | 5,155,555 | 176,938,647.6 | 2.1024 | 2.9836 | 09/30/2025 |
| 3 | BVF Partners LP | 3,203,917 | 1,432,500 | 109,958,431.44 | 3.0874 | 1.8542 | 09/30/2025 |
| 4 | Baker Bros. Advisors LP | 1,556,109 | 1,194,544 | 53,405,660.88 | 0.2769 | 0.9006 | 09/30/2025 |
| 5 | FIAM LLC | 961,909 | 875,230 | 33,012,716.88 | 0.0177 | 0.5567 | 09/30/2025 |
| 6 | Casdin Capital LLC | 1,555,000 | 855,000 | 53,367,600 | 3.6034 | 0.8999 | 09/30/2025 |
| 7 | Pacific Heights Asset Management LLC | 700,000 | 700,000 | 24,024,000 | 1.1106 | 0.4051 | 09/30/2025 |
| 8 | Millennium Management LLC | 1,274,551 | 484,392 | 43,742,590.32 | 0.0357 | 0.7376 | 09/30/2025 |
| 9 | Logos Global Management LP | 850,000 | 425,000 | 29,172,000 | 2.1983 | 0.4919 | 09/30/2025 |
| 10 | Paradigm BioCapital Advisors LP | 372,869 | 372,869 | 12,796,864.08 | 0.2969 | 0.2158 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Capital Research & Management Co. (Global Investors) | 0 | -2,164,145 | 0 | 0 | 0 | |
| 2 | Vestal Point Capital LP | 0 | -1,788,990 | 0 | 0 | 0 | |
| 3 | Capital Research & Management Co. (International Investors) | 0 | -1,619,026 | 0 | 0 | 0 | |
| 4 | Fidelity Management & Research Co. LLC | 4,271,011 | -1,508,569 | 146,581,097.52 | 0.0085 | 2.4717 | 09/30/2025 |
| 5 | Federated Global Investment Management Corp. | 2,500 | -1,168,448 | 85,800 | 0.0007 | 0.0014 | 09/30/2025 |
| 6 | FIL Investments International | 0 | -1,110,193 | 0 | 0 | 0 | |
| 7 | T. Rowe Price Associates, Inc. (IM) | 289,393 | -487,780 | 9,931,967.76 | 0.0012 | 0.1675 | 09/30/2025 |
| 8 | Driehaus Capital Management LLC | 873,504 | -399,239 | 29,978,657.28 | 0.1657 | 0.5055 | 09/30/2025 |
| 9 | Citadel Advisors LLC | 384,201 | -357,064 | 13,185,778.32 | 0.0149 | 0.2223 | 09/30/2025 |
| 10 | Camber Capital Management LP | 0 | -300,000 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.