| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 36,391,063 | 2,668,089 | 586,623,935.56 | 2.9166 | 4.8884 | 12/31/2025 |
| 2 | Fidelity Management & Research Co. LLC | 13,338,535 | 4,113,123 | 215,017,184.2 | 0.0116 | 1.7917 | 12/31/2025 |
| 3 | The Vanguard Group, Inc. | 10,203,794 | 1,651,690 | 164,485,159.28 | 0.0021 | 1.3707 | 12/31/2025 |
| 4 | T. Rowe Price Associates, Inc. (IM) | 9,262,149 | 5,461,471 | 149,305,841.88 | 0.0177 | 1.2442 | 12/31/2025 |
| 5 | SSgA Funds Management, Inc. | 6,636,361 | 2,618,664 | 106,978,139.32 | 0.0034 | 0.8915 | 12/31/2025 |
| 6 | BlackRock Fund Advisors | 6,467,786 | 548,269 | 104,260,710.32 | 0.0021 | 0.8688 | 12/31/2025 |
| 7 | Geode Capital Management LLC | 3,147,480 | 212,665 | 50,737,377.6 | 0.0025 | 0.4228 | 12/31/2025 |
| 8 | Citadel Advisors LLC | 1,860,490 | 1,758,084 | 29,991,098.8 | 0.0291 | 0.2499 | 12/31/2025 |
| 9 | Polymer Capital Management (HK) Ltd. | 1,421,155 | 531,126 | 22,909,018.6 | 3.1645 | 0.1909 | 12/31/2025 |
| 10 | Pictet Asset Management SA | 1,383,775 | -780,098 | 22,306,453 | 0.014 | 0.1859 | 12/31/2025 |
| 11 | Norges Bank Investment Management | 1,373,943 | -15,919 | 22,147,961.16 | 0.0013 | 0.1846 | 12/31/2025 |
| 12 | Apeiron Capital Ltd. (Hong Kong) | 1,309,241 | 108,300 | 21,104,964.92 | 24.197 | 0.1759 | 12/31/2025 |
| 13 | TD Asset Management, Inc. | 1,205,272 | 721,262 | 19,428,984.64 | 0.0095 | 0.1619 | 12/31/2025 |
| 14 | BlackRock Advisors LLC | 1,182,472 | 861,124 | 19,061,448.64 | 0.0082 | 0.1588 | 12/31/2025 |
| 15 | abrdn, Inc. | 927,171 | -212,359 | 14,945,996.52 | 0.1348 | 0.1245 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T Rowe Price Health Sciences Fund | 7,286,202 | 4,538,789 | 117,453,576.24 | 0.974 | 0.9787 | 12/31/2025 |
| 2 | State Street SPDR S&P Biotech ETF | 5,030,235 | 2,616,139 | 81,087,388.2 | 0.9396 | 0.6757 | 01/30/2026 |
| 3 | Vanguard Total Stock Market ETF | 3,538,744 | 1,173,416 | 57,044,553.28 | 0.0027 | 0.4754 | 01/31/2026 |
| 4 | Fidelity Growth Company Commingled Pool | 2,952,615 | 232,959 | 47,596,153.8 | 0.0433 | 0.3966 | 12/31/2025 |
| 5 | Vanguard Small Cap Index Fund | 2,529,333 | 727,679 | 40,772,847.96 | 0.0233 | 0.3398 | 01/31/2026 |
| 6 | Fidelity Growth Company Fund | 2,221,537 | 134,326 | 35,811,176.44 | 0.0435 | 0.2984 | 12/31/2025 |
| 7 | Government Pension Fund - Global (The) | 2,197,266 | 0 | 35,419,927.92 | 0.0022 | 0.2952 | 06/30/2025 |
| 8 | Fidelity Select Port. - Biotechnology Portfolio | 1,731,591 | 99,213 | 27,913,246.92 | 0.5134 | 0.2326 | 12/31/2025 |
| 9 | Vanguard Small Cap Value Index Fund | 1,624,007 | 467,131 | 26,178,992.84 | 0.0405 | 0.2182 | 01/31/2026 |
| 10 | Vanguard Extended Market Index Fund | 1,608,921 | 92,075 | 25,935,806.52 | 0.0299 | 0.2161 | 01/31/2026 |
| 11 | Fidelity Contrafund | 1,544,985 | 1,544,985 | 24,905,158.2 | 0.0142 | 0.2075 | 12/31/2025 |
| 12 | Fidelity Select Port. - Health Care Portfolio | 1,000,000 | 430,000 | 16,120,000 | 0.2548 | 0.1343 | 12/31/2025 |
| 13 | BlackRock Health Sciences Opportunities Portfolio | 931,071 | 703,351 | 15,008,864.52 | 0.2282 | 0.1251 | 01/30/2026 |
| 14 | iShares Russell Mid Cap Growth ETF | 801,103 | 20,202 | 12,913,780.36 | 0.0651 | 0.1076 | 01/30/2026 |
| 15 | Fidelity Extended Market Index Fund | 783,524 | 20,014 | 12,630,406.88 | 0.0306 | 0.1052 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Associates, Inc. (IM) | 9,262,149 | 5,461,471 | 149,305,841.88 | 0.0177 | 1.2442 | 12/31/2025 |
| 2 | Fidelity Management & Research Co. LLC | 13,338,535 | 4,113,123 | 215,017,184.2 | 0.0116 | 1.7917 | 12/31/2025 |
| 3 | Baker Bros. Advisors LP | 36,391,063 | 2,668,089 | 586,623,935.56 | 2.9166 | 4.8884 | 12/31/2025 |
| 4 | SSgA Funds Management, Inc. | 6,636,361 | 2,618,664 | 106,978,139.32 | 0.0034 | 0.8915 | 12/31/2025 |
| 5 | Citadel Advisors LLC | 1,860,490 | 1,758,084 | 29,991,098.8 | 0.0291 | 0.2499 | 12/31/2025 |
| 6 | The Vanguard Group, Inc. | 10,203,794 | 1,651,690 | 164,485,159.28 | 0.0021 | 1.3707 | 12/31/2025 |
| 7 | Vanguard Fiduciary Trust Co. | 893,007 | 861,179 | 14,395,272.84 | 0.0032 | 0.12 | 12/31/2025 |
| 8 | BlackRock Advisors LLC | 1,182,472 | 861,124 | 19,061,448.64 | 0.0082 | 0.1588 | 12/31/2025 |
| 9 | BlackRock Investment Management (UK) Ltd. | 770,488 | 750,955 | 12,420,266.56 | 0.0015 | 0.1035 | 12/31/2025 |
| 10 | TD Asset Management, Inc. | 1,205,272 | 721,262 | 19,428,984.64 | 0.0095 | 0.1619 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | UBS Securities LLC | 800,760 | -1,280,366 | 12,908,251.2 | 0.0052 | 0.1076 | 12/31/2025 |
| 2 | Polar Capital LLP | 0 | -1,000,000 | 0 | 0 | 0 | |
| 3 | Pictet Asset Management SA | 1,383,775 | -780,098 | 22,306,453 | 0.014 | 0.1859 | 12/31/2025 |
| 4 | Fiera Capital, Inc. | 0 | -759,430 | 0 | 0 | 0 | |
| 5 | Rockland Trust Co. | 0 | -400,000 | 0 | 0 | 0 | |
| 6 | Charles Schwab Investment Management, Inc. | 892,629 | -399,042 | 14,389,179.48 | 0.0015 | 0.1199 | 12/31/2025 |
| 7 | Susquehanna Financial Group LLLP | 0 | -299,973 | 0 | 0 | 0 | |
| 8 | Medical Strategy GmbH | 0 | -278,000 | 0 | 0 | 0 | |
| 9 | Marshall Wace LLP | 0 | -271,641 | 0 | 0 | 0 | |
| 10 | Caption Management LLC | 0 | -267,255 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.