| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 36,391,063 | 2,668,089 | 509,838,792.63 | 2.2802 | 4.6886 | 03/31/2026 |
| 2 | Fidelity Management & Research Co. LLC | 10,852,786 | 1,935,818 | 152,047,531.86 | 0.0076 | 1.3983 | 03/31/2026 |
| 3 | T. Rowe Price Associates, Inc. (IM) | 8,153,895 | 3,726,016 | 114,236,068.95 | 0.013 | 1.0505 | 03/31/2026 |
| 4 | SSgA Funds Management, Inc. | 7,028,160 | 666,224 | 98,464,521.6 | 0.0029 | 0.9055 | 03/31/2026 |
| 5 | BlackRock Fund Advisors | 6,661,394 | 438,765 | 93,326,129.94 | 0.0018 | 0.8582 | 03/31/2026 |
| 6 | Vanguard Capital Management LLC | 5,711,802 | 5,711,802 | 80,022,346.02 | 0.0014 | 0.7359 | 03/31/2026 |
| 7 | Vanguard Portfolio Management LLC | 5,233,252 | 5,233,252 | 73,317,860.52 | 0.0034 | 0.6742 | 03/31/2026 |
| 8 | UBS Securities LLC | 3,612,436 | 2,410,669 | 50,610,228.36 | 0.018 | 0.4654 | 03/31/2026 |
| 9 | Geode Capital Management LLC | 3,315,854 | 183,119 | 46,455,114.54 | 0.0021 | 0.4272 | 03/31/2026 |
| 10 | D. E. Shaw & Co. LP | 2,242,229 | 2,111,602 | 31,413,628.29 | 0.0216 | 0.2889 | 03/31/2026 |
| 11 | Morgan Stanley & Co. LLC | 1,488,628 | -264,675 | 20,855,678.28 | 0.0062 | 0.1918 | 03/31/2026 |
| 12 | Norges Bank Investment Management | 1,373,943 | -15,919 | 19,248,941.43 | 0.0011 | 0.177 | 12/31/2025 |
| 13 | Pictet Asset Management SA | 1,323,179 | -280,984 | 18,537,737.79 | 0.0115 | 0.1705 | 03/31/2026 |
| 14 | Apeiron Capital Ltd. (Hong Kong) | 1,309,141 | -1,800 | 18,341,065.41 | 13.7383 | 0.1687 | 03/31/2026 |
| 15 | BlackRock Advisors LLC | 1,175,549 | 767,172 | 16,469,441.49 | 0.0066 | 0.1515 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T Rowe Price Health Sciences Fund | 6,177,431 | 2,903,710 | 86,545,808.31 | 0.7128 | 0.7959 | 03/31/2026 |
| 2 | State Street SPDR S&P Biotech ETF | 5,419,875 | 119,149 | 75,932,448.75 | 0.7978 | 0.6983 | 05/29/2026 |
| 3 | Vanguard Total Stock Market ETF | 3,732,815 | 220,030 | 52,296,738.15 | 0.0023 | 0.4809 | 05/31/2026 |
| 4 | Fidelity Growth Company Commingled Pool | 3,526,036 | 703,804 | 49,399,764.36 | 0.0396 | 0.4543 | 04/30/2026 |
| 5 | Vanguard Small Cap Index Fund | 2,677,877 | 57,888 | 37,517,056.77 | 0.0198 | 0.345 | 05/31/2026 |
| 6 | Fidelity Growth Company Fund | 2,651,037 | 511,159 | 37,141,028.37 | 0.0392 | 0.3416 | 04/30/2026 |
| 7 | Government Pension Fund - Global (The) | 1,790,394 | -406,872 | 25,083,419.94 | 0.0014 | 0.2307 | 12/31/2025 |
| 8 | Vanguard Extended Market Index Fund | 1,746,400 | 161,638 | 24,467,064 | 0.0249 | 0.225 | 05/31/2026 |
| 9 | Vanguard Small Cap Value Index Fund | 1,724,201 | 37,097 | 24,156,056.01 | 0.0354 | 0.2221 | 05/31/2026 |
| 10 | Fidelity Select Port. - Biotechnology Portfolio | 1,067,669 | -663,922 | 14,958,042.69 | 0.2543 | 0.1376 | 04/30/2026 |
| 11 | Fidelity Extended Market Index Fund | 819,398 | 37,179 | 11,479,765.98 | 0.0255 | 0.1056 | 04/30/2026 |
| 12 | Fidelity Select Port. - Health Care Portfolio | 800,000 | -200,000 | 11,208,000 | 0.1748 | 0.1031 | 04/30/2026 |
| 13 | Fidelity Growth Company K6 Fund | 780,965 | 123,937 | 10,941,319.65 | 0.0416 | 0.1006 | 04/30/2026 |
| 14 | iShares Biotechnology ETF | 777,357 | -40,416 | 10,890,771.57 | 0.1261 | 0.1002 | 05/29/2026 |
| 15 | iShares Russell Mid Cap Growth ETF | 772,986 | -17,470 | 10,829,533.86 | 0.0531 | 0.0996 | 05/29/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Capital Management LLC | 5,711,802 | 5,711,802 | 80,022,346.02 | 0.0014 | 0.7359 | 03/31/2026 |
| 2 | Vanguard Portfolio Management LLC | 5,233,252 | 5,233,252 | 73,317,860.52 | 0.0034 | 0.6742 | 03/31/2026 |
| 3 | T. Rowe Price Associates, Inc. (IM) | 8,153,895 | 3,726,016 | 114,236,068.95 | 0.013 | 1.0505 | 03/31/2026 |
| 4 | Baker Bros. Advisors LP | 36,391,063 | 2,668,089 | 509,838,792.63 | 2.2802 | 4.6886 | 03/31/2026 |
| 5 | UBS Securities LLC | 3,612,436 | 2,410,669 | 50,610,228.36 | 0.018 | 0.4654 | 03/31/2026 |
| 6 | D. E. Shaw & Co. LP | 2,242,229 | 2,111,602 | 31,413,628.29 | 0.0216 | 0.2889 | 03/31/2026 |
| 7 | Fidelity Management & Research Co. LLC | 10,852,786 | 1,935,818 | 152,047,531.86 | 0.0076 | 1.3983 | 03/31/2026 |
| 8 | Two Sigma Investments LP | 981,185 | 956,155 | 13,746,401.85 | 0.0102 | 0.1264 | 03/31/2026 |
| 9 | Point72 Asset Management LP | 784,186 | 784,186 | 10,986,445.86 | 0.016 | 0.101 | 03/31/2026 |
| 10 | BlackRock Advisors LLC | 1,175,549 | 767,172 | 16,469,441.49 | 0.0066 | 0.1515 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | The Vanguard Group, Inc. | 0 | -10,441,680 | 0 | 0 | 0 | |
| 2 | Polar Capital LLP | 0 | -746,393 | 0 | 0 | 0 | |
| 3 | Fiera Capital, Inc. | 0 | -742,465 | 0 | 0 | 0 | |
| 4 | Nomura Global Financial Products, Inc. | 313,981 | -734,946 | 4,398,873.81 | 0.0481 | 0.0405 | 03/31/2026 |
| 5 | Polymer Capital Management (HK) Ltd. | 133,034 | -684,242 | 1,863,806.34 | 0.1976 | 0.0171 | 03/31/2026 |
| 6 | Tang Capital Management LLC | 0 | -550,000 | 0 | 0 | 0 | |
| 7 | Capricorn Fund Managers Ltd. | 0 | -496,266 | 0 | 0 | 0 | |
| 8 | abrdn, Inc. | 665,364 | -474,166 | 9,321,749.64 | 0.0804 | 0.0857 | 03/31/2026 |
| 9 | Barclays Bank Plc (Private Banking) | 47,021 | -428,674 | 658,764.21 | 0.0003 | 0.0061 | 03/31/2026 |
| 10 | Goldman Sachs Asset Management LP | 121,385 | -344,661 | 1,700,603.85 | 0.0003 | 0.0156 | 03/31/2026 |
Data provided by FactSet Research Systems Inc.