| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 36,391,063 | 2,668,089 | 683,788,073.77 | 3.2183 | 4.6895 | 12/31/2025 |
| 2 | Fidelity Management & Research Co. LLC | 13,338,535 | 4,421,567 | 250,631,072.65 | 0.0125 | 1.7188 | 12/31/2025 |
| 3 | T. Rowe Price Associates, Inc. (IM) | 9,262,149 | 4,834,270 | 174,035,779.71 | 0.0192 | 1.1935 | 12/31/2025 |
| 4 | BlackRock Fund Advisors | 6,661,394 | 438,765 | 125,167,593.26 | 0.0024 | 0.8584 | 03/31/2026 |
| 5 | SSgA Funds Management, Inc. | 6,636,361 | 274,425 | 124,697,223.19 | 0.0037 | 0.8552 | 12/31/2025 |
| 6 | Vanguard Capital Management LLC | 5,711,802 | 5,711,802 | 107,324,759.58 | 0.0018 | 0.736 | 03/31/2026 |
| 7 | Vanguard Portfolio Management LLC | 5,233,252 | 5,233,252 | 98,332,805.08 | 0.0046 | 0.6744 | 03/31/2026 |
| 8 | UBS Securities LLC | 3,612,436 | 2,410,669 | 67,877,672.44 | 0.0247 | 0.4655 | 03/31/2026 |
| 9 | Geode Capital Management LLC | 3,147,480 | 14,745 | 59,141,149.2 | 0.0028 | 0.4056 | 12/31/2025 |
| 10 | Citadel Advisors LLC | 1,860,490 | 1,860,461 | 34,958,607.1 | 0.0329 | 0.2397 | 12/31/2025 |
| 11 | Polymer Capital Management (HK) Ltd. | 1,421,155 | 603,879 | 26,703,502.45 | 3.2334 | 0.1831 | 12/31/2025 |
| 12 | Norges Bank Investment Management | 1,373,943 | -15,919 | 25,816,388.97 | 0.0015 | 0.1771 | 12/31/2025 |
| 13 | Pictet Asset Management SA | 1,323,179 | -280,984 | 24,862,533.41 | 0.0156 | 0.1705 | 03/31/2026 |
| 14 | Apeiron Capital Ltd. (Hong Kong) | 1,309,141 | -1,800 | 24,598,759.39 | 18.788 | 0.1687 | 03/31/2026 |
| 15 | BlackRock Advisors LLC | 1,175,549 | 767,172 | 22,088,565.71 | 0.0091 | 0.1515 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T Rowe Price Health Sciences Fund | 6,177,431 | 2,903,710 | 116,073,928.49 | 1.0345 | 0.796 | 03/31/2026 |
| 2 | State Street SPDR S&P Biotech ETF | 5,424,733 | 698,121 | 101,930,733.07 | 1.1874 | 0.699 | 04/30/2026 |
| 3 | Vanguard Total Stock Market ETF | 3,756,712 | 247,888 | 70,588,618.48 | 0.0031 | 0.4841 | 03/31/2026 |
| 4 | Fidelity Growth Company Commingled Pool | 3,357,100 | 618,468 | 63,079,909 | 0.0493 | 0.4326 | 03/31/2026 |
| 5 | Vanguard Small Cap Index Fund | 2,689,474 | 65,094 | 50,535,216.46 | 0.0281 | 0.3466 | 03/31/2026 |
| 6 | Fidelity Growth Company Fund | 2,519,237 | 434,859 | 47,336,463.23 | 0.0486 | 0.3246 | 03/31/2026 |
| 7 | Government Pension Fund - Global (The) | 1,790,394 | -406,872 | 33,641,503.26 | 0.0018 | 0.2307 | 12/31/2025 |
| 8 | Vanguard Extended Market Index Fund | 1,725,562 | 145,869 | 32,423,309.98 | 0.0355 | 0.2224 | 03/31/2026 |
| 9 | Vanguard Small Cap Value Index Fund | 1,708,610 | 19,769 | 32,104,781.9 | 0.0503 | 0.2202 | 03/31/2026 |
| 10 | Fidelity Select Port. - Biotechnology Portfolio | 1,089,169 | -668,822 | 20,465,485.51 | 0.3808 | 0.1404 | 03/31/2026 |
| 11 | Fidelity Select Port. - Health Care Portfolio | 1,000,000 | 430,000 | 18,790,000 | 0.3228 | 0.1289 | 03/31/2026 |
| 12 | BlackRock Health Sciences Opportunities Portfolio | 924,148 | 635,195 | 17,364,740.92 | 0.289 | 0.1191 | 03/31/2026 |
| 13 | Fidelity Extended Market Index Fund | 822,391 | 37,934 | 15,452,726.89 | 0.0362 | 0.106 | 03/31/2026 |
| 14 | iShares Biotechnology ETF | 782,857 | 116,800 | 14,709,883.03 | 0.1809 | 0.1009 | 04/30/2026 |
| 15 | iShares Russell Mid Cap Growth ETF | 772,179 | -25,921 | 14,509,243.41 | 0.0741 | 0.0995 | 04/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Capital Management LLC | 5,711,802 | 5,711,802 | 107,324,759.58 | 0.0018 | 0.736 | 03/31/2026 |
| 2 | Vanguard Portfolio Management LLC | 5,233,252 | 5,233,252 | 98,332,805.08 | 0.0046 | 0.6744 | 03/31/2026 |
| 3 | T. Rowe Price Associates, Inc. (IM) | 9,262,149 | 4,834,270 | 174,035,779.71 | 0.0192 | 1.1935 | 12/31/2025 |
| 4 | Fidelity Management & Research Co. LLC | 13,338,535 | 4,421,567 | 250,631,072.65 | 0.0125 | 1.7188 | 12/31/2025 |
| 5 | Baker Bros. Advisors LP | 36,391,063 | 2,668,089 | 683,788,073.77 | 3.2183 | 4.6895 | 12/31/2025 |
| 6 | UBS Securities LLC | 3,612,436 | 2,410,669 | 67,877,672.44 | 0.0247 | 0.4655 | 03/31/2026 |
| 7 | Citadel Advisors LLC | 1,860,490 | 1,860,461 | 34,958,607.1 | 0.0329 | 0.2397 | 12/31/2025 |
| 8 | BlackRock Advisors LLC | 1,175,549 | 767,172 | 22,088,565.71 | 0.0091 | 0.1515 | 03/31/2026 |
| 9 | BlackRock Investment Management (UK) Ltd. | 749,688 | 709,074 | 14,086,637.52 | 0.0016 | 0.0966 | 03/31/2026 |
| 10 | Squarepoint OPS LLC | 715,410 | 605,584 | 13,442,553.9 | 0.0257 | 0.0922 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | The Vanguard Group, Inc. | 0 | -10,441,680 | 0 | 0 | 0 | |
| 2 | Morgan Stanley & Co. LLC | 790,037 | -963,266 | 14,844,795.23 | 0.0048 | 0.1018 | 12/31/2025 |
| 3 | Polar Capital LLP | 0 | -746,393 | 0 | 0 | 0 | |
| 4 | Fiera Capital, Inc. | 0 | -742,465 | 0 | 0 | 0 | |
| 5 | Tang Capital Management LLC | 0 | -550,000 | 0 | 0 | 0 | |
| 6 | Nomura Global Financial Products, Inc. | 542,234 | -506,693 | 10,188,576.86 | 0.0854 | 0.0699 | 12/31/2025 |
| 7 | Capricorn Fund Managers Ltd. | 0 | -496,266 | 0 | 0 | 0 | |
| 8 | abrdn, Inc. | 665,364 | -474,166 | 12,502,189.56 | 0.1107 | 0.0857 | 03/31/2026 |
| 9 | SEB Funds AB | 0 | -338,363 | 0 | 0 | 0 | |
| 10 | Goldman Sachs Asset Management LP | 133,042 | -333,004 | 2,499,859.18 | 0.0005 | 0.0171 | 12/31/2025 |
Data provided by FactSet Research Systems Inc.