| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 32,786,348 | -3,604,715 | 584,908,448.32 | 1.9608 | 4.1099 | 06/30/2026 |
| 2 | Fidelity Management & Research Co. LLC | 10,042,979 | -809,807 | 179,166,745.36 | 0.0089 | 1.2589 | 06/30/2026 |
| 3 | SSgA Funds Management, Inc. | 9,536,796 | 2,508,636 | 170,136,440.64 | 0.0049 | 1.1955 | 06/30/2026 |
| 4 | BlackRock Fund Advisors | 7,565,079 | 903,685 | 134,961,009.36 | 0.0025 | 0.9483 | 06/30/2026 |
| 5 | Vanguard Capital Management LLC | 5,734,484 | 22,682 | 102,303,194.56 | 0.0017 | 0.7188 | 06/30/2026 |
| 6 | UBS Securities LLC | 5,159,918 | 1,547,482 | 92,052,937.12 | 0.0352 | 0.6468 | 06/30/2026 |
| 7 | Vanguard Portfolio Management LLC | 5,042,190 | -191,062 | 89,952,669.6 | 0.0041 | 0.6321 | 06/30/2026 |
| 8 | Goldman Sachs & Co. LLC (Private Banking) | 4,219,688 | 4,030,345 | 75,279,233.92 | 0.0199 | 0.5289 | 06/30/2026 |
| 9 | T. Rowe Price Associates, Inc. (IM) | 3,743,023 | -4,410,872 | 66,775,530.32 | 0.0075 | 0.4692 | 06/30/2026 |
| 10 | Point72 Asset Management LP | 3,697,803 | 2,913,617 | 65,968,805.52 | 0.1062 | 0.4635 | 06/30/2026 |
| 11 | Geode Capital Management LLC | 3,489,224 | 173,370 | 62,247,756.16 | 0.0027 | 0.4374 | 09/30/2026 |
| 12 | Millennium Management LLC | 2,349,081 | 2,222,808 | 41,907,605.04 | 0.0296 | 0.2945 | 06/30/2026 |
| 13 | Adage Capital Management LP | 1,989,591 | 1,989,591 | 35,494,303.44 | 0.0496 | 0.2494 | 06/30/2026 |
| 14 | Balyasny Asset Management LP | 1,904,254 | 1,355,919 | 33,971,891.36 | 0.0652 | 0.2387 | 06/30/2026 |
| 15 | Citadel Securities LLC | 1,725,716 | 1,376,673 | 30,786,773.44 | 0.0762 | 0.2163 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Morningstar Total Stock Market Index Fund | 5,120,666 | 1,352,205 | 91,352,681.44 | 0.004 | 0.6419 | 09/30/2026 |
| 2 | State Street SPDR S&P Biotech ETF | 3,900,811 | -1,523,922 | 69,590,468.24 | 0.6372 | 0.489 | 10/30/2026 |
| 3 | Vanguard Morningstar Small-Cap Index Fund | 3,593,738 | 915,105 | 64,112,285.92 | 0.035 | 0.4505 | 09/30/2026 |
| 4 | T Rowe Price Health Sciences Fund | 3,354,831 | -2,822,600 | 59,850,185.04 | 0.4503 | 0.4205 | 09/30/2026 |
| 5 | Fidelity Growth Company Commingled Pool | 2,733,383 | -792,653 | 48,763,552.72 | 0.04 | 0.3426 | 09/30/2026 |
| 6 | Vanguard Morningstar Small-Cap Value Index Fund | 2,337,222 | 616,435 | 41,696,040.48 | 0.0607 | 0.293 | 09/30/2026 |
| 7 | BB Biotech AG | 2,100,000 | 2,100,000 | 37,464,000 | 0.8825 | 0.2632 | 09/30/2026 |
| 8 | Fidelity Growth Company Fund | 2,047,862 | -603,175 | 36,533,858.08 | 0.0394 | 0.2567 | 09/30/2026 |
| 9 | Vanguard Extended Market Index Fund | 1,802,700 | 63,538 | 32,160,168 | 0.0345 | 0.226 | 09/30/2026 |
| 10 | iShares Biotechnology ETF | 1,190,283 | 407,426 | 21,234,648.72 | 0.1831 | 0.1492 | 10/30/2026 |
| 11 | abrdn Healthcare Investors | 1,062,820 | 460,382 | 18,960,708.8 | 1.4321 | 0.1332 | 09/30/2026 |
| 12 | Fidelity Select Port. - Biotechnology Portfolio | 1,002,469 | -65,200 | 17,884,046.96 | 0.2872 | 0.1257 | 09/30/2026 |
| 13 | Franklin Biotechnology Discovery Fund | 808,977 | 808,977 | 14,432,149.68 | 0.4501 | 0.1014 | 09/30/2026 |
| 14 | iShares Russell Mid Cap Growth ETF | 782,056 | 9,877 | 13,951,879.04 | 0.0769 | 0.098 | 10/30/2026 |
| 15 | Fidelity Select Port. - Health Care Portfolio | 750,000 | -50,000 | 13,380,000 | 0.1858 | 0.094 | 09/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Goldman Sachs & Co. LLC (Private Banking) | 4,219,688 | 4,030,345 | 75,279,233.92 | 0.0199 | 0.5289 | 06/30/2026 |
| 2 | Point72 Asset Management LP | 3,697,803 | 2,913,617 | 65,968,805.52 | 0.1062 | 0.4635 | 06/30/2026 |
| 3 | SSgA Funds Management, Inc. | 9,536,796 | 2,508,636 | 170,136,440.64 | 0.0049 | 1.1955 | 06/30/2026 |
| 4 | Millennium Management LLC | 2,349,081 | 2,222,808 | 41,907,605.04 | 0.0296 | 0.2945 | 06/30/2026 |
| 5 | Adage Capital Management LP | 1,989,591 | 1,989,591 | 35,494,303.44 | 0.0496 | 0.2494 | 06/30/2026 |
| 6 | UBS Securities LLC | 5,159,918 | 1,547,482 | 92,052,937.12 | 0.0352 | 0.6468 | 06/30/2026 |
| 7 | Citadel Securities LLC | 1,725,716 | 1,376,673 | 30,786,773.44 | 0.0762 | 0.2163 | 06/30/2026 |
| 8 | Balyasny Asset Management LP | 1,904,254 | 1,355,919 | 33,971,891.36 | 0.0652 | 0.2387 | 06/30/2026 |
| 9 | Logos Global Management LP | 1,350,000 | 1,350,000 | 24,084,000 | 1.1992 | 0.1692 | 06/30/2026 |
| 10 | Octagon Capital Advisors LP | 1,250,000 | 1,250,000 | 22,300,000 | 2.7519 | 0.1567 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Associates, Inc. (IM) | 3,743,023 | -4,410,872 | 66,775,530.32 | 0.0075 | 0.4692 | 06/30/2026 |
| 2 | Baker Bros. Advisors LP | 32,786,348 | -3,604,715 | 584,908,448.32 | 1.9608 | 4.1099 | 06/30/2026 |
| 3 | Apeiron Capital Ltd. (Hong Kong) | 0 | -1,309,141 | 0 | 0 | 0 | |
| 4 | D. E. Shaw & Co. LP | 1,243,556 | -998,673 | 22,185,039.04 | 0.0144 | 0.1559 | 06/30/2026 |
| 5 | Superstring Capital Management LP | 0 | -892,873 | 0 | 0 | 0 | |
| 6 | Fidelity Management & Research Co. LLC | 10,042,979 | -809,807 | 179,166,745.36 | 0.0089 | 1.2589 | 06/30/2026 |
| 7 | BlackRock Advisors LLC | 475,301 | -700,248 | 8,479,369.84 | 0.0033 | 0.0596 | 06/30/2026 |
| 8 | TD Asset Management, Inc. | 426,084 | -530,810 | 7,601,338.56 | 0.0036 | 0.0534 | 06/30/2026 |
| 9 | BlackRock Investment Management (UK) Ltd. | 297,618 | -452,070 | 5,309,505.12 | 0.0006 | 0.0373 | 06/30/2026 |
| 10 | Tudor Investment Corp. | 0 | -384,988 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.