| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 33,722,974 | 9,298,109 | 599,594,477.72 | 2.9881 | 4.53 | 09/30/2025 |
| 2 | The Vanguard Group, Inc. | 10,441,680 | -1,026,290 | 185,653,070.4 | 0.0025 | 1.4026 | 09/30/2025 |
| 3 | Fidelity Management & Research Co. LLC | 8,916,968 | -392,647 | 158,543,691.04 | 0.0087 | 1.1978 | 09/30/2025 |
| 4 | SSgA Funds Management, Inc. | 6,361,936 | 1,510,548 | 113,115,222.08 | 0.0037 | 0.8546 | 09/30/2025 |
| 5 | BlackRock Fund Advisors | 6,222,629 | -1,283,297 | 110,638,343.62 | 0.0024 | 0.8359 | 09/30/2025 |
| 6 | T. Rowe Price Associates, Inc. (IM) | 4,427,879 | -2,027,814 | 78,727,688.62 | 0.009 | 0.5948 | 09/30/2025 |
| 7 | Geode Capital Management LLC | 3,132,735 | -152,147 | 55,700,028.3 | 0.0029 | 0.4208 | 09/30/2025 |
| 8 | Morgan Stanley & Co. LLC | 1,753,303 | 1,441,574 | 31,173,727.34 | 0.0106 | 0.2355 | 09/30/2025 |
| 9 | Pictet Asset Management SA | 1,604,163 | -1,057,441 | 28,522,018.14 | 0.0182 | 0.2155 | 09/30/2025 |
| 10 | Norges Bank Investment Management | 1,389,862 | 1,289,862 | 24,711,746.36 | 0.0016 | 0.1867 | 06/30/2025 |
| 11 | Apeiron Capital Ltd. (Hong Kong) | 1,310,941 | 1,310,941 | 23,308,530.98 | 12.1025 | 0.1761 | 09/30/2025 |
| 12 | UBS Securities LLC | 1,201,767 | -50,813 | 21,367,417.26 | 0.0086 | 0.1614 | 09/30/2025 |
| 13 | abrdn, Inc. | 1,139,530 | -61,280 | 20,260,843.4 | 0.1873 | 0.1531 | 09/30/2025 |
| 14 | Nomura Global Financial Products, Inc. | 1,048,927 | 1,048,927 | 18,649,922.06 | 0.1254 | 0.1409 | 09/30/2025 |
| 15 | Charles Schwab Investment Management, Inc. | 876,390 | -584,327 | 15,582,214.2 | 0.0018 | 0.1177 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | State Street SPDR S&P Biotech ETF | 5,300,726 | 2,672,804 | 94,246,908.28 | 1.1269 | 0.712 | 11/28/2025 |
| 2 | Vanguard Total Stock Market ETF | 3,512,785 | -40,194 | 62,457,317.3 | 0.003 | 0.4719 | 11/30/2025 |
| 3 | T Rowe Price Health Sciences Fund | 3,273,721 | 3,273,721 | 58,206,759.38 | 0.4616 | 0.4398 | 09/30/2025 |
| 4 | Fidelity Growth Company Commingled Pool | 2,822,232 | 233,073 | 50,179,284.96 | 0.0466 | 0.3791 | 11/30/2025 |
| 5 | Vanguard Small Cap Index Fund | 2,619,989 | -173,480 | 46,583,404.42 | 0.0278 | 0.3519 | 11/30/2025 |
| 6 | Fidelity Contrafund | 2,248,185 | 1,886,339 | 39,972,729.3 | 0.0227 | 0.302 | 11/30/2025 |
| 7 | Government Pension Fund - Global (The) | 2,197,266 | 1,947,266 | 39,067,389.48 | 0.0025 | 0.2952 | 06/30/2025 |
| 8 | Fidelity Growth Company Fund | 2,139,878 | 140,738 | 38,047,030.84 | 0.0474 | 0.2874 | 11/30/2025 |
| 9 | Fidelity Select Port. - Biotechnology Portfolio | 1,731,591 | 4,113 | 30,787,687.98 | 0.5797 | 0.2326 | 11/30/2025 |
| 10 | Vanguard Small Cap Value Index Fund | 1,687,104 | -107,167 | 29,996,709.12 | 0.0491 | 0.2266 | 11/30/2025 |
| 11 | Vanguard Extended Market Index Fund | 1,584,762 | -597,897 | 28,177,068.36 | 0.0329 | 0.2129 | 11/30/2025 |
| 12 | Fidelity Select Port. - Health Care Portfolio | 1,000,000 | 430,000 | 17,780,000 | 0.272 | 0.1343 | 11/30/2025 |
| 13 | Fidelity Contrafund Commingled Pool | 835,576 | 702,273 | 14,856,541.28 | 0.0231 | 0.1122 | 11/30/2025 |
| 14 | iShares Biotechnology ETF | 817,773 | 122,068 | 14,540,003.94 | 0.168 | 0.1099 | 11/28/2025 |
| 15 | iShares Russell Mid Cap Growth ETF | 790,456 | 790,456 | 14,054,307.68 | 0.0698 | 0.1062 | 11/28/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 33,722,974 | 9,298,109 | 599,594,477.72 | 2.9881 | 4.53 | 09/30/2025 |
| 2 | SSgA Funds Management, Inc. | 6,361,936 | 1,510,548 | 113,115,222.08 | 0.0037 | 0.8546 | 09/30/2025 |
| 3 | Morgan Stanley & Co. LLC | 1,753,303 | 1,441,574 | 31,173,727.34 | 0.0106 | 0.2355 | 09/30/2025 |
| 4 | Apeiron Capital Ltd. (Hong Kong) | 1,310,941 | 1,310,941 | 23,308,530.98 | 12.1025 | 0.1761 | 09/30/2025 |
| 5 | Norges Bank Investment Management | 1,389,862 | 1,289,862 | 24,711,746.36 | 0.0016 | 0.1867 | 06/30/2025 |
| 6 | Nomura Global Financial Products, Inc. | 1,048,927 | 1,048,927 | 18,649,922.06 | 0.1254 | 0.1409 | 09/30/2025 |
| 7 | Vanguard Fiduciary Trust Co. | 847,166 | 762,239 | 15,062,611.48 | 0.0035 | 0.1138 | 09/30/2025 |
| 8 | Polar Capital LLP | 746,393 | 746,393 | 13,270,867.54 | 0.0362 | 0.1003 | 09/30/2025 |
| 9 | Fiera Capital, Inc. | 742,465 | 742,465 | 13,201,027.7 | 0.1522 | 0.0997 | 09/30/2025 |
| 10 | Tang Capital Management LLC | 550,000 | 550,000 | 9,779,000 | 0.2929 | 0.0739 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Associates, Inc. (IM) | 4,427,879 | -2,027,814 | 78,727,688.62 | 0.009 | 0.5948 | 09/30/2025 |
| 2 | Balyasny Asset Management LP | 194,851 | -1,508,329 | 3,464,450.78 | 0.0069 | 0.0262 | 09/30/2025 |
| 3 | BlackRock Fund Advisors | 6,222,629 | -1,283,297 | 110,638,343.62 | 0.0024 | 0.8359 | 09/30/2025 |
| 4 | BNP Paribas Financial Markets | 29,176 | -1,069,313 | 518,749.28 | 0.0004 | 0.0039 | 09/30/2025 |
| 5 | Pictet Asset Management SA | 1,604,163 | -1,057,441 | 28,522,018.14 | 0.0182 | 0.2155 | 09/30/2025 |
| 6 | The Vanguard Group, Inc. | 10,441,680 | -1,026,290 | 185,653,070.4 | 0.0025 | 1.4026 | 09/30/2025 |
| 7 | Citadel Advisors LLC | 29 | -894,697 | 515.62 | 0 | 0 | 09/30/2025 |
| 8 | Millennium Management LLC | 120,514 | -766,495 | 2,142,738.92 | 0.0017 | 0.0162 | 09/30/2025 |
| 9 | Charles Schwab Investment Management, Inc. | 876,390 | -584,327 | 15,582,214.2 | 0.0018 | 0.1177 | 09/30/2025 |
| 10 | Adage Capital Management LP | 0 | -538,000 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.