| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 33,722,974 | 9,298,109 | 628,596,235.36 | 3.5681 | 4.5715 | 06/30/2025 |
| 2 | Fidelity Management & Research Co. LLC | 9,225,412 | -84,203 | 171,961,679.68 | 0.0094 | 1.2506 | 06/30/2025 |
| 3 | The Vanguard Group, Inc. | 8,552,104 | -2,915,866 | 159,411,218.56 | 0.0021 | 1.1593 | 06/30/2025 |
| 4 | BlackRock Fund Advisors | 5,919,517 | -1,586,409 | 110,339,796.88 | 0.0024 | 0.8025 | 06/30/2025 |
| 5 | SSgA Funds Management, Inc. | 4,017,697 | -833,691 | 74,889,872.08 | 0.0025 | 0.5446 | 06/30/2025 |
| 6 | T. Rowe Price Associates, Inc. (IM) | 3,800,678 | -2,655,015 | 70,844,637.92 | 0.0081 | 0.5152 | 06/30/2025 |
| 7 | Geode Capital Management LLC | 2,934,815 | -350,067 | 54,704,951.6 | 0.0029 | 0.3978 | 06/30/2025 |
| 8 | Pictet Asset Management SA | 2,163,873 | -497,731 | 40,334,592.72 | 0.0259 | 0.2933 | 06/30/2025 |
| 9 | UBS Securities LLC | 2,081,126 | 828,546 | 38,792,188.64 | 0.0159 | 0.2821 | 06/30/2025 |
| 10 | Norges Bank Investment Management | 1,389,862 | 1,289,862 | 25,907,027.68 | 0.0017 | 0.1884 | 06/30/2025 |
| 11 | Apeiron Capital Ltd. (Hong Kong) | 1,310,941 | 1,310,941 | 24,435,940.24 | 11.593 | 0.1777 | 09/30/2025 |
| 12 | Charles Schwab Investment Management, Inc. | 1,291,671 | -169,046 | 24,076,747.44 | 0.0028 | 0.1751 | 06/30/2025 |
| 13 | abrdn, Inc. | 1,139,530 | -61,280 | 21,240,839.2 | 0.2016 | 0.1545 | 06/30/2025 |
| 14 | Polar Capital LLP | 1,000,000 | 1,000,000 | 18,640,000 | 0.0495 | 0.1356 | 06/30/2025 |
| 15 | Polymer Capital Management (HK) Ltd. | 890,029 | 493,854 | 16,590,140.56 | 2.0755 | 0.1207 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | SPDR S&P Biotech ETF | 4,379,690 | 1,565,229 | 81,637,421.6 | 1.2791 | 0.5937 | 09/30/2025 |
| 2 | Vanguard Total Stock Market ETF | 3,557,066 | 59,484 | 66,303,710.24 | 0.0032 | 0.4822 | 09/30/2025 |
| 3 | T Rowe Price Health Sciences Fund | 3,273,721 | 3,273,721 | 61,022,159.44 | 0.5157 | 0.4438 | 09/30/2025 |
| 4 | Fidelity Growth Company Commingled Pool | 2,719,656 | 426,093 | 50,694,387.84 | 0.0463 | 0.3687 | 08/31/2025 |
| 5 | Vanguard Small Cap Index Fund | 2,638,380 | -119,763 | 49,179,403.2 | 0.03 | 0.3577 | 09/30/2025 |
| 6 | Government Pension Fund - Global (The) | 2,197,266 | 1,947,266 | 40,957,038.24 | 0.0026 | 0.2979 | 06/30/2025 |
| 7 | Fidelity Growth Company Fund | 2,087,211 | 306,534 | 38,905,613.04 | 0.0479 | 0.2829 | 08/31/2025 |
| 8 | Vanguard Small Cap Value Index Fund | 1,691,239 | -98,888 | 31,524,694.96 | 0.0536 | 0.2293 | 09/30/2025 |
| 9 | Vanguard Extended Market Index Fund | 1,585,024 | -570,785 | 29,544,847.36 | 0.0346 | 0.2149 | 09/30/2025 |
| 10 | Fidelity Select Port. - Biotechnology Portfolio | 1,468,678 | -779,280 | 27,376,157.92 | 0.5555 | 0.1991 | 08/31/2025 |
| 11 | Polar Capital Funds Plc - Biotechnology Fund | 1,000,000 | 813,853 | 18,640,000 | 0.7506 | 0.1356 | 08/29/2025 |
| 12 | Pictet - Biotech | 978,826 | 0 | 18,245,316.64 | 1.0875 | 0.1327 | 03/31/2025 |
| 13 | iShares Russell Mid Cap Growth ETF | 795,643 | 795,643 | 14,830,785.52 | 0.0725 | 0.1079 | 09/30/2025 |
| 14 | Fidelity Extended Market Index Fund | 765,248 | -10,806 | 14,264,222.72 | 0.0341 | 0.1037 | 08/31/2025 |
| 15 | abrdn Healthcare Investors | 745,674 | -93,212 | 13,899,363.36 | 1.1365 | 0.1011 | 08/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 33,722,974 | 9,298,109 | 628,596,235.36 | 3.5681 | 4.5715 | 06/30/2025 |
| 2 | Apeiron Capital Ltd. (Hong Kong) | 1,310,941 | 1,310,941 | 24,435,940.24 | 11.593 | 0.1777 | 09/30/2025 |
| 3 | Norges Bank Investment Management | 1,389,862 | 1,289,862 | 25,907,027.68 | 0.0017 | 0.1884 | 06/30/2025 |
| 4 | Polar Capital LLP | 1,000,000 | 1,000,000 | 18,640,000 | 0.0495 | 0.1356 | 06/30/2025 |
| 5 | UBS Securities LLC | 2,081,126 | 828,546 | 38,792,188.64 | 0.0159 | 0.2821 | 06/30/2025 |
| 6 | Fiera Capital, Inc. | 759,430 | 759,430 | 14,155,775.2 | 0.1594 | 0.1029 | 06/30/2025 |
| 7 | Capricorn Fund Managers Ltd. | 496,266 | 496,266 | 9,250,398.24 | 2.1117 | 0.0673 | 09/30/2025 |
| 8 | Polymer Capital Management (HK) Ltd. | 890,029 | 493,854 | 16,590,140.56 | 2.0755 | 0.1207 | 06/30/2025 |
| 9 | Rockland Trust Co. | 400,000 | 400,000 | 7,456,000 | 0.3436 | 0.0542 | 06/30/2025 |
| 10 | Squarepoint OPS LLC | 291,222 | 291,222 | 5,428,378.08 | 0.0112 | 0.0395 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | The Vanguard Group, Inc. | 8,552,104 | -2,915,866 | 159,411,218.56 | 0.0021 | 1.1593 | 06/30/2025 |
| 2 | T. Rowe Price Associates, Inc. (IM) | 3,800,678 | -2,655,015 | 70,844,637.92 | 0.0081 | 0.5152 | 06/30/2025 |
| 3 | Balyasny Asset Management LP | 0 | -1,703,180 | 0 | 0 | 0 | |
| 4 | BlackRock Fund Advisors | 5,919,517 | -1,586,409 | 110,339,796.88 | 0.0024 | 0.8025 | 06/30/2025 |
| 5 | BNP Paribas Financial Markets | 29,844 | -1,068,645 | 556,292.16 | 0.0004 | 0.004 | 06/30/2025 |
| 6 | SSgA Funds Management, Inc. | 4,017,697 | -833,691 | 74,889,872.08 | 0.0025 | 0.5446 | 06/30/2025 |
| 7 | Citadel Advisors LLC | 102,406 | -792,320 | 1,908,847.84 | 0.0021 | 0.0139 | 06/30/2025 |
| 8 | Adage Capital Management LP | 0 | -538,000 | 0 | 0 | 0 | |
| 9 | Pictet Asset Management SA | 2,163,873 | -497,731 | 40,334,592.72 | 0.0259 | 0.2933 | 06/30/2025 |
| 10 | Cutter Capital Management LP | 0 | -400,000 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.