| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Baker Bros. Advisors LP | 36,391,063 | 0 | 549,505,051.3 | 2.2057 | 4.5617 | 03/31/2026 |
| 2 | Fidelity Management & Research Co. LLC | 10,852,786 | -2,485,749 | 163,877,068.6 | 0.0079 | 1.3604 | 03/31/2026 |
| 3 | SSgA Funds Management, Inc. | 9,536,796 | 2,900,435 | 144,005,619.6 | 0.004 | 1.1955 | 06/30/2026 |
| 4 | T. Rowe Price Associates, Inc. (IM) | 8,153,895 | -1,108,254 | 123,123,814.5 | 0.0132 | 1.0221 | 03/31/2026 |
| 5 | BlackRock Fund Advisors | 7,565,079 | 1,097,293 | 114,232,692.9 | 0.0021 | 0.9483 | 06/30/2026 |
| 6 | Vanguard Capital Management LLC | 5,711,802 | 5,711,802 | 86,248,210.2 | 0.0014 | 0.716 | 03/31/2026 |
| 7 | Vanguard Portfolio Management LLC | 5,233,252 | 5,233,252 | 79,022,105.2 | 0.0035 | 0.656 | 03/31/2026 |
| 8 | UBS Securities LLC | 3,612,436 | 2,811,676 | 54,547,783.6 | 0.0189 | 0.4528 | 03/31/2026 |
| 9 | Geode Capital Management LLC | 3,427,263 | 279,783 | 51,751,671.3 | 0.0022 | 0.4296 | 06/30/2026 |
| 10 | D. E. Shaw & Co. LP | 2,242,229 | 1,826,945 | 33,857,657.9 | 0.0225 | 0.2811 | 03/31/2026 |
| 11 | abrdn, Inc. | 1,693,626 | 766,455 | 25,573,752.6 | 0.2222 | 0.2123 | 06/30/2026 |
| 12 | Morgan Stanley & Co. LLC | 1,488,628 | 698,591 | 22,478,282.8 | 0.0065 | 0.1866 | 03/31/2026 |
| 13 | Norges Bank Investment Management | 1,382,519 | 8,576 | 20,876,036.9 | 0.0012 | 0.1733 | 06/30/2026 |
| 14 | Pictet Asset Management SA | 1,134,299 | -249,476 | 17,127,914.9 | 0.0105 | 0.1422 | 06/30/2026 |
| 15 | Two Sigma Investments LP | 981,185 | 402,937 | 14,815,893.5 | 0.0106 | 0.123 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | State Street SPDR S&P Biotech ETF | 7,318,128 | 2,287,893 | 110,503,732.8 | 1.065 | 0.9173 | 07/31/2026 |
| 2 | Vanguard Morningstar Total Stock Market Index Fund | 3,708,976 | 170,232 | 56,005,537.6 | 0.0024 | 0.4649 | 06/30/2026 |
| 3 | Fidelity Growth Company Commingled Pool | 3,528,583 | 470,229 | 53,281,603.3 | 0.0407 | 0.4423 | 06/30/2026 |
| 4 | Vanguard Morningstar Small-Cap Index Fund | 2,673,084 | 143,751 | 40,363,568.4 | 0.0209 | 0.3351 | 06/30/2026 |
| 5 | Fidelity Growth Company Fund | 2,649,462 | 366,225 | 40,006,876.2 | 0.0401 | 0.3321 | 06/30/2026 |
| 6 | T Rowe Price Health Sciences Fund | 2,531,231 | -4,754,971 | 38,221,588.1 | 0.308 | 0.3173 | 06/30/2026 |
| 7 | Government Pension Fund - Global (The) | 1,790,394 | 0 | 27,034,949.4 | 0.0014 | 0.2244 | 12/31/2025 |
| 8 | Vanguard Extended Market Index Fund | 1,777,877 | 168,956 | 26,845,942.7 | 0.0263 | 0.2229 | 06/30/2026 |
| 9 | Vanguard Morningstar Small-Cap Value Index Fund | 1,691,686 | 67,679 | 25,544,458.6 | 0.0366 | 0.2121 | 06/30/2026 |
| 10 | Fidelity Select Port. - Biotechnology Portfolio | 1,067,669 | -663,922 | 16,121,801.9 | 0.2686 | 0.1338 | 06/30/2026 |
| 11 | abrdn Healthcare Investors | 1,062,820 | 460,382 | 16,048,582 | 1.1192 | 0.1332 | 07/31/2026 |
| 12 | iShares Biotechnology ETF | 987,912 | 231,304 | 14,917,471.2 | 0.1505 | 0.1238 | 07/31/2026 |
| 13 | Fidelity Select Port. - Health Care Portfolio | 800,000 | -200,000 | 12,080,000 | 0.1817 | 0.1003 | 06/30/2026 |
| 14 | Fidelity Extended Market Index Fund | 797,217 | 32,119 | 12,037,976.7 | 0.0277 | 0.0999 | 06/30/2026 |
| 15 | Fidelity Growth Company K6 Fund | 782,193 | 90,746 | 11,811,114.3 | 0.0424 | 0.098 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Vanguard Capital Management LLC | 5,711,802 | 5,711,802 | 86,248,210.2 | 0.0014 | 0.716 | 03/31/2026 |
| 2 | Vanguard Portfolio Management LLC | 5,233,252 | 5,233,252 | 79,022,105.2 | 0.0035 | 0.656 | 03/31/2026 |
| 3 | SSgA Funds Management, Inc. | 9,536,796 | 2,900,435 | 144,005,619.6 | 0.004 | 1.1955 | 06/30/2026 |
| 4 | UBS Securities LLC | 3,612,436 | 2,811,676 | 54,547,783.6 | 0.0189 | 0.4528 | 03/31/2026 |
| 5 | D. E. Shaw & Co. LP | 2,242,229 | 1,826,945 | 33,857,657.9 | 0.0225 | 0.2811 | 03/31/2026 |
| 6 | BlackRock Fund Advisors | 7,565,079 | 1,097,293 | 114,232,692.9 | 0.0021 | 0.9483 | 06/30/2026 |
| 7 | Superstring Capital Management LP | 892,873 | 892,873 | 13,482,382.3 | 7.5506 | 0.1119 | 03/31/2026 |
| 8 | Point72 Asset Management LP | 784,186 | 784,186 | 11,841,208.6 | 0.0169 | 0.0983 | 03/31/2026 |
| 9 | abrdn, Inc. | 1,693,626 | 766,455 | 25,573,752.6 | 0.2222 | 0.2123 | 06/30/2026 |
| 10 | Morgan Stanley & Co. LLC | 1,488,628 | 698,591 | 22,478,282.8 | 0.0065 | 0.1866 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | The Vanguard Group, Inc. | 0 | -10,203,794 | 0 | 0 | 0 | |
| 2 | Fidelity Management & Research Co. LLC | 10,852,786 | -2,485,749 | 163,877,068.6 | 0.0079 | 1.3604 | 03/31/2026 |
| 3 | Citadel Advisors LLC | 92,700 | -1,767,790 | 1,399,770 | 0.0012 | 0.0116 | 03/31/2026 |
| 4 | Polymer Capital Management (HK) Ltd. | 133,034 | -1,288,121 | 2,008,813.4 | 0.2098 | 0.0167 | 03/31/2026 |
| 5 | T. Rowe Price Associates, Inc. (IM) | 8,153,895 | -1,108,254 | 123,123,814.5 | 0.0132 | 1.0221 | 03/31/2026 |
| 6 | TD Asset Management, Inc. | 426,084 | -779,188 | 6,433,868.4 | 0.003 | 0.0534 | 06/30/2026 |
| 7 | BlackRock Advisors LLC | 475,301 | -707,171 | 7,177,045.1 | 0.0027 | 0.0596 | 06/30/2026 |
| 8 | BlackRock Investment Management (UK) Ltd. | 297,618 | -472,870 | 4,494,031.8 | 0.0005 | 0.0373 | 06/30/2026 |
| 9 | Sculptor Capital LP | 0 | -356,900 | 0 | 0 | 0 | |
| 10 | Apeiron Capital Ltd. (Hong Kong) | 961,866 | -347,375 | 14,524,176.6 | 10.8598 | 0.1206 | 06/30/2026 |
Data provided by FactSet Research Systems Inc.