| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Capital Research & Management Co. (World Investors) | 6,036,185 | 27,766 | 158,872,389.2 | 0.0158 | 5.4009 | 06/30/2025 |
| 2 | RTW Investments LP | 5,536,876 | 2,400,196 | 145,730,576.32 | 1.5476 | 4.9541 | 06/30/2025 |
| 3 | Fidelity Management & Research Co. LLC | 4,724,362 | 206,804 | 124,345,207.84 | 0.0069 | 4.2271 | 06/30/2025 |
| 4 | ClearBridge Investments LLC | 4,011,956 | 732,389 | 105,594,681.92 | 0.0756 | 3.5897 | 06/30/2025 |
| 5 | Janus Henderson Investors US LLC | 2,193,181 | -1,614,754 | 57,724,523.92 | 0.0271 | 1.9624 | 06/30/2025 |
| 6 | BAMCO, Inc. | 1,587,814 | -241,680 | 41,791,264.48 | 0.0996 | 1.4207 | 06/30/2025 |
| 7 | FIAM LLC | 1,310,361 | -387,509 | 34,488,701.52 | 0.0186 | 1.1724 | 06/30/2025 |
| 8 | Woodline Partners LP | 1,201,016 | 0 | 31,610,741.12 | 0.1498 | 1.0746 | 06/30/2025 |
| 9 | Wellington Management Co. LLP | 1,058,838 | -1,935,243 | 27,868,616.16 | 0.0045 | 0.9474 | 06/30/2025 |
| 10 | Allianz Global Investors Asia Pacific Ltd. | 932,000 | -936,469 | 24,530,240 | 0.2666 | 0.8339 | 06/30/2025 |
| 11 | Rock Springs Capital Management LP | 871,392 | -33,200 | 22,935,037.44 | 1.1557 | 0.7797 | 06/30/2025 |
| 12 | Adar1 Capital Management LLC | 850,437 | -90,421 | 22,383,501.84 | 2.2776 | 0.7609 | 06/30/2025 |
| 13 | Jennison Associates LLC | 592,332 | -119,968 | 15,590,178.24 | 0.0081 | 0.53 | 06/30/2025 |
| 14 | C WorldWide Asset Management Fondsmaeglerselskab A/S | 510,000 | 50,000 | 13,423,200 | 0.1203 | 0.4563 | 06/30/2025 |
| 15 | C Worldwide Asset Management Fondsmaeglerselskab A/S (Sweden) | 510,000 | 10,000 | 13,423,200 | 0.7858 | 0.4563 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | American Funds New World Fund | 3,274,106 | 0 | 86,174,469.92 | 0.1219 | 2.9295 | 09/30/2025 |
| 2 | American Funds Small Cap World Fund | 2,083,023 | 0 | 54,825,165.36 | 0.0686 | 1.8638 | 09/30/2025 |
| 3 | Fidelity Contrafund | 1,658,656 | 463,468 | 43,655,825.92 | 0.0246 | 1.4841 | 08/31/2025 |
| 4 | ClearBridge International Growth Fund | 1,629,746 | -26,363 | 42,894,914.72 | 0.5829 | 1.4582 | 09/30/2025 |
| 5 | Government Pension Fund - Global (The) | 1,308,703 | -180,950 | 34,445,062.96 | 0.0022 | 1.171 | 06/30/2025 |
| 6 | Baron Emerging Markets Fund | 1,146,339 | -190,051 | 30,171,642.48 | 0.7862 | 1.0257 | 08/31/2025 |
| 7 | T Rowe Price Health Sciences Fund | 737,906 | -1,035,128 | 19,421,685.92 | 0.1653 | 0.6602 | 09/30/2025 |
| 8 | Allianz Global Investors Fund - Oriental Income | 712,000 | -71,000 | 18,739,840 | 1.4626 | 0.6371 | 06/30/2025 |
| 9 | Fidelity Contrafund Commingled Pool | 638,885 | 188,612 | 16,815,453.2 | 0.0261 | 0.5716 | 08/31/2025 |
| 10 | Janus Henderson Global Life Sciences Fund | 610,394 | -189,404 | 16,065,570.08 | 0.3191 | 0.5462 | 06/30/2025 |
| 11 | Fidelity Growth Company Commingled Pool | 510,501 | 164,637 | 13,436,386.32 | 0.0125 | 0.4568 | 08/31/2025 |
| 12 | C Worldwide - Healthcare Select | 510,000 | 10,000 | 13,423,200 | 1.7373 | 0.4563 | 06/30/2025 |
| 13 | Janus Henderson Capital Funds Plc - Global Life Sciences Fund | 492,859 | -154,934 | 12,972,048.88 | 0.3185 | 0.441 | 08/31/2025 |
| 14 | iShares Biotechnology ETF | 455,502 | -33,541 | 11,988,812.64 | 0.1877 | 0.4076 | 09/30/2025 |
| 15 | Strategic Advisers Fidelity Emerging Markets Fund | 375,672 | -383,528 | 9,887,687.04 | 0.0316 | 0.3361 | 08/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RTW Investments LP | 5,536,876 | 2,400,196 | 145,730,576.32 | 1.5476 | 4.9541 | 06/30/2025 |
| 2 | ClearBridge Investments LLC | 4,011,956 | 732,389 | 105,594,681.92 | 0.0756 | 3.5897 | 06/30/2025 |
| 3 | Nan Fung Trinity (HK) Ltd. | 269,975 | 269,975 | 7,105,742 | 0.757 | 0.2416 | 06/30/2025 |
| 4 | StemPoint Capital LP | 250,438 | 224,017 | 6,591,528.16 | 1.4068 | 0.2241 | 06/30/2025 |
| 5 | Fidelity Management & Research Co. LLC | 4,724,362 | 206,804 | 124,345,207.84 | 0.0069 | 4.2271 | 06/30/2025 |
| 6 | Point72 Asset Management LP | 252,800 | 164,630 | 6,653,696 | 0.0123 | 0.2262 | 06/30/2025 |
| 7 | Renaissance Technologies LLC | 232,900 | 148,400 | 6,129,928 | 0.0075 | 0.2084 | 06/30/2025 |
| 8 | HSBC Bank Plc (Broker) | 158,254 | 133,254 | 4,165,245.28 | 0.0094 | 0.1416 | 06/30/2025 |
| 9 | Qube Research & Technologies Ltd. | 97,273 | 97,273 | 2,560,225.36 | 0.0034 | 0.087 | 06/30/2025 |
| 10 | BNP Paribas Financial Markets | 84,026 | 83,188 | 2,211,564.32 | 0.0015 | 0.0752 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Principal Global Investors LLC | 104,513 | -2,780,297 | 2,750,782.16 | 0.0013 | 0.0935 | 06/30/2025 |
| 2 | Morgan Stanley & Co. LLC | 204,050 | -2,244,163 | 5,370,596 | 0.0018 | 0.1826 | 06/30/2025 |
| 3 | T. Rowe Price Associates, Inc. (IM) | 153,037 | -2,114,274 | 4,027,933.84 | 0.0005 | 0.1369 | 06/30/2025 |
| 4 | Wellington Management Co. LLP | 1,058,838 | -1,935,243 | 27,868,616.16 | 0.0045 | 0.9474 | 06/30/2025 |
| 5 | Janus Henderson Investors US LLC | 2,193,181 | -1,614,754 | 57,724,523.92 | 0.0271 | 1.9624 | 06/30/2025 |
| 6 | RA Capital Management LP | 0 | -1,295,040 | 0 | 0 | 0 | |
| 7 | Allianz Global Investors Asia Pacific Ltd. | 932,000 | -936,469 | 24,530,240 | 0.2666 | 0.8339 | 06/30/2025 |
| 8 | Connor, Clark & Lunn Investment Management Ltd. | 387,362 | -621,658 | 10,195,367.84 | 0.029 | 0.3466 | 06/30/2025 |
| 9 | FIAM LLC | 1,310,361 | -387,509 | 34,488,701.52 | 0.0186 | 1.1724 | 06/30/2025 |
| 10 | Manulife Investment Management (US) LLC | 20,364 | -380,718 | 535,980.48 | 0.0004 | 0.0182 | 06/30/2025 |
Data provided by FactSet Research Systems Inc.