| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RTW Investments LP | 7,133,390 | 4,842,018 | 132,681,054 | 1.3353 | 6.3232 | 03/05/2026 |
| 2 | RA Capital Management LP | 5,743,533 | 5,743,533 | 106,829,713.8 | 1.0415 | 5.0912 | 03/30/2026 |
| 3 | ClearBridge Investments LLC | 1,808,035 | -1,711,302 | 33,629,451 | 0.0251 | 1.6027 | 12/31/2025 |
| 4 | Citadel Advisors LLC | 1,658,290 | 722,566 | 30,844,194 | 0.0289 | 1.4699 | 12/31/2025 |
| 5 | BAMCO, Inc. | 1,418,005 | 46,762 | 26,374,893 | 0.0687 | 1.257 | 12/31/2025 |
| 6 | Fidelity Management & Research Co. LLC | 1,277,410 | -2,836,280 | 23,759,826 | 0.0012 | 1.1323 | 12/31/2025 |
| 7 | Adar1 Capital Management LLC | 1,246,520 | 377,740 | 23,185,272 | 1.7178 | 1.1049 | 12/31/2025 |
| 8 | Rock Springs Capital Management LP | 811,546 | 20,353 | 15,094,755.6 | 0.8176 | 0.7194 | 12/31/2025 |
| 9 | BlackRock Fund Advisors | 608,579 | 163,584 | 11,319,569.4 | 0.0002 | 0.5395 | 12/31/2025 |
| 10 | T. Rowe Price Associates, Inc. (IM) | 602,954 | -345,717 | 11,214,944.4 | 0.0012 | 0.5345 | 12/31/2025 |
| 11 | Wellington Management Co. LLP | 595,969 | -692,712 | 11,085,023.4 | 0.0017 | 0.5283 | 12/31/2025 |
| 12 | C WorldWide Asset Management Fondsmaeglerselskab A/S | 510,000 | 0 | 9,486,000 | 0.1072 | 0.4521 | 03/31/2026 |
| 13 | C Worldwide Asset Management Fondsmaeglerselskab A/S (Sweden) | 510,000 | 0 | 9,486,000 | 0.5777 | 0.4521 | 06/30/2025 |
| 14 | UBS Securities LLC | 498,776 | 192,290 | 9,277,233.6 | 0.0034 | 0.4421 | 03/31/2026 |
| 15 | The B Group, Inc. | 400,000 | 0 | 7,440,000 | 6.0888 | 0.3546 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Government Pension Fund - Global (The) | 3,843,149 | 2,534,446 | 71,482,571.4 | 0.0039 | 3.4067 | 12/31/2025 |
| 2 | Baron Emerging Markets Fund | 1,397,386 | 190,065 | 25,991,379.6 | 0.6446 | 1.2387 | 03/31/2026 |
| 3 | iShares Biotechnology ETF | 600,987 | 142,294 | 11,178,358.2 | 0.1397 | 0.5327 | 04/30/2026 |
| 4 | Fidelity Growth Company Commingled Pool | 517,819 | 3,416 | 9,631,433.4 | 0.0076 | 0.459 | 03/31/2026 |
| 5 | C Worldwide - Healthcare Select | 510,000 | 0 | 9,486,000 | 1.3237 | 0.4521 | 06/30/2025 |
| 6 | Fidelity Growth Company Fund | 332,190 | -1,873 | 6,178,734 | 0.0064 | 0.2945 | 03/31/2026 |
| 7 | abrdn World Healthcare Fund | 237,739 | 237,739 | 4,421,945.4 | 0.7706 | 0.2107 | 03/31/2026 |
| 8 | T Rowe Price Health Sciences Fund | 213,174 | -524,732 | 3,965,036.4 | 0.0361 | 0.189 | 03/31/2026 |
| 9 | Tema Oncology ETF | 207,772 | 145,261 | 3,864,559.2 | 2.2089 | 0.1842 | 04/30/2026 |
| 10 | Fidelity Inv. Trust - Pacific Basin Fund | 162,700 | 0 | 3,026,220 | 0.2432 | 0.1442 | 03/31/2026 |
| 11 | Fidelity Growth Company K6 Fund | 132,791 | -4,143 | 2,469,912.6 | 0.0092 | 0.1177 | 03/31/2026 |
| 12 | Janus Henderson International Alpha Equity Collective Fund | 109,306 | 0 | 2,033,091.6 | 0.2578 | 0.0969 | 12/31/2024 |
| 13 | ALPS Medical Breakthroughs ETF | 108,612 | 66,619 | 2,020,183.2 | 1.2563 | 0.0963 | 04/30/2026 |
| 14 | Fidelity Series Growth Company Fund | 89,500 | -1,800 | 1,664,700 | 0.0066 | 0.0793 | 03/31/2026 |
| 15 | Vanguard International Explorer Fund | 85,899 | -47,869 | 1,597,721.4 | 0.0996 | 0.0761 | 01/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 5,743,533 | 5,743,533 | 106,829,713.8 | 1.0415 | 5.0912 | 03/30/2026 |
| 2 | RTW Investments LP | 7,133,390 | 4,842,018 | 132,681,054 | 1.3353 | 6.3232 | 03/05/2026 |
| 3 | Citadel Advisors LLC | 1,658,290 | 722,566 | 30,844,194 | 0.0289 | 1.4699 | 12/31/2025 |
| 4 | Jane Street Capital LLC | 382,062 | 382,062 | 7,106,353.2 | 0.0073 | 0.3387 | 12/31/2025 |
| 5 | Adar1 Capital Management LLC | 1,246,520 | 377,740 | 23,185,272 | 1.7178 | 1.1049 | 12/31/2025 |
| 6 | Walleye Capital LLC | 373,399 | 373,399 | 6,945,221.4 | 0.0268 | 0.331 | 12/31/2025 |
| 7 | JPMorgan Securities LLC (Investment Management) | 293,545 | 285,812 | 5,459,937 | 0.0034 | 0.2602 | 12/31/2025 |
| 8 | Bank of America, NA (Private Banking) | 373,926 | 242,557 | 6,955,023.6 | 0.0019 | 0.3315 | 12/31/2025 |
| 9 | abrdn, Inc. | 237,739 | 237,739 | 4,421,945.4 | 0.039 | 0.2107 | 03/31/2026 |
| 10 | D. E. Shaw & Co. LP | 238,609 | 204,319 | 4,438,127.4 | 0.0031 | 0.2115 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Capital Research & Management Co. (World Investors) | 0 | -6,077,666 | 0 | 0 | 0 | |
| 2 | Fidelity Management & Research Co. LLC | 1,277,410 | -2,836,280 | 23,759,826 | 0.0012 | 1.1323 | 12/31/2025 |
| 3 | Janus Henderson Investors US LLC | 0 | -2,044,924 | 0 | 0 | 0 | |
| 4 | ClearBridge Investments LLC | 1,808,035 | -1,711,302 | 33,629,451 | 0.0251 | 1.6027 | 12/31/2025 |
| 5 | Allianz Global Investors Asia Pacific Ltd. | 0 | -815,000 | 0 | 0 | 0 | |
| 6 | Wellington Management Co. LLP | 595,969 | -692,712 | 11,085,023.4 | 0.0017 | 0.5283 | 12/31/2025 |
| 7 | FIAM LLC | 296 | -425,025 | 5,505.6 | 0 | 0.0003 | 12/31/2025 |
| 8 | T. Rowe Price Associates, Inc. (IM) | 602,954 | -345,717 | 11,214,944.4 | 0.0012 | 0.5345 | 12/31/2025 |
| 9 | Legal & General Investment Management Ltd. | 67,858 | -314,601 | 1,262,158.8 | 0.0004 | 0.0602 | 03/31/2026 |
| 10 | Envestnet Asset Management, Inc. | 24,781 | -227,249 | 460,926.6 | 0.0001 | 0.022 | 03/31/2026 |
Data provided by FactSet Research Systems Inc.