| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RTW Investments LP | 12,117,985 | 5,543,953 | 308,766,257.8 | 2.8133 | 10.6501 | 10/07/2026 |
| 2 | RA Capital Management LP | 4,723,533 | -983,729 | 120,355,620.84 | 1.134 | 4.1514 | 08/13/2026 |
| 3 | Adar1 Capital Management LLC | 3,369,034 | 1,943,667 | 85,842,986.32 | 4.6661 | 2.9609 | 06/30/2026 |
| 4 | Goldman Sachs & Co. LLC (Private Banking) | 2,315,480 | 2,204,893 | 58,998,430.4 | 0.016 | 2.035 | 06/30/2026 |
| 5 | Woodline Partners LP | 2,207,293 | 2,207,293 | 56,241,825.64 | 0.1782 | 1.9399 | 06/30/2026 |
| 6 | BAMCO, Inc. | 1,623,694 | -34,624 | 41,371,723.12 | 0.0616 | 1.427 | 06/30/2026 |
| 7 | Fidelity Management & Research Co. LLC | 1,605,995 | 506,600 | 40,920,752.6 | 0.0021 | 1.4115 | 06/30/2026 |
| 8 | Two Sigma Investments LP | 1,299,394 | 989,671 | 33,108,559.12 | 0.0259 | 1.142 | 06/30/2026 |
| 9 | Citadel Advisors LLC | 1,284,706 | -287,102 | 32,734,308.88 | 0.0249 | 1.1291 | 06/30/2026 |
| 10 | FIAM LLC | 1,046,519 | 1,046,223 | 26,665,304.12 | 0.0108 | 0.9198 | 06/30/2026 |
| 11 | Rock Springs Capital Management LP | 814,707 | 0 | 20,758,734.36 | 1.0888 | 0.716 | 06/30/2026 |
| 12 | BlackRock Fund Advisors | 640,158 | -197,865 | 16,311,225.84 | 0.0003 | 0.5626 | 06/30/2026 |
| 13 | C WorldWide Asset Management Fondsmaeglerselskab A/S | 510,000 | 0 | 12,994,800 | 0.1852 | 0.4482 | 09/30/2026 |
| 14 | C Worldwide Asset Management Fondsmaeglerselskab A/S (Sweden) | 510,000 | 0 | 12,994,800 | 0.8158 | 0.4482 | 06/30/2026 |
| 15 | Jane Street Capital LLC | 476,541 | 208,615 | 12,142,264.68 | 0.008 | 0.4188 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Government Pension Fund - Global | 2,890,897 | -952,252 | 73,660,055.56 | 0.004 | 2.5407 | 06/30/2026 |
| 2 | Baron Emerging Markets Fund | 1,332,429 | -64,957 | 33,950,290.92 | 1.0343 | 1.171 | 09/30/2026 |
| 3 | iShares Biotechnology ETF | 741,195 | 140,208 | 18,885,648.6 | 0.1672 | 0.6514 | 10/30/2026 |
| 4 | Fidelity Growth Company Commingled Pool | 518,676 | 431 | 13,215,864.48 | 0.0111 | 0.4558 | 09/30/2026 |
| 5 | C Worldwide - Healthcare Select | 510,000 | 0 | 12,994,800 | 1.6882 | 0.4482 | 06/30/2026 |
| 6 | Fidelity Growth Company Fund | 331,780 | -410 | 8,453,754.4 | 0.0093 | 0.2916 | 09/30/2026 |
| 7 | Tema Oncology ETF | 156,963 | -50,809 | 3,999,417.24 | 1.8792 | 0.1379 | 10/30/2026 |
| 8 | abrdn World Healthcare Fund | 155,547 | -69,084 | 3,963,337.56 | 0.6335 | 0.1367 | 09/30/2026 |
| 9 | ALPS Medical Breakthroughs ETF | 137,696 | 29,084 | 3,508,494.08 | 1.8768 | 0.121 | 10/30/2026 |
| 10 | Fidelity Growth Company K6 Fund | 132,344 | -21 | 3,372,125.12 | 0.0129 | 0.1163 | 09/30/2026 |
| 11 | Virtus Biotech ETF | 102,699 | 49,443 | 2,616,770.52 | 1.9639 | 0.0903 | 10/30/2026 |
| 12 | Baron International Growth Fund | 81,821 | 0 | 2,084,799.08 | 0.677 | 0.0719 | 09/30/2026 |
| 13 | Destinations International Equity Fund | 71,804 | -3,762 | 1,829,565.92 | 0.1024 | 0.0631 | 09/30/2026 |
| 14 | Fidelity Series Growth Company Fund | 70,800 | -14,100 | 1,803,984 | 0.0082 | 0.0622 | 09/30/2026 |
| 15 | GBAM Funds SICAV - CGE - Tech Care Fund | 66,150 | 0 | 1,685,502 | 1.9801 | 0.0581 | 12/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RTW Investments LP | 12,117,985 | 5,543,953 | 308,766,257.8 | 2.8133 | 10.6501 | 10/07/2026 |
| 2 | Woodline Partners LP | 2,207,293 | 2,207,293 | 56,241,825.64 | 0.1782 | 1.9399 | 06/30/2026 |
| 3 | Goldman Sachs & Co. LLC (Private Banking) | 2,315,480 | 2,204,893 | 58,998,430.4 | 0.016 | 2.035 | 06/30/2026 |
| 4 | Adar1 Capital Management LLC | 3,369,034 | 1,943,667 | 85,842,986.32 | 4.6661 | 2.9609 | 06/30/2026 |
| 5 | FIAM LLC | 1,046,519 | 1,046,223 | 26,665,304.12 | 0.0108 | 0.9198 | 06/30/2026 |
| 6 | Two Sigma Investments LP | 1,299,394 | 989,671 | 33,108,559.12 | 0.0259 | 1.142 | 06/30/2026 |
| 7 | Fidelity Management & Research Co. LLC | 1,605,995 | 506,600 | 40,920,752.6 | 0.0021 | 1.4115 | 06/30/2026 |
| 8 | Spruce Street Capital LP | 279,110 | 279,110 | 7,111,722.8 | 1.4958 | 0.2453 | 06/30/2026 |
| 9 | Jane Street Capital LLC | 476,541 | 208,615 | 12,142,264.68 | 0.008 | 0.4188 | 06/30/2026 |
| 10 | Nantahala Capital Management LLC | 200,000 | 200,000 | 5,096,000 | 0.3229 | 0.1758 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 4,723,533 | -983,729 | 120,355,620.84 | 1.134 | 4.1514 | 08/13/2026 |
| 2 | UBS Securities LLC | 25,049 | -473,727 | 638,248.52 | 0.0002 | 0.022 | 06/30/2026 |
| 3 | T. Rowe Price Associates, Inc. (IM) | 0 | -291,639 | 0 | 0 | 0 | |
| 4 | Citadel Advisors LLC | 1,284,706 | -287,102 | 32,734,308.88 | 0.0249 | 1.1291 | 06/30/2026 |
| 5 | BlackRock Fund Advisors | 640,158 | -197,865 | 16,311,225.84 | 0.0003 | 0.5626 | 06/30/2026 |
| 6 | Fidelity Management & Research (Hong Kong) Ltd. | 0 | -162,700 | 0 | 0 | 0 | |
| 7 | Dimensional Fund Advisors LP | 0 | -151,426 | 0 | 0 | 0 | |
| 8 | Privium Fund Management BV | 0 | -132,189 | 0 | 0 | 0 | |
| 9 | Superstring Capital Management LP | 155,813 | -120,005 | 3,970,115.24 | 2.4927 | 0.1369 | 06/30/2026 |
| 10 | Citadel Securities LLC | 0 | -116,824 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.