| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RTW Investments LP | 6,574,032 | -385,000 | 153,306,426.24 | 1.2443 | 5.7777 | 03/31/2026 |
| 2 | RA Capital Management LP | 5,707,262 | 5,707,262 | 133,093,349.84 | 1.0077 | 5.0159 | 03/31/2026 |
| 3 | BAMCO, Inc. | 1,658,318 | 240,313 | 38,671,975.76 | 0.0936 | 1.4574 | 03/31/2026 |
| 4 | Citadel Advisors LLC | 1,571,808 | -86,482 | 36,654,562.56 | 0.0313 | 1.3814 | 03/31/2026 |
| 5 | Adar1 Capital Management LLC | 1,425,367 | 178,847 | 33,239,558.44 | 1.6706 | 1.2527 | 03/31/2026 |
| 6 | Fidelity Management & Research Co. LLC | 1,099,395 | -178,015 | 25,637,891.4 | 0.0012 | 0.9662 | 03/31/2026 |
| 7 | Rock Springs Capital Management LP | 814,707 | 3,161 | 18,998,967.24 | 0.9254 | 0.716 | 03/31/2026 |
| 8 | BlackRock Fund Advisors | 640,158 | 31,579 | 14,928,484.56 | 0.0003 | 0.5626 | 06/30/2026 |
| 9 | C WorldWide Asset Management Fondsmaeglerselskab A/S | 510,000 | 0 | 11,893,200 | 0.1513 | 0.4482 | 06/30/2026 |
| 10 | C Worldwide Asset Management Fondsmaeglerselskab A/S (Sweden) | 510,000 | 0 | 11,893,200 | 0.7004 | 0.4482 | 12/31/2025 |
| 11 | UBS Securities LLC | 498,776 | -1,283,451 | 11,631,456.32 | 0.004 | 0.4384 | 03/31/2026 |
| 12 | The B Group, Inc. | 450,646 | 50,646 | 10,509,064.72 | 6.114 | 0.3961 | 03/31/2026 |
| 13 | Schroder Investment Management Ltd. | 393,167 | 93,323 | 9,168,654.44 | 0.0033 | 0.3455 | 03/31/2026 |
| 14 | Nan Fung Trinity (HK) Ltd. | 346,466 | 76,491 | 8,079,587.12 | 0.7846 | 0.3045 | 06/30/2026 |
| 15 | abrdn, Inc. | 311,294 | 311,294 | 7,259,376.08 | 0.0634 | 0.2736 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Government Pension Fund - Global (The) | 3,843,149 | 0 | 89,622,234.68 | 0.0047 | 3.3776 | 12/31/2025 |
| 2 | Baron Emerging Markets Fund | 1,370,904 | 67,554 | 31,969,481.28 | 0.8435 | 1.2048 | 06/30/2026 |
| 3 | iShares Biotechnology ETF | 659,407 | 43,986 | 15,377,371.24 | 0.1575 | 0.5795 | 07/31/2026 |
| 4 | Strategic Advisers Fidelity Emerging Markets Fund | 614,333 | 614,333 | 14,326,245.56 | 0.0366 | 0.5399 | 06/30/2026 |
| 5 | Fidelity Growth Company Commingled Pool | 518,676 | 1,721 | 12,095,524.32 | 0.0093 | 0.4558 | 06/30/2026 |
| 6 | C Worldwide - Healthcare Select | 510,000 | 0 | 11,893,200 | 1.586 | 0.4482 | 12/31/2025 |
| 7 | Fidelity Series Emerging Markets Fund | 499,588 | 499,588 | 11,650,392.16 | 0.1482 | 0.4391 | 06/30/2026 |
| 8 | Fidelity Growth Company Fund | 331,780 | -410 | 7,737,109.6 | 0.0078 | 0.2916 | 06/30/2026 |
| 9 | abrdn World Healthcare Fund | 311,294 | 114,953 | 7,259,376.08 | 1.1142 | 0.2736 | 06/30/2026 |
| 10 | FIAM Select Emerging Markets Equity | 239,059 | 239,059 | 5,574,855.88 | 0.1412 | 0.2101 | 06/30/2026 |
| 11 | Fidelity Inv. Trust - Pacific Basin Fund | 162,700 | 0 | 3,794,164 | 0.3042 | 0.143 | 06/30/2026 |
| 12 | Tema Oncology ETF | 157,648 | 51,090 | 3,676,351.36 | 1.807 | 0.1386 | 07/31/2026 |
| 13 | Fidelity Strategic Advisers Emerging Markets Fund | 155,900 | 155,900 | 3,635,588 | 0.0236 | 0.137 | 06/30/2026 |
| 14 | Fidelity Growth Company K6 Fund | 132,344 | -1,311 | 3,086,262.08 | 0.0111 | 0.1163 | 06/30/2026 |
| 15 | ALPS Medical Breakthroughs ETF | 118,855 | 18,964 | 2,771,698.6 | 1.2893 | 0.1045 | 07/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 5,707,262 | 5,707,262 | 133,093,349.84 | 1.0077 | 5.0159 | 03/31/2026 |
| 2 | abrdn, Inc. | 311,294 | 311,294 | 7,259,376.08 | 0.0634 | 0.2736 | 06/30/2026 |
| 3 | Citigroup Global Markets, Inc. (Investment Management) | 300,775 | 296,780 | 7,014,073 | 0.0034 | 0.2643 | 06/30/2026 |
| 4 | Two Sigma Investments LP | 309,723 | 280,200 | 7,222,740.36 | 0.0052 | 0.2722 | 03/31/2026 |
| 5 | BAMCO, Inc. | 1,658,318 | 240,313 | 38,671,975.76 | 0.0936 | 1.4574 | 03/31/2026 |
| 6 | Tidal Investments LLC | 183,691 | 183,691 | 4,283,674.12 | 0.0107 | 0.1614 | 03/31/2026 |
| 7 | Adar1 Capital Management LLC | 1,425,367 | 178,847 | 33,239,558.44 | 1.6706 | 1.2527 | 03/31/2026 |
| 8 | Schroder Investment Management Ltd. | 393,167 | 93,323 | 9,168,654.44 | 0.0033 | 0.3455 | 03/31/2026 |
| 9 | Citadel Securities LLC | 116,824 | 87,268 | 2,724,335.68 | 0.0055 | 0.1027 | 03/31/2026 |
| 10 | Superstring Capital Management LP | 275,818 | 78,965 | 6,432,075.76 | 3.5326 | 0.2424 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | ClearBridge Investments LLC | 0 | -1,808,035 | 0 | 0 | 0 | |
| 2 | UBS Securities LLC | 498,776 | -1,283,451 | 11,631,456.32 | 0.004 | 0.4384 | 03/31/2026 |
| 3 | Wellington Management Co. LLP | 0 | -595,969 | 0 | 0 | 0 | |
| 4 | RTW Investments LP | 6,574,032 | -385,000 | 153,306,426.24 | 1.2443 | 5.7777 | 03/31/2026 |
| 5 | Bank of America, NA (Private Banking) | 0 | -373,926 | 0 | 0 | 0 | |
| 6 | Walleye Capital LLC | 0 | -373,399 | 0 | 0 | 0 | |
| 7 | Legal & General Investment Management Ltd. | 67,858 | -317,786 | 1,582,448.56 | 0.0005 | 0.0596 | 03/31/2026 |
| 8 | T. Rowe Price Associates, Inc. (IM) | 291,639 | -311,315 | 6,801,021.48 | 0.0007 | 0.2563 | 03/31/2026 |
| 9 | JPMorgan Securities LLC (Investment Management) | 6,777 | -286,768 | 158,039.64 | 0.0001 | 0.006 | 03/31/2026 |
| 10 | Marshall Wace LLP | 0 | -231,802 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.