| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RTW Investments LP | 6,574,032 | 4,282,660 | 120,764,967.84 | 1.0566 | 5.7966 | 03/31/2026 |
| 2 | RA Capital Management LP | 5,707,262 | 5,707,262 | 104,842,402.94 | 0.8911 | 5.0323 | 03/31/2026 |
| 3 | BAMCO, Inc. | 1,658,318 | 287,075 | 30,463,301.66 | 0.0775 | 1.4622 | 03/31/2026 |
| 4 | Citadel Advisors LLC | 1,571,808 | 636,084 | 28,874,112.96 | 0.0262 | 1.3859 | 03/31/2026 |
| 5 | Adar1 Capital Management LLC | 1,425,367 | 556,587 | 26,183,991.79 | 1.4537 | 1.2568 | 03/31/2026 |
| 6 | Fidelity Management & Research Co. LLC | 1,099,395 | -3,014,295 | 20,195,886.15 | 0.001 | 0.9694 | 03/31/2026 |
| 7 | BlackRock Fund Advisors | 838,023 | 393,028 | 15,394,482.51 | 0.0003 | 0.7389 | 03/31/2026 |
| 8 | Rock Springs Capital Management LP | 814,707 | 23,514 | 14,966,167.59 | 0.7797 | 0.7184 | 03/31/2026 |
| 9 | C WorldWide Asset Management Fondsmaeglerselskab A/S | 510,000 | 0 | 9,368,700 | 0.1073 | 0.4497 | 03/31/2026 |
| 10 | C Worldwide Asset Management Fondsmaeglerselskab A/S (Sweden) | 510,000 | 0 | 9,368,700 | 0.5784 | 0.4497 | 06/30/2025 |
| 11 | UBS Securities LLC | 498,776 | 192,290 | 9,162,515.12 | 0.0033 | 0.4398 | 03/31/2026 |
| 12 | The B Group, Inc. | 450,646 | 50,646 | 8,278,367.02 | 5.4412 | 0.3974 | 03/31/2026 |
| 13 | Schroder Investment Management Ltd. | 393,167 | 236,106 | 7,222,477.79 | 0.0028 | 0.3467 | 03/31/2026 |
| 14 | Nan Fung Trinity (HK) Ltd. | 346,466 | 76,491 | 6,364,580.42 | 0.6275 | 0.3055 | 03/31/2026 |
| 15 | Two Sigma Investments LP | 309,723 | 309,723 | 5,689,611.51 | 0.0043 | 0.2731 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Government Pension Fund - Global (The) | 3,843,149 | 2,534,446 | 70,598,647.13 | 0.0039 | 3.3886 | 12/31/2025 |
| 2 | Baron Emerging Markets Fund | 1,397,386 | 190,065 | 25,669,980.82 | 0.6364 | 1.2321 | 04/30/2026 |
| 3 | Strategic Advisers Fidelity Emerging Markets Fund | 1,090,509 | 1,090,509 | 20,032,650.33 | 0.0483 | 0.9615 | 04/30/2026 |
| 4 | Fidelity Series Emerging Markets Fund | 894,582 | 894,582 | 16,433,471.34 | 0.2026 | 0.7888 | 04/30/2026 |
| 5 | iShares Biotechnology ETF | 597,406 | 34,185 | 10,974,348.22 | 0.1312 | 0.5268 | 05/29/2026 |
| 6 | Fidelity Growth Company Commingled Pool | 518,245 | 3,842 | 9,520,160.65 | 0.0076 | 0.457 | 04/30/2026 |
| 7 | C Worldwide - Healthcare Select | 510,000 | 0 | 9,368,700 | 1.2516 | 0.4497 | 06/30/2025 |
| 8 | FIAM Select Emerging Markets Equity | 467,051 | 467,051 | 8,579,726.87 | 0.2108 | 0.4118 | 04/30/2026 |
| 9 | Fidelity Growth Company Fund | 332,190 | -1,873 | 6,102,330.3 | 0.0064 | 0.2929 | 04/30/2026 |
| 10 | Fidelity Strategic Advisers Emerging Markets Fund | 304,300 | 304,300 | 5,589,991 | 0.0327 | 0.2683 | 04/30/2026 |
| 11 | abrdn World Healthcare Fund | 240,888 | 240,888 | 4,425,112.56 | 0.7234 | 0.2124 | 05/31/2026 |
| 12 | T Rowe Price Health Sciences Fund | 213,174 | -524,732 | 3,916,006.38 | 0.0335 | 0.188 | 03/31/2026 |
| 13 | Tema Oncology ETF | 196,972 | 131,575 | 3,618,375.64 | 2.0019 | 0.1737 | 05/29/2026 |
| 14 | Fidelity Inv. Trust - Pacific Basin Fund | 162,700 | 0 | 2,988,799 | 0.2401 | 0.1435 | 04/30/2026 |
| 15 | Fidelity Growth Company K6 Fund | 132,365 | -4,569 | 2,431,545.05 | 0.0092 | 0.1167 | 04/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 5,707,262 | 5,707,262 | 104,842,402.94 | 0.8911 | 5.0323 | 03/31/2026 |
| 2 | RTW Investments LP | 6,574,032 | 4,282,660 | 120,764,967.84 | 1.0566 | 5.7966 | 03/31/2026 |
| 3 | Citadel Advisors LLC | 1,571,808 | 636,084 | 28,874,112.96 | 0.0262 | 1.3859 | 03/31/2026 |
| 4 | Adar1 Capital Management LLC | 1,425,367 | 556,587 | 26,183,991.79 | 1.4537 | 1.2568 | 03/31/2026 |
| 5 | BlackRock Fund Advisors | 838,023 | 393,028 | 15,394,482.51 | 0.0003 | 0.7389 | 03/31/2026 |
| 6 | Two Sigma Investments LP | 309,723 | 309,723 | 5,689,611.51 | 0.0043 | 0.2731 | 03/31/2026 |
| 7 | BAMCO, Inc. | 1,658,318 | 287,075 | 30,463,301.66 | 0.0775 | 1.4622 | 03/31/2026 |
| 8 | Jane Street Capital LLC | 267,926 | 267,926 | 4,921,800.62 | 0.0043 | 0.2362 | 03/31/2026 |
| 9 | Columbia Management Investment Advisers LLC | 243,557 | 243,557 | 4,474,142.09 | 0.001 | 0.2148 | 03/31/2026 |
| 10 | abrdn, Inc. | 237,739 | 237,739 | 4,367,265.43 | 0.038 | 0.2096 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Capital Research & Management Co. (World Investors) | 0 | -6,077,666 | 0 | 0 | 0 | |
| 2 | ClearBridge Investments LLC | 0 | -3,519,337 | 0 | 0 | 0 | |
| 3 | Fidelity Management & Research Co. LLC | 1,099,395 | -3,014,295 | 20,195,886.15 | 0.001 | 0.9694 | 03/31/2026 |
| 4 | Janus Henderson Investors US LLC | 0 | -2,044,924 | 0 | 0 | 0 | |
| 5 | Wellington Management Co. LLP | 0 | -1,288,681 | 0 | 0 | 0 | |
| 6 | Allianz Global Investors Asia Pacific Ltd. | 0 | -815,000 | 0 | 0 | 0 | |
| 7 | T. Rowe Price Associates, Inc. (IM) | 291,639 | -657,032 | 5,357,408.43 | 0.0006 | 0.2571 | 03/31/2026 |
| 8 | FIAM LLC | 296 | -425,025 | 5,437.52 | 0 | 0.0003 | 03/31/2026 |
| 9 | Legal & General Investment Management Ltd. | 67,858 | -314,601 | 1,246,551.46 | 0.0004 | 0.0598 | 03/31/2026 |
| 10 | Envestnet Asset Management, Inc. | 24,781 | -227,249 | 455,226.97 | 0.0001 | 0.0219 | 03/31/2026 |
Data provided by FactSet Research Systems Inc.